Abstract：
:Oxidative phosphorylation (OXPHOS) accounts for approximately 95% of the adenosine triphosphate (ATP) produced by the cell. The central nervous system, peripheral nervous system, cardiac muscle, skeletal muscle, and smooth muscle are highly susceptible to dysfunction of this complex enzyme system. Although most OXPHOS diseases are multisystem disorders, the neuromuscular manifestations are often prominent and play an important role in patient diagnosis. To assist the neurologist in evaluating these complex patients, this article focuses on selected samples of OXPHOS diseases with identifiable neuromuscular abnormalities and presents an evaluation algorithm to facilitate patient diagnosis.
journal_name
Neurol Clinjournal_title
Neurologic clinicsauthors
Shoffner JMdoi
10.1016/s0733-8619(05)70180-8subject
Has Abstractpub_date
2000-02-01 00:00:00pages
105-23issue
1eissn
0733-8619issn
1557-9875pii
S0733-8619(05)70180-8journal_volume
18pub_type
杂志文章,评审abstract：:Idiopathic intracranial hypertension is a syndrome of increased intracranial pressure of unknown cause that most often occurs in women of childbearing age. Most patients are overweight or obese with a history of recent weight gain. Following a brief review of the symptoms and signs, we discuss the approach to assessme...
journal_title：Neurologic clinics
pub_type： 杂志文章,评审
doi：10.1016/j.ncl.2020.09.008
更新日期：2021-02-01 00:00:00
abstract：:Face recognition is one of the most complex visual tasks performed by the human brain. Data from monkeys suggest that area IT may play a key role in identifying faces, and functional imaging research suggests that the human homologue of IT may be located in the medial occipitotemporal cortex, where a FFA has been loca...
journal_title：Neurologic clinics
pub_type： 杂志文章,评审
doi：10.1016/s0733-8619(02)00106-8
更新日期：2003-05-01 00:00:00
abstract：:In patients with TIA or ischemic stroke of noncardiac origin antiplatelet drugs are able to decrease the risk of stroke by 11-15%, and the risk of stroke, MI, and vascular death by 15-22%, but not mortality. Low doses of aspirin (50-325 mg) are as effective as high doses and cause less gastrointestinal side effects. S...
journal_title：Neurologic clinics
pub_type： 杂志文章,评审
doi：10.1016/s0733-8619(05)70196-1
更新日期：2000-05-01 00:00:00
abstract：:The vasculitides are a heterogeneous group of disorders that cause blood vessel inflammation and necrosis. Vasculitis may represent a primary disease process or a secondary manifestation of an underlying systemic condition. Neurologic symptoms and signs are common in most of the vasculitic syndromes and may be the pre...
journal_title：Neurologic clinics
pub_type： 杂志文章,评审
doi：
更新日期：1989-08-01 00:00:00
abstract：:The substantial societal and individual burdens associated with tension-type headache (TTH) constitute a previously overlooked major public health issue. TTH is prevalent, affecting up to 78% of the general population, and 3% suffer from chronic TTH. Pericranial myofascial nociception probably is important for the pat...
journal_title：Neurologic clinics
pub_type： 杂志文章,评审
doi：10.1016/j.ncl.2008.11.010
更新日期：2009-05-01 00:00:00
abstract：:Cervicogenic headache is pain referred to the head from a source in the cervical spine or mediated by cervical nerves. Clinical features allow for no more than a diagnosis of probable cervicogenic headache. Definitive diagnosis requires evidence of a cervical source of pain. For most treatments, the evidence is limite...
journal_title：Neurologic clinics
pub_type： 杂志文章,评审
doi：10.1016/j.ncl.2013.11.005
更新日期：2014-05-01 00:00:00
abstract：:The past 40 years have seen the evolution of acute ischemic stroke management from unproven therapies du jour, such as steroids, heparin for stroke in evolution, and hypervolemic-hemodilution, to more of a scientific basis for our decision-making process. This evolution is directly related to the advancements in imagi...
journal_title：Neurologic clinics
pub_type： 杂志文章,评审
doi：10.1016/j.ncl.2011.09.014
更新日期：2012-02-01 00:00:00
abstract：:Nonsurgical, conservative approaches to spine pain include medication and physical therapy. In addition, several invasive procedures have been developed to provide relief when conservative options fail. These include facet joint injection and radiofrequency ablation techniques, translaminar and transforaminal epidural...
