Biological neurotoxins.

abstract：:Postamputation phenomena, including painful and nonpainful phantom sensations occur following loss of limbs and other body parts. Peripheral and central nervous system mechanisms play a role in persistent phantom pain. Understanding the pathophysiology of this syndrome has improved in recent years. Comprehensive evalu...

journal_title：Neurologic clinics

authors： Weinstein SM

更新日期：1998-11-01 00:00:00

abstract：:Motor fluctuations and dyskinesias are common motor complications that manifest within the first few years from the initiation of therapy in patients with Parkinson disease. These complications negatively affect the quality of life and represent an important source of disability. A growing number of therapeutic option...

journal_title：Neurologic clinics

authors： Espay AJ

更新日期：2010-11-01 00:00:00

abstract：:Focal, small-to-moderate and transient improvement occurred in the muscle strength and function of patients with ALS who received TRH in dose-response and screening studies. In a small pilot study of 12 patients, 3 months administration of TRH at 10 mg per kg on alternate days resulted in localized increased strength ...

journal_title：Neurologic clinics

authors： Brooks BR,Sufit RL,Montgomery GK,Beaulieu DA,Erickson LM

更新日期：1987-02-01 00:00:00

abstract：:Sports-related concussions (SRCs) are common among athletes in the United States. Most athletes who sustain an SRC recover within 7 to 10 days; however, many athletes who sustain the injury do not recover as expected and experience prolonged, persistent symptoms. In this document, the authors provide an overview of th...

journal_title：Neurologic clinics

authors： Anto-Ocrah M,Jones CMC,Diacovo D,Bazarian JJ

更新日期：2017-08-01 00:00:00

abstract：:Neurologic complications are a major cause of morbidity, complicating open heart surgery, cardiac catheterization, and interventional techniques. Global or focal brain ischemia related to embolism or hypoperfusion predominates. Breakthrough cerebral hemorrhage and infection can complicate cardiac transplantation. Iden...

journal_title：Neurologic clinics

authors： Furlan AJ,Sila CA,Chimowitz MI,Jones SC

更新日期：1992-02-01 00:00:00

abstract：:Nonsurgical, conservative approaches to spine pain include medication and physical therapy. In addition, several invasive procedures have been developed to provide relief when conservative options fail. These include facet joint injection and radiofrequency ablation techniques, translaminar and transforaminal epidural...

journal_title：Neurologic clinics

authors： Levin KH

更新日期：2007-05-01 00:00:00

abstract：:The etiology of pyogenic infections of the brain and meninges varies principally by age, predisposing causes or conditions, and anatomic site of the infection. An appreciation of these factors, plus the prudent use of noninvasive anatomic diagnostic techniques (such as CT) and examination of the CSF, will provide a ba...

journal_title：Neurologic clinics

authors： Overturf GD

更新日期：1986-02-01 00:00:00

abstract：:Neuropathies due to nutritional problems can affect certain patient populations and have a varied presentation because of multiple coexistent nutritional deficiencies. Clinicians should consider nutritional neuropathies in patients presenting with neuropathies. Clinicians should be alert for signs and symptoms of neur...

journal_title：Neurologic clinics

authors： Hammond N,Wang Y,Dimachkie MM,Barohn RJ

更新日期：2013-05-01 00:00:00

abstract：:Smartphones make mobile computing at point of care practical. Smartphones can think, sync, and link. Built-in and user-installed applications facilitate communications between neurologists and their medical colleagues and patients and augment data acquisition and processing in the core medical information domains of p...

journal_title：Neurologic clinics

authors： Busis N

更新日期：2010-05-01 00:00:00

abstract：:Glycogen is a crucial source of energy in the initial stages of muscle activity and during exercise of high intensity. There are 10 well-defined biochemical defects of glycogen metabolism expressed in muscle and affecting the following enzymes: alpha 1,4 glucosidase (glycogenesis type II), debrancher enzyme (III), bra...

