解剖学和形态学
麻醉学
听力与言语-语言病理学
行为科学
心脏和心血管系统
细胞和组织工程学
临床神经病学
危重症监护医学
牙科,口腔外科和医学
皮肤病学
急诊医学
内分泌学和新陈代谢
肠胃学和肝脏学
老人病学和老年医学
卫生保健科学和服务
血液学
免疫学
传染病
综合和补充性医学
医学伦理学
医学信息学
医学实验室技术
医学,全科和内科
医学,法律
医学,研究和试验
神经系统科学
护理
营养学和饮食学
产科医学和妇科医学
肿瘤学
眼科学
整形外科学
耳鼻喉科学
病理学
儿科学
周围血管疾病
药理学和药剂学
生理学
基本医疗保健
精神病学
公共、环境和职业卫生
放射学,核医学和医学成像
康复学
生殖生物学
呼吸系统
风湿病学
运动科学
外科学
毒理学
热带医学
泌尿学和肾脏学
病毒学
老年医学
健康政策和服务
心理学,临床
abstract::Herein, the cytotoxicity of a novel zwitterionic sulfobetaine hydrogel system with a nano-clay crosslinker has been investigated. We demonstrate that careful selection of the composition of the system (monomer to Laponite content) allows the material to be formed into controlled shapes using an extrusion based additiv...
journal_title:Journal of tissue engineering
pub_type: 杂志文章
doi:10.1177/2041731420967294
更新日期:2020-10-29 00:00:00
abstract::Spinal fusion has become a common surgical technique to join two or more vertebrae to stabilize a damaged spine; however, the rate of pseudarthrosis (failure of fusion) is still high. To minimize pseudarthrosis, bone morphogenetic protein-2 (BMP2) has been approved for use in humans. In this study, we developed a poly...
journal_title:Journal of tissue engineering
pub_type: 杂志文章
doi:10.1177/2041731420967591
更新日期:2020-10-24 00:00:00
abstract::Biomaterial with the dual-functions of bone regeneration and antibacterial is a novel therapy for infective bone defects. Three-dimensional (3D)-printed porous titanium (pTi) benefits bone ingrowth, but its microporous structure conducive to bacteria reproduction. Herein, a multifunctional hydrogel was prepared from d...
journal_title:Journal of tissue engineering
pub_type: 杂志文章
doi:10.1177/2041731420965797
更新日期:2020-10-23 00:00:00
abstract::A range of bioreactors use linear actuators to apply tensile forces in vitro, but differences in their culture environments can limit a direct comparison between studies. The widespread availability of 3D printing now provides an opportunity to develop a 'universal' bioreactor chamber that, with minimal exterior editi...
journal_title:Journal of tissue engineering
pub_type: 杂志文章
doi:10.1177/2041731420942462
更新日期:2020-09-01 00:00:00
abstract::To reduce excessive scarring in wound healing, electrospun nanofibrous meshes, composed of haloarchaea-produced biodegradable elastomer poly(3-hydroxybutyrate-co-3-hydroxyvalerate) (PHBV), are fabricated for use as a wound dressing. Three PHBV polymers with different 3HV content are used to prepare either solution-cas...
journal_title:Journal of tissue engineering
pub_type: 杂志文章
doi:10.1177/2041731420949332
更新日期:2020-08-23 00:00:00
abstract::Image-based cell/colony analyses offer promising solutions to compensate for the lack of quality control (QC) tools for noninvasive monitoring of cultured cells, a regulatory challenge in regenerative medicine. Here, the feasibility of two image analysis algorithms, optical flow and normalised cross-correlation, to no...
journal_title:Journal of tissue engineering
pub_type: 杂志文章
doi:10.1177/2041731419881528
更新日期:2019-10-15 00:00:00
abstract::Angiogenesis in adipose tissue is promoted by insulin-like growth factor 1 signaling. We analyzed whether this regulatory mechanism also improves the angiogenic activity of adipose tissue-derived microvascular fragments. Murine adipose tissue-derived microvascular fragments were cultivated for 24 h in the University o...
