听力与言语-语言病理学

行为科学

医学伦理学

你正在浏览Annual Review of Immunology期刊下所有文献
  • Hypoxia and Innate Immunity: Keeping Up with the HIFsters.

    abstract::Recent years have witnessed an emergence of interest in understanding metabolic changes associated with immune responses, termed immunometabolism. As oxygen is central to all aerobic metabolism, hypoxia is now recognized to contribute fundamentally to inflammatory and immune responses. Studies from a number of groups ...

    journal_title:Annual review of immunology

    pub_type: 杂志文章

    doi:10.1146/annurev-immunol-100819-121537

    authors: Colgan SP,Furuta GT,Taylor CT

    更新日期:2020-04-26 00:00:00

  • Mast Cells in Inflammation and Disease: Recent Progress and Ongoing Concerns.

    abstract::Mast cells have existed long before the development of adaptive immunity, although they have been given different names. Thus, in the marine urochordate Styela plicata, they have been designated as test cells. However, based on their morphological characteristics (including prominent cytoplasmic granules) and mediator...

    journal_title:Annual review of immunology

    pub_type: 杂志文章

    doi:10.1146/annurev-immunol-071719-094903

    authors: Galli SJ,Gaudenzio N,Tsai M

    更新日期:2020-04-26 00:00:00

  • Interaction Between the Microbiota, Epithelia, and Immune Cells in the Intestine.

    abstract::The gastrointestinal tract harbors numerous commensal bacteria, referred to as the microbiota, that benefit host health by digesting dietary components and eliminating pathogens. The intestinal microbiota maintains epithelial barrier integrity and shapes the mucosal immune system, balancing host defense and oral toler...

    journal_title:Annual review of immunology

    pub_type: 杂志文章

    doi:10.1146/annurev-immunol-070119-115104

    authors: Kayama H,Okumura R,Takeda K

    更新日期:2020-04-26 00:00:00

  • Chromatin-Modifying Enzymes in T Cell Development.

    abstract::T cell development involves stepwise progression through defined stages that give rise to multiple T cell subtypes, and this is accompanied by the establishment of stage-specific gene expression. Changes in chromatin accessibility and chromatin modifications accompany changes in gene expression during T cell developme...

    journal_title:Annual review of immunology

    pub_type: 杂志文章

    doi:10.1146/annurev-immunol-092719-082622

    authors: Shapiro MJ,Shapiro VS

    更新日期:2020-04-26 00:00:00

  • Siglecs as Immune Cell Checkpoints in Disease.

    abstract::Sialic acid-binding immunoglobulin-type lectins (Siglecs) are expressed on the majority of white blood cells of the immune system and play critical roles in immune cell signaling. Through recognition of sialic acid-containing glycans as ligands, they help the immune system distinguish between self and nonself. Because...

    journal_title:Annual review of immunology

    pub_type: 杂志文章

    doi:10.1146/annurev-immunol-102419-035900

    authors: Duan S,Paulson JC

    更新日期:2020-04-26 00:00:00

  • Using T Cell Receptor Repertoires to Understand the Principles of Adaptive Immune Recognition.

    abstract::Adaptive immune recognition is mediated by antigen receptors on B and T cells generated by somatic recombination during lineage development. The high level of diversity resulting from this process posed technical limitations that previously limited the comprehensive analysis of adaptive immune recognition. Advances ov...

    journal_title:Annual review of immunology

    pub_type: 杂志文章,评审

    doi:10.1146/annurev-immunol-042718-041757

    authors: Bradley P,Thomas PG

    更新日期:2019-04-26 00:00:00

  • Emerging Cellular Therapies for Cancer.

    abstract::Genetically engineered T cells are powerful new medicines, offering hope for curative responses in patients with cancer. Chimeric antigen receptor (CAR) T cells were recently approved by the US Food and Drug Administration and are poised to enter the practice of medicine for leukemia and lymphoma, demonstrating that e...

