Abstract:
:The oldest-old represent the fastest growing segment of society, and the risk of developing dementia continues to increase with advancing age into the 9th and 10th decades of life. The most common form of dementia in the oldest-old is Alzheimer disease (AD), although there are often mixed pathologies contributing to dementia in addition to amyloid plaques and neurofibrillary tangles. Diagnosing AD in the oldest-old is challenging due to cognitive and physical changes associated with aging. Treatment remains supportive, with current approved medications able to provide modest symptomatic benefit but unable to slow the progression of disease.
journal_name
Neurol Clinjournal_title
Neurologic clinicsauthors
Pierce AL,Bullain SS,Kawas CHdoi
10.1016/j.ncl.2017.01.006subject
Has Abstractpub_date
2017-05-01 00:00:00pages
283-293issue
2eissn
0733-8619issn
1557-9875pii
S0733-8619(17)30006-3journal_volume
35pub_type
杂志文章,评审abstract::The nosology of dementia has evolved from the simple distinctions between senility, degenerative dementia, and vascular insults that existed a few decades ago. The differentiation of normal cognitive aging from very mild dementia has sharpened considerably; however, appreciation of the heterogeneity of Alzheimer's dis...
journal_title:Neurologic clinics
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journal_title:Neurologic clinics
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journal_title:Neurologic clinics
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journal_title:Neurologic clinics
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journal_title:Neurologic clinics
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journal_title:Neurologic clinics
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pub_type: 杂志文章,评审
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journal_title:Neurologic clinics
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journal_title:Neurologic clinics
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