Regulation of hypoxia inducible factors (HIF) in hypoxia and normoxia during placental development.

abstract：INTRODUCTION:Umbilical artery (UA) hemodynamics reflect blood flow and vascular resistance in the placental circulation. We examined non-invasively the hemodynamic effects of propofol, etomidate, and alphaxalone on the placental circulation of a sheep model by means of UA Doppler ultrasonography. METHODS:Eleven sheep ...

journal_title：Placenta

authors： Domínguez E,Rivera Del Álamo MM,Novellas R,Espada Y,Santos L,García F,Andaluz A,Fresno L

更新日期：2013-09-01 00:00:00

abstract：INTRODUCTION:Preeclampsia is characterized by maternal endothelial dysfunction. While the mechanisms leading to preeclampsia are unclear, a factor(s) from the placenta is responsible for triggering the disease. One placental factor implicated in triggering preeclampsia is trophoblast debris which may transmit pathogeni...

journal_title：Placenta

authors： Shen F,Wei J,Snowise S,DeSousa J,Stone P,Viall C,Chen Q,Chamley L

更新日期：2014-10-01 00:00:00

abstract：:Twinning and placental fusion occur at a low frequency in species like humans and mice. They are linked to reduced birth weight and intertwin growth discrepancy with important consequences for perinatal survival. Despite this, little is known about the histological characteristics of the twin or fused placenta and how...

journal_title：Placenta

authors： Lopez-Tello J,Sferruzzi-Perri AN

更新日期：2020-11-02 00:00:00

abstract：:Direct measurements of electrical potential and input resistance were performed on the syncytial membrane facing maternal blood. The potentials varied according to the external potassium ion levels and, to a lesser extent, with sodium ion concentrations. Ouabain provoked a rapid and consistent depolarization which ind...

journal_title：Placenta

authors： Bara M,Challier JC,Guiet-Bara A

更新日期：1988-03-01 00:00:00

abstract：:The placenta provides all energy and nutrient requirements for healthy fetal development. The placenta in rats is capable of storing glycogen, although the placenta cells must therefore mobilize stored glycogen to its own glucose supply. Moreover, maternal glucose and/or placental lactate furnished the fetal growth. A...

journal_title：Placenta

authors： Toledo MT,Gomes Marcondes MC

更新日期：2004-05-01 00:00:00

abstract：:Vascularization within the human placenta is the result of the de novo formation of vessels derived from pluripotent precursor cells in the mesenchymal core of the villi. Vascularization of placental villi starts at around day 21 post conception (p.c.) with a four somite embryo. At this stage progenitors of haemangiog...

journal_title：Placenta

authors： Demir R,Kayisli UA,Seval Y,Celik-Ozenci C,Korgun ET,Demir-Weusten AY,Huppertz B

更新日期：2004-07-01 00:00:00

abstract：:Placental stem cells are of growing interest for a variety of clinical applications due to their multipotency and ready availability from otherwise frequently discarded biomaterial. Stem cells derived from the placenta have been investigated in a number of disease processes, including wound healing, ischemic heart dis...

journal_title：Placenta

authors： Vanover M,Wang A,Farmer D

更新日期：2017-11-01 00:00:00

abstract：:Placental ultrasonographic, bio- and histochemical studies were performed on four unrelated fetuses affected with Niemann-Pick disease Type A, following prostaglandin-induced abortion at about the 19th week of gestation. An accumulation of sphingomyelin in the placentae of affected fetuses indicates the essential role...

journal_title：Placenta

authors： Schoenfeld A,Abramovici A,Klibanski C,Ovadia J

更新日期：1985-01-01 00:00:00

abstract：INTRODUCTION:Alcohol consumption is a common social practice among women of childbearing age. With 50% of pregnancies being unplanned, many embryos are exposed to alcohol prior to pregnancy recognition and formation of the placenta. The effects of periconceptional (PC) alcohol exposure on the placenta are unknown. MET...

journal_title：Placenta

authors： Gårdebjer EM,Cuffe JS,Pantaleon M,Wlodek ME,Moritz KM

更新日期：2014-01-01 00:00:00

abstract：OBJECTIVE:To investigate whether telomere shortening may play a role in senescence of the placenta. STUDY DESIGN:Villous tissue was collected from single, random sites of full-term placentas (39-41 weeks of gestation; n=10) as well as multiple, specific sites of the same placenta (39-41 weeks of gestation; n=5). For t...

journal_title：Placenta

authors： Allsopp R,Shimoda J,Easa D,Ward K

更新日期：2007-04-01 00:00:00

abstract：INTRODUCTION:Elevated circulating soluble FLT1 (sFLT1) levels seen in preeclampsia may play a role in its development. Aspirin is recommended for prevention of preeclampsia. We hypothesized that aspirin may inhibit the production of sFlt1. METHODS:Placentas from women with and without preeclampsia were collected. Prim...

