Developmental considerations of neurotoxic exposures.

Abstract:

:In this article, the authors provide a conceptual framework in which to consider alternative approaches to identify the developmental consequences of exposing the developing brain to neurotoxic substances. Concepts underlying brain development and issues regarding neurobehavioral testing in children are reviewed. In addition, the authors selectively review preclinical data identifying mechanisms contributing to neurobehavioral compromise, and clinical data identifying deficits resulting from exposure to two classes of neurotoxins: exposure to drugs of abuse, including alcohol, nicotine, and cocaine; and exposure to environmental agents, including lead, methyl-mercury, PCBs, and organophosphorus compounds.

journal_name

Neurol Clin

journal_title

Neurologic clinics

authors

Trask CL,Kosofsky BE

doi

10.1016/s0733-8619(05)70210-3

subject

Has Abstract

pub_date

2000-08-01 00:00:00

pages

541-62

issue

3

eissn

0733-8619

issn

1557-9875

pii

S0733-8619(05)70210-3

journal_volume

18

pub_type

杂志文章,评审
  • Neuropsychiatry of aggression.

    abstract::Aggression is a serious medical problem that can place both the patient and the health care provider at risk. Aggression can result from medical, neurologic, and/or psychiatric disorders. A comprehensive patient evaluation is needed. Treatment options include pharmacotherapy as well as nonpharmacologic interventions, ...

    journal_title:Neurologic clinics

    pub_type: 杂志文章,评审

    doi:10.1016/j.ncl.2010.10.006

    authors: Lane SD,Kjome KL,Moeller FG

    更新日期:2011-02-01 00:00:00

  • Brain death.

    abstract::Current law in the United States authorizes physicians to diagnose brain death by applying generally accepted neurologic criteria for determining loss of function of the entire brain. This article offers a medical-legal perspective on problems that may arise with respect to the determination of brain death. These incl...

    journal_title:Neurologic clinics

    pub_type: 杂志文章,评审

    doi:10.1016/s0733-8619(05)70132-8

    authors: Beresford HR

    更新日期:1999-05-01 00:00:00

  • Pediatric Brain Tumors.

    abstract::Pediatric central nervous system (CNS) tumors are the most common solid tumors in children and comprise 15% to 20% of all malignancies in children. Presentation, symptoms, and signs depend on tumor location and age of the patient at the time of diagnosis. This article summarizes the common childhood CNS tumors, presen...

    journal_title:Neurologic clinics

    pub_type: 杂志文章,评审

    doi:10.1016/j.ncl.2018.04.009

    authors: Udaka YT,Packer RJ

    更新日期:2018-08-01 00:00:00

  • Management of motor complications in Parkinson disease: current and emerging therapies.

    abstract::Motor fluctuations and dyskinesias are common motor complications that manifest within the first few years from the initiation of therapy in patients with Parkinson disease. These complications negatively affect the quality of life and represent an important source of disability. A growing number of therapeutic option...

    journal_title:Neurologic clinics

    pub_type: 杂志文章,评审

    doi:10.1016/j.ncl.2010.03.014

    authors: Espay AJ

    更新日期:2010-11-01 00:00:00

  • Neuroimaging in multiple sclerosis.

    abstract::Since its clinical introduction in the early 1980s, MRI has transformed the practice of differential diagnosis and disease monitoring for disorders affecting the central nervous system, in particular multiple sclerosis and the allied inflammatory demyelinating diseases. Widespread and dynamic inflammatory processes of...

    journal_title:Neurologic clinics

    pub_type: 杂志文章,评审

    doi:10.1016/j.ncl.2008.09.012

    authors: Ali EN,Buckle GJ

    更新日期:2009-02-01 00:00:00

  • Headache epidemiology. Emphasis on migraine.

    abstract::Through the use of IHS criteria, large population-based epidemiologic studies in Denmark, the United States, France, Canada, and elsewhere have shed light on the descriptive epidemiology of migraine. Although migraine is a remarkably common cause of temporary disability, many migraineurs, even those with disabling hea...

    journal_title:Neurologic clinics

    pub_type: 杂志文章,评审

    doi:10.1016/s0733-8619(05)70265-6

    authors: Silberstein SD,Lipton RB

    更新日期:1996-05-01 00:00:00

  • Tuberous sclerosis.

