Transcriptional control of early T and B cell developmental choices.

Abstract:

:T and B cells share a common somatic gene rearrangement mechanism for assembling the genes that code for their antigen receptors; they also have developmental pathways with many parallels. Shared usage of basic helix-loop-helix E proteins as transcriptional drivers underlies these common features. However, the transcription factor networks in which these E proteins are embedded are different both in membership and in architecture for T and B cell gene regulatory programs. These differences permit lineage commitment decisions to be made in different hierarchical orders. Furthermore, in contrast to B cell gene networks, the T cell gene network architecture for effector differentiation is sufficiently modular so that E protein inputs can be removed. Complete T cell-like effector differentiation can proceed without T cell receptor rearrangement or selection when E proteins are neutralized, yielding natural killer and other innate lymphoid cells.

journal_name

Annu Rev Immunol

authors

Rothenberg EV

doi

10.1146/annurev-immunol-032712-100024

subject

Has Abstract

pub_date

2014-01-01 00:00:00

pages

283-321

eissn

0732-0582

issn

1545-3278

journal_volume

32

pub_type

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