Abstract:
:Neutrophils provide the first line of defense of the innate immune system by phagocytosing, killing, and digesting bacteria and fungi. Killing was previously believed to be accomplished by oxygen free radicals and other reactive oxygen species generated by the NADPH oxidase, and by oxidized halides produced by myeloperoxidase. We now know this is incorrect. The oxidase pumps electrons into the phagocytic vacuole, thereby inducing a charge across the membrane that must be compensated. The movement of compensating ions produces conditions in the vacuole conducive to microbial killing and digestion by enzymes released into the vacuole from the cytoplasmic granules.
journal_name
Annu Rev Immunoljournal_title
Annual review of immunologyauthors
Segal AWdoi
10.1146/annurev.immunol.23.021704.115653subject
Has Abstractpub_date
2005-01-01 00:00:00pages
197-223eissn
0732-0582issn
1545-3278journal_volume
23pub_type
杂志文章,评审abstract::Inflammation is an unstable state. It either resolves or persists. Why inflammation persists and the factors that define tissue tropism remain obscure. Increasing evidence suggests that tissue-resident stromal cells not only provide positional memory but also actively regulate the differential accumulation of inflamma...
journal_title:Annual review of immunology
pub_type: 杂志文章,评审
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journal_title:Annual review of immunology
pub_type: 杂志文章,评审
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abstract::Based on T cell subset depletion studies and the analysis of gene knockout mice, it is evident that CD8(+) T cells contribute to resistance against intracellular infections with certain viral, protozoan, and bacterial pathogens. Although they are known primarily for their capacity to kill infected cells, CD8(+) T cell...
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journal_title:Annual review of immunology
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doi:10.1146/annurev.immunol.22.012703.104622
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journal_title:Annual review of immunology
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doi:10.1146/annurev.iy.09.040191.000435
更新日期:1991-01-01 00:00:00
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journal_title:Annual review of immunology
pub_type: 杂志文章,评审
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journal_title:Annual review of immunology
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journal_title:Annual review of immunology
pub_type: 杂志文章,评审
doi:10.1146/annurev.immunol.15.1.297
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journal_title:Annual review of immunology
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更新日期:1999-01-01 00:00:00
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journal_title:Annual review of immunology
pub_type: 杂志文章,评审
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更新日期:1994-01-01 00:00:00
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journal_title:Annual review of immunology
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更新日期:2010-01-01 00:00:00
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journal_title:Annual review of immunology
pub_type: 杂志文章,评审
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更新日期:2004-01-01 00:00:00
abstract::In contrast to T cell receptors, signal transducing cell surface membrane molecules involved in the regulation of responses by cells of the innate immune system employ structures that are encoded in the genome rather than generated by somatic recombination and that recognize either classical MHC-I molecules or their s...
journal_title:Annual review of immunology
pub_type: 杂志文章,评审
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journal_title:Annual review of immunology
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更新日期:1995-01-01 00:00:00
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journal_title:Annual review of immunology
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journal_title:Annual review of immunology
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journal_title:Annual review of immunology
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abstract::The epithelial architecture of the thymus fosters growth, differentiation, and T cell receptor repertoire selection of large numbers of immature T cells that continuously feed the mature peripheral T cell pool. Failure to build or to maintain a proper thymus structure can lead to defects ranging from immunodeficiency ...
journal_title:Annual review of immunology
pub_type: 杂志文章,评审
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更新日期:2008-01-01 00:00:00
abstract::The mammalian Rel/NF-kappaB family of transcription factors, including RelA, c-Rel, RelB, NF-kappaB1 (p50 and its precursor p105), and NF-kappaB2 (p52 and its precursor p100), plays a central role in the immune system by regulating several processes ranging from the development and survival of lymphocytes and lymphoid...
journal_title:Annual review of immunology
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更新日期:2009-01-01 00:00:00
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journal_title:Annual review of immunology
pub_type: 杂志文章,评审
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journal_title:Annual review of immunology
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doi:10.1146/annurev-immunol-030409-101302
更新日期:2011-01-01 00:00:00
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journal_title:Annual review of immunology
pub_type: 杂志文章,评审
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journal_title:Annual review of immunology
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更新日期:2012-01-01 00:00:00
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journal_title:Annual review of immunology
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更新日期:2019-04-26 00:00:00
abstract::B lymphopoiesis is regulated by multiple signals from stromal cell contact, soluble cytokines, antigen, and T helper cells. In vitro and biochemical experiments have implicated tyrosine kinases as key components of many of these signaling pathways. Genetic analysis of the role of these tyrosine kinases has been facili...
journal_title:Annual review of immunology
pub_type: 杂志文章,评审
doi:10.1146/annurev.immunol.14.1.131
更新日期:1996-01-01 00:00:00
abstract::NK cells sit at the crossroads of innate and adaptive immunity and help coordinate tumor immunosurveillance and the immune response against pathogens. Balancing signals to NK cell precursors is crucial for their early development, when transcription factors compete to specify the different lymphocyte subsets. Despite ...
journal_title:Annual review of immunology
pub_type: 杂志文章,评审
doi:10.1146/annurev.immunol.24.021605.090700
更新日期:2006-01-01 00:00:00