    journal_title:Annual review of immunology

    pub_type: 杂志文章,评审

    doi:10.1146/annurev-immunol-042718-041407

    authors: Guedan S,Ruella M,June CH

    更新日期:2019-04-26 00:00:00

  • The Microbiome and Food Allergy.

    abstract::The gut-associated lymphoid tissue (GALT) faces a considerable challenge. It encounters antigens derived from an estimated 1014 commensal microbes and greater than 30 kg of food proteins yearly. It must distinguish these harmless antigens from potential pathogens and mount the appropriate host immune response. Local a...

    journal_title:Annual review of immunology

    pub_type: 杂志文章,评审

    doi:10.1146/annurev-immunol-042718-041621

    authors: Iweala OI,Nagler CR

    更新日期:2019-04-26 00:00:00

  • Complement and the Regulation of T Cell Responses.

    abstract::The complement system is an evolutionarily ancient key component of innate immunity required for the detection and removal of invading pathogens. It was discovered more than 100 years ago and was originally defined as a liver-derived, blood-circulating sentinel system that classically mediates the opsonization and lyt...

    journal_title:Annual review of immunology

    pub_type: 杂志文章,评审

    doi:10.1146/annurev-immunol-042617-053245

    authors: West EE,Kolev M,Kemper C

    更新日期:2018-04-26 00:00:00

  • The Innate Lymphoid Cell Precursor.

    abstract::The discovery of tissue-resident innate lymphoid cell populations effecting different forms of type 1, 2, and 3 immunity; tissue repair; and immune regulation has transformed our understanding of mucosal immunity and allergy. The emerging complexity of these populations along with compounding issues of redundancy and ...

    journal_title:Annual review of immunology

    pub_type: 杂志文章,评审

    doi:10.1146/annurev-immunol-041015-055549

    authors: Ishizuka IE,Constantinides MG,Gudjonson H,Bendelac A

    更新日期:2016-05-20 00:00:00

  • Stromal cells in chronic inflammation and tertiary lymphoid organ formation.

    abstract::Inflammation is an unstable state. It either resolves or persists. Why inflammation persists and the factors that define tissue tropism remain obscure. Increasing evidence suggests that tissue-resident stromal cells not only provide positional memory but also actively regulate the differential accumulation of inflamma...

    journal_title:Annual review of immunology

    pub_type: 杂志文章,评审

    doi:10.1146/annurev-immunol-032713-120252

    authors: Buckley CD,Barone F,Nayar S,Bénézech C,Caamaño J

    更新日期:2015-01-01 00:00:00

  • Microbiota-mediated inflammation and antimicrobial defense in the intestine.

    abstract::The diverse microbial populations constituting the intestinal microbiota promote immune development and differentiation, but because of their complex metabolic requirements and the consequent difficulty culturing them, they remained, until recently, largely uncharacterized and mysterious. In the last decade, deep nucl...

    journal_title:Annual review of immunology

    pub_type: 杂志文章,评审

    doi:10.1146/annurev-immunol-032713-120238

    authors: Caballero S,Pamer EG

    更新日期:2015-01-01 00:00:00

  • Transcriptional control of early T and B cell developmental choices.

    abstract::T and B cells share a common somatic gene rearrangement mechanism for assembling the genes that code for their antigen receptors; they also have developmental pathways with many parallels. Shared usage of basic helix-loop-helix E proteins as transcriptional drivers underlies these common features. However, the transcr...

    journal_title:Annual review of immunology

    pub_type: 杂志文章,评审

    doi:10.1146/annurev-immunol-032712-100024

    authors: Rothenberg EV

    更新日期:2014-01-01 00:00:00

  • Chemokines and chemokine receptors: positioning cells for host defense and immunity.

    abstract::Chemokines are chemotactic cytokines that control the migratory patterns and positioning of all immune cells. Although chemokines were initially appreciated as important mediators of acute inflammation, we now know that this complex system of approximately 50 endogenous chemokine ligands and 20 G protein-coupled seven...