    abstract::Tuberous sclerosis is a multisystem disorder characterized by changes primarily involving the skin, eye, and central nervous system. Although the disease often produces mental retardation and seizures, this is not universal, and some patients with tuberous sclerosis lead a relatively normal life. ...

    journal_title:Neurologic clinics

    pub_type: 杂志文章,评审

    doi:

    authors: Hanno R,Beck R

    更新日期:1987-08-01 00:00:00

  • New strategies for endovascular recanalization of acute ischemic stroke.

    abstract::Although intravenous thrombolysis with recombinant tissue plasminogen activator is a proven effective therapy for acute ischemic stroke, it is often insufficient to achieve recanalization in patients with large intracranial artery occlusions. In these cases, intra-arterial reperfusion techniques may be useful. Intra-a...

    journal_title:Neurologic clinics

    pub_type: 杂志文章,评审

    doi:10.1016/j.ncl.2013.03.009

    authors: Cohen JE,Leker RR,Rabinstein A

    更新日期:2013-08-01 00:00:00

  • Neurologic manifestations of renal disease.

    abstract::Mortality and morbidity from kidney disease and the spectrum of renal-associated neurologic disease have changed markedly since the introduction of renal dialysis and with the advent of renal transplantation. This article includes historical studies of the neurologic complications of acute uremia, now fairly uncommon,...

    journal_title:Neurologic clinics

    pub_type: 杂志文章,评审

    doi:10.1016/s0733-8619(03)00052-5

    authors: Palmer CA

    更新日期:2002-02-01 00:00:00

  • Migraine in the Emergency Department.

    abstract::Diagnostic testing is of limited value among patients with migraine who present to an emergency department. Various nonopioid, disease-specific treatments are available for patients who present to an emergency department with migraine headache and associated features. Emergency physicians should recognize that the acu...

    journal_title:Neurologic clinics

    pub_type: 杂志文章,评审

    doi:10.1016/j.ncl.2019.07.005

    authors: Friedman BW

    更新日期:2019-11-01 00:00:00

  • Functional visual loss.

    abstract::Neurologists frequently evaluate patients complaining of vision loss, especially when the patient has been examined by an ophthalmologist who has found no ocular disease. A significant proportion of patients presenting to the neurologist with visual complaints have nonorganic or functional visual loss. Although there ...

    journal_title:Neurologic clinics

    pub_type: 杂志文章

    doi:10.1016/j.ncl.2010.03.012

    authors: Bruce BB,Newman NJ

    更新日期:2010-08-01 00:00:00

  • Legal aspects of termination of treatment decisions.

    abstract::A large body of medical and ethical opinion holds that it is justifiable to terminate medical treatment for permanently unconscious persons. But opponents of particular decisions to withhold or withdraw treatment may argue that the decisions violate laws against homicide, pose a threat to the lives of other less sever...

    journal_title:Neurologic clinics

    pub_type: 杂志文章

    doi:

    authors: Beresford HR

    更新日期:1989-11-01 00:00:00

  • Postinfectious and postvaccinial encephalomyelitis.

    abstract::Addressed are the features of postviral and postvaccinial syndromes affecting the CNS. The relationships among acute disseminated encephalomyelitis, EAE, and MS are discussed. Among the postvaccination syndromes covered are the neurologic sequelae of pertussis immunizations, with a description of a mouse model of this...

    journal_title:Neurologic clinics

    pub_type: 杂志文章

    doi:

    authors: Sriram S,Steinman L

    更新日期:1984-05-01 00:00:00

  • The electrodiagnostic approach to carpal tunnel syndrome.

    abstract::CTS is a clinically defined syndrome; however, there is value added by an evidence-based electrodiagnostic approach to (1) efficiently confirm the diagnosis (particularly before invasive interventions), (2) to identify neurogenic mimickers or superimposed processes that may influence the response to treatment, and (3)...

    journal_title:Neurologic clinics

    pub_type: 杂志文章,评审

    doi:10.1016/j.ncl.2011.12.001

    authors: Watson JC

    更新日期:2012-05-01 00:00:00

  • Neurologic pain syndromes in patients with cancer.

    abstract::Recognizing and treating the cause of pain in the patient with cancer should be the initial approach to the management of this common symptom. Careful analysis of patients with cancer and pain has led to the elucidation of common neurologic pain syndromes unique to this disease process. Pain in patients with cancer is...

