abstract：:"Deep brain stimulation is a safe and effective therapy for the management of a variety of neurologic conditions with Food and Drug Administration or humanitarian exception approval for Parkinson disease, dystonia, tremor, and obsessive-compulsive disorder. Advances in neurophysiology, neuroimaging, and technology hav...

journal_title：Neurologic clinics

authors： Burns MR,Chiu SY,Patel B,Mitropanopoulos SG,Wong JK,Ramirez-Zamora A

更新日期：2021-02-01 00:00:00

abstract：:Idiopathic intracranial hypertension is a syndrome of increased intracranial pressure of unknown cause that most often occurs in women of childbearing age. Most patients are overweight or obese with a history of recent weight gain. Following a brief review of the symptoms and signs, we discuss the approach to assessme...

journal_title：Neurologic clinics

authors： Thurtell MJ,Kawasaki A

更新日期：2021-02-01 00:00:00

abstract：:The calcineurin inhibitors cyclosporine and tacrolimus are used for their immunosuppressive effects. Neurotoxic side effects include tremor, paresthesia, and headache. Rarer neurotoxicities include seizure, posterior reversible encephalopathy syndrome, and encephalopathy. Tacrolimus tends to be more neurotoxic than cy...

journal_title：Neurologic clinics

authors： Coe CL,Horst SN,Izzy MJ

更新日期：2020-11-01 00:00:00

abstract：:Channelopathies, neuromuscular junction disorders, and myopathies represent multiple mechanisms by which toxins can affect the peripheral nervous system. These toxins include ciguatoxin, tetrodotoxin, botulinum toxin, metabolic poisons, venomous snake bites, and several medications. These toxins are important to be aw...

journal_title：Neurologic clinics

authors： Janecek J,Kushlaf H

更新日期：2020-11-01 00:00:00

abstract：:"Myasthenia gravis (MG) is the most common autoimmune neuromuscular disorder. This article highlights several cases that the practicing neurologist may encounter in the treatment of MG. Diagnostic uncertainty continues to be an issue in patients who are seronegative to the 2 most common antibodies, acetylcholine recep...

journal_title：Neurologic clinics

authors： Nguyen T,Phan CL,Supsupin E Jr,Sheikh K

更新日期：2020-08-01 00:00:00

abstract：:Cerebellar ataxia can be caused by a variety of disorders, including degenerative processes, autoimmune and paraneoplastic illness as well as by gene mutations inherited in autosomal dominant, autosomal recessive, or X-linked fashions. In this review, we highlight the treatments for cerebellar ataxia in a systematic w...

journal_title：Neurologic clinics

authors： Kwei KT,Kuo SH

更新日期：2020-05-01 00:00:00

abstract：:Parkinson disease (PD) is well recognized by its motor features of bradykinesia, tremor, rigidity, and gait and balance difficulties. However, PD is also characterized by a myriad of nonmotor symptoms, which may occur even before motor symptoms, early in the course of disease, and throughout the advancing disease. The...

journal_title：Neurologic clinics

authors： Goldman JG,Guerra CM

更新日期：2020-05-01 00:00:00

abstract：:Transcranial Doppler ultrasonography (TCD) is a noninvasive, bedside, portable tool for assessment of cerebral hemodynamics. Modern TCD head frames allow continuous hands-free emboli detection for risk stratification and assessment of treatment efficacy in several cardiovascular diseases. Identifying a focal stenosis,...

journal_title：Neurologic clinics

authors： Hakimi R,Alexandrov AV,Garami Z

更新日期：2020-02-01 00:00:00

abstract：:Diagnostic testing is of limited value among patients with migraine who present to an emergency department. Various nonopioid, disease-specific treatments are available for patients who present to an emergency department with migraine headache and associated features. Emergency physicians should recognize that the acu...

journal_title：Neurologic clinics

authors： Friedman BW

更新日期：2019-11-01 00:00:00

abstract：:Shift work and its negative consequences are becoming more relevant as the economy becomes increasing globalized. For many individuals, shift work serves as a significant biological and psychosocial challenge leading to Shift Work Disorder (SWD). Beyond the symptoms of sleep and excessive sleepiness, the range of cons...