    journal_title:Annual review of immunology

    pub_type: 杂志文章,评审

    doi:10.1146/annurev-immunol-032713-120145

    authors: Griffith JW,Sokol CL,Luster AD

    更新日期:2014-01-01 00:00:00

  • Metabolic regulation of T lymphocytes.

    abstract::T cell activation leads to dramatic shifts in cell metabolism to protect against pathogens and to orchestrate the action of other immune cells. Quiescent T cells require predominantly ATP-generating processes, whereas proliferating effector T cells require high metabolic flux through growth-promoting pathways. Further...

    journal_title:Annual review of immunology

    pub_type: 杂志文章,评审

    doi:10.1146/annurev-immunol-032712-095956

    authors: MacIver NJ,Michalek RD,Rathmell JC

    更新日期:2013-01-01 00:00:00

  • Autophagy and the immune system.

    abstract::Stressors ranging from nutrient deprivation to immune signaling can induce the degradation of cytoplasmic material by a process known as autophagy. Increasingly, research on autophagy has begun to focus on its role in inflammation and the immune response. Autophagy acts as an immune effector that mediates pathogen cle...

    journal_title:Annual review of immunology

    pub_type: 杂志文章,评审

    doi:10.1146/annurev-immunol-020711-074948

    authors: Kuballa P,Nolte WM,Castoreno AB,Xavier RJ

    更新日期:2012-01-01 00:00:00

  • Adaptive immunity to fungi.

    abstract::Only a handful of the more than 100,000 fungal species on our planet cause disease in humans, yet the number of life-threatening fungal infections in patients has recently skyrocketed as a result of advances in medical care that often suppress immunity intensely. This emerging crisis has created pressing needs to clar...

    journal_title:Annual review of immunology

    pub_type: 杂志文章,评审

    doi:10.1146/annurev-immunol-020711-074958

    authors: Wüthrich M,Deepe GS Jr,Klein B

    更新日期:2012-01-01 00:00:00

  • Tolerance of infections.

    abstract::A host has two methods to defend against pathogens: It can clear the pathogens or reduce their impact on health in other ways. The first, resistance, is well studied. Study of the second, which ecologists call tolerance, is in its infancy. Tolerance measures the dose response curve of a host's health in reaction to a ...

    journal_title:Annual review of immunology

    pub_type: 杂志文章,评审

    doi:10.1146/annurev-immunol-020711-075030

    authors: Ayres JS,Schneider DS

    更新日期:2012-01-01 00:00:00

  • Transcriptional and epigenetic control of T helper cell specification: molecular mechanisms underlying commitment and plasticity.

    abstract::T helper cell differentiation occurs in the context of the extracellular cytokine milieu evoked by diverse microbes and other pathogenic stimuli along with T cell receptor stimulation. The culmination of these signals results in specification of T helper lineages, which occurs through the combinatorial action of multi...

    journal_title:Annual review of immunology

    pub_type: 杂志文章,评审

    doi:10.1146/annurev-immunol-020711-075058

    authors: Kanno Y,Vahedi G,Hirahara K,Singleton K,O'Shea JJ

    更新日期:2012-01-01 00:00:00

  • Regulation and functions of the IL-10 family of cytokines in inflammation and disease.

    abstract::The IL-10 family of cytokines consists of nine members: IL-10, IL-19, IL-20, IL-22, IL-24, IL-26, and the more distantly related IL-28A, IL-28B, and IL-29. Evolutionarily, IL-10 family cytokines emerged before the adaptive immune response. These cytokines elicit diverse host defense mechanisms, especially from epithel...

    journal_title:Annual review of immunology

    pub_type: 杂志文章,评审

    doi:10.1146/annurev-immunol-031210-101312

    authors: Ouyang W,Rutz S,Crellin NK,Valdez PA,Hymowitz SG

    更新日期:2011-01-01 00:00:00

  • SLAM family receptors and SAP adaptors in immunity.

