Growth factors and oncogenes in human malignant glioma.

Abstract:

:Normal cell replication is regulated by growth factors such as epidermal growth factor (EGF) and platelet-derived growth factor (PDGF) that act through binding to specific surface receptors on target cells. Oncogenes may exert their transforming activity by encoding proteins that mimic the function of the normal regulatory factors along the mitogenic pathway, growth factors, their receptors or elements along the postreceptor signaling system. This may be exemplified by the human malignant glioma, in which the sis gene (encoding a growth factor homologous to PDGF) and the erb B gene (encoding a membrane protein homologous to the EGF receptor) have been implicated.

journal_name

Neurol Clin

journal_title

Neurologic clinics

authors

Westermark B,Nister M,Heldin CH

subject

Has Abstract

pub_date

1985-11-01 00:00:00

pages

785-99

issue

4

eissn

0733-8619

issn

1557-9875

journal_volume

3

pub_type

杂志文章,评审
  • Herpes simplex infections of the nervous system.

    abstract::Dramatic progress has been made recently in diagnosing and treating herpes simplex virus encephalitis (HSVE). Advances in imaging technology have greatly enhanced our ability to diagnose the illness noninvasively. Acyclovir is of proven efficacy and is generally well-tolerated. The major clinical management problem is...

    journal_title:Neurologic clinics

    pub_type: 杂志文章,评审

    doi:10.1016/j.ncl.2008.03.005

    authors: Baringer JR

    更新日期:2008-08-01 00:00:00

  • Legal aspects of epilepsy.

    abstract::Legal issues must be considered in caring for patients with epilepsy. Doctors caring for people with epilepsy may be legally involved in three primary ways: as the agent of social control, as patient advocate, and as the target of liability or malpractice suits. This article examines these factors and the implications...

    journal_title:Neurologic clinics

    pub_type: 杂志文章,评审

    doi:

    authors: Hughes JT,Devinsky O

    更新日期:1994-02-01 00:00:00

  • The natural history of multiple sclerosis.

    abstract::The natural history of MS is highly variable. There is substantial heterogeneity in the clinical manifestations but, at this point, it is reasonable to consider all idiopathic inflammatory demyelinating diseases of the central nervous system as representing a spectrum of the same disease. In large populations, 20% to ...

    journal_title:Neurologic clinics

    pub_type: 杂志文章,评审

    doi:

    authors: Weinshenker BG

    更新日期:1995-02-01 00:00:00

  • Management of motor complications in Parkinson disease: current and emerging therapies.

    abstract::Motor fluctuations and dyskinesias are common motor complications that manifest within the first few years from the initiation of therapy in patients with Parkinson disease. These complications negatively affect the quality of life and represent an important source of disability. A growing number of therapeutic option...

    journal_title:Neurologic clinics

    pub_type: 杂志文章,评审

    doi:10.1016/j.ncl.2010.03.014

    authors: Espay AJ

    更新日期:2010-11-01 00:00:00

  • Phantom limb pain and related disorders.

    abstract::Postamputation phenomena, including painful and nonpainful phantom sensations occur following loss of limbs and other body parts. Peripheral and central nervous system mechanisms play a role in persistent phantom pain. Understanding the pathophysiology of this syndrome has improved in recent years. Comprehensive evalu...

    journal_title:Neurologic clinics

    pub_type: 杂志文章,评审

    doi:10.1016/s0733-8619(05)70105-5

    authors: Weinstein SM

    更新日期:1998-11-01 00:00:00

  • The electrodiagnostic approach to carpal tunnel syndrome.

    abstract::CTS is a clinically defined syndrome; however, there is value added by an evidence-based electrodiagnostic approach to (1) efficiently confirm the diagnosis (particularly before invasive interventions), (2) to identify neurogenic mimickers or superimposed processes that may influence the response to treatment, and (3)...

    journal_title:Neurologic clinics

    pub_type: 杂志文章,评审

    doi:10.1016/j.ncl.2011.12.001

    authors: Watson JC

    更新日期:2012-05-01 00:00:00

  • Cardiogenic syncope. Seizure versus syncope.