journal_title：Neurologic clinics

authors： Servidei S,DiMauro S

更新日期：1989-02-01 00:00:00

abstract：:Intensive care unit-acquired weakness (ICUAW) is a substantial contributor to long-term disability in survivors of critical illness. Critical illness polyneuropathy, critical illness myopathy, and muscle atrophy from disuse contribute in various proportions to ICUAW. ICUAW is a clinical diagnosis supported by electrop...

journal_title：Neurologic clinics

authors： Kramer CL

更新日期：2017-11-01 00:00:00

abstract：:The immune system plays a significant role in Alzheimer disease (AD). β-Amyloid deposition in the cortex is thought to be an initiating event in AD and the widely believed amyloid hypothesis proposes removal of amyloid may delay disease progression. Human trials of active or passive immune agents have failed to show b...

journal_title：Neurologic clinics

authors： Farlow MR,Brosch JR

更新日期：2013-08-01 00:00:00

abstract：:This article defines the evolving role of the neurologist as a provider of palliative care. As neurologists care for chronically and critically ill, dying patients, and individuals whose diseases are incurable at the time of diagnosis, clinical competence requires expertise in the principles and practice of palliative...

journal_title：Neurologic clinics

authors： Foley KM,Carver AC

更新日期：2001-11-01 00:00:00

abstract：:Pseudotumor cerebri is a perplexing syndrome of increased intra-cranial pressure without a space-occupying lesion. The terminology for the disorder has changed over the years and the diagnostic criteria revised to reflect advances in diagnostic technology and insights into the disease process. The classification and n...

journal_title：Neurologic clinics

authors： Friedman DI

更新日期：2004-02-01 00:00:00

abstract：:Legal issues must be considered in caring for patients with epilepsy. Doctors caring for people with epilepsy may be legally involved in three primary ways: as the agent of social control, as patient advocate, and as the target of liability or malpractice suits. This article examines these factors and the implications...

journal_title：Neurologic clinics

authors： Hughes JT,Devinsky O

更新日期：1994-02-01 00:00:00

abstract：:Drug-induced seizures are a commonly encountered problem for physicians. In this article, drugs that cause seizures are discussed with regards to the incidence of seizures, associated clinical factors, risk factors, and special treatment considerations. This information should help physicians determine appropriate eva...

journal_title：Neurologic clinics

authors： Garcia PA,Alldredge BK

更新日期：1994-02-01 00:00:00

abstract：:There is no single definition of pharmacoresistant (intractable, refractory) epilepsy. Prospective identification of pharmacoresistance is complicated by the variability of its appearance across different types of epilepsy and the variability of seizure control within a given patient over time. Failure of informative ...

journal_title：Neurologic clinics

authors： Berg AT

更新日期：2009-11-01 00:00:00

abstract：:The three states of mammalian being--wakefulness, REM sleep, and NREM sleep--are not mutually exclusive and may occur simultaneously, oscillate rapidly, or appear in dissociated or incomplete form to produce primary sleep parasomnias. Dysfunctions of a wide variety of organ systems may take advantage of the sleeping s...

journal_title：Neurologic clinics

authors： Mahowald MW,Schenck CH

更新日期：1996-11-01 00:00:00

abstract：:Normal cell replication is regulated by growth factors such as epidermal growth factor (EGF) and platelet-derived growth factor (PDGF) that act through binding to specific surface receptors on target cells. Oncogenes may exert their transforming activity by encoding proteins that mimic the function of the normal regul...

journal_title：Neurologic clinics

authors： Westermark B,Nister M,Heldin CH

更新日期：1985-11-01 00:00:00

abstract：:Research models show a strong interrelationship between sleep quality and immune function. The proinflammatory cytokines, interleukin-1, interleukin-6, and tumor necrosis factor α are classified as official sleep-regulatory substances. However, sleep-promoting properties are also possessed by several other immune and ...