journal_title:Journal of tissue engineering
pub_type: 杂志文章
doi:10.1177/2041731419879837
更新日期:2019-09-27 00:00:00
abstract::Research into cellular engineered bone grafts offers a promising solution to problems associated with the currently used auto- and allografts. Bioreactor systems can facilitate the development of functional cellular bone grafts by augmenting mass transport through media convection and shear flow-induced mechanical sti...
journal_title:Journal of tissue engineering
pub_type: 杂志文章
doi:10.1177/2041731419827922
更新日期:2019-02-22 00:00:00
abstract::Mineral trioxide aggregate, which comprises three major inorganic components, namely, tricalcium silicate (C3S), dicalcium silicate (C2S), and tricalcium aluminate (C3A), is promising regenerative cement for dentistry. While mineral trioxide aggregate has been successfully applied in retrograde filling, the exact role...
journal_title:Journal of tissue engineering
pub_type: 杂志文章
doi:10.1177/2041731418807396
更新日期:2018-10-30 00:00:00
abstract::The ability to influence stem cell differentiation is highly desirable as it would help us improve clinical outcomes for patients in various aspects. Many different techniques to achieve this have previously been investigated. This concise study, however, has focused on the topography on which cells grow. Current unce...
journal_title:Journal of tissue engineering
pub_type: 杂志文章
doi:10.1177/2041731418784098
更新日期:2018-07-11 00:00:00
abstract::Donor organ shortage remains a clear problem for many end-stage organ patients around the world. The number of available donor organs pales in comparison with the number of patients in need of these organs. The field of tissue engineering proposes a plausible solution. Using stem cells, a patient's autologous cells, o...
journal_title:Journal of tissue engineering
pub_type: 杂志文章,评审
doi:10.1177/2041731418772949
更新日期:2018-05-10 00:00:00
abstract::Three-dimensional printing technology is getting more attention recently, especially in the craniofacial region. This is a review of literature enlightening the materials that have been used to date and the application of such technology within the scope of maxillofacial surgery. ...
journal_title:Journal of tissue engineering
pub_type: 杂志文章
doi:10.1177/2041731418770909
更新日期:2018-04-20 00:00:00
abstract::The tissue-engineered heart valve may be the ideal valve replacement option but still must overcome challenges in leaflet recellularization. This study sought to investigate the potential for leaflet matrix restoration and repopulation following mononuclear cell seeding and extended periods of bioreactor conditioning....
journal_title:Journal of tissue engineering
pub_type: 杂志文章
doi:10.1177/2041731418767216
更新日期:2018-04-10 00:00:00
abstract::In vitro-generated soft tissue could provide alternate therapies for soft tissue defects. The aim of this study was to evaluate methacrylated gelatin/hyaluronan as scaffolds for soft tissue engineering and their interaction with human adipose-derived stem cells (hASCs). ASCs were incorporated into methacrylated gelati...
journal_title:Journal of tissue engineering
pub_type: 杂志文章
doi:10.1177/2041731417744157
更新日期:2017-12-21 00:00:00
abstract::Current materials used for adipose tissue reconstruction have critical shortcomings such as suboptimal volume retention, donor-site morbidity, and poor biocompatibility. The aim of this study was to examine a controlled delivery system of dexamethasone to generate stable adipose tissue when mixed with disaggregated hu...
journal_title:Journal of tissue engineering
pub_type: 杂志文章
doi:10.1177/2041731417735402
更新日期:2017-10-09 00:00:00
abstract::The tissue-engineered heart valve portends a new era in the field of valve replacement. Decellularized heart valves are of great interest as a scaffold for the tissue-engineered heart valve due to their naturally bioactive composition, clinical relevance as a stand-alone implant, and partial recellularization in vivo....