    abstract::Our recommendations for the evaluation of the patient with suspected cardiogenic syncope are as follows: An initial thorough history and physical examination of the patient will suggest the diagnosis of cardiogenic syncope in at least 50 per cent of patients. A sudden occurrence of syncope, or "drop attack", is most s...

    journal_title:Neurologic clinics

    pub_type: 杂志文章,评审

    doi:

    authors: Dohrmann ML,Cheitlin MD

    更新日期:1986-08-01 00:00:00

  • Neurologic manifestations of gastrointestinal disease.

    abstract::The neurologic manifestations of gastrointestinal disease are generally thought to be uncommon, although an increasing number of previously unidentified associations are being established. These neurologic disorders may result from nutritional or non-nutritional causes. In the absence of clear malnutrition, it is like...

    journal_title:Neurologic clinics

    pub_type: 杂志文章,评审

    doi:

    authors: Albers JW,Nostrant TT,Riggs JE

    更新日期:1989-08-01 00:00:00

  • Neurologic complications of respiratory disease.

    abstract::The respiratory system and the central nervous system are interconnected in a delicate balance; disorders in this equilibrium can have devastating consequences. Respiratory dysfunction, whether acute or chronic, may cause neurologic disease, including headache, encephalopathy, and in extreme cases, coma and death. Thi...

    journal_title:Neurologic clinics

    pub_type: 杂志文章,评审

    doi:10.1016/s0733-8619(03)00062-8

    authors: Kirsch DB,Józefowicz RF

    更新日期:2002-02-01 00:00:00

  • Neuropsychologic rehabilitation for visuoperceptual impairments.

    abstract::Impairments of visual perception resulting from brain damage can have serious implications for many aspects of patients' lives, and these impairments should be targeted for intervention. Rehabilitation programs need to be individually tailored to each patient's needs; thus, characterization of a patient's visual perce...

    journal_title:Neurologic clinics

    pub_type: 杂志文章,评审

    doi:10.1016/s0733-8619(02)00105-6

    authors: Anderson SW

    更新日期:2003-08-01 00:00:00

  • Parkinson's disease.

    abstract::A number of changes have occurred in the management of Parkinson's disease in recent years, with the development of new therapeutic strategies based upon advances in pharmacotherapy and interventional procedures. The treatment of patients with Parkinson's disease is considered here with these advances in mind. Potenti...

    journal_title:Neurologic clinics

    pub_type: 杂志文章,评审

    doi:10.1016/s0733-8619(05)70008-6

    authors: Aminoff MJ

    更新日期:2001-02-01 00:00:00

  • Nature and Action of Antibodies in Myasthenia Gravis.

    abstract::This article discusses antibodies associated with immune-mediated myasthenia gravis and the pathologic action of these antibodies at the neuromuscular junctions of skeletal muscle. To explain how these antibodies act, we consider the physiology of neuromuscular transmission with emphasis on 4 features: the structure o...

    journal_title:Neurologic clinics

    pub_type: 杂志文章,评审

    doi:10.1016/j.ncl.2018.01.001

    authors: Ruff RL,Lisak RP

    更新日期:2018-05-01 00:00:00

  • Parasomnias and their mimics.

    abstract::Parasomnias are classified into nonrapid eye movement and rapid eye movement sleep parasomnias. It is important for the clinician to consider other parasomnia mimics that present to the sleep disorders clinic. These conditions can be differentiated by taking a detailed sleep history and conducting nocturnal polysomnog...

    journal_title:Neurologic clinics

    pub_type: 杂志文章,评审

    doi:10.1016/j.ncl.2012.08.016

    authors: Malhotra RK,Avidan AY

    更新日期:2012-11-01 00:00:00

  • Periodic limb movements and restless legs syndrome.

    abstract::The criteria that characterize restless legs syndrome (RLS) and the differential diagnoses are discussed. Clinical signs include sleep disturbance, involuntary movements in sleep or wakefulness, a normal neurologic examination, a chronic clinical course, and, in some cases, a positive family history. Periodic limb mov...

    journal_title:Neurologic clinics

    pub_type: 杂志文章,评审

    doi:10.1016/s0733-8619(05)70277-2

    authors: Trenkwalder C,Walters AS,Hening W

    更新日期:1996-08-01 00:00:00

  • Surgical management of acute intracranial hemorrhage, surgical aneurysmal and arteriovenous malformation ablation, and other surgical principles.

