Review: Differential placental macrovascular and microvascular endothelial dysfunction in gestational diabetes.

abstract：INTRODUCTION:The objective of this study was to explore serum levels of differentially abundant proteins between women with hypertensive disorders of pregnancy (HDP) and women with normal-term pregnancy, and to explore the contribution of SH3BGRL3 to the pathogenesis of HDP. METHODS:At 6-20 weeks gestation 48 pregnant...

journal_title：Placenta

authors： Jiang M,Lash GE,Zeng S,Liu F,Han M,Long Y,Cai M,Hou H,Ning F,Hu Y,Yang H

更新日期：2020-11-14 00:00:00

abstract：:The implantation of the blastocyst and early development of the placenta are crucial for the success of implantation and pregnancy. However, the formative stages of human placental development are largely unknown because of their existence in a 'black box' where access to samples is extremely limited for ethical reaso...

journal_title：Placenta

authors： James JL,Carter AM,Chamley LW

更新日期：2012-05-01 00:00:00

abstract：:Changes in placental lipid content in rats at the 15th and 20th days of pregnancy were investigates. It was found that progress of gestation is accompanied by a significant increase in triglycerides per mg placental DNA. Maternal starvation caused additional increase in the placental triglyceride content. By incubatio...

journal_title：Placenta

authors： Diamant YZ,Diamant S,Freinkel N

更新日期：1980-10-01 00:00:00

abstract：INTRODUCTION:Placental blood flow is closely associated with fetal growth and wellbeing. Recent studies suggest that there are differences in blood flow between male and female fetuses. We hypothesized that sexual dimorphism exists in fetal and placental blood flow at 22-24 weeks of gestation. METHODS:This was a prosp...

journal_title：Placenta

authors： Widnes C,Flo K,Acharya G

更新日期：2017-01-01 00:00:00

abstract：OBJECTIVE:Receptor-activator of NF-κB ligand (TNFSF11, also known as RANKL) and its receptor RANK are essential regulators on bone remodeling, mammary gland development and hormone-associated breast cancer development. However, the expression pattern and role of RANKL/RANK axis in decidual stromal cells (DSCs) are uncl...

journal_title：Placenta

authors： Meng YH,Li H,Chen X,Liu LB,Shao J,Chang KK,Du MR,Jin LP,Li MQ,Li DJ

更新日期：2013-08-01 00:00:00

abstract：:Stereological methods were used to test whether or not altitudinal, ethnic and sex differences in birthweight in Bolivia are associated with differences in placental morphology. Estimates of the volumes, surface areas, lengths and diameters of villi and of fetal capillaries were obtained by analysing paraffin sections...

journal_title：Placenta

authors： Jackson MR,Mayhew TM,Haas JD

更新日期：1987-09-01 00:00:00

abstract：:The ontogeny of Ia antigen expression on cells within the decidua basalis of the placenta and on decidual cells differentiating in vitro was investigated in the mouse. The results indicate that Ia antigen expression is temporarily restricted and can be detected in short-term cultures of decidual tissue only during the...

journal_title：Placenta

authors： Searle RF,Bell SC,Billington WD

更新日期：1983-04-01 00:00:00

abstract：INTRODUCTION:The pro-inflammatory mediator and potent vasoconstrictor Endothelin-1 (ET-1) is known to be expressed in the placenta. We have recently demonstrated that very low, non-toxic doses of carbon monoxide (CO), prevented infection-induced preterm birth in mice. However the effect(s) of CO on human gestational ti...

journal_title：Placenta

authors： Olgun NS,Arita Y,Hanna M,Murthy A,Tristan S,Peltier MR,Hanna N

更新日期：2014-06-01 00:00:00

abstract：OBJECTIVES:The antiphospholipid syndrome (APS) is characterized by the presence of circulating antiphospholipid antibodies (aPLs), is a leading cause for thromboembolic events, repeated miscarriage, fetal loss and is a major risk factor for fetal growth restriction (FGR) and preeclampsia. In human, anti-β2 glycoprotein...

journal_title：Placenta

authors： Kawaguchi R,Nunomura S,Umehara N,Nikaido T,Huppertz B,Tanaka T,Ra C

更新日期：2012-07-01 00:00:00

abstract：:Abnormalities in glucose metabolism linked to D-chiro-inostol phosphoglycans (IPGs) have been described in human placentas of preeclamptic women. In this study, a semi-quantitative approach to assess the histological assessment of IPGs revealed no significant differences between early and late onset preeclampsia and g...

journal_title：Placenta

authors： Scioscia M,Siwetz M,Fascilla F,Huppertz B

更新日期：2012-10-01 00:00:00

abstract：:Respiratory parameters were studied in mitochondria from human placenta. Respiratory control and ADP/O ratios were low in this preparation. The adenine nucleotide content of placental mitochondria was found to be only one quarter of that found for adult uterine muscle tissue mitochondria prepared in the same way. Load...