journal_title:Journal of tissue engineering
pub_type: 杂志文章,评审
doi:10.1177/2041731417726327
更新日期:2017-08-25 00:00:00
abstract::The aim of this study was to adapt a proprietary decellularisation process for human dermis for use with porcine skin. Porcine skin was subject to: sodium chloride (1 M) to detach the epidermis, trypsin paste to remove hair follicles, peracetic acid (0.1% v/v) disinfection, washed in hypotonic buffer and 0.1% (w/v) so...
journal_title:Journal of tissue engineering
pub_type: 杂志文章
doi:10.1177/2041731417724011
更新日期:2017-08-03 00:00:00
abstract::Cartilage defects are a source of pain, immobility, and reduced quality of life for patients who have acquired these defects through injury, wear, or disease. The avascular nature of cartilage tissue adds to the complexity of cartilage tissue repair or regeneration efforts. The known limitations of using autografts, a...
journal_title:Journal of tissue engineering
pub_type: 杂志文章
doi:10.1177/2041731417697500
更新日期:2017-04-13 00:00:00
abstract::The clinical management of large-size cartilage lesions is difficult due to the limited regenerative ability of the cartilage. Different biomaterials have been used to develop tissue engineering substitutes for cartilage repair, including chitosan alone or in combination with growth factors to improve its chondrogenic...
journal_title:Journal of tissue engineering
pub_type: 杂志文章
doi:10.1177/2041731417697545
更新日期:2017-03-23 00:00:00
abstract::Although endovascular stenting has been used as an interventional therapy to treat cardio- and cerebro-vascular diseases, it is associated with recurrent vascular diseases following stent thrombosis and in-stent restenosis. In this study, a metallic stent was coated with dopamine-conjugated hyaluronic acid with differ...
journal_title:Journal of tissue engineering
pub_type: 杂志文章
doi:10.1177/2041731416683745
更新日期:2016-12-17 00:00:00
abstract::It was demonstrated that octacalcium phosphate collagen composite achieved notable bone regeneration in bone defects in preclinical studies. On the basis of the research results, an investigator-initiated exploratory clinical trial was conducted after approval from a local Institutional Review Board. This clinical stu...
journal_title:Journal of tissue engineering
pub_type: 杂志文章
doi:10.1177/2041731416670770
更新日期:2016-10-03 00:00:00
abstract::Apoptosis and inflammatory processes may be at the basis of reducing graft survival. Erythropoietin is a tissue-protective hormone with pleiotropic potential, and it interferes with the activities of pro-inflammatory cytokines and stimulates healing following injury, preventing destruction of tissue surrounding the in...
journal_title:Journal of tissue engineering
pub_type: 杂志文章
doi:10.1177/2041731416671278
更新日期:2016-09-27 00:00:00
abstract::Breast carcinomas are complex, three-dimensional tissues composed of cancer epithelial cells and stromal components, including fibroblasts and extracellular matrix. In vitro models that more faithfully recapitulate this dimensionality and stromal microenvironment should more accurately elucidate the processes driving ...
journal_title:Journal of tissue engineering
pub_type: 杂志文章
doi:10.1177/2041731416660739
更新日期:2016-07-29 00:00:00
abstract::Transdifferentiation is the direct conversion from one somatic cell type into another desired somatic cell type. This reprogramming method offers an attractive approach for regenerative medicine. Here, we demonstrate that neonatal fibroblasts can be transdifferentiated into endothelial cells using only four endothelia...
journal_title:Journal of tissue engineering
pub_type: 杂志文章
doi:10.1177/2041731416628329
更新日期:2016-02-01 00:00:00
abstract::The use of a monoclonal antibody to block the neurite outgrowth inhibitor Nogo-A has been of great interest for promoting axonal recovery as a treatment for spinal cord injury. While several cellular and non-cellular assays have been developed to quantify the bioactive effects of Nogo-A signaling, demand still exists ...
