Abstract:
:T helper cell differentiation occurs in the context of the extracellular cytokine milieu evoked by diverse microbes and other pathogenic stimuli along with T cell receptor stimulation. The culmination of these signals results in specification of T helper lineages, which occurs through the combinatorial action of multiple transcription factors that establish distinctive transcriptomes. In this manner, inducible, but constitutively active, master regulators work in conjunction with factors such as the signal transducer and activator of transcriptions (STATs) that sense the extracellular environment. The acquisition of a distinctive transcriptome also depends on chromatin modifications that impact key cis elements as well as the changes in global genomic organization. Thus, signal transduction and epigenetics are linked in these processes of differentiation. In this review, recent advances in understanding T helper lineage specification and deciphering the action of transcription factors are summarized with emphasis on comprehensive views of the dynamic T cell epigenome.
journal_name
Annu Rev Immunoljournal_title
Annual review of immunologyauthors
Kanno Y,Vahedi G,Hirahara K,Singleton K,O'Shea JJdoi
10.1146/annurev-immunol-020711-075058subject
Has Abstractpub_date
2012-01-01 00:00:00pages
707-31eissn
0732-0582issn
1545-3278journal_volume
30pub_type
杂志文章,评审abstract::The transcription factor NF-kappa B, more than a decade after its discovery, remains an exciting and active area of study. The involvement of NF-kappa B in the expression of numerous cytokines and adhesion molecules has supported its role as an evolutionarily conserved coordinating element in the organism's response t...
journal_title:Annual review of immunology
pub_type: 杂志文章,评审
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journal_title:Annual review of immunology
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journal_title:Annual review of immunology
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journal_title:Annual review of immunology
pub_type: 杂志文章,评审
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journal_title:Annual review of immunology
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更新日期:2009-01-01 00:00:00
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journal_title:Annual review of immunology
pub_type: 杂志文章,评审
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journal_title:Annual review of immunology
pub_type: 杂志文章,评审
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更新日期:1997-01-01 00:00:00
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journal_title:Annual review of immunology
pub_type: 杂志文章,评审
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更新日期:1999-01-01 00:00:00
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更新日期:2009-01-01 00:00:00
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journal_title:Annual review of immunology
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更新日期:2010-01-01 00:00:00
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journal_title:Annual review of immunology
pub_type: 杂志文章,评审
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journal_title:Annual review of immunology
pub_type: 杂志文章,评审
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更新日期:2012-01-01 00:00:00
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journal_title:Annual review of immunology
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journal_title:Annual review of immunology
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journal_title:Annual review of immunology
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更新日期:1991-01-01 00:00:00
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journal_title:Annual review of immunology
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更新日期:2007-01-01 00:00:00
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更新日期:1991-01-01 00:00:00
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journal_title:Annual review of immunology
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更新日期:2003-01-01 00:00:00
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journal_title:Annual review of immunology
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更新日期:2009-01-01 00:00:00
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journal_title:Annual review of immunology
pub_type: 杂志文章,评审
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更新日期:1985-01-01 00:00:00
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journal_title:Annual review of immunology
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更新日期:1991-01-01 00:00:00