journal_title：Neurologic clinics

authors： Gamaldo CE,Shaikh AK,McArthur JC

更新日期：2012-11-01 00:00:00

abstract：:Through the use of IHS criteria, large population-based epidemiologic studies in Denmark, the United States, France, Canada, and elsewhere have shed light on the descriptive epidemiology of migraine. Although migraine is a remarkably common cause of temporary disability, many migraineurs, even those with disabling hea...

journal_title：Neurologic clinics

authors： Silberstein SD,Lipton RB

更新日期：1996-05-01 00:00:00

abstract：:Psychiatric disorders occurring in patients with epilepsy are complications, not an essential part of the illness, and may be prevented or ameliorated. Outlined are risk factors and medical treatment and the need for education concerning epilepsy and for encouragement of the patient by the physician. ...

journal_title：Neurologic clinics

authors： Green JB,Mercille RA

更新日期：1984-02-01 00:00:00

abstract：:Amyotrophic lateral sclerosis can be described as a disease with a poorly understood pathophysiologic mechanism and no treatment that dramatically impacts the course of the disease. Clinical trialists are faced with finding small treatment effects against a background of multiple potential treatments, a past history o...

journal_title：Neurologic clinics

authors： Katz JS,Barohn RJ,Dimachkie MM,Mitsumoto H

更新日期：2015-11-01 00:00:00

abstract：:Traditionally, diseases affecting the motor unit had been subdivided based on anatomic criteria into diseases of the anterior horn cell, the peripheral nerve, the neuromuscular junction, and the muscle itself. For therapeutic considerations, however, a more precise cellular and clinicopathologic characterization of th...

journal_title：Neurologic clinics

authors： Dalakas M

更新日期：1990-02-01 00:00:00

abstract：:Neurologic syndromes in AIDS are of four types: infections, para-infections, neoplastic, and paraneoplastic. All levels of the neuraxis can be affected. Neurologic complications may be the initial symptom or the cause of death. Aggressive evaluation, including biopsy of cerebral lesions, is indicated because effective...

journal_title：Neurologic clinics

authors： Britton CB,Miller JR

更新日期：1984-05-01 00:00:00

abstract：:Metabolic and mitochondrial myopathies encompass a heterogeneous group of disorders that result in impaired energy production in skeletal muscle. Symptoms of premature muscle fatigue, sometimes leading to myalgia, rhabdomyolysis, and myoglobinuria, typically occur with exercise that would normally depend on the defect...

journal_title：Neurologic clinics

authors： Sharp LJ,Haller RG

更新日期：2014-08-01 00:00:00

abstract：:Supratentorial low-grade gliomas comprise a group of primary central nervous system neoplasms with characteristics of neuroglial cells (i.e., astrocytes and oligodendrocytes) and relatively low anaplastic potential, although through time they tend to behave more aggressively. Immediate surgical intervention and subseq...

journal_title：Neurologic clinics

authors： Recht LD,Bernstein M

更新日期：1995-11-01 00:00:00

abstract：:The autosomal dominant spinocerebellar ataxias are a diverse and clinically heterogeneous group of disorders characterized by degeneration and dysfunction of the cerebellum and its associated pathways. Clinical and diagnostic evaluation can be challenging because of phenotypic overlap among causes, and a stratified an...

journal_title：Neurologic clinics

authors： Shakkottai VG,Fogel BL

更新日期：2013-11-01 00:00:00

abstract：:Our recommendations for the evaluation of the patient with suspected cardiogenic syncope are as follows: An initial thorough history and physical examination of the patient will suggest the diagnosis of cardiogenic syncope in at least 50 per cent of patients. A sudden occurrence of syncope, or "drop attack", is most s...

journal_title：Neurologic clinics

authors： Dohrmann ML,Cheitlin MD

更新日期：1986-08-01 00:00:00

abstract：:Neuroepidemiology is the application of the methods of epidemiology to the problems of clinical neurology. After diagnosis, the most basic characterization of a disease is its frequency. This characterization requires ascertainment of case (numerator) within their population at risk (denominator) to provide incidence,...

journal_title：Neurologic clinics

authors： Kurtzke JF

更新日期：1996-05-01 00:00:00