journal_title：Neurologic clinics

authors： Cheng P,Drake C

更新日期：2019-08-01 00:00:00

abstract：:The vasculitides are diseases characterized by inflammation of blood vessels and inflammatory leukocytes in vessel walls. There is an increased propensity for ischemic stroke, resulting from compromise of vessel lumina with distal tissue ischemia; and hemorrhagic or nonhemorrhagic stroke, and aneurysmal formation and ...

journal_title：Neurologic clinics

authors： Younger DS

更新日期：2019-05-01 00:00:00

abstract：:Myasthenia gravis is an autoimmune disorder characterized by fluctuating weakness of extraocular and proximal limb muscles. It occurs in 1 in 5000 in the overall population and is 2 times more common in women than men. The onset in women is most common in the third decade, and risk of severe exacerbation occurs most f...

journal_title：Neurologic clinics

authors： Waters J

更新日期：2019-02-01 00:00:00

abstract：:Prions diseases are uniformly fatal neurodegenerative diseases that occur in sporadic, genetic, and acquired forms. Acquired prion diseases, caused by infectious transmission, are least common. Most prion diseases are not infectious, but occur spontaneously through misfolding of normal prion proteins or genetic mutati...

journal_title：Neurologic clinics

authors： Tee BL,Longoria Ibarrola EM,Geschwind MD

更新日期：2018-11-01 00:00:00

abstract：:Viruses are a frequent cause of encephalitis. Common or important viruses causing encephalitis include herpesviruses, arboviruses, enteroviruses, parechoviruses, mumps, measles, rabies, Ebola, lymphocytic choriomeningitis virus, and henipaviruses. Other viruses may cause an encephalopathy. Host factors and clinical fe...

journal_title：Neurologic clinics

authors： Venkatesan A,Murphy OC

更新日期：2018-11-01 00:00:00

abstract：:Pediatric central nervous system (CNS) tumors are the most common solid tumors in children and comprise 15% to 20% of all malignancies in children. Presentation, symptoms, and signs depend on tumor location and age of the patient at the time of diagnosis. This article summarizes the common childhood CNS tumors, presen...

journal_title：Neurologic clinics

authors： Udaka YT,Packer RJ

更新日期：2018-08-01 00:00:00

abstract：:This article discusses antibodies associated with immune-mediated myasthenia gravis and the pathologic action of these antibodies at the neuromuscular junctions of skeletal muscle. To explain how these antibodies act, we consider the physiology of neuromuscular transmission with emphasis on 4 features: the structure o...

journal_title：Neurologic clinics

authors： Ruff RL,Lisak RP

更新日期：2018-05-01 00:00:00

abstract：:Meaningful symptom management can have a profound impact on quality of life. It can challenge time parameters during clinic, and therefore thought should be given to strategies that can improve efficiency and thereby make the undertaking more tenable. For any given symptom, the building blocks of care, such as vitamin...

journal_title：Neurologic clinics

authors： Crabtree-Hartman E

更新日期：2018-02-01 00:00:00

abstract：:Intensive care unit-acquired weakness (ICUAW) is a substantial contributor to long-term disability in survivors of critical illness. Critical illness polyneuropathy, critical illness myopathy, and muscle atrophy from disuse contribute in various proportions to ICUAW. ICUAW is a clinical diagnosis supported by electrop...

journal_title：Neurologic clinics

authors： Kramer CL

更新日期：2017-11-01 00:00:00

abstract：:Sports-related concussions (SRCs) are common among athletes in the United States. Most athletes who sustain an SRC recover within 7 to 10 days; however, many athletes who sustain the injury do not recover as expected and experience prolonged, persistent symptoms. In this document, the authors provide an overview of th...

journal_title：Neurologic clinics

authors： Anto-Ocrah M,Jones CMC,Diacovo D,Bazarian JJ

更新日期：2017-08-01 00:00:00

abstract：:The oldest-old represent the fastest growing segment of society, and the risk of developing dementia continues to increase with advancing age into the 9th and 10th decades of life. The most common form of dementia in the oldest-old is Alzheimer disease (AD), although there are often mixed pathologies contributing to d...

