Monoclonal antibody defining a human syncytiotrophoblastic polypeptide immunologically related to mammalian retrovirus structural protein p30.

abstract：INTRODUCTION:We have identified some critical aspects concerning umbilical cord tissue mesenchymal stem cells: the lack of standards for cell isolation, expansion and cryopreservation, the lack of unanimous opinions upon their multilineage differentiation potential and the existence of very few results related to the f...

journal_title：Placenta

authors： Dulugiac M,Moldovan L,Zarnescu O

更新日期：2015-10-01 00:00:00

abstract：:The diversity of placental structures in Eutherian mammals is such that drawing generalizations from the definitive forms is problematic. There are always areas of reduced interhaemal distance whether the placenta is epitheliochorial, synepitheliochorial, endotheliochorial or haemochorial. However, the thinning may be...

journal_title：Placenta

authors： Enders AC,Carter AM

更新日期：2004-04-01 00:00:00

abstract：INTRODUCTION:Umbilical artery (UA) hemodynamics reflect blood flow and vascular resistance in the placental circulation. We examined non-invasively the hemodynamic effects of propofol, etomidate, and alphaxalone on the placental circulation of a sheep model by means of UA Doppler ultrasonography. METHODS:Eleven sheep ...

journal_title：Placenta

authors： Domínguez E,Rivera Del Álamo MM,Novellas R,Espada Y,Santos L,García F,Andaluz A,Fresno L

更新日期：2013-09-01 00:00:00

abstract：:Members of the transmembrane emp24 domain (Tmed)/p24 family of proteins are required for transport of proteins between the endoplasmic reticulum and the Golgi. One member of this family, Tmed2/p24β1, is expressed during placental development in mice and its expression is required for normal development of the labyrint...

journal_title：Placenta

authors： Zakariyah A,Hou W,Slim R,Jerome-Majewska L

更新日期：2012-03-01 00:00:00

abstract：:In the present study, we characterized the expression of lymphocyte antigen 6, locus E (Ly6e) in mouse placental trophoblast. We identified Ly6e mRNA expression in trophoblast stem (TS) cells by a gene expression screen. In vivo, Ly6e was first detectable by mRNA in situ hybridization in the chorion beginning at E8.5 ...

journal_title：Placenta

authors： Hughes M,Natale BV,Simmons DG,Natale DR

更新日期：2013-09-01 00:00:00

abstract：:The establishment of an appropriate fetomaternal vessel system is a prerequisite for prevention of pregnancy associated pathologies. Notch receptors and ligands are manifoldly involved in vascular development and angiogenesis. To further characterize the process of human placental vasculo- and angiogenesis we investig...

journal_title：Placenta

authors： Herr F,Schreiner I,Baal N,Pfarrer C,Zygmunt M

更新日期：2011-08-01 00:00:00

abstract：:Human endothelial dysfunction is a common feature in many diseases of pregnancy, such as gestational diabetes (GD). Metabolic changes include abnormal synthesis of nitric oxide (NO) and abnormal membrane transport of l-arginine and adenosine in primary cultures of human umbilical vein (HUVEC, macrovascular) and placen...

journal_title：Placenta

authors： Sobrevia L,Abarzúa F,Nien JK,Salomón C,Westermeier F,Puebla C,Cifuentes F,Guzmán-Gutiérrez E,Leiva A,Casanello P

更新日期：2011-03-01 00:00:00

abstract：:Matrix metalloproteinases (MMPs) are involved in placental remodelling throughout pregnancy. Diabetes mellitus induces alterations in tissue production of NO, a regulator of MMPs activity. The present work evaluates placental and fetal MMPs and NO levels during midpregnancy in neonatal streptozotocin-induced diabetic ...

journal_title：Placenta

authors： Pustovrh MC,Jawerbaum A,Capobianco E,White V,López-Costa JJ,González E

更新日期：2005-04-01 00:00:00

abstract：INTRODUCTION:Human decidual stromal cells (DSCs) play a key role in maternal-fetal interactions. Precursors of DSCs (preDSCs) localize around vessels in both the endometrium and decidua. Previous studies suggested a relationship between preDSCs and pericytes because these cells share a perivascular location, alpha smoo...

journal_title：Placenta

authors： Muñoz-Fernández R,de la Mata C,Prados A,Perea A,Ruiz-Magaña MJ,Llorca T,Fernández-Rubio P,Blanco O,Abadía-Molina AC,Olivares EG

更新日期：2018-01-01 00:00:00

abstract：:Nitrotyrosine residues (NT), an index of oxidative stress arising from peroxynitrite formation and action, are found in placental vasculature of pregnancies complicated by pre-eclampsia (PE) or pregestational insulin-dependent diabetes mellitus (IDDM). This study correlates conventional placental pathology with NT imm...