    abstract::The signaling lymphocyte activation molecule (SLAM)-associated protein, SAP, was first identified as the protein affected in most cases of X-linked lymphoproliferative (XLP) syndrome, a rare genetic disorder characterized by abnormal responses to Epstein-Barr virus infection, lymphoproliferative syndromes, and dysgamm...

    journal_title:Annual review of immunology

    pub_type: 杂志文章,评审

    doi:10.1146/annurev-immunol-030409-101302

    authors: Cannons JL,Tangye SG,Schwartzberg PL

    更新日期:2011-01-01 00:00:00

  • The role of ThPOK in control of CD4/CD8 lineage commitment.

    abstract::During alphabeta T cell development, cells diverge into alternate CD4 helper and CD8(+) cytotoxic T cell lineages. The precise correlation between a T cell's CD8 and CD4 choice and its TCR specificity to class I or class II MHC was noted more than 20 years ago, and establishing the underlying mechanism has remained a ...

    journal_title:Annual review of immunology

    pub_type: 杂志文章,评审

    doi:10.1146/annurev.immunol.25.022106.141715

    authors: He X,Park K,Kappes DJ

    更新日期:2010-01-01 00:00:00

  • A life of adventure in immunobiology.

    abstract::This article outlines my early start in medicine, a late start in immunology research, and my efforts to integrate the two activities. I first describe some of the background information, excitement, and implications of the recognition of T and B cells as separate but functionally intertwined arms of the adaptive immu...

    journal_title:Annual review of immunology

    pub_type: 杂志文章,评审

    doi:10.1146/annurev-immunol-030409-101248

    authors: Cooper MD

    更新日期:2010-01-01 00:00:00

  • The role of antibodies in HIV vaccines.

    abstract::Licensed vaccines against viral diseases generate antibodies that neutralize the infecting virus and protect against infection or disease. Similarly, an effective vaccine against HIV-1 will likely need to induce antibodies that prevent initial infection of host cells or that limit early events of viral dissemination. ...

    journal_title:Annual review of immunology

    pub_type: 杂志文章,评审

    doi:10.1146/annurev-immunol-030409-101256

    authors: Mascola JR,Montefiori DC

    更新日期:2010-01-01 00:00:00

  • Translating molecular insights in autoimmunity into effective therapy.

    abstract::Autoimmunity and the pathogenesis of autoimmune diseases were a major focus of the Walter and Eliza Hall Institute, where I started my research career. After my initial studies on immune cell culture and immune regulation, I returned to an analysis of the pathogenesis of human autoimmunity in London. Linking upregulat...

    journal_title:Annual review of immunology

    pub_type: 传,历史文章,杂志文章

    doi:10.1146/annurev-immunol-082708-100732

    authors: Feldmann M

    更新日期:2009-01-01 00:00:00

  • Structural biology of shared cytokine receptors.

    abstract::Recent structural information for complexes of cytokine receptor ectodomains bound to their ligands has significantly expanded our understanding of the macromolecular topology and ligand recognition mechanisms used by our three principal shared cytokine signaling receptors-gp130, gamma(c), and beta(c). The gp130 famil...

    journal_title:Annual review of immunology

    pub_type: 杂志文章,评审

    doi:10.1146/annurev.immunol.24.021605.090616

    authors: Wang X,Lupardus P,Laporte SL,Garcia KC

    更新日期:2009-01-01 00:00:00

  • Regulation and function of NF-kappaB transcription factors in the immune system.

    abstract::The mammalian Rel/NF-kappaB family of transcription factors, including RelA, c-Rel, RelB, NF-kappaB1 (p50 and its precursor p105), and NF-kappaB2 (p52 and its precursor p100), plays a central role in the immune system by regulating several processes ranging from the development and survival of lymphocytes and lymphoid...

    journal_title:Annual review of immunology

    pub_type: 杂志文章,评审

    doi:10.1146/annurev.immunol.021908.132641

    authors: Vallabhapurapu S,Karin M

    更新日期:2009-01-01 00:00:00

  • The inflammasomes: guardians of the body.