    journal_title:Neurologic clinics

    pub_type: 杂志文章,评审

    doi:

    authors: Elliott K,Foley KM

    更新日期:1989-05-01 00:00:00

  • Neurologic complications in acquired immunodeficiency syndrome (AIDS).

    abstract::Neurologic syndromes in AIDS are of four types: infections, para-infections, neoplastic, and paraneoplastic. All levels of the neuraxis can be affected. Neurologic complications may be the initial symptom or the cause of death. Aggressive evaluation, including biopsy of cerebral lesions, is indicated because effective...

    journal_title:Neurologic clinics

    pub_type: 杂志文章

    doi:

    authors: Britton CB,Miller JR

    更新日期:1984-05-01 00:00:00

  • Management of traumatic brain injury in the intensive care unit.

    abstract::Traumatic brain injury is a common and complex clinical entity that deserves better and continued research on interventions and initial treatment postinjury. Current medical management of traumatic brain injury is articulated on minimizing secondary injury by optimizing cerebral perfusion and oxygenation and preventin...

    journal_title:Neurologic clinics

    pub_type: 杂志文章,评审

    doi:10.1016/j.ncl.2008.02.001

    authors: Ling GS,Marshall SA

    更新日期:2008-05-01 00:00:00

  • The endocrinology of anorexia nervosa and bulimia nervosa.

    abstract::Considerable evidence exists of hypothalamic dysfunction in patients with anorexia nervosa and bulimia nervosa. This dysfunction is reflected in disturbances of endocrine function including abnormalities of gonadotropin, growth hormone, and corticotropin-releasing hormone secretion. Whereas these disturbances are gene...

    journal_title:Neurologic clinics

    pub_type: 杂志文章,评审

    doi:

    authors: Newman MM,Halmi KA

    更新日期:1988-02-01 00:00:00

  • Cardiogenic syncope. Seizure versus syncope.

    abstract::Our recommendations for the evaluation of the patient with suspected cardiogenic syncope are as follows: An initial thorough history and physical examination of the patient will suggest the diagnosis of cardiogenic syncope in at least 50 per cent of patients. A sudden occurrence of syncope, or "drop attack", is most s...

    journal_title:Neurologic clinics

    pub_type: 杂志文章,评审

    doi:

    authors: Dohrmann ML,Cheitlin MD

    更新日期:1986-08-01 00:00:00

  • Medical management of motor fluctuations.

    abstract::Given the magnitude of the problem of motor fluctuations in patients who have Parkinson's disease treated with levodopa, a significant effort has been expended by physicians, researchers, and pharmaceutical manufacturers over the years to find effective treatments. This article briefly reviews the medical options for ...

    journal_title:Neurologic clinics

    pub_type: 杂志文章,评审

    doi:10.1016/j.ncl.2008.05.006

    authors: Dewey RB Jr

    更新日期:2008-08-01 00:00:00

  • Rapidly progressive dementia.

    abstract::Rapidly progressive dementias (RPDs) are neurologic conditions that develop subacutely over weeks to months or, rarely, acutely over days. In contrast to most dementing conditions that take years to progress to death, RPD quickly can be fatal. It is critical to evaluate patients who have RPD without delay, usually in ...

    journal_title:Neurologic clinics

    pub_type: 杂志文章,评审

    doi:10.1016/j.ncl.2007.04.001

    authors: Geschwind MD,Haman A,Miller BL

    更新日期:2007-08-01 00:00:00

  • Spine and spinal cord trauma: diagnosis and management.

    abstract::Spine trauma is a devastating clinical condition that affects many people annually on a worldwide basis. Management of spinal trauma has become much more surgically oriented with advances in stabilization techniques over the past two decades. The degree of injury to the spinal cord dictates the prognosis of the patien...

    journal_title:Neurologic clinics

    pub_type: 杂志文章,评审

    doi:10.1016/j.ncl.2012.09.012

    authors: Zhang S,Wadhwa R,Haydel J,Toms J,Johnson K,Guthikonda B

    更新日期:2013-02-01 00:00:00

  • Neurologic presentations of systemic vasculitides.

