Abstract:
:The complement system is an evolutionarily ancient key component of innate immunity required for the detection and removal of invading pathogens. It was discovered more than 100 years ago and was originally defined as a liver-derived, blood-circulating sentinel system that classically mediates the opsonization and lytic killing of dangerous microbes and the initiation of the general inflammatory reaction. More recently, complement has also emerged as a critical player in adaptive immunity via its ability to instruct both B and T cell responses. In particular, work on the impact of complement on T cell responses led to the surprising discoveries that the complement system also functions within cells and is involved in regulating basic cellular processes, predominantly those of metabolic nature. Here, we review current knowledge about complement's role in T cell biology, with a focus on the novel intracellular and noncanonical activities of this ancient system.
journal_name
Annu Rev Immunoljournal_title
Annual review of immunologyauthors
West EE,Kolev M,Kemper Cdoi
10.1146/annurev-immunol-042617-053245subject
Has Abstractpub_date
2018-04-26 00:00:00pages
309-338eissn
0732-0582issn
1545-3278journal_volume
36pub_type
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