journal_title：Placenta

authors： Stanek J,Eis AL,Myatt L

更新日期：2001-04-01 00:00:00

abstract：OBJECTIVE:Maternal magnesium (Mg) deficiency has been associated with fetal growth restriction. Using a mouse model of maternal Mg deficiency-induced fetal growth restriction, we sought to investigate the effect of Mg deficiency on placental physiology and function. METHODS:In vivo: Pregnant Swiss Webster mice were fe...

journal_title：Placenta

authors： Rosner JY,Gupta M,McGill M,Xue X,Chatterjee PK,Yoshida-Hay M,Robeson W,Metz CN

更新日期：2016-03-01 00:00:00

abstract：:Intrauterine inflammation contributes to neonatal infection-related morbidity. A new histological framework of placental inflammation has recently been proposed; however, the association between this method and clinical findings has not been defined. To assess the clinical relevance of this system, we studied placenta...

journal_title：Placenta

authors： Yamada N,Sato Y,Moriguchi-Goto S,Yamashita A,Kodama Y,Sameshima H,Asada Y

更新日期：2015-12-01 00:00:00

abstract：INTRODUCTION:Statins induce heme oxygenase-1 (HO-1) expression in vitro and in vivo. Low HO-1 expression is associated with pregnancy complications, e.g. preeclampsia and recurrent miscarriages. Here, we investigated the effects of pravastatin on HO-1 expression, placental development, and fetal survival in mice with a...

journal_title：Placenta

authors： Tsur A,Kalish F,Burgess J,Nayak NR,Zhao H,Casey KM,Druzin ML,Wong RJ,Stevenson DK

更新日期：2019-01-01 00:00:00

abstract：:Prior studies have shown that levels of corticotrophin-releasing hormone (CRH) in the umbilical cord blood of infants born after pregnancies complicated by pre-eclampsia are significantly higher than fetal plasma CRH concentrations in uncomplicated pregnancies. In the present study we have measured CRH by radioimmunoa...

journal_title：Placenta

authors： Goland RS,Conwell IM,Jozak S

更新日期：1995-06-01 00:00:00

abstract：:The human placenta in vivo consumes large amounts of oxygen. After delivery the placenta is exposed to anoxia and under in vitro experimental conditions oxygen consumption is only a fraction of in vivo estimates. In spite of a reduced oxygen supply, structural and functional integrity of the tissue is surprisingly wel...

journal_title：Placenta

authors： Schneider H

更新日期：2000-03-01 00:00:00

abstract：:ED(27) trophoblast-like cells were prepared from human chorionic villus samples obtained at 9 weeks gestation and have been grown continuously in vitro without phenotypic drift for nearly a decade. These cells express many trophoblast markers, including cytokeratin, placental alkaline phosphatase (PLAP), secretion of ...

journal_title：Placenta

authors： Kniss DA,Xie Y,Li Y,Kumar S,Linton EA,Cohen P,Fan-Havard P,Redman CW,Sargent IL

更新日期：2002-01-01 00:00:00

abstract：:To characterize the placental activity for the transport of amino acids, the uptake of L-alanine was investigated by rapid membrane filtration using brush border membrane vesicles separated from the human placenta of early pregnant (12-13 gestational weeks) and late pregnant (37-38 gestational weeks) women. The uptake...

journal_title：Placenta

authors： Iioka H,Hisanaga H,Moriyama IS,Akada S,Shimamoto T,Yamada Y,Ichijo M

更新日期：1992-03-01 00:00:00

abstract：:Maternal infection of Trypanosoma cruzi is associated with premature births, abortions and placentitis. A decrease in EGF levels has been suggested to occur in animals infected by T. cruzi, but there is no research about the levels of EGF in human patients with Chagas' disease. We evaluated serum EGF levels in pregnan...

journal_title：Placenta

authors： Lin S,Sartori MJ,Mezzano L,de Fabro SP

更新日期：2004-04-01 00:00:00

abstract：:Maternal diabetes affects the development of the offspring by altering the uterine environment. We aimed to investigate the extent to which the blood flow (measured as Tissue Perfusion Units; TPU) to implantation sites and the expression of developmentally important genes in the offspring are affected by maternal diab...

journal_title：Placenta

authors： Zabihi S,Wentzel P,Eriksson UJ

更新日期：2008-05-01 00:00:00

abstract：:The ANP knockout mouse is reported to exhibit pregnancy-associated hypertension, proteinuria and impaired placental trophoblast invasion and spiral artery remodeling, key features of pre-eclampsia (PE). We hypothesized that these mice may provide a relevant model of human PE with associated fetal growth restriction (F...