journal_title：Placenta

authors： Illsley NP,Coade SB,Harkness RA

更新日期：1985-05-01 00:00:00

abstract：:Spatial arrangement of the capillary bed, manifestations of its growth and symmetry of capillary branching were studied in peripheral villi of normal human placenta at term using confocal microscopy and image analysis. Unlike the model that has been accepted so far, it was shown that the arrangement of the capillary b...

journal_title：Placenta

authors： Jirkovská M,Janácek J,Kaláb J,Kubínová L

更新日期：2008-10-01 00:00:00

abstract：BACKGROUND:Previous studies have shown that pregnancies complicated by placentas with an isolated single umbilical artery (iSUA) are at increased risk for small-for-gestational-age (SGA) births. The etiology of SGA in this population, however, remains unknown. OBJECTIVE:The primary objective of this study was to evalu...

journal_title：Placenta

authors： Battarbee AN,Palatnik A,Ernst LM,Grobman WA

更新日期：2017-11-01 00:00:00

abstract：:Fetoplacental blood vessel constriction in response to reduced oxygenation has been demonstrated in placenta perfused in vitro. In pulmonary vessels, hypoxic vasoconstriction involves Ca2+ influx into smooth muscle through membrane ion channels including voltage-gated Ca2+ channels (VGCCs). We hypothesised that VGCCs ...

journal_title：Placenta

authors： Cooper EJ,Wareing M,Greenwood SL,Baker PN

更新日期：2006-04-01 00:00:00

abstract：INTRODUCTION:We investigated the feasibility of dynamic glucose enhanced (DGE) MRI in accessing placental function in a mouse model of intrauterine inflammatory injury (IUI). DGE uses the glucose chemical exchange saturation transfer (glucoCEST) effect to reflect infused d-glucose. METHODS:IUI was induced in pregnant ...

journal_title：Placenta

authors： Wu D,Xu J,Lei J,Mclane M,van Zijl PC,Burd I

更新日期：2018-09-01 00:00:00

abstract：:Placental endoplasmic reticulum (ER) stress has been postulated in the pathophysiology of pre-eclampsia (PE) and intrauterine growth restriction (IUGR), but its activation remains elusive. Oxidative stress induced by ischaemia/hypoxia-reoxygenation activates ER stress in vitro. Here, we explored whether exposure to la...

journal_title：Placenta

authors： Veerbeek JH,Tissot Van Patot MC,Burton GJ,Yung HW

更新日期：2015-01-01 00:00:00

abstract：:Abnormal maternal lipid profiles, a hallmark of increased maternal adiposity, are associated with pregnancy complications such as preeclampsia and gestational diabetes, and offspring long-term metabolic health is impacted as the consequence of altered fetal growth, physiology and often iatrogenic prematurity. The meta...

journal_title：Placenta

authors： Delhaes F,Giza SA,Koreman T,Eastabrook G,McKenzie CA,Bedell S,Regnault TRH,de Vrijer B

更新日期：2018-09-01 00:00:00

abstract：INTRODUCTION:Statins induce heme oxygenase-1 (HO-1) expression in vitro and in vivo. Low HO-1 expression is associated with pregnancy complications, e.g. preeclampsia and recurrent miscarriages. Here, we investigated the effects of pravastatin on HO-1 expression, placental development, and fetal survival in mice with a...

journal_title：Placenta

authors： Tsur A,Kalish F,Burgess J,Nayak NR,Zhao H,Casey KM,Druzin ML,Wong RJ,Stevenson DK

更新日期：2019-01-01 00:00:00

abstract：:Preeclampsia (PE) is a serious pregnancy-related syndrome, which is characterized by gestational hypertension and proteinuria. The microRNA-93 (miR-93) is upregulated in the maternal plasma of patients with PE. However, the functional role of miR-93 in PE remains unknown. Here, we identified that miR-93 inhibits troph...

journal_title：Placenta

authors： Pan Q,Niu H,Cheng L,Li X,Zhang Q,Ning Y

更新日期：2017-05-01 00:00:00

abstract：:The establishment of an appropriate fetomaternal vessel system is a prerequisite for prevention of pregnancy associated pathologies. Notch receptors and ligands are manifoldly involved in vascular development and angiogenesis. To further characterize the process of human placental vasculo- and angiogenesis we investig...

