Blood-Based Biomarkers for the Identification of Sports-Related Concussion.

Abstract:

:Sports-related concussions (SRCs) are common among athletes in the United States. Most athletes who sustain an SRC recover within 7 to 10 days; however, many athletes who sustain the injury do not recover as expected and experience prolonged, persistent symptoms. In this document, the authors provide an overview of the empirical evidence related to the use of blood-based brain biomarkers in the athlete population for diagnosis of SRCs, prognosis of recovery and return to play guidelines, and indications of neurodegeneration. The authors also provide a summary of research challenges, gaps in the literature, and future directions for research.

journal_name

Neurol Clin

journal_title

Neurologic clinics

authors

Anto-Ocrah M,Jones CMC,Diacovo D,Bazarian JJ

doi

10.1016/j.ncl.2017.03.008

subject

Has Abstract

pub_date

2017-08-01 00:00:00

pages

473-485

issue

3

eissn

0733-8619

issn

1557-9875

pii

S0733-8619(17)30030-0

journal_volume

35

pub_type

杂志文章,评审
  • Neuropsychiatry of aggression.

    abstract::Aggression is a serious medical problem that can place both the patient and the health care provider at risk. Aggression can result from medical, neurologic, and/or psychiatric disorders. A comprehensive patient evaluation is needed. Treatment options include pharmacotherapy as well as nonpharmacologic interventions, ...

    journal_title:Neurologic clinics

    pub_type: 杂志文章,评审

    doi:10.1016/j.ncl.2010.10.006

    authors: Lane SD,Kjome KL,Moeller FG

    更新日期:2011-02-01 00:00:00

  • Pathogenic mechanisms of neurodegeneration in Parkinson disease.

    abstract::The last 2 decades represent a period of unparalleled advancement in the understanding of the pathogenesis of Parkinson disease (PD). The discovery of several forms of familial parkinsonism with mendelian inheritance has elucidated insights into the mechanisms underlying the degeneration of dopaminergic neurons of the...

    journal_title:Neurologic clinics

    pub_type: 杂志文章,评审

    doi:10.1016/j.ncl.2014.09.010

    authors: Mullin S,Schapira AH

    更新日期:2015-02-01 00:00:00

  • Comorbidity of migraine and psychiatric disorders.

    abstract::This article reviews the evidence for comorbidity of migraine with psychiatric disorders, particularly the affective and anxiety disorders. Studies of the association between migraine and depression in both clinical and community studies have provided consistent evidence regarding a substantial degree of comorbidity b...

    journal_title:Neurologic clinics

    pub_type: 杂志文章,评审

    doi:10.1016/s0733-8619(05)70298-x

    authors: Merikangas KR,Stevens DE

    更新日期:1997-02-01 00:00:00

  • The neck and headaches.

    abstract::Cervicogenic headache is pain referred to the head from a source in the cervical spine or mediated by cervical nerves. Clinical features allow for no more than a diagnosis of probable cervicogenic headache. Definitive diagnosis requires evidence of a cervical source of pain. For most treatments, the evidence is limite...

    journal_title:Neurologic clinics

    pub_type: 杂志文章,评审

    doi:10.1016/j.ncl.2013.11.005

    authors: Bogduk N

    更新日期:2014-05-01 00:00:00

  • Congenital infections.

    abstract::Despite major medical advances, such as the introduction of the rubella vaccine and prolonged postnatal therapy of infants with congenital toxoplasmosis, intrauterine infections remain important causes of deafness, vision loss, and behavioral or neurologic disorders among children worldwide. This article describes the...

    journal_title:Neurologic clinics

    pub_type: 杂志文章,评审

    doi:10.1016/s0733-8619(02)00014-2

    authors: Bale JF Jr

    更新日期:2002-11-01 00:00:00

  • Neurophysiologic monitoring in the neuroscience intensive care unit.

    abstract::Neurologically critically ill patients, more often than others, are unable to communicate and, for a crucial period of time, have the vital functions of their brains hidden in the "black box" of the cranial vault behind a curtain of ambiguity and immobility. Customarily--and naively--we have relied upon beside clinica...

    journal_title:Neurologic clinics

    pub_type: 杂志文章,评审

    doi:

    authors: Jordan KG

    更新日期:1995-08-01 00:00:00

  • Chorea and its disorders.