journal_title：Placenta

authors： Finn-Sell SL,Renshall LJ,Cowley EJ,Dilworth MR,Wareing M,Greenwood SL,Sibley CP,Cottrell EC

更新日期：2016-06-01 00:00:00

abstract：:The purpose of this study was to examine evidence for the presence of activated leukocytes in the fetal membranes from patients with preterm delivery. Polymorphonuclear leukocytes in fetal membranes from seven patients with preterm delivery (26-32 weeks of gestation) were analysed using transmission electron microscop...

journal_title：Placenta

authors： Matsubara S,Yamada T,Minakami H,Watanabe T,Takizawa T,Sato I

更新日期：1999-03-01 00:00:00

abstract：:The effects of 8-epi-prostaglandin F(2alpha)(8-epi-PGF(2alpha)) and the thromboxane A(2)-mimetic U46619 were examined on isolated human fetal placental arteries obtained from normal pregnancies and from those complicated by pre-eclampsia. The effects of these agents were examined on both conduit and resistance arterie...

journal_title：Placenta

authors： Kwek K,Read MA,Khong TY,Bisits AT,Walters WA

更新日期：2001-07-01 00:00:00

abstract：INTRODUCTION:In the placenta, the (pro)renin receptor (ATP6AP2) is localised to the syncytiotrophoblast. ATP6AP2 can activate the placental renin-angiotensin system (RAS), producing Angiotensin II (Ang II) which, acting via the angiotensin II type 1 receptor (AGTR1), is important for placental development and function....

journal_title：Placenta

authors： Morosin SK,Delforce SJ,Lumbers ER,Pringle KG

更新日期：2020-08-01 00:00:00

abstract：:The fetus has a substantial demand for glycine, which is satisfied in part by placental formation. The ability to form glycine through the activity of alanine:glyoxylate aminotransferase enzyme was measured in placentae from normal term human pregnancies and placentae from rats at day 20 of gestation. There was no det...

journal_title：Placenta

authors： Bennett FI,Jackson AA

更新日期：1998-05-01 00:00:00

abstract：:Although secretory phospholipase A2 (PLA2) isozymes have been identified in human gestational tissues, their role in homeostasis and pathophysiology during pregnancy has yet to be clearly established. The aims of this brief commentary are: (1) to review recent data concerning the expression of secretory PLA2 isozymes ...

journal_title：Placenta

authors： Rice GE

更新日期：1998-01-01 00:00:00

abstract：:Homeobox genes of the Distal-less (Dlx) family are expressed in the vertebrate embryo in regions where epithelial cell layers contact adjacent mesenchymal cells. This study shows that the human Dlx family member, DLX4, is expressed in the placenta, primarily in regions where epithelial and mesenchymal cell layers cont...

journal_title：Placenta

authors： Quinn LM,Latham SE,Kalionis B

更新日期：1998-01-01 00:00:00

abstract：INTRODUCTION:The aquaporins (AQP1, 3, 8, 9 and 11) are known to be expressed, and involved in the transport of water and small molecules through fetal membranes. To exert these crucial functions, these AQPs have to be finely regulated. All-trans-retinoic acid (atRA) was previously found to regulate some genes in this e...

journal_title：Placenta

authors： Prat C,Bouvier D,Comptour A,Marceau G,Belville C,Clairefond G,Blanc P,Gallot D,Blanchon L,Sapin V

更新日期：2015-08-01 00:00:00

abstract：INTRODUCTION:Preterm birth is a heterogeneous phenotype, with placental abnormalities underlying many cases. The etiology of preterm births that occur in the absence of placental abnormalities, however, remain enigmatic and we considered that early pregnancy biomarkers may provide clues. METHODS:Women from a hospital-...

journal_title：Placenta

authors： Sun B,Parks WT,Simhan HN,Bertolet M,Catov JM

更新日期：2020-01-01 00:00:00

abstract：:The interaction of cocaine and its analog 2 beta-carbomethoxy-3 beta-(4-iodophenyl) tropane (RTI-55) with the human placental serotonin transporter was investigated. The function of the placental serotonin transporter was assayed using three different approaches: serotonin uptake in purified human placental brush bord...

journal_title：Placenta

authors： Prasad PD,Leibach FH,Mahesh VB,Ganapathy V

更新日期：1994-04-01 00:00:00

abstract：:The transport of large amounts of Ca2+ by the plasma membranes of human placental syncytiotrophoblast is essential to the mineralization of the growing fetal skeleton. We have investigated transport by the basal (fetal-facing) plasma membrane (BPM). Ca2+ was taken up by purified BPM vesicles in a time-dependent manner...

journal_title：Placenta

authors： Kamath SG,Haider N,Smith CH

更新日期：1994-02-01 00:00:00