journal_title：Neurologic clinics

authors： Pierce AL,Bullain SS,Kawas CH

更新日期：2017-05-01 00:00:00

abstract：:Many abnormalities of the orbit present with neuro-ophthalmic findings, such as impaired ocular motility or alignment, and sensory changes, including optic neuropathy. Comprehensive coverage of all orbital diseases is beyond the scope of this article. This review focuses on diagnosis and management of the most common ...

journal_title：Neurologic clinics

authors： Chang JR,Gruener AM,McCulley TJ

更新日期：2017-02-01 00:00:00

abstract：:The epidemiology of vasculitis has witnessed extraordinary advances in the past decade influenced by the worldwide increased recognition and accurate classification and diagnosis of the vasculitides, and insights brought by genome-wide association studies and other genetic investigations that contribute to the underst...

journal_title：Neurologic clinics

authors： Younger DS

更新日期：2016-11-01 00:00:00

abstract：:A network of family-based community-oriented primary health programs, or Programa Agentes Communita˙rios de Saúde, and family health programs, or Programa Saúde da Família, introduced almost 2 decades ago were the Brazilian government's health care models to restructure primary care under the Unified Health System, or...

journal_title：Neurologic clinics

authors： Younger DS

更新日期：2016-11-01 00:00:00

abstract：:The anatomic and physiologic changes that occur during pregnancy are unique. A neurologist needs to be aware of normal pregnancy-induced physiologic changes in the cardiovascular, renal, hematologic, and autoimmune systems, and the local anatomic changes, which include alteration of body habitus and pelvic ligaments. ...

journal_title：Neurologic clinics

authors： O'Neal MA

更新日期：2016-08-01 00:00:00

abstract：:Syncope, or the sudden loss of consciousness, is a common presenting symptom for evaluation by neurologists. It is not a unique diagnosis but rather a common manifestation of disorders with diverse mechanisms. Loss of consciousness is typically preceded by a prodrome of symptoms and sometimes there is a clear trigger....

journal_title：Neurologic clinics

authors： Kleyman I,Weimer LH

更新日期：2016-08-01 00:00:00

abstract：:Guidelines and quality measures for epilepsy care have the potential to improve the quality of epilepsy care. Quality measures are increasingly used for pay-for-performance. This article describes different guidelines and quality measures that have been used to identify best practices, types of best practices for use ...

journal_title：Neurologic clinics

authors： Pugh MJ,McMillan KK

更新日期：2016-05-01 00:00:00

abstract：:Most patients who have endured a stroke sustain behavioral changes, although in many instances these effects can be subtle. Although behavioral changes after a stroke tend to improve, they may persist and have serious effects on daily living activities. This article reviews the more familiar behavioral changes that fo...

journal_title：Neurologic clinics

authors： Mark VW

更新日期：2016-02-01 00:00:00

abstract：:Amyotrophic lateral sclerosis can be described as a disease with a poorly understood pathophysiologic mechanism and no treatment that dramatically impacts the course of the disease. Clinical trialists are faced with finding small treatment effects against a background of multiple potential treatments, a past history o...

journal_title：Neurologic clinics

authors： Katz JS,Barohn RJ,Dimachkie MM,Mitsumoto H

更新日期：2015-11-01 00:00:00

abstract：:Progressive muscular atrophy (PMA) is a rare, sporadic, adult-onset motor neuron disease, clinically characterized by isolated lower motor neuron features; however, clinically evident upper motor neuron signs may emerge in some patients. Subclinical upper motor neuron involvement is identified pathologically, radiolog...

journal_title：Neurologic clinics

authors： Liewluck T,Saperstein DS

更新日期：2015-11-01 00:00:00

abstract：:Stroke involving the brainstem and cerebellum frequently presents acute vestibular syndrome. Although vascular vertigo is known to usually accompany other neurologic symptoms and signs, isolated vertigo from small infarcts involving the cerebellum or brainstem has been increasingly recognized. Bedside neuro-otologic e...

