Abstract：
:Approximately 2 per cent of organ transplant recipients develop primary CNS lymphomas. There is no pathognomonic clinical or radiographic presentation of the tumor, although multicentric involvement of deep white matter is common. Evidence has linked PCNSL to immunosuppression and to infection with the EBV. The most reasonable sequence of events leading to the development of this tumor appears first to be an infection with (or reactivation of) EBV following immunosuppression. The virus then produces B cell lymphoproliferation that is unchecked because of suppression of the normal immune mechanisms. At some point, the lymphoproliferation becomes neoplastic, and a lymphoma results. Reduction in immunosuppression and antiviral treatment may be of use in the treatment of PCNSL in transplant patients.
journal_name
Neurol Clinjournal_title
Neurologic clinicsauthors
Patchell RAsubject
Has Abstractpub_date
1988-05-01 00:00:00pages
297-303issue
2eissn
0733-8619issn
1557-9875journal_volume
6pub_type
杂志文章,评审abstract：:Normal cell replication is regulated by growth factors such as epidermal growth factor (EGF) and platelet-derived growth factor (PDGF) that act through binding to specific surface receptors on target cells. Oncogenes may exert their transforming activity by encoding proteins that mimic the function of the normal regul...
journal_title：Neurologic clinics
pub_type： 杂志文章,评审
doi：
更新日期：1985-11-01 00:00:00
abstract：:The last 2 decades represent a period of unparalleled advancement in the understanding of the pathogenesis of Parkinson disease (PD). The discovery of several forms of familial parkinsonism with mendelian inheritance has elucidated insights into the mechanisms underlying the degeneration of dopaminergic neurons of the...
journal_title：Neurologic clinics
pub_type： 杂志文章,评审
doi：10.1016/j.ncl.2014.09.010
更新日期：2015-02-01 00:00:00
abstract：:Myoclonus is defined as sudden, brief, shock-like, involuntary movements caused by muscular contractions or inhibitions. Etiologic classification organizes the myoclonus disorders and provides major categories of clinical presentation. However, classifying myoclonus according to its source provides insight about its p...
journal_title：Neurologic clinics
pub_type： 杂志文章,评审
doi：10.1016/j.ncl.2009.04.002
更新日期：2009-08-01 00:00:00
abstract：:The diagnostic approach to the patient with cancer with suspected CNS infection depends on an analysis of the patient's immune defect, the time course of development of manifestations of infection, and the type of clinical syndrome with supportive evidence for a specific diagnosis coming from laboratory and neuroradio...
journal_title：Neurologic clinics
pub_type： 杂志文章,评审
doi：10.1016/s0733-8619(02)00075-0
更新日期：2003-02-01 00:00:00
abstract：:Disorders of the autonomic and small nerve fibers comprise a wide spectrum of disease states that cross a multitude of clinical specialties.The evaluation of these disorders allows the investigator to determine the presence or absence of abnormalities in the lightly myelinated and unmyelinated nerve fibers with minima...
journal_title：Neurologic clinics
pub_type： 杂志文章,评审
doi：10.1016/j.ncl.2004.03.002
更新日期：2004-08-01 00:00:00
abstract：:Classifications and definitions are essential to facilitate communication; promote accurate diagnostic criteria; develop, test, and use effective therapies; and specify knowledge gaps. This article describes the development of the International Classification of Vestibular Disorders (ICVD) initiative. It describes its...
journal_title：Neurologic clinics
pub_type： 杂志文章,评审
doi：10.1016/j.ncl.2015.04.010
更新日期：2015-08-01 00:00:00
abstract：:Intensive care unit-acquired weakness (ICUAW) is a substantial contributor to long-term disability in survivors of critical illness. Critical illness polyneuropathy, critical illness myopathy, and muscle atrophy from disuse contribute in various proportions to ICUAW. ICUAW is a clinical diagnosis supported by electrop...
journal_title：Neurologic clinics
pub_type： 杂志文章,评审
doi：10.1016/j.ncl.2017.06.008
更新日期：2017-11-01 00:00:00
abstract：:The evaluation, diagnosis, and treatment of childhood epilepsy or isolated seizures deserve special consideration. Whenever possible, a working diagnosis of an epilepsy syndrome should be implemented early in the course of evaluation to help plan the necessary investigations and acute and chronic treatment. The plan w...
journal_title：Neurologic clinics
pub_type： 杂志文章,评审
doi：
更新日期：1993-11-01 00:00:00
abstract：:The natural history of MS is highly variable. There is substantial heterogeneity in the clinical manifestations but, at this point, it is reasonable to consider all idiopathic inflammatory demyelinating diseases of the central nervous system as representing a spectrum of the same disease. In large populations, 20% to ...
