The sleep-immunity relationship.

Abstract:

:Research models show a strong interrelationship between sleep quality and immune function. The proinflammatory cytokines, interleukin-1, interleukin-6, and tumor necrosis factor α are classified as official sleep-regulatory substances. However, sleep-promoting properties are also possessed by several other immune and proinflammatory cellular classes. This article reviews the current physiologic evidence for the prominent somnogenic and sleep-regulatory properties inherent to these immune substances. Clinical examples of this relationship are discussed from the perspective of infectious and primarily immune-related conditions associated with significant sleep disruption and from the perspective of immune dysregulation associated with several primary sleep disorders.

journal_name

Neurol Clin

journal_title

Neurologic clinics

authors

Gamaldo CE,Shaikh AK,McArthur JC

doi

10.1016/j.ncl.2012.08.007

subject

Has Abstract

pub_date

2012-11-01 00:00:00

pages

1313-43

issue

4

eissn

0733-8619

issn

1557-9875

pii

S0733-8619(12)00048-5

journal_volume

30

pub_type

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