Abstract:
:The discovery of tissue-resident innate lymphoid cell populations effecting different forms of type 1, 2, and 3 immunity; tissue repair; and immune regulation has transformed our understanding of mucosal immunity and allergy. The emerging complexity of these populations along with compounding issues of redundancy and plasticity raise intriguing questions about their precise lineage relationship. Here we review advances in mapping the emergence of these lineages from early lymphoid precursors. We discuss the identification of a common innate lymphoid cell precursor characterized by transient expression of the transcription factor PLZF, and the lineage relationships of innate lymphoid cells with conventional natural killer cells and lymphoid tissue inducer cells. We also review the rapidly growing understanding of the network of transcription factors that direct the development of these lineages.
journal_name
Annu Rev Immunoljournal_title
Annual review of immunologyauthors
Ishizuka IE,Constantinides MG,Gudjonson H,Bendelac Adoi
10.1146/annurev-immunol-041015-055549subject
Has Abstractpub_date
2016-05-20 00:00:00pages
299-316eissn
0732-0582issn
1545-3278journal_volume
34pub_type
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