journal_title：Neurologic clinics
pub_type： 杂志文章,评审
doi：
更新日期：1995-02-01 00:00:00
abstract：:Nerve conduction studies and needle electromyography provide important and complementary information as part of an electrodiagnostic study. Potential technical problems that are encountered during the studies may interfere with accurate and reliable acquisition of information and interpretation of the data. Recognitio...
journal_title：Neurologic clinics
pub_type： 杂志文章,评审
doi：10.1016/j.ncl.2011.12.008
更新日期：2012-05-01 00:00:00
abstract：:The calcineurin inhibitors cyclosporine and tacrolimus are used for their immunosuppressive effects. Neurotoxic side effects include tremor, paresthesia, and headache. Rarer neurotoxicities include seizure, posterior reversible encephalopathy syndrome, and encephalopathy. Tacrolimus tends to be more neurotoxic than cy...
journal_title：Neurologic clinics
pub_type： 杂志文章,评审
doi：10.1016/j.ncl.2020.07.009
更新日期：2020-11-01 00:00:00
abstract：:Botulinum toxin therapy has emerged as a treatment modality for a variety of spastic- or contracture-related muscle diseases. Its safety has been proven for long-term use in the treatment of benign essential blepharospasm, hemifacial spasm, and certain types of strabismus. Recent approval from the Federal Drug Adminis...
journal_title：Neurologic clinics
pub_type： 杂志文章,评审
doi：
更新日期：1991-02-01 00:00:00
abstract：:This article reviews the acquired causes of polyneuropathy other than diabetic and acute-onset neuropathies. The author gives a general method to simplify the diagnosis of chronic polyneuropathy. The acquired polyneuropathies are discussed under four main headings: metabolic disorders, toxic or deficiency states, infe...
journal_title：Neurologic clinics
pub_type： 杂志文章,评审
doi：10.1016/s0733-8619(05)70331-5
更新日期：1997-08-01 00:00:00
abstract：:Despite major medical advances, such as the introduction of the rubella vaccine and prolonged postnatal therapy of infants with congenital toxoplasmosis, intrauterine infections remain important causes of deafness, vision loss, and behavioral or neurologic disorders among children worldwide. This article describes the...
journal_title：Neurologic clinics
pub_type： 杂志文章,评审
doi：10.1016/s0733-8619(02)00014-2
更新日期：2002-11-01 00:00:00
abstract：:Psychogenic movement disorders (PMDs) can present with varied phenomenology that may resemble organic movement disorders. The diagnosis is based on clinical evaluation with a supporting history and classic features on neurologic examination. Ancillary testing, such as imaging and neurophysiologic studies, can provide ...
journal_title：Neurologic clinics
pub_type： 杂志文章,评审
doi：10.1016/j.ncl.2014.09.013
更新日期：2015-02-01 00:00:00
abstract：:Most patients who have endured a stroke sustain behavioral changes, although in many instances these effects can be subtle. Although behavioral changes after a stroke tend to improve, they may persist and have serious effects on daily living activities. This article reviews the more familiar behavioral changes that fo...
journal_title：Neurologic clinics
pub_type： 杂志文章,评审
doi：10.1016/j.ncl.2015.08.009
更新日期：2016-02-01 00:00:00
abstract：:"Deep brain stimulation is a safe and effective therapy for the management of a variety of neurologic conditions with Food and Drug Administration or humanitarian exception approval for Parkinson disease, dystonia, tremor, and obsessive-compulsive disorder. Advances in neurophysiology, neuroimaging, and technology hav...
journal_title：Neurologic clinics
pub_type： 杂志文章,评审
doi：10.1016/j.ncl.2020.09.004
更新日期：2021-02-01 00:00:00
abstract：:Traumatic brain injury is a common and complex clinical entity that deserves better and continued research on interventions and initial treatment postinjury. Current medical management of traumatic brain injury is articulated on minimizing secondary injury by optimizing cerebral perfusion and oxygenation and preventin...
journal_title：Neurologic clinics
pub_type： 杂志文章,评审
doi：10.1016/j.ncl.2008.02.001
更新日期：2008-05-01 00:00:00
abstract：:"Myasthenia gravis (MG) is the most common autoimmune neuromuscular disorder. This article highlights several cases that the practicing neurologist may encounter in the treatment of MG. Diagnostic uncertainty continues to be an issue in patients who are seronegative to the 2 most common antibodies, acetylcholine recep...
journal_title：Neurologic clinics
pub_type： 杂志文章,评审
doi：10.1016/j.ncl.2020.03.005
更新日期：2020-08-01 00:00:00
abstract：:Brain metastases are a common complication of cancer and alter patient management more than metastases at any other site of distant progression. Supportive therapies include steroids and antiseizure medications. Definitive treatments include radiation therapy, surgery, and chemotherapy. The optimal choice of treatment...
