How neutrophils kill microbes.

Abstract:

:Neutrophils provide the first line of defense of the innate immune system by phagocytosing, killing, and digesting bacteria and fungi. Killing was previously believed to be accomplished by oxygen free radicals and other reactive oxygen species generated by the NADPH oxidase, and by oxidized halides produced by myeloperoxidase. We now know this is incorrect. The oxidase pumps electrons into the phagocytic vacuole, thereby inducing a charge across the membrane that must be compensated. The movement of compensating ions produces conditions in the vacuole conducive to microbial killing and digestion by enzymes released into the vacuole from the cytoplasmic granules.

journal_name

Annu Rev Immunol

authors

Segal AW

doi

10.1146/annurev.immunol.23.021704.115653

subject

Has Abstract

pub_date

2005-01-01 00:00:00

pages

197-223

eissn

0732-0582

issn

1545-3278

journal_volume

23

pub_type

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