Identification of pharmacoresistant epilepsy.

abstract：:The author defines lacunes, classifies types of lacunes and their causes, discusses the correlation between lacunes and specific syndromes, and suggests appropriate therapy. ...

journal_title：Neurologic clinics

authors： Mohr JP

更新日期：1983-02-01 00:00:00

abstract：:The presence of a monoclonal protein in the serum of a patient with peripheral neuropathy raises the suspicion of systemic amyloidosis, POEMS syndrome, macroglobulinemia, multiple myeloma, or lymphoma. If these conditions are excluded, the patient is classified as having a monoclonal gammopathy of undetermined signifi...

journal_title：Neurologic clinics

authors： Kyle RA

更新日期：1992-08-01 00:00:00

abstract：:Approximately 2 per cent of organ transplant recipients develop primary CNS lymphomas. There is no pathognomonic clinical or radiographic presentation of the tumor, although multicentric involvement of deep white matter is common. Evidence has linked PCNSL to immunosuppression and to infection with the EBV. The most r...

journal_title：Neurologic clinics

authors： Patchell RA

更新日期：1988-05-01 00:00:00

abstract：:The last 2 decades represent a period of unparalleled advancement in the understanding of the pathogenesis of Parkinson disease (PD). The discovery of several forms of familial parkinsonism with mendelian inheritance has elucidated insights into the mechanisms underlying the degeneration of dopaminergic neurons of the...

journal_title：Neurologic clinics

authors： Mullin S,Schapira AH

更新日期：2015-02-01 00:00:00

abstract：:Overall, the majority of patients with optic pathway tumors will have stable disease regardless if they are radiated or receive chemotherapy. This is a very indolent tumor system and, for the most part, not a threat to life. Because of this, issues regarding appropriate therapeutic approaches have yet to be resolved. ...

journal_title：Neurologic clinics

authors： Cohen ME,Duffner PK

更新日期：1991-05-01 00:00:00

abstract：:In the current era of escalating globalization with rapid transport, changing climate, and an ever growing human population with associated changes in lifestyle, poverty, and war, the emergence of new neurologic infections is accelerated. Understanding their origins using epidemiologic and molecular tools will contrib...

journal_title：Neurologic clinics

authors： Johnson RT,Power C

更新日期：2008-08-01 00:00:00

abstract：:This review explores the principle features of the immunopathology of multiple sclerosis (MS), particularly relapsing-remitting MS. It highlights the emerging concepts in the pathogenesis of MS in the context of known features of pathology, including the characterization of cytokine networks promoting inflammatory dam...

journal_title：Neurologic clinics

authors： Wu GF,Alvarez E

更新日期：2011-05-01 00:00:00

abstract：:Pediatric central nervous system (CNS) tumors are the most common solid tumors in children and comprise 15% to 20% of all malignancies in children. Presentation, symptoms, and signs depend on tumor location and age of the patient at the time of diagnosis. This article summarizes the common childhood CNS tumors, presen...

journal_title：Neurologic clinics

authors： Udaka YT,Packer RJ

更新日期：2018-08-01 00:00:00

abstract：:The epidemiology of vasculitis has witnessed extraordinary advances in the past decade influenced by the worldwide increased recognition and accurate classification and diagnosis of the vasculitides, and insights brought by genome-wide association studies and other genetic investigations that contribute to the underst...

journal_title：Neurologic clinics

authors： Younger DS

更新日期：2016-11-01 00:00:00

abstract：:The authors review iatrogenic complications of stereotactic surgery, including tumor biopsy, cyst or abscess aspiration, movement disorder surgery, and radiosurgery. The expected morbidities and steps taken to reduce complications are also discussed. ...

journal_title：Neurologic clinics

authors： Kondziolka D,Firlik AD,Lunsford LD

更新日期：1998-02-01 00:00:00

abstract：:Personal experience indicates we sleep differently when sick. Data reviewed demonstrate the extent to which sleep is altered during the course of infection of host organisms by several classes of pathogens. One important unanswered question is whether or not the alterations in sleep during infection are of functional ...