    abstract::Chorea (Greek for "dance") refers to irregular, rapid, flowing, non-stereotyped and random involuntary movements that often possess a writhing quality, referred to as choreoathetosis. When mild, it may be difficult to differentiate from restlessness. The movements can be strikingly asymmetric, as in hemichorea, or gen...

    journal_title:Neurologic clinics

    pub_type: 杂志文章,评审

    doi:10.1016/s0733-8619(05)70041-4

    authors: Higgins DS Jr

    更新日期:2001-08-01 00:00:00

  • Nutritional neuropathies.

    abstract::Neuropathies due to nutritional problems can affect certain patient populations and have a varied presentation because of multiple coexistent nutritional deficiencies. Clinicians should consider nutritional neuropathies in patients presenting with neuropathies. Clinicians should be alert for signs and symptoms of neur...

    journal_title:Neurologic clinics

    pub_type: 杂志文章,评审

    doi:10.1016/j.ncl.2013.02.002

    authors: Hammond N,Wang Y,Dimachkie MM,Barohn RJ

    更新日期:2013-05-01 00:00:00

  • Pediatric Brain Tumors.

    abstract::Pediatric central nervous system (CNS) tumors are the most common solid tumors in children and comprise 15% to 20% of all malignancies in children. Presentation, symptoms, and signs depend on tumor location and age of the patient at the time of diagnosis. This article summarizes the common childhood CNS tumors, presen...

    journal_title:Neurologic clinics

    pub_type: 杂志文章,评审

    doi:10.1016/j.ncl.2018.04.009

    authors: Udaka YT,Packer RJ

    更新日期:2018-08-01 00:00:00

  • Paraproteinemic neuropathy.

    abstract::Paraproteinemia frequently is associated with peripheral neuropathy. The clinical manifestations can be protean owing to the potential for multiple organ involvement. A methodical diagnostic approach to patients who have a plasma cell dyscrasia and neuropathy is necessary to ensure the appropriate detection of more wi...

    journal_title:Neurologic clinics

    pub_type: 杂志文章,评审

    doi:10.1016/j.ncl.2006.12.002

    authors: Kwan JY

    更新日期:2007-02-01 00:00:00

  • Fungal infections of the CNS.

    abstract::Most CNS fungal infections can be divided into those that occur in normal hosts and those that occur in the immunosuppressed host. Cryptococcal infection, however, is common in both groups. The usual clinical presentation of a CNS fungal infection is chronic headache and mental status change. The CSF shows a lymphocyt...

    journal_title:Neurologic clinics

    pub_type: 杂志文章,评审

    doi:

    authors: Lyons RW,Andriole VT

    更新日期:1986-02-01 00:00:00

  • Parasomnias and their mimics.

    abstract::Parasomnias are classified into nonrapid eye movement and rapid eye movement sleep parasomnias. It is important for the clinician to consider other parasomnia mimics that present to the sleep disorders clinic. These conditions can be differentiated by taking a detailed sleep history and conducting nocturnal polysomnog...

    journal_title:Neurologic clinics

    pub_type: 杂志文章,评审

    doi:10.1016/j.ncl.2012.08.016

    authors: Malhotra RK,Avidan AY

    更新日期:2012-11-01 00:00:00

  • Clinical utility of echocardiography in neurologic disorders.

    abstract::Echocardiography is an established technology encompassing an increasingly wide variety of clinical situations including cardioembolism and the detection of CAD in patients with cerebral ischemia and in patients undergoing neurovascular surgery. Echocardiography will continue to occupy a pivotal role in clinical manag...

    journal_title:Neurologic clinics

    pub_type: 杂志文章,评审

    doi:

    authors: Tegeler CH,Kitzman DW

    更新日期:1993-05-01 00:00:00

  • Functional visual loss.

    abstract::Neurologists frequently evaluate patients complaining of vision loss, especially when the patient has been examined by an ophthalmologist who has found no ocular disease. A significant proportion of patients presenting to the neurologist with visual complaints have nonorganic or functional visual loss. Although there ...