journal_title：Neurologic clinics

authors： Lee SH,Kim JS

更新日期：2015-08-01 00:00:00

abstract：:Classifications and definitions are essential to facilitate communication; promote accurate diagnostic criteria; develop, test, and use effective therapies; and specify knowledge gaps. This article describes the development of the International Classification of Vestibular Disorders (ICVD) initiative. It describes its...

journal_title：Neurologic clinics

authors： Bisdorff AR,Staab JP,Newman-Toker DE

更新日期：2015-08-01 00:00:00

abstract：:Primary angiitis of the central nervous system (PACNS) is a vasculitis of small arteries and veins of unknown cause restricted to the central nervous system (CNS), and controversy and disagreement exist over the means to establish the diagnosis. Cerebral arteriography, cerebrospinal fluid examination, and MRI singly o...

journal_title：Neurologic clinics

authors： Powers WJ

更新日期：2015-05-01 00:00:00

abstract：:In a recent trial limited to arteriovenous malformations discovered not to have bled, medical management was superior to medical management plus intervention. The trial was halted after 226 randomizations and a mean follow-up of 3.3 years owing to a disparity favoring the medical arm. Eligible patients were selected a...

journal_title：Neurologic clinics

authors： Mohr JP,Yaghi S

更新日期：2015-05-01 00:00:00

abstract：:Psychogenic movement disorders (PMDs) can present with varied phenomenology that may resemble organic movement disorders. The diagnosis is based on clinical evaluation with a supporting history and classic features on neurologic examination. Ancillary testing, such as imaging and neurophysiologic studies, can provide ...

journal_title：Neurologic clinics

authors： Thenganatt MA,Jankovic J

更新日期：2015-02-01 00:00:00

abstract：:The last 2 decades represent a period of unparalleled advancement in the understanding of the pathogenesis of Parkinson disease (PD). The discovery of several forms of familial parkinsonism with mendelian inheritance has elucidated insights into the mechanisms underlying the degeneration of dopaminergic neurons of the...

journal_title：Neurologic clinics

authors： Mullin S,Schapira AH

更新日期：2015-02-01 00:00:00

abstract：:Traumatic injury to the posterior fossa is a complex pathologic condition because of the great heterogeneity of lesions present. Treatment of primary brain injuries and prevention of secondary brain injuries is the mainstay of management. It is imperative to recognize traumatic lesions of the posterior fossa early bec...

journal_title：Neurologic clinics

authors： Nixon M,Ambekar S,Zhang S,Markham C,Akbarian-Tefaghi H,Morrow K,Nanda A,Guthikonda B

更新日期：2014-11-01 00:00:00

abstract：:Metabolic and mitochondrial myopathies encompass a heterogeneous group of disorders that result in impaired energy production in skeletal muscle. Symptoms of premature muscle fatigue, sometimes leading to myalgia, rhabdomyolysis, and myoglobinuria, typically occur with exercise that would normally depend on the defect...

journal_title：Neurologic clinics

authors： Sharp LJ,Haller RG

更新日期：2014-08-01 00:00:00

abstract：:Myopathies are a heterogeneous group of disorders that can be challenging to diagnose. This review provides a diagnostic approach based predominantly on the clinical history and neurologic examination. Laboratory testing that can be used to confirm the suspected diagnosis based on this pattern recognition approach is ...

journal_title：Neurologic clinics

authors： Barohn RJ,Dimachkie MM,Jackson CE

更新日期：2014-08-01 00:00:00

abstract：:Cervicogenic headache is pain referred to the head from a source in the cervical spine or mediated by cervical nerves. Clinical features allow for no more than a diagnosis of probable cervicogenic headache. Definitive diagnosis requires evidence of a cervical source of pain. For most treatments, the evidence is limite...

journal_title：Neurologic clinics

authors： Bogduk N

更新日期：2014-05-01 00:00:00

abstract：:Cerebral ischemia manifests widely in patient symptoms. Along with the clinical examination, imaging serves as a powerful tool throughout the course of ischemia-from acute onset to evolution. A thorough understanding of imaging modalities, their strengths and their limitations, is essential for capitalizing on the ben...

journal_title：Neurologic clinics

authors： Nour M,Liebeskind DS

更新日期：2014-02-01 00:00:00