journal_title：Placenta

authors： Li C,Raikwar NS,Santillan MK,Santillan DA,Thomas CP

更新日期：2015-04-01 00:00:00

abstract：:Embryo implantation in the human and rodents relies on the trophoblast's ability to invade into the uterine stroma, partly depending on proteinases degrading components of basement membrane and underlying extracellular matrix (ECM). We have utilized mouse trophoblast stem (TS) cells (Science, 1998, 282:2072) to study ...

journal_title：Placenta

authors： Lei T,Hohn HP,Behr R,Denker HW

更新日期：2007-01-01 00:00:00

abstract：:We have investigated whether maternal peripheral blood from the first trimester of pregnancy is a reliable source of identifiable trophoblast cells. The cells were enriched from 30 ml of venous blood, with multiple antibodies shown previously to enrich trophoblasts and a new cocktail based on known trophoblast surface...

journal_title：Placenta

authors： Schueler PA,Yamanishi DT,Pearson J,Lee Y,Wu X,Hashima S,Madlansacay MR,Cain CA,Collarini EJ,Foltz L,Mahoney W

更新日期：2001-09-01 00:00:00

abstract：:Intrauterine growth and development can impact upon the long-term health of an individual. The fetus is dependent upon the placenta for its supply of nutrients and oxygen from the mother. In turn, the functional capacity of the placenta to supply that demand is under the control of the fetal and maternal genomes. Rece...

journal_title：Placenta

authors： Angiolini E,Fowden A,Coan P,Sandovici I,Smith P,Dean W,Burton G,Tycko B,Reik W,Sibley C,Constância M

更新日期：2006-04-01 00:00:00

abstract：:ED(27) trophoblast-like cells were prepared from human chorionic villus samples obtained at 9 weeks gestation and have been grown continuously in vitro without phenotypic drift for nearly a decade. These cells express many trophoblast markers, including cytokeratin, placental alkaline phosphatase (PLAP), secretion of ...

journal_title：Placenta

authors： Kniss DA,Xie Y,Li Y,Kumar S,Linton EA,Cohen P,Fan-Havard P,Redman CW,Sargent IL

更新日期：2002-01-01 00:00:00

abstract：:The mechanism of iron release from the placenta into the fetal circulation is not well understood. Ceruloplasmin, a plasma ferroxidase, has been implicated in iron efflux from a variety of cell types. The hypothesis is that circulating ceruloplasmin facilitates iron efflux by oxidizing the released Fe(II) to Fe(III) f...

journal_title：Placenta

authors： Danzeisen R,Ponnambalam S,Lea RG,Page K,Gambling L,McArdle HJ

更新日期：2000-11-01 00:00:00

abstract：:Previous studies have shown that human and mouse placentas have hematopoietic potential during mid-gestation. In this investigation, we used histological and immunohistological approaches to visualize hematopoietic cells in mouse placenta between 9.5 and 12.5 days of gestation (gd), identifying their topography and ni...

journal_title：Placenta

authors： Azevedo Portilho N,Tavares Guedes P,Croy BA,Pelajo-Machado M

更新日期：2016-11-01 00:00:00

abstract：:Neuropeptides play an important role in the regional regulation of blood flow and hormone secretion. Few studies report the presence of peptides in the human placenta. Our experiment evaluates neuropeptides in the human placenta using immunocytochemical techniques. Representative tissue sections from full-term placent...

journal_title：Placenta

authors： Graf AH,Hütter W,Hacker GW,Steiner H,Anderson V,Staudach A,Dietze O

更新日期：1996-09-01 00:00:00

abstract：INTRODUCTION:The aim of this study is to determine whether the gene expression and associated DNA methylation regulation of H19 and IGF2 are altered in placentas conceived by assisted reproductive technologies (ART) compared to natural conceptions. METHODS:113 pregnancies were recruited resulting in 119 placentas (83 ...

journal_title：Placenta

authors： Sakian S,Louie K,Wong EC,Havelock J,Kashyap S,Rowe T,Taylor B,Ma S

更新日期：2015-10-01 00:00:00

abstract：:Placentas from women with preeclampsia overexpress the hypoxia-inducible transcription factor proteins, HIF-1alpha and -2alpha (Rajakumar 2001, Biol Reprod 64; p499-506 and p1019-1020). As a first step in evaluating whether HIF-alpha overexpressed in preeclamptic placentae is capable of transactivation, we tested its ...