    journal_title:Neurologic clinics

    pub_type: 杂志文章

    doi:10.1016/j.ncl.2010.03.012

    authors: Bruce BB,Newman NJ

    更新日期:2010-08-01 00:00:00

  • Neoplastic meningitis.

    abstract::Neoplastic meningitis appears to be increasing in frequency with improvements in the treatment of many cancers. It is most often recognized in patients with leukemia, breast cancer, lymphomas, and small-cell cancer of the lung, although it may be seen with virtually any malignancy. Treatment should include intrathecal...

    journal_title:Neurologic clinics

    pub_type: 杂志文章,评审

    doi:

    authors: Grossman SA,Moynihan TJ

    更新日期:1991-11-01 00:00:00

  • Brain metastases.

    abstract::Brain metastases are a common complication of cancer and alter patient management more than metastases at any other site of distant progression. Supportive therapies include steroids and antiseizure medications. Definitive treatments include radiation therapy, surgery, and chemotherapy. The optimal choice of treatment...

    journal_title:Neurologic clinics

    pub_type: 杂志文章,评审

    doi:10.1016/j.ncl.2007.07.011

    authors: Nguyen TD,DeAngelis LM

    更新日期:2007-11-01 00:00:00

  • Medicolegal aspects of iatrogenic injuries.

    abstract::There is often a fine line between medical malpractice and maloccurrance. Physicians need to develop techniques and skills that enhance the patient-physician relationship based on honesty and informed consent. Documentation and proper maintenance of medical records is demanded by the current legal and health care syst...

    journal_title:Neurologic clinics

    pub_type: 杂志文章

    doi:10.1016/s0733-8619(05)70376-5

    authors: Weintraub MI

    更新日期:1998-02-01 00:00:00

  • Antidepressant overdose-induced seizures.

    abstract::Antidepressants are the most commonly prescribed class of medications in the United States. The clinician should be mindful of the many antidepressants that can produce seizures following an accidental exposure or an overdose. A broader understanding of the seizure potential of antidepressants, combined with the abili...

    journal_title:Neurologic clinics

    pub_type: 杂志文章,评审

    doi:10.1016/j.ncl.2011.05.003

    authors: Judge BS,Rentmeester LL

    更新日期:2011-08-01 00:00:00

  • Acute Diagnosis and Management of Stroke Presenting Dizziness or Vertigo.

    abstract::Stroke involving the brainstem and cerebellum frequently presents acute vestibular syndrome. Although vascular vertigo is known to usually accompany other neurologic symptoms and signs, isolated vertigo from small infarcts involving the cerebellum or brainstem has been increasingly recognized. Bedside neuro-otologic e...

    journal_title:Neurologic clinics

    pub_type: 杂志文章,评审

    doi:10.1016/j.ncl.2015.04.006

    authors: Lee SH,Kim JS

    更新日期:2015-08-01 00:00:00

  • Intensive Care Unit-Acquired Weakness.

    abstract::Intensive care unit-acquired weakness (ICUAW) is a substantial contributor to long-term disability in survivors of critical illness. Critical illness polyneuropathy, critical illness myopathy, and muscle atrophy from disuse contribute in various proportions to ICUAW. ICUAW is a clinical diagnosis supported by electrop...

    journal_title:Neurologic clinics

    pub_type: 杂志文章,评审

    doi:10.1016/j.ncl.2017.06.008

    authors: Kramer CL

    更新日期:2017-11-01 00:00:00

  • Primary central nervous system lymphoma in the transplant patient.

    abstract::Approximately 2 per cent of organ transplant recipients develop primary CNS lymphomas. There is no pathognomonic clinical or radiographic presentation of the tumor, although multicentric involvement of deep white matter is common. Evidence has linked PCNSL to immunosuppression and to infection with the EBV. The most r...

    journal_title:Neurologic clinics

    pub_type: 杂志文章,评审

    doi:

    authors: Patchell RA

    更新日期:1988-05-01 00:00:00

  • Thoracic outlet syndromes.

    abstract::The term thoracic outlet syndromes, is a group designation for several distinct disorders (one of questionable validity) involving various components of the brachial plexus, the blood vessels, or both, at various points between the base of the neck and the axilla. Four of the five subgroups (true neurologic TOS, arter...