journal_title：Neurologic clinics
pub_type： 杂志文章,评审
doi：10.1016/j.ncl.2007.01.010
更新日期：2007-05-01 00:00:00
abstract：:In summary, PET and SPECT are versatile imaging modalities capable of providing dynamic information regarding the metabolism and physiology of brain and brain tumor. PET and SPECT are useful adjuncts to MRI and CT scanning in the important clinical areas of presurgical estimations of tumor grade. In addition, PET can ...
journal_title：Neurologic clinics
pub_type： 杂志文章,评审
doi：
更新日期：1991-05-01 00:00:00
abstract：:Severe acquired brain injury has profound impact on alertness, cognition, and behavior. Among those who survive the initial injury, a significant minority fail to fully recover self and environmental awareness, and go on to experience prolonged disorders of consciousness (DOC) that can last a lifetime. Although there ...
journal_title：Neurologic clinics
pub_type： 历史文章,杂志文章,评审
doi：10.1016/j.ncl.2011.07.009
更新日期：2011-11-01 00:00:00
abstract：:Disorders of the autonomic and small nerve fibers comprise a wide spectrum of disease states that cross a multitude of clinical specialties.The evaluation of these disorders allows the investigator to determine the presence or absence of abnormalities in the lightly myelinated and unmyelinated nerve fibers with minima...
journal_title：Neurologic clinics
pub_type： 杂志文章,评审
doi：10.1016/j.ncl.2004.03.002
更新日期：2004-08-01 00:00:00
abstract：:Reflex sympathetic dystrophy (RSD) and causalgia appear to reflect identical pictures even though the latter is related to nerve injury and the former is not. Overriding past and present skepticism about a role for the sympathetic system in their cause and treatment, the International Association for the Study of Pain...
journal_title：Neurologic clinics
pub_type： 杂志文章,评审
doi：
更新日期：1995-05-01 00:00:00
abstract：:Nerve conduction studies and needle electromyography provide important and complementary information as part of an electrodiagnostic study. Potential technical problems that are encountered during the studies may interfere with accurate and reliable acquisition of information and interpretation of the data. Recognitio...
journal_title：Neurologic clinics
pub_type： 杂志文章,评审
doi：10.1016/j.ncl.2011.12.008
更新日期：2012-05-01 00:00:00
abstract：:There is often a fine line between medical malpractice and maloccurrance. Physicians need to develop techniques and skills that enhance the patient-physician relationship based on honesty and informed consent. Documentation and proper maintenance of medical records is demanded by the current legal and health care syst...
journal_title：Neurologic clinics
pub_type： 杂志文章
doi：10.1016/s0733-8619(05)70376-5
更新日期：1998-02-01 00:00:00
abstract：:Use of the somatosensory evoked potential (SEP) in the evaluation of the peripheral nervous system is described. When using SEPs to evaluate peripheral nervous system disease, it is assumed that the central nervous system is intact. SEPs can be used to measure conduction through nerves that, by nature of their anatomi...
journal_title：Neurologic clinics
pub_type： 杂志文章,评审
doi：
更新日期：1988-11-01 00:00:00
abstract：:Legal issues must be considered in caring for patients with epilepsy. Doctors caring for people with epilepsy may be legally involved in three primary ways: as the agent of social control, as patient advocate, and as the target of liability or malpractice suits. This article examines these factors and the implications...
journal_title：Neurologic clinics
pub_type： 杂志文章,评审
doi：
更新日期：1994-02-01 00:00:00
abstract：:Dramatic progress has been made recently in diagnosing and treating herpes simplex virus encephalitis (HSVE). Advances in imaging technology have greatly enhanced our ability to diagnose the illness noninvasively. Acyclovir is of proven efficacy and is generally well-tolerated. The major clinical management problem is...
journal_title：Neurologic clinics
pub_type： 杂志文章,评审
doi：10.1016/j.ncl.2008.03.005
更新日期：2008-08-01 00:00:00
abstract：:Traditionally, diseases affecting the motor unit had been subdivided based on anatomic criteria into diseases of the anterior horn cell, the peripheral nerve, the neuromuscular junction, and the muscle itself. For therapeutic considerations, however, a more precise cellular and clinicopathologic characterization of th...
journal_title：Neurologic clinics
pub_type： 杂志文章,评审
doi：
更新日期：1990-02-01 00:00:00
abstract：:Unresponsive patients with or without catatonic motor signs are etiologically heterogeneous, and all require a comprehensive neurodiagnostic assessment to rule out organic causes. Most cases prove to be due to primary psychiatric disorders, mostly mood disorders, especially mania, rather than schizophrenia. These pati...