journal_title：Neurologic clinics
pub_type： 杂志文章,评审
doi：10.1016/j.ncl.2007.07.011
更新日期：2007-11-01 00:00:00
abstract：:In vitro and in vivo studies of striatal dopamine receptor changes have been reviewed in this article. A background of receptor pharmacology methods has been included to assist the reader in assessing the merits of the published studies. Overall the literature is not consistent in the relevant observations in parkinso...
journal_title：Neurologic clinics
pub_type： 杂志文章,评审
doi：
更新日期：1992-05-01 00:00:00
abstract：:Traumatic injury to the posterior fossa is a complex pathologic condition because of the great heterogeneity of lesions present. Treatment of primary brain injuries and prevention of secondary brain injuries is the mainstay of management. It is imperative to recognize traumatic lesions of the posterior fossa early bec...
journal_title：Neurologic clinics
pub_type： 杂志文章,评审
doi：10.1016/j.ncl.2014.07.010
更新日期：2014-11-01 00:00:00
abstract：:Chorea (Greek for "dance") refers to irregular, rapid, flowing, non-stereotyped and random involuntary movements that often possess a writhing quality, referred to as choreoathetosis. When mild, it may be difficult to differentiate from restlessness. The movements can be strikingly asymmetric, as in hemichorea, or gen...
journal_title：Neurologic clinics
pub_type： 杂志文章,评审
doi：10.1016/s0733-8619(05)70041-4
更新日期：2001-08-01 00:00:00
abstract：:Transcranial Doppler ultrasonography (TCD) is a noninvasive, bedside, portable tool for assessment of cerebral hemodynamics. Modern TCD head frames allow continuous hands-free emboli detection for risk stratification and assessment of treatment efficacy in several cardiovascular diseases. Identifying a focal stenosis,...
journal_title：Neurologic clinics
pub_type： 杂志文章,评审
doi：10.1016/j.ncl.2019.09.006
更新日期：2020-02-01 00:00:00
abstract：:Parasomnias are classified into nonrapid eye movement and rapid eye movement sleep parasomnias. It is important for the clinician to consider other parasomnia mimics that present to the sleep disorders clinic. These conditions can be differentiated by taking a detailed sleep history and conducting nocturnal polysomnog...
journal_title：Neurologic clinics
pub_type： 杂志文章,评审
doi：10.1016/j.ncl.2012.08.016
更新日期：2012-11-01 00:00:00
abstract：:The vasculitides are a heterogeneous group of disorders that cause blood vessel inflammation and necrosis. Vasculitis may represent a primary disease process or a secondary manifestation of an underlying systemic condition. Neurologic symptoms and signs are common in most of the vasculitic syndromes and may be the pre...
journal_title：Neurologic clinics
pub_type： 杂志文章,评审
doi：
更新日期：1989-08-01 00:00:00
abstract：:Meaningful symptom management can have a profound impact on quality of life. It can challenge time parameters during clinic, and therefore thought should be given to strategies that can improve efficiency and thereby make the undertaking more tenable. For any given symptom, the building blocks of care, such as vitamin...
journal_title：Neurologic clinics
pub_type： 杂志文章,评审
doi：10.1016/j.ncl.2017.08.015
更新日期：2018-02-01 00:00:00
abstract：:The immune system plays a significant role in Alzheimer disease (AD). β-Amyloid deposition in the cortex is thought to be an initiating event in AD and the widely believed amyloid hypothesis proposes removal of amyloid may delay disease progression. Human trials of active or passive immune agents have failed to show b...
journal_title：Neurologic clinics
pub_type： 杂志文章,评审
doi：10.1016/j.ncl.2013.03.012
更新日期：2013-08-01 00:00:00
abstract：:Postamputation phenomena, including painful and nonpainful phantom sensations occur following loss of limbs and other body parts. Peripheral and central nervous system mechanisms play a role in persistent phantom pain. Understanding the pathophysiology of this syndrome has improved in recent years. Comprehensive evalu...
journal_title：Neurologic clinics
pub_type： 杂志文章,评审
doi：10.1016/s0733-8619(05)70105-5
更新日期：1998-11-01 00:00:00
abstract：:The fourth edition of The Diagnostic and Statistical Manual of Mental Disorders defines delirium as "a reversible state of confusion with a reduced level of consciousness manifest as an inability to focus, sustain or shift attention." Pharmacologic agents are important contributors to delirium in hospitalized elderly ...
journal_title：Neurologic clinics
pub_type： 杂志文章,评审
doi：10.1016/j.ncl.2004.01.001
更新日期：2004-05-01 00:00:00