    abstract::The innate immune system relies on its capacity to rapidly detect invading pathogenic microbes as foreign and to eliminate them. The discovery of Toll-like receptors (TLRs) provided a class of membrane receptors that sense extracellular microbes and trigger antipathogen signaling cascades. More recently, intracellular...

    journal_title:Annual review of immunology

    pub_type: 杂志文章,评审

    doi:10.1146/annurev.immunol.021908.132715

    authors: Martinon F,Mayor A,Tschopp J

    更新日期:2009-01-01 00:00:00

  • Thymus organogenesis.

    abstract::The epithelial architecture of the thymus fosters growth, differentiation, and T cell receptor repertoire selection of large numbers of immature T cells that continuously feed the mature peripheral T cell pool. Failure to build or to maintain a proper thymus structure can lead to defects ranging from immunodeficiency ...

    journal_title:Annual review of immunology

    pub_type: 杂志文章,评审

    doi:10.1146/annurev.immunol.26.021607.090408

    authors: Rodewald HR

    更新日期:2008-01-01 00:00:00

  • Interleukin-21: basic biology and implications for cancer and autoimmunity.

    abstract::Interleukin-21 (IL-21), a potent immunomodulatory four-alpha-helical-bundle type I cytokine, is produced by NKT and CD4(+) T cells and has pleiotropic effects on both innate and adaptive immune responses. These actions include positive effects such as enhanced proliferation of lymphoid cells, increased cytotoxicity of...

    journal_title:Annual review of immunology

    pub_type: 杂志文章,评审

    doi:10.1146/annurev.immunol.26.021607.090316

    authors: Spolski R,Leonard WJ

    更新日期:2008-01-01 00:00:00

  • TSLP: an epithelial cell cytokine that regulates T cell differentiation by conditioning dendritic cell maturation.

    abstract::Dendritic cells (DCs) are professional antigen-presenting cells that have the ability to sense infection and tissue stress, sample and present antigen to T lymphocytes, and induce different forms of immunity and tolerance. The functional versatility of DCs depends on their remarkable ability to translate collectively ...

    journal_title:Annual review of immunology

    pub_type: 杂志文章,评审

    doi:10.1146/annurev.immunol.25.022106.141718

    authors: Liu YJ,Soumelis V,Watanabe N,Ito T,Wang YH,Malefyt Rde W,Omori M,Zhou B,Ziegler SF

    更新日期:2007-01-01 00:00:00

  • T cells as a self-referential, sensory organ.

    abstract::In light of recent data showing that both helper and cytotoxic T cells can detect even a single molecule of an agonist peptide-MHC, alphabeta T cells are clearly a type of sensory cell, comparable to any in the nervous system. In addition, endogenous (self) peptides bound to MHCs are not just important for thymic sele...

    journal_title:Annual review of immunology

    pub_type: 杂志文章,评审

    doi:10.1146/annurev.immunol.24.021605.090600

    authors: Davis MM,Krogsgaard M,Huse M,Huppa J,Lillemeier BF,Li QJ

    更新日期:2007-01-01 00:00:00

  • The host defense of Drosophila melanogaster.

    abstract::To combat infection, the fruit fly Drosophila melanogaster relies on multiple innate defense reactions, many of which are shared with higher organisms. These reactions include the use of physical barriers together with local and systemic immune responses. First, epithelia, such as those beneath the cuticle, in the ali...

    journal_title:Annual review of immunology

    pub_type: 杂志文章,评审

    doi:10.1146/annurev.immunol.25.022106.141615

    authors: Lemaitre B,Hoffmann J

    更新日期:2007-01-01 00:00:00

  • A central role for central tolerance.

    abstract::Recent elucidation of the role of central tolerance in preventing organ-specific autoimmunity has changed our concepts of self/nonself discrimination. This paradigmatic shift is largely attributable to the discovery of promiscuous expression of tissue-restricted self-antigens (TRAs) by medullary thymic epithelial cell...