    abstract::In light of the potentially devastating effects of hemorrhagic stroke, it is critical that an effective treatment paradigm be defined. This report briefly reviews the various subtypes of hemorrhagic stroke, considers the indications for surgery, and discusses specific surgical treatment options. ...

    journal_title:Neurologic clinics

    pub_type: 杂志文章,评审

    doi:10.1016/j.ncl.2008.06.006

    authors: Ashley WW Jr,Charbel FT,Amin-Hanjani S

    更新日期:2008-11-01 00:00:00

  • Neurologic pain syndromes in patients with cancer.

    abstract::Recognizing and treating the cause of pain in the patient with cancer should be the initial approach to the management of this common symptom. Careful analysis of patients with cancer and pain has led to the elucidation of common neurologic pain syndromes unique to this disease process. Pain in patients with cancer is...

    journal_title:Neurologic clinics

    pub_type: 杂志文章,评审

    doi:

    authors: Elliott K,Foley KM

    更新日期:1989-05-01 00:00:00

  • Clinical utility of echocardiography in neurologic disorders.

    abstract::Echocardiography is an established technology encompassing an increasingly wide variety of clinical situations including cardioembolism and the detection of CAD in patients with cerebral ischemia and in patients undergoing neurovascular surgery. Echocardiography will continue to occupy a pivotal role in clinical manag...

    journal_title:Neurologic clinics

    pub_type: 杂志文章,评审

    doi:

    authors: Tegeler CH,Kitzman DW

    更新日期:1993-05-01 00:00:00

  • Biochemical and molecular teratology of fetal hydantoin syndrome.

    abstract::Animal and human research has clearly shown that anticonvulsants are teratogens and pose a risk for fetal malformations. In the case of dilantin it appears that fetal susceptibility correlates with the fetal level of the microsomal detoxifying enzyme epoxide hydrolase. The genetics of seizures in the parents does not ...

    journal_title:Neurologic clinics

    pub_type: 杂志文章,评审

    doi:

    authors: Buehler BA,Rao V,Finnell RH

    更新日期:1994-11-01 00:00:00

  • New strategies for endovascular recanalization of acute ischemic stroke.

    abstract::Although intravenous thrombolysis with recombinant tissue plasminogen activator is a proven effective therapy for acute ischemic stroke, it is often insufficient to achieve recanalization in patients with large intracranial artery occlusions. In these cases, intra-arterial reperfusion techniques may be useful. Intra-a...

    journal_title:Neurologic clinics

    pub_type: 杂志文章,评审

    doi:10.1016/j.ncl.2013.03.009

    authors: Cohen JE,Leker RR,Rabinstein A

    更新日期:2013-08-01 00:00:00

  • Thoracic outlet syndromes.

    abstract::The term thoracic outlet syndromes, is a group designation for several distinct disorders (one of questionable validity) involving various components of the brachial plexus, the blood vessels, or both, at various points between the base of the neck and the axilla. Four of the five subgroups (true neurologic TOS, arter...

    journal_title:Neurologic clinics

    pub_type: 杂志文章,评审

    doi:10.1016/s0733-8619(05)70149-3

    authors: Wilbourn AJ

    更新日期:1999-08-01 00:00:00

  • Mitochondrial myopathy diagnosis.

    abstract::Oxidative phosphorylation (OXPHOS) accounts for approximately 95% of the adenosine triphosphate (ATP) produced by the cell. The central nervous system, peripheral nervous system, cardiac muscle, skeletal muscle, and smooth muscle are highly susceptible to dysfunction of this complex enzyme system. Although most OXPHOS...

    journal_title:Neurologic clinics

    pub_type: 杂志文章,评审

    doi:10.1016/s0733-8619(05)70180-8

    authors: Shoffner JM

    更新日期:2000-02-01 00:00:00

  • Neuromuscular fatigue in racquet sports.

    abstract::This article describes the physiologic and neural mechanisms that cause neuromuscular fatigue in racquet sports: table tennis, tennis, squash, and badminton. In these intermittent and dual activities, performance may be limited as a match progresses because of a reduced central activation, linked to changes in neurotr...

