Abstract：
:Nerve agents cause a rapidly fatal cholinergic crisis, but rapid, appropriate antidotal treatment saves lives. Survivors of nerve-agent poisoning generally are healthy, unlike survivors of some other chemical agent attacks. Neurologists can assist first responders and mass casualty planners materially by serving as resources for information on nerve agents and the syndromes they cause. They also can help their communities by reinforcing that treatment for nerve-agent poisoning is effective.
journal_name
Neurol Clinjournal_title
Neurologic clinicsauthors
Newmark Jdoi
10.1016/j.ncl.2004.12.013subject
Has Abstractpub_date
2005-05-01 00:00:00pages
623-41issue
2eissn
0733-8619issn
1557-9875pii
S0733-8619(04)00145-8journal_volume
23pub_type
杂志文章,评审abstract：:The dysphagia of ALS is characterized by an impaired oral stage of swallowing, which has a direct impact on the seemingly more robust pharyngeal stage. Increased duration of the volitional stage (PPRT) of swallowing, including DT and lingual motility deficits, appear to be the major contributors to the dysphagia. The ...
journal_title：Neurologic clinics
pub_type： 杂志文章
doi：
更新日期：1987-05-01 00:00:00
abstract：:Myasthenia gravis is an autoimmune disorder characterized by fluctuating weakness of extraocular and proximal limb muscles. It occurs in 1 in 5000 in the overall population and is 2 times more common in women than men. The onset in women is most common in the third decade, and risk of severe exacerbation occurs most f...
journal_title：Neurologic clinics
pub_type： 杂志文章,评审
doi：10.1016/j.ncl.2018.09.003
更新日期：2019-02-01 00:00:00
abstract：:The substantial societal and individual burdens associated with tension-type headache (TTH) constitute a previously overlooked major public health issue. TTH is prevalent, affecting up to 78% of the general population, and 3% suffer from chronic TTH. Pericranial myofascial nociception probably is important for the pat...
journal_title：Neurologic clinics
pub_type： 杂志文章,评审
doi：10.1016/j.ncl.2008.11.010
更新日期：2009-05-01 00:00:00
abstract：:The appropriate diagnosis of the patient with epilepsy is first dependent on a determination of the type of seizure. When the type of seizure has been determined, consideration must be given to the nature of the epileptic syndrome, including concerns regarding the etiology of the attacks. The gradual evolution of the ...
journal_title：Neurologic clinics
pub_type： 杂志文章
doi：
更新日期：1986-08-01 00:00:00
abstract：:In this review, the authors present a critical overview of the historical development, indications, complications, operative techniques, and results of procedures for the alleviation of the major dyskinesias. Emphasis is placed upon recent refinement of technique, particularly stereotaxis, as well as neurophysiologic ...
journal_title：Neurologic clinics
pub_type： 杂志文章,评审
doi：
更新日期：1987-11-01 00:00:00
abstract：:Pediatric central nervous system (CNS) tumors are the most common solid tumors in children and comprise 15% to 20% of all malignancies in children. Presentation, symptoms, and signs depend on tumor location and age of the patient at the time of diagnosis. This article summarizes the common childhood CNS tumors, presen...
journal_title：Neurologic clinics
pub_type： 杂志文章,评审
doi：10.1016/j.ncl.2018.04.009
更新日期：2018-08-01 00:00:00
abstract：:Neuroepidemiology is the application of the methods of epidemiology to the problems of clinical neurology. After diagnosis, the most basic characterization of a disease is its frequency. This characterization requires ascertainment of case (numerator) within their population at risk (denominator) to provide incidence,...
journal_title：Neurologic clinics
pub_type： 杂志文章,评审
doi：10.1016/s0733-8619(05)70255-3
更新日期：1996-05-01 00:00:00
abstract：:Dementia, defined as progressive cognitive decline, is a feature of a wide variety of genetic disorders. For example, a search of "dementia" in the Online Mendelian Inheritance in Man (www.ncbi.nlm.nih.gov/Omim) reveals 162 entries. Therefore this article cannot be encyclopedic and will be necessarily restricted to mo...
journal_title：Neurologic clinics
pub_type： 杂志文章,评审
doi：10.1016/s0733-8619(01)00020-2
更新日期：2002-08-01 00:00:00
abstract：:The oldest-old represent the fastest growing segment of society, and the risk of developing dementia continues to increase with advancing age into the 9th and 10th decades of life. The most common form of dementia in the oldest-old is Alzheimer disease (AD), although there are often mixed pathologies contributing to d...
journal_title：Neurologic clinics
pub_type： 杂志文章,评审
doi：10.1016/j.ncl.2017.01.006
更新日期：2017-05-01 00:00:00
abstract：:Cerebral ischemia manifests widely in patient symptoms. Along with the clinical examination, imaging serves as a powerful tool throughout the course of ischemia-from acute onset to evolution. A thorough understanding of imaging modalities, their strengths and their limitations, is essential for capitalizing on the ben...
journal_title：Neurologic clinics
pub_type： 杂志文章,评审
doi：10.1016/j.ncl.2013.07.005
更新日期：2014-02-01 00:00:00
abstract：:Postherpetic pain persisting 1 month or longer occurs in only a small percentage of all patients with herpes zoster. In most patients, PHN tends to diminish with time. The incidence is, however, directly related to age. Any therapeutic claim for prophylaxis or treatment of PHN has to be evaluated with these observatio...