journal_title:Journal of tissue engineering
pub_type: 杂志文章
doi:10.1177/2041731416629767
更新日期:2016-01-28 00:00:00
abstract::This study evaluated the effect of pulsed low-intensity ultrasound on cell proliferation, collagen production and glycosaminoglycan deposition by human dermal fibroblasts encapsulated in alginate. Hoechst 33258 assay for cell number, hydroxyproline assay for collagen content, dimethylmethylene blue assay for glycosami...
journal_title:Journal of tissue engineering
pub_type: 杂志文章
doi:10.1177/2041731415615777
更新日期:2015-11-19 00:00:00
abstract::Ultrasound at 5.0 MHz was noted to be chondro-inductive, with improved SOX-9 gene and COL2A1 protein expression in constructs that allowed for cell-to-cell contact. To achieve tissue-engineered cartilage using macroporous scaffolds, it is hypothesized that a combination of ultrasound at 5.0 MHz and transforming growth...
journal_title:Journal of tissue engineering
pub_type: 杂志文章
doi:10.1177/2041731414566529
更新日期:2015-01-16 00:00:00
abstract::Tendon disease and injuries carry significant morbidity worldwide in both athletic and non-athletic populations. It is estimated that tendon injuries account for 30%-50% of all musculoskeletal injuries globally. Current treatments have been inadequate in providing an accelerated process of repair resulting in high rel...
journal_title:Journal of tissue engineering
pub_type: 杂志文章,评审
doi:10.1177/2041731414549678
更新日期:2014-09-18 00:00:00
abstract::The development of biomaterial surfaces possessing the topographical cues that can promote mesenchymal stem cell recruitment and, in particular, those capable of subsequently directing osteogenic differentiation is of increasing importance for the advancement of tissue engineering. While it is accepted that it is the ...
journal_title:Journal of tissue engineering
pub_type: 杂志文章
doi:10.1177/2041731414537513
更新日期:2014-05-27 00:00:00
abstract::Tissue engineering skeletal muscle in vitro is of great importance for the production of tissue-like constructs for treating tissue loss due to traumatic injury or surgery. However, it is essential to find new sources of cells for muscle engineering as efficient in vitro expansion and culture of primary myoblasts are ...
journal_title:Journal of tissue engineering
pub_type: 杂志文章
doi:10.1177/2041731414530138
更新日期:2014-03-27 00:00:00
abstract::As part of our clinical tests on bone regeneration using cultured periosteal sheets, here, we prepared cultured periosteal sheets in two types of stem-cell culture media, STK1 and STK3. Human periosteum was expanded either in 1% human serum-supplemented STK1 for 28 days, in 1% human serum-supplemented STK1 for 14 days...
journal_title:Journal of tissue engineering
pub_type: 杂志文章
doi:10.1177/2041731413509646
更新日期:2013-10-23 00:00:00
abstract::The purpose of this study was to assess the biological revitalization and mechanical integrity of Strattice(™) Reconstructive Tissue Matrix, a porcine-derived acellular dermal matrix, in vivo over time. We expanded the traditional subcutaneous model to incorporate biologic matrix scaffolds large enough to allow evalua...
journal_title:Journal of tissue engineering
pub_type: 杂志文章
doi:10.1177/2041731413490182
更新日期:2013-05-17 00:00:00
abstract::This study aimed to develop a contamination-free porous titanium scaffold by a plasma-activated sintering within an originally developed TiN-coated graphite mold. The surface of porous titanium sheet with or without a coated graphite mold was characterized. The cell adhesion property of porous titanium sheet was also ...
journal_title:Journal of tissue engineering
pub_type: 杂志文章
doi:10.4061/2010/425402
更新日期:2011-01-09 00:00:00
abstract::Stem cells have the capacity to differentiate into various lineages, and the ability to reliably direct stem cell fate determination would have tremendous potential for basic research and clinical therapy. Nanotopography provides a useful tool for guiding differentiation, as the features are more durable than surface ...
journal_title:Journal of tissue engineering
pub_type: 杂志文章
doi:10.4061/2010/120623
更新日期:2010-08-18 00:00:00