    abstract::Vasculitis or angiitis refers to a group of inflammatory disorders of the blood vessels that cause structural damage to the affected vessel, including thickening and weakening of the vessel wall, narrowing of its lumen, and, usually, vascular necrosis. Systemic vasculitis is classified according to the vessel size and...

    journal_title:Neurologic clinics

    pub_type: 杂志文章,评审

    doi:10.1016/j.ncl.2009.09.015

    authors: Minagar A,Fowler M,Harris MK,Jaffe SL

    更新日期:2010-02-01 00:00:00

  • Stroke due to Vasculitis in Children and Adults.

    abstract::The vasculitides are diseases characterized by inflammation of blood vessels and inflammatory leukocytes in vessel walls. There is an increased propensity for ischemic stroke, resulting from compromise of vessel lumina with distal tissue ischemia; and hemorrhagic or nonhemorrhagic stroke, and aneurysmal formation and ...

    journal_title:Neurologic clinics

    pub_type: 杂志文章,评审

    doi:10.1016/j.ncl.2019.01.004

    authors: Younger DS

    更新日期:2019-05-01 00:00:00

  • The vegetative and minimally conscious states: diagnosis, prognosis and treatment.

    abstract::Severe acquired brain injury has profound impact on alertness, cognition, and behavior. Among those who survive the initial injury, a significant minority fail to fully recover self and environmental awareness, and go on to experience prolonged disorders of consciousness (DOC) that can last a lifetime. Although there ...

    journal_title:Neurologic clinics

    pub_type: 历史文章,杂志文章,评审

    doi:10.1016/j.ncl.2011.07.009

    authors: Hirschberg R,Giacino JT

    更新日期:2011-11-01 00:00:00

  • Immunotherapy for Alzheimer's disease.

    abstract::The immune system plays a significant role in Alzheimer disease (AD). β-Amyloid deposition in the cortex is thought to be an initiating event in AD and the widely believed amyloid hypothesis proposes removal of amyloid may delay disease progression. Human trials of active or passive immune agents have failed to show b...

    journal_title:Neurologic clinics

    pub_type: 杂志文章,评审

    doi:10.1016/j.ncl.2013.03.012

    authors: Farlow MR,Brosch JR

    更新日期:2013-08-01 00:00:00

  • Seizures and epilepsy in infancy and childhood.

    abstract::The evaluation, diagnosis, and treatment of childhood epilepsy or isolated seizures deserve special consideration. Whenever possible, a working diagnosis of an epilepsy syndrome should be implemented early in the course of evaluation to help plan the necessary investigations and acute and chronic treatment. The plan w...

    journal_title:Neurologic clinics

    pub_type: 杂志文章,评审

    doi:

    authors: Pellock JM

    更新日期:1993-11-01 00:00:00

  • Clinical features of myasthenia gravis.

    abstract::Myasthenia gravis (MG) is an antibody-mediated muscle disease in which any skeletal muscle can be affected. MG may produce numerous symptoms and signs. To doctors and patients, it may seem like lung disease, stroke, heart disease, or the effects of emotional stress. This article explores the "territory" between MG and...

    journal_title:Neurologic clinics

    pub_type: 杂志文章,评审

    doi:

    authors: Hopkins LC

    更新日期:1994-05-01 00:00:00

  • Nerve agents.

    abstract::Nerve agents cause a rapidly fatal cholinergic crisis, but rapid, appropriate antidotal treatment saves lives. Survivors of nerve-agent poisoning generally are healthy, unlike survivors of some other chemical agent attacks. Neurologists can assist first responders and mass casualty planners materially by serving as re...

    journal_title:Neurologic clinics

    pub_type: 杂志文章,评审

    doi:10.1016/j.ncl.2004.12.013

    authors: Newmark J

    更新日期:2005-05-01 00:00:00

  • Blood-Based Biomarkers for the Identification of Sports-Related Concussion.

    abstract::Sports-related concussions (SRCs) are common among athletes in the United States. Most athletes who sustain an SRC recover within 7 to 10 days; however, many athletes who sustain the injury do not recover as expected and experience prolonged, persistent symptoms. In this document, the authors provide an overview of th...

    journal_title:Neurologic clinics

    pub_type: 杂志文章,评审

    doi:10.1016/j.ncl.2017.03.008

    authors: Anto-Ocrah M,Jones CMC,Diacovo D,Bazarian JJ

    更新日期:2017-08-01 00:00:00