    journal_title:Annual review of immunology

    pub_type: 杂志文章,评审

    doi:10.1146/annurev.immunol.23.021704.115601

    authors: Kyewski B,Klein L

    更新日期:2006-01-01 00:00:00

  • Natural killer cell developmental pathways: a question of balance.

    abstract::NK cells sit at the crossroads of innate and adaptive immunity and help coordinate tumor immunosurveillance and the immune response against pathogens. Balancing signals to NK cell precursors is crucial for their early development, when transcription factors compete to specify the different lymphocyte subsets. Despite ...

    journal_title:Annual review of immunology

    pub_type: 杂志文章,评审

    doi:10.1146/annurev.immunol.24.021605.090700

    authors: Di Santo JP

    更新日期:2006-01-01 00:00:00

  • Regulation of lymphoid development, differentiation, and function by the Notch pathway.

    abstract::The Notch pathway is gaining increasing recognition as a key regulator of developmental choices, differentiation, and function throughout the hematolymphoid system. Notch controls the generation of hematopoietic stem cells during embryonic development and may affect their subsequent homeostasis. Commitment to the T ce...

    journal_title:Annual review of immunology

    pub_type: 杂志文章,评审

    doi:10.1146/annurev.immunol.23.021704.115747

    authors: Maillard I,Fang T,Pear WS

    更新日期:2005-01-01 00:00:00

  • The B7 family revisited.

    abstract::The discovery of new functions for the original B7 family members, together with the identification of additional B7 and CD28 family members, have revealed new ways in which the B7:CD28 family regulates T cell activation and tolerance. B7-1/B7-2:CD28 interactions not only promote initial T cell activation but also reg...

    journal_title:Annual review of immunology

    pub_type: 杂志文章,评审

    doi:10.1146/annurev.immunol.23.021704.115611

    authors: Greenwald RJ,Freeman GJ,Sharpe AH

    更新日期:2005-01-01 00:00:00

  • How neutrophils kill microbes.

    abstract::Neutrophils provide the first line of defense of the innate immune system by phagocytosing, killing, and digesting bacteria and fungi. Killing was previously believed to be accomplished by oxygen free radicals and other reactive oxygen species generated by the NADPH oxidase, and by oxidized halides produced by myelope...

    journal_title:Annual review of immunology

    pub_type: 杂志文章,评审

    doi:10.1146/annurev.immunol.23.021704.115653

    authors: Segal AW

    更新日期:2005-01-01 00:00:00

  • Interleukin-10 and related cytokines and receptors.

    abstract::The Class 2 alpha-helical cytokines consist of interleukin-10 (IL-10), IL-19, IL-20, IL-22, IL-24 (Mda-7), and IL-26, interferons (IFN-alpha, -beta, -epsilon, -kappa, -omega, -delta, -tau, and -gamma) and interferon-like molecules (limitin, IL-28A, IL-28B, and IL-29). The interaction of these cytokines with their spec...

    journal_title:Annual review of immunology

    pub_type: 杂志文章,评审

    doi:10.1146/annurev.immunol.22.012703.104622

    authors: Pestka S,Krause CD,Sarkar D,Walter MR,Shi Y,Fisher PB

    更新日期:2004-01-01 00:00:00

  • Immunity to tuberculosis.

    abstract::Only 5 to 10% of immunocompetent humans are susceptible to tuberculosis, and over 85% of them develop the disease exclusively in the lungs. Human immunodeficiency virus (HIV)-infected humans, in contrast, can develop systemic disease that is more quickly lethal. This is in keeping with other evidence showing that susc...

    journal_title:Annual review of immunology

    pub_type: 杂志文章,评审

    doi:10.1146/annurev.immunol.22.012703.104635

    authors: North RJ,Jung YJ

    更新日期:2004-01-01 00:00:00

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