journal_title：Neurologic clinics

authors： Opp MR

更新日期：2006-08-01 00:00:00

abstract：:Syncope, or the sudden loss of consciousness, is a common presenting symptom for evaluation by neurologists. It is not a unique diagnosis but rather a common manifestation of disorders with diverse mechanisms. Loss of consciousness is typically preceded by a prodrome of symptoms and sometimes there is a clear trigger....

journal_title：Neurologic clinics

authors： Kleyman I,Weimer LH

更新日期：2016-08-01 00:00:00

abstract：:Research models show a strong interrelationship between sleep quality and immune function. The proinflammatory cytokines, interleukin-1, interleukin-6, and tumor necrosis factor α are classified as official sleep-regulatory substances. However, sleep-promoting properties are also possessed by several other immune and ...

journal_title：Neurologic clinics

authors： Gamaldo CE,Shaikh AK,McArthur JC

更新日期：2012-11-01 00:00:00

abstract：:The clinician should be alert to the possibility of cerebrovascular disease in cancer patients who develop signs of diffuse or focal cerebral dysfunction. The cause of cerebrovascular disease can usually be determined by knowing the primary tumor type, extent of metastatic disease, and type of antineoplastic treatment...

journal_title：Neurologic clinics

authors： Rogers LR

更新日期：1991-11-01 00:00:00

abstract：:The calcineurin inhibitors cyclosporine and tacrolimus are used for their immunosuppressive effects. Neurotoxic side effects include tremor, paresthesia, and headache. Rarer neurotoxicities include seizure, posterior reversible encephalopathy syndrome, and encephalopathy. Tacrolimus tends to be more neurotoxic than cy...

journal_title：Neurologic clinics

authors： Coe CL,Horst SN,Izzy MJ

更新日期：2020-11-01 00:00:00

abstract：:Nerve conduction studies and needle electromyography provide important and complementary information as part of an electrodiagnostic study. Potential technical problems that are encountered during the studies may interfere with accurate and reliable acquisition of information and interpretation of the data. Recognitio...

journal_title：Neurologic clinics

authors： Rubin DI

更新日期：2012-05-01 00:00:00

abstract：:Use of the somatosensory evoked potential (SEP) in the evaluation of the peripheral nervous system is described. When using SEPs to evaluate peripheral nervous system disease, it is assumed that the central nervous system is intact. SEPs can be used to measure conduction through nerves that, by nature of their anatomi...

journal_title：Neurologic clinics

authors： Eisen A

更新日期：1988-11-01 00:00:00

abstract：:In vitro and in vivo studies of striatal dopamine receptor changes have been reviewed in this article. A background of receptor pharmacology methods has been included to assist the reader in assessing the merits of the published studies. Overall the literature is not consistent in the relevant observations in parkinso...

journal_title：Neurologic clinics

authors： Guttman M

更新日期：1992-05-01 00:00:00

abstract：:Given the magnitude of the problem of motor fluctuations in patients who have Parkinson's disease treated with levodopa, a significant effort has been expended by physicians, researchers, and pharmaceutical manufacturers over the years to find effective treatments. This article briefly reviews the medical options for ...

journal_title：Neurologic clinics

authors： Dewey RB Jr

更新日期：2008-08-01 00:00:00

abstract：:Our recommendations for the evaluation of the patient with suspected cardiogenic syncope are as follows: An initial thorough history and physical examination of the patient will suggest the diagnosis of cardiogenic syncope in at least 50 per cent of patients. A sudden occurrence of syncope, or "drop attack", is most s...

journal_title：Neurologic clinics

authors： Dohrmann ML,Cheitlin MD

更新日期：1986-08-01 00:00:00

abstract：:Nonsurgical, conservative approaches to spine pain include medication and physical therapy. In addition, several invasive procedures have been developed to provide relief when conservative options fail. These include facet joint injection and radiofrequency ablation techniques, translaminar and transforaminal epidural...

