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Placental release of distinct DNA-associated micro-particles into maternal circulation: reflective of gestation time and preeclampsia.

Abstract：

BACKGROUND:The aim of this study was to determine whether DNA-associated micro-particles (MPs) in maternal plasma express fetal-derived human leukocyte antigen-G (HLA-G) or placental alkaline phosphatase (PLAP) and whether the levels differ between women with normotensive pregnancies and preeclampsia. METHODS:DNA-associated MPs expressing HLA-G or PLAP were examined in the plasma of normal pregnant women and preeclamptic patients using flow cytometric analysis. RESULTS:DNA-associated HLA-G(+) MPs were significantly increased in maternal plasma compared to plasma from non-pregnant controls (p<0.005), with highest levels found in the first and second trimesters. DNA-associated PLAP(+) MPs were also increased in maternal plasma compared to plasma from non-pregnant controls (p<0.006), with highest levels in the second and third trimesters. Term preeclamptic women had higher levels of DNA-associated MPs than control pregnant women. HLA-G(+) MPs from the plasma of preeclamptic women had more DNA per MP than HLA-G(+) MPs from the plasma of normal pregnant women (p<0.03). CONCLUSIONS:HLA-G(+) and PLAP(+) MPs increase in maternal circulation at different times during gestation. DNA amounts per HLA-G(+) MP increase in preeclamptic women which might indicate dysfunctional extravillous cytotrophoblasts.

journal_name

Placenta

journal_title

Placenta

authors

Orozco AF,Jorgez CJ,Ramos-Perez WD,Popek EJ,Yu X,Kozinetz CA,Bischoff FZ,Lewis DE

doi

10.1016/j.placenta.2009.06.012

subject

Has Abstract

pub_date

2009-10-01 00:00:00

pages

891-7

issue

10

eissn

0143-4004

issn

1532-3102

pii

S0143-4004(09)00210-0

journal_volume

30

pub_type

杂志文章

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