journal_title：Neurologic clinics
pub_type： 杂志文章,评审
doi：10.1016/j.ncl.2011.07.006
更新日期：2011-11-01 00:00:00
abstract：:In this article, the authors provide a conceptual framework in which to consider alternative approaches to identify the developmental consequences of exposing the developing brain to neurotoxic substances. Concepts underlying brain development and issues regarding neurobehavioral testing in children are reviewed. In a...
journal_title：Neurologic clinics
pub_type： 杂志文章,评审
doi：10.1016/s0733-8619(05)70210-3
更新日期：2000-08-01 00:00:00
abstract：:Syncope, or the sudden loss of consciousness, is a common presenting symptom for evaluation by neurologists. It is not a unique diagnosis but rather a common manifestation of disorders with diverse mechanisms. Loss of consciousness is typically preceded by a prodrome of symptoms and sometimes there is a clear trigger....
journal_title：Neurologic clinics
pub_type： 杂志文章,评审
doi：10.1016/j.ncl.2016.04.002
更新日期：2016-08-01 00:00:00
abstract：:Our recommendations for the evaluation of the patient with suspected cardiogenic syncope are as follows: An initial thorough history and physical examination of the patient will suggest the diagnosis of cardiogenic syncope in at least 50 per cent of patients. A sudden occurrence of syncope, or "drop attack", is most s...
journal_title：Neurologic clinics
pub_type： 杂志文章,评审
doi：
更新日期：1986-08-01 00:00:00
abstract：:Traumatic injury to the posterior fossa is a complex pathologic condition because of the great heterogeneity of lesions present. Treatment of primary brain injuries and prevention of secondary brain injuries is the mainstay of management. It is imperative to recognize traumatic lesions of the posterior fossa early bec...
journal_title：Neurologic clinics
pub_type： 杂志文章,评审
doi：10.1016/j.ncl.2014.07.010
更新日期：2014-11-01 00:00:00
abstract：:We believe that our present understanding of these syndromes is insufficient to separate CIDP from MMN clearly and consider MMN to be a remarkably multifocal, predominantly motor variant of CIDP with the very unusual electrophysiologic feature of conduction block confined to motor axons. Further studies are clearly ne...
journal_title：Neurologic clinics
pub_type： 杂志文章,评审
doi：
更新日期：1992-08-01 00:00:00
abstract：:In this review, the authors present a critical overview of the historical development, indications, complications, operative techniques, and results of procedures for the alleviation of the major dyskinesias. Emphasis is placed upon recent refinement of technique, particularly stereotaxis, as well as neurophysiologic ...
journal_title：Neurologic clinics
pub_type： 杂志文章,评审
doi：
更新日期：1987-11-01 00:00:00
abstract：:The authors divide biological toxins into animal, plant, and bacterial classes and discuss each within a context of demographic, clinical and research examples. Advances in our knowledge are highlighted, and the authors relate the implications of this knowledge to target-specific neurologic involvement. ...
journal_title：Neurologic clinics
pub_type： 杂志文章,评审
doi：10.1016/s0733-8619(05)70220-6
更新日期：2000-08-01 00:00:00
abstract：:The neurologic manifestations of gastrointestinal disease are generally thought to be uncommon, although an increasing number of previously unidentified associations are being established. These neurologic disorders may result from nutritional or non-nutritional causes. In the absence of clear malnutrition, it is like...
journal_title：Neurologic clinics
pub_type： 杂志文章,评审
doi：
更新日期：1989-08-01 00:00:00
abstract：:Myasthenia gravis (MG) is an antibody-mediated muscle disease in which any skeletal muscle can be affected. MG may produce numerous symptoms and signs. To doctors and patients, it may seem like lung disease, stroke, heart disease, or the effects of emotional stress. This article explores the "territory" between MG and...
journal_title：Neurologic clinics
pub_type： 杂志文章,评审
doi：
更新日期：1994-05-01 00:00:00
abstract：:Most patients who have endured a stroke sustain behavioral changes, although in many instances these effects can be subtle. Although behavioral changes after a stroke tend to improve, they may persist and have serious effects on daily living activities. This article reviews the more familiar behavioral changes that fo...
journal_title：Neurologic clinics
pub_type： 杂志文章,评审
doi：10.1016/j.ncl.2015.08.009
更新日期：2016-02-01 00:00:00
abstract：:Rapidly progressive dementias (RPDs) are neurologic conditions that develop subacutely over weeks to months or, rarely, acutely over days. In contrast to most dementing conditions that take years to progress to death, RPD quickly can be fatal. It is critical to evaluate patients who have RPD without delay, usually in ...
journal_title：Neurologic clinics
pub_type： 杂志文章,评审
doi：10.1016/j.ncl.2007.04.001
更新日期：2007-08-01 00:00:00