journal_title：Neurologic clinics

authors： Levin KH

更新日期：2007-05-01 00:00:00

abstract：:Impairments of visual perception resulting from brain damage can have serious implications for many aspects of patients' lives, and these impairments should be targeted for intervention. Rehabilitation programs need to be individually tailored to each patient's needs; thus, characterization of a patient's visual perce...

journal_title：Neurologic clinics

authors： Anderson SW

更新日期：2003-08-01 00:00:00

abstract：:Rapidly progressive dementias (RPDs) are neurologic conditions that develop subacutely over weeks to months or, rarely, acutely over days. In contrast to most dementing conditions that take years to progress to death, RPD quickly can be fatal. It is critical to evaluate patients who have RPD without delay, usually in ...

journal_title：Neurologic clinics

authors： Geschwind MD,Haman A,Miller BL

更新日期：2007-08-01 00:00:00

abstract：:The fourth edition of The Diagnostic and Statistical Manual of Mental Disorders defines delirium as "a reversible state of confusion with a reduced level of consciousness manifest as an inability to focus, sustain or shift attention." Pharmacologic agents are important contributors to delirium in hospitalized elderly ...

journal_title：Neurologic clinics

authors： Hanson MR,Gálvez-Jiménez N

更新日期：2004-05-01 00:00:00

abstract：:Many abnormalities of the orbit present with neuro-ophthalmic findings, such as impaired ocular motility or alignment, and sensory changes, including optic neuropathy. Comprehensive coverage of all orbital diseases is beyond the scope of this article. This review focuses on diagnosis and management of the most common ...

journal_title：Neurologic clinics

authors： Chang JR,Gruener AM,McCulley TJ

更新日期：2017-02-01 00:00:00

abstract：:Drug-induced seizures are a commonly encountered problem for physicians. In this article, drugs that cause seizures are discussed with regards to the incidence of seizures, associated clinical factors, risk factors, and special treatment considerations. This information should help physicians determine appropriate eva...

journal_title：Neurologic clinics

authors： Garcia PA,Alldredge BK

更新日期：1994-02-01 00:00:00

abstract：:Motor and phonic tics represent the clinic hallmark of Tourette syndrome. Since there is no diagnostic test for tics, the clinical recognition of phenomenology is essential for proper diagnosis. Some, and possibly most, motor tics are preceded by a premonitory urge or sensation that is relieved by the execution of the...

journal_title：Neurologic clinics

authors： Jankovic J

更新日期：1997-05-01 00:00:00

abstract：:Primary brain tumors consist of neoplasms with varied molecular defects, morphologic phenotypes, and clinical outcomes. The genetic and signaling abnormalities involved in tumor initiation and progression of the most prevalent adult primary brain tumors, including gliomas, meningiomas, and medulloblastomas, are descri...

journal_title：Neurologic clinics

authors： Sauvageot CM,Kesari S,Stiles CD

更新日期：2007-11-01 00:00:00

abstract：:Shift work and its negative consequences are becoming more relevant as the economy becomes increasing globalized. For many individuals, shift work serves as a significant biological and psychosocial challenge leading to Shift Work Disorder (SWD). Beyond the symptoms of sleep and excessive sleepiness, the range of cons...

journal_title：Neurologic clinics

authors： Cheng P,Drake C

更新日期：2019-08-01 00:00:00

abstract：:Injury to cranial nerves is a common sequela of blunt head trauma. The olfactory, facial, and audiovestibular nerves are damaged most often, followed by the optic and ocular motor nerves. The trigeminal and lower cranial nerves are rarely involved. Chances of recovery are greatest for the facial nerve, intermediate fo...

journal_title：Neurologic clinics

authors： Keane JR,Baloh RW

更新日期：1992-11-01 00:00:00