    journal_title:Neurologic clinics

    pub_type: 杂志文章,评审

    doi:10.1016/j.ncl.2007.11.011

    authors: Girard O,Millet GP

    更新日期:2008-02-01 00:00:00

  • Congenital infections.

    abstract::Despite major medical advances, such as the introduction of the rubella vaccine and prolonged postnatal therapy of infants with congenital toxoplasmosis, intrauterine infections remain important causes of deafness, vision loss, and behavioral or neurologic disorders among children worldwide. This article describes the...

    journal_title:Neurologic clinics

    pub_type: 杂志文章,评审

    doi:10.1016/s0733-8619(02)00014-2

    authors: Bale JF Jr

    更新日期:2002-11-01 00:00:00

  • Therapeutic hypothermia after cardiac arrest.

    abstract::The use of IH for 24 hours in patients who remain comatose following resuscitation from out-of-hospital cardiac arrest improves outcomes. How-ever, the induction of hypothermia has several physiologic effects that need to be considered. A protocol for the rapid induction of hypothermia is described. At present, the ra...

    journal_title:Neurologic clinics

    pub_type: 杂志文章,评审

    doi:10.1016/j.ncl.2005.10.007

    authors: Bernard S

    更新日期:2006-02-01 00:00:00

  • Spinal cord injury.

    abstract::The evaluation and treatment of spinal cord injury continues to evolve, enhanced by new imaging modalities. Their application in reference to the cervical, thoracic, and lumbar spine is discussed. Treatment options, both conservative and surgical, are outlined. ...

    journal_title:Neurologic clinics

    pub_type: 杂志文章,评审

    doi:

    authors: Meyer PR Jr,Cybulski GR,Rusin JJ,Haak MH

    更新日期:1991-08-01 00:00:00

  • Pathology of multiple sclerosis.

    abstract::MS has certain salient morphologic features that distinguish it from other disorders of white matter and that may represent points of departure for investigation. ...

    journal_title:Neurologic clinics

    pub_type: 杂志文章

    doi:

    authors: Powell HC,Lampert PW

    更新日期:1983-08-01 00:00:00

  • Neuro-ultrasonography.

    abstract::Transcranial Doppler ultrasonography (TCD) is a noninvasive, bedside, portable tool for assessment of cerebral hemodynamics. Modern TCD head frames allow continuous hands-free emboli detection for risk stratification and assessment of treatment efficacy in several cardiovascular diseases. Identifying a focal stenosis,...

    journal_title:Neurologic clinics

    pub_type: 杂志文章,评审

    doi:10.1016/j.ncl.2019.09.006

    authors: Hakimi R,Alexandrov AV,Garami Z

    更新日期:2020-02-01 00:00:00

  • Neurologic infections of the fetus and newborn.

    abstract::This article concentrates primarily on infections of viral origin, although numerous microorganisms can infect the fetal and newborn brain (see Tables 1 and 2). Intrauterine infections occur most often for HIV, CMV and rubella, whereas HSV is preferentially transmitted intrapartum. In the last decade, changes in the e...

    journal_title:Neurologic clinics

    pub_type: 杂志文章,评审

    doi:

    authors: Griffith BP,Booss J

    更新日期:1994-08-01 00:00:00

  • Posttraumatic cranial neuropathies.

    abstract::Injury to cranial nerves is a common sequela of blunt head trauma. The olfactory, facial, and audiovestibular nerves are damaged most often, followed by the optic and ocular motor nerves. The trigeminal and lower cranial nerves are rarely involved. Chances of recovery are greatest for the facial nerve, intermediate fo...

    journal_title:Neurologic clinics

    pub_type: 杂志文章,评审

    doi:

    authors: Keane JR,Baloh RW

    更新日期:1992-11-01 00:00:00

  • Toxic myopathies.

    abstract::Toxic myopathies may occur with a variety of prescribed medications, illicit drug abuse, or other toxins. The article discusses an overview of some of the compounds that may cause myopathy, the clinical and laboratory features, histology, mechanisms of action, and potential risk factors of myopathy. The ability to rec...

    journal_title:Neurologic clinics

    pub_type: 杂志文章,评审

    doi:10.1016/s0733-8619(05)70341-8

    authors: George KK,Pourmand R

    更新日期:1997-08-01 00:00:00