    journal_title:Neurologic clinics

    pub_type: 杂志文章,评审

    doi:10.1016/s0733-8619(05)70149-3

    authors: Wilbourn AJ

    更新日期:1999-08-01 00:00:00

  • Wegener's granulomatosis and ANCA syndromes.

    abstract::The nervous system is involved in approximately 25% of patients with classical Wegener's granulomatosis. The spectrum of this disease has been broadened with the discovery of the anti-neutrophil cytoplasmic antibodies, which are found in diseases sharing many clinical features. The ANCA testing may indicate a common m...

    journal_title:Neurologic clinics

    pub_type: 杂志文章,评审

    doi:10.1016/s0733-8619(05)70353-4

    authors: Jaffe IA

    更新日期:1997-11-01 00:00:00

  • Neuro-ultrasonography.

    abstract::Transcranial Doppler ultrasonography (TCD) is a noninvasive, bedside, portable tool for assessment of cerebral hemodynamics. Modern TCD head frames allow continuous hands-free emboli detection for risk stratification and assessment of treatment efficacy in several cardiovascular diseases. Identifying a focal stenosis,...

    journal_title:Neurologic clinics

    pub_type: 杂志文章,评审

    doi:10.1016/j.ncl.2019.09.006

    authors: Hakimi R,Alexandrov AV,Garami Z

    更新日期:2020-02-01 00:00:00

  • Neurotology.

    abstract::As in most areas of clinical medicine, the history often is the key to determining the diagnosis in patients presenting with neurotologic symptoms. The most common cause of vertigo--benign positional vertigo--can be diagnosed at the bedside based on the characteristic history and the finding of fatigable positional ny...

    journal_title:Neurologic clinics

    pub_type: 杂志文章,评审

    doi:10.1016/s0733-8619(05)70244-9

    authors: Baloh RW,Jacobson KM

    更新日期:1996-02-01 00:00:00

  • Relevance of experimental allergic encephalomyelitis to multiple sclerosis.

    abstract::What the study of EAE has taught us that has relevance to human demyelinating diseases is discussed. ...

    journal_title:Neurologic clinics

    pub_type: 杂志文章

    doi:

    authors: Arnason BG

    更新日期:1983-08-01 00:00:00

  • Shift Work Disorder.

    abstract::Shift work and its negative consequences are becoming more relevant as the economy becomes increasing globalized. For many individuals, shift work serves as a significant biological and psychosocial challenge leading to Shift Work Disorder (SWD). Beyond the symptoms of sleep and excessive sleepiness, the range of cons...

    journal_title:Neurologic clinics

    pub_type: 杂志文章,评审

    doi:10.1016/j.ncl.2019.03.003

    authors: Cheng P,Drake C

    更新日期:2019-08-01 00:00:00

  • The sleep-immunity relationship.

    abstract::Research models show a strong interrelationship between sleep quality and immune function. The proinflammatory cytokines, interleukin-1, interleukin-6, and tumor necrosis factor α are classified as official sleep-regulatory substances. However, sleep-promoting properties are also possessed by several other immune and ...

    journal_title:Neurologic clinics

    pub_type: 杂志文章,评审

    doi:10.1016/j.ncl.2012.08.007

    authors: Gamaldo CE,Shaikh AK,McArthur JC

    更新日期:2012-11-01 00:00:00

  • The nosology of dementia.

    abstract::The nosology of dementia has evolved from the simple distinctions between senility, degenerative dementia, and vascular insults that existed a few decades ago. The differentiation of normal cognitive aging from very mild dementia has sharpened considerably; however, appreciation of the heterogeneity of Alzheimer's dis...

    journal_title:Neurologic clinics

    pub_type: 杂志文章,评审

    doi:10.1016/s0733-8619(05)70225-5

    authors: Morris JC

    更新日期:2000-11-01 00:00:00

  • Fetal effects.

    abstract::The adverse effects of fetal drug exposures are well documented. Evidence for FAS, impaired intrauterine growth, birth defects, and mental retardation related to alcohol is compelling; evidence for alcohol-induced adverse behaviors and impaired speech is tenuous. Teratogenic, cognitive, or behavioral effects associate...

    journal_title:Neurologic clinics

    pub_type: 杂志文章,评审

    doi:

    authors: Chiriboga CA

    更新日期:1993-08-01 00:00:00