Abstract:
:Dendritic cells (DCs) are professional antigen-presenting cells that have the ability to sense infection and tissue stress, sample and present antigen to T lymphocytes, and induce different forms of immunity and tolerance. The functional versatility of DCs depends on their remarkable ability to translate collectively the information from both the invading microbes and their resident tissue microenvironments and then make an appropriate immune response. Recent progress in understanding TLR biology has illuminated the mechanisms by which DCs link innate and adaptive antimicrobial immune responses. However, how tissue microenvironments shape the function of DCs has remained elusive. Recent studies of TSLP (thymic stromal lymphopoietin), an epithelial cell-derived cytokine that strongly activates DCs, provide evidence at a molecular level that epithelial cells/tissue microenvironments directly communicate with DCs. We review recent progress on how TSLP expressed within thymus and peripheral lymphoid and nonlymphoid tissues regulates DC-mediated central tolerance, peripheral T cell homeostasis, and inflammatory Th2 responses.
journal_name
Annu Rev Immunoljournal_title
Annual review of immunologyauthors
Liu YJ,Soumelis V,Watanabe N,Ito T,Wang YH,Malefyt Rde W,Omori M,Zhou B,Ziegler SFdoi
10.1146/annurev.immunol.25.022106.141718subject
Has Abstractpub_date
2007-01-01 00:00:00pages
193-219eissn
0732-0582issn
1545-3278journal_volume
25pub_type
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