journal_title：Placenta

authors： Rajakumar A,Brandon HM,Daftary A,Ness R,Conrad KP

更新日期：2004-11-01 00:00:00

abstract：:TRH immunological and biological activity was characterized in rat placental extracts. Placentae were extracted sequentially with 2 N acetic acid and glacial acetic acid. The lyophilized residues were further extracted with 90 per cent methanol, and the extracts were then dried, and reextracted with distilled water. W...

journal_title：Placenta

authors： Shambaugh GE 3rd,Kubek M,Wilber JF

更新日期：1983-10-01 00:00:00

abstract：OBJECTIVES:To compare the distribution of placental protein 13 (PP13) in fetal and maternal blood and amnionic fluid and to correlate it with PP13 protein and mRNA in the placenta. METHODS:Umbilical arterial serum, amnionic fluid, maternal venous serum and placental tissues were collected from normal outcome pregnanci...

journal_title：Placenta

authors： Sammar M,Nisemblat S,Fleischfarb Z,Golan A,Sadan O,Meiri H,Huppertz B,Gonen R

更新日期：2011-02-01 00:00:00

abstract：:Second trimester maternal serum human chorionic gonadotrophin (hCG) levels in women who remained normotensive but delivered an unexplained growth retarded infant were compared with those from a control group and a group of women who developed pre-eclampsia in a retrospective observational study. Our hypothesis was tha...

journal_title：Placenta

authors： Luckas MJ,Sandland R,Hawe J,Neilson JP,McFadyen IR,Meekins JW

更新日期：1998-03-01 00:00:00

abstract：:Indiscriminate invasion upon the endometrium by normal trophoblasts is strictly regulated unlike that by choriocarcinoma cells. In this study, we focused on the activity of matrix metalloproteinase (MMP)-2 and MMP-9 as parameters of invasion in normal human placenta. In situ hybridization (ISH), immunohistochemical st...

journal_title：Placenta

authors： Isaka K,Usuda S,Ito H,Sagawa Y,Nakamura H,Nishi H,Suzuki Y,Li YF,Takayama M

更新日期：2003-01-01 00:00:00

abstract：:The processes of proliferation, migration, and invasion of extravillous trophoblasts are critical for placental implantation and early development, and directly influence pregnancy outcome. Dysregulation of these processes has been associated with placental dysfunction, implicated in clinical conditions such as preecl...

journal_title：Placenta

authors： Xie L,Sadovsky Y

更新日期：2016-12-01 00:00:00

abstract：:Intrauterine infection has been associated with fetal brain injury and preterm birth. We have recently shown that repeated exposure to bacterial endotoxin leads to hypoxia and brain injury in the preterm ovine fetus and we considered it possible that endotoxin could also damage the placenta. Our aim therefore was to a...

journal_title：Placenta

authors： Duncan JR,Cock ML,Rees S,Harding R

更新日期：2003-08-01 00:00:00

abstract：:This study was conducted to investigate the association between uterine artery Doppler flow patterns and uteroplacental vascular pathology in normal and complicated pregnancies in view of the recently described concept of heterogeneous causes of hypertensive pregnancy complications. Forty-three women whose pregnancies...

journal_title：Placenta

authors： Aardema MW,Oosterhof H,Timmer A,van Rooy I,Aarnoudse JG

更新日期：2001-05-01 00:00:00

abstract：BACKGROUND:Preeclampsia is characterized by a systemic inflammatory response involving cytokines, chemokines, and anti-angiogenic factors such as sFLT-1. In many other inflammatory diseases related responses are triggered by toll-like receptor (TLR) stimulation. Therefore, we tested the hypothesis that TLR stimulation ...

journal_title：Placenta

authors： Nakada E,Walley KR,Nakada T,Hu Y,von Dadelszen P,Boyd JH

更新日期：2009-09-01 00:00:00

abstract：:Decidualization process involves the morphological and functional transformation of endometrial stromal cells into decidual cells. This is a finely regulated process, which involves proliferation and differentiation of stromal cells into decidual cells, which is followed by regression of the decidual tissue, mainly by...

journal_title：Placenta

authors： Fonseca BM,Teixeira NA,Almada M,Taylor AH,Konje JC,Correia-da-Silva G

更新日期：2011-06-01 00:00:00

abstract：:In order to assess the characteristics of its stromal cells and the distribution of extracellular matrix proteins, we investigated, immunohistochemically and ultrastructurally, term, first and second trimester human umbilical cords. A differential distribution pattern of the various cytoskeletal proteins of stromal ce...

journal_title：Placenta

authors： Nanaev AK,Kohnen G,Milovanov AP,Domogatsky SP,Kaufmann P

更新日期：1997-01-01 00:00:00