journal_title：Placenta

authors： Herr F,Schreiner I,Baal N,Pfarrer C,Zygmunt M

更新日期：2011-08-01 00:00:00

abstract：:Placental protein 5 (PP5)/tissue factor pathway inhibitor-2 (TFPI-2), a serine proteinase inhibitor, is homologous to tissue factor pathway inhibitor (TFPI) and commonly found in peripheral blood of pregnant woman. Although TFPI is well known to be synthesized primarily in endothelium and to play an important role in ...

journal_title：Placenta

authors： Udagawa K,Yasumitsu H,Esaki M,Sawada H,Nagashima Y,Aoki I,Jin M,Miyagi E,Nakazawa T,Hirahara F,Miyazaki K,Miyagi Y

更新日期：2002-02-01 00:00:00

abstract：:The expression pattern of MHC class I genes in trophoblast cells at the feto-maternal interface is thought to be the basis of the maintenance of pregnancy by protecting the fetus from maternal immune rejection. Transcription of classical HLA class I genes is low or undetectable in most trophoblast cells as well as in ...

journal_title：Placenta

authors： Lefebvre S,Moreau P,Dausset J,Carosella ED,Paul P

更新日期：1999-05-01 00:00:00

abstract：:Matrix metalloproteinases (MMPs) are involved in placental remodelling throughout pregnancy. Diabetes mellitus induces alterations in tissue production of NO, a regulator of MMPs activity. The present work evaluates placental and fetal MMPs and NO levels during midpregnancy in neonatal streptozotocin-induced diabetic ...

journal_title：Placenta

authors： Pustovrh MC,Jawerbaum A,Capobianco E,White V,López-Costa JJ,González E

更新日期：2005-04-01 00:00:00

abstract：:In the present study the possible role of decidual cells in the pregnancy-associated increased sensitivity of glomerular ecto-ADP-ase to endotoxin was investigated. Early (day 5) pregnant (E-Pr; n = 10), pseudopregnant (E-PSP; n = 10), (day 5), pseudopregnant rats with a decidualized uterus (E-DEC; n - 10), as well as...

journal_title：Placenta

authors： Faas MM,Schuiling GA,Baller JF,Valkhof N,Bakker WW

更新日期：1996-03-01 00:00:00

abstract：INTRODUCTION:Abnormally invasive placenta (AIP) is a rare pregnancy complication often resulting in postpartum haemorrhage (PPH) and emergency peripartum hysterectomy (EPH). The risk of developing post traumatic stress disorder (PTSD) following unexpectedly traumatic childbirth is known however there is no evidence reg...

journal_title：Placenta

authors： Tol ID,Yousif M,Collins SL

更新日期：2019-06-01 00:00:00

abstract：INTRODUCTION:Preeclampsia is one of the main causes of morbidity and mortality in pregnant women and mothers. Numerous studies showed that microRNAs (miRNAs) played important roles in the occurrence and development of preeclampsia. However, the regulation of microRNA-142-3p (miR-142-3p) in preeclampsia has not been cla...

journal_title：Placenta

authors： Mao Y,Hou B,Shan L,Sun X,Wang L

更新日期：2021-01-06 00:00:00

abstract：OBJECTIVE:To evaluate umbilical cord abnormalities predisposing to mechanical cord compression and determine their relationship to adverse clinical outcomes and stasis-associated histologic changes in the placenta. METHODS:Placental slides of 224 singleton pregnancies with gross cord abnormality (true knots, long cord...

journal_title：Placenta

authors： Tantbirojn P,Saleemuddin A,Sirois K,Crum CP,Boyd TK,Tworoger S,Parast MM

更新日期：2009-12-01 00:00:00

abstract：:The aim of our work was to investigate the presence of non-selective cation channels (NSCC) in freshly isolated smooth muscle cells from the human umbilical artery (HUA), one of the vessels involved in fetal-placental circulation. We studied the electrophysiological properties of NSCC using the patch-clamp technique i...

journal_title：Placenta

authors： Raingo J,Rebolledo A,Iveli F,Grassi de Gende AO,Milesi V

更新日期：2004-09-01 00:00:00

abstract：:A rapid method to determine quality for placental proteomic studies is required due to varying lengths of time between delivery and sampling in routine protocols. We developed a rapid 10 min LC-MS based scanning method to profile free peptides liberated from natural proteolytic degradation. The assay was applied to pl...

journal_title：Placenta

authors： Heywood WE,Pryce J,Virasami A,Preece RL,Dezateux C,Mills K,Sebire NJ

更新日期：2016-08-01 00:00:00

abstract：:Physiological data indicate that both a transcellular and a paracellular pathway are available for transfer across the human placenta but the morphological correlate of the latter is uncertain. We measured the permeability of the dually perfused human placental cotyledon to the predominantly cationic protein horseradi...

journal_title：Placenta

authors： Edwards D,Jones CJ,Sibley CP,Nelson DM

更新日期：1993-01-01 00:00:00