journal_title：Neurologic clinics
pub_type： 杂志文章,评审
doi：
更新日期：1989-05-01 00:00:00
abstract：:MS has certain salient morphologic features that distinguish it from other disorders of white matter and that may represent points of departure for investigation. ...
journal_title：Neurologic clinics
pub_type： 杂志文章
doi：
更新日期：1983-08-01 00:00:00
abstract：:Neurologically critically ill patients, more often than others, are unable to communicate and, for a crucial period of time, have the vital functions of their brains hidden in the "black box" of the cranial vault behind a curtain of ambiguity and immobility. Customarily--and naively--we have relied upon beside clinica...
journal_title：Neurologic clinics
pub_type： 杂志文章,评审
doi：
更新日期：1995-08-01 00:00:00
abstract：:Most CNS fungal infections can be divided into those that occur in normal hosts and those that occur in the immunosuppressed host. Cryptococcal infection, however, is common in both groups. The usual clinical presentation of a CNS fungal infection is chronic headache and mental status change. The CSF shows a lymphocyt...
journal_title：Neurologic clinics
pub_type： 杂志文章,评审
doi：
更新日期：1986-02-01 00:00:00
abstract：:Epilepsy affects over one percent of the population, including nearly one million women of childbearing potential. Women with epilepsy represent a particularly challenging group for neurologists and other health care professionals. Affected women are unaware of many of the unique issues they face, including the relati...
journal_title：Neurologic clinics
pub_type： 杂志文章,评审
doi：10.1016/s0733-8619(05)70024-4
更新日期：2001-05-01 00:00:00
abstract：:Supratentorial low-grade gliomas comprise a group of primary central nervous system neoplasms with characteristics of neuroglial cells (i.e., astrocytes and oligodendrocytes) and relatively low anaplastic potential, although through time they tend to behave more aggressively. Immediate surgical intervention and subseq...
journal_title：Neurologic clinics
pub_type： 杂志文章,评审
doi：
更新日期：1995-11-01 00:00:00
abstract：:Spontaneous ICH remains a formidable disease that continues to disable and kill the majority of its victims. Treatment of the disease continues to be controversial and without any proved success, such as improvement in the disease mortality or the resulting disability in survivors. Primary prevention is the most effec...
journal_title：Neurologic clinics
pub_type： 杂志文章,评审
doi：10.1016/j.ncl.2006.05.005
更新日期：2006-11-01 00:00:00
abstract：:The fourth edition of The Diagnostic and Statistical Manual of Mental Disorders defines delirium as "a reversible state of confusion with a reduced level of consciousness manifest as an inability to focus, sustain or shift attention." Pharmacologic agents are important contributors to delirium in hospitalized elderly ...
journal_title：Neurologic clinics
pub_type： 杂志文章,评审
doi：10.1016/j.ncl.2004.01.001
更新日期：2004-05-01 00:00:00
abstract：:This article describes the physiologic and neural mechanisms that cause neuromuscular fatigue in racquet sports: table tennis, tennis, squash, and badminton. In these intermittent and dual activities, performance may be limited as a match progresses because of a reduced central activation, linked to changes in neurotr...
journal_title：Neurologic clinics
pub_type： 杂志文章,评审
doi：10.1016/j.ncl.2007.11.011
更新日期：2008-02-01 00:00:00
abstract：:Conventional disease-modifying agents are only moderately effective, so breakthrough disease activity is commonly seen. The evidence from randomized clinical trials and real-world observational data supporting the use of the second-line agents natalizumab, mitoxantrone, and cyclophosphamide are reviewed. Potential fut...
journal_title：Neurologic clinics
pub_type： 杂志文章,评审
doi：10.1016/j.ncl.2010.12.005
更新日期：2011-05-01 00:00:00
abstract：:Rapidly progressive dementias (RPDs) are neurologic conditions that develop subacutely over weeks to months or, rarely, acutely over days. In contrast to most dementing conditions that take years to progress to death, RPD quickly can be fatal. It is critical to evaluate patients who have RPD without delay, usually in ...
journal_title：Neurologic clinics
pub_type： 杂志文章,评审
doi：10.1016/j.ncl.2007.04.001
更新日期：2007-08-01 00:00:00
abstract：:The author defines lacunes, classifies types of lacunes and their causes, discusses the correlation between lacunes and specific syndromes, and suggests appropriate therapy. ...
journal_title：Neurologic clinics
pub_type： 杂志文章
doi：
更新日期：1983-02-01 00:00:00
abstract：:Oxidative phosphorylation (OXPHOS) accounts for approximately 95% of the adenosine triphosphate (ATP) produced by the cell. The central nervous system, peripheral nervous system, cardiac muscle, skeletal muscle, and smooth muscle are highly susceptible to dysfunction of this complex enzyme system. Although most OXPHOS...
journal_title：Neurologic clinics
pub_type： 杂志文章,评审
doi：10.1016/s0733-8619(05)70180-8
更新日期：2000-02-01 00:00:00
abstract：:The major clinical uses for opioids are to control pain, suppress cough, and to treat diarrhea. These drugs, however, have the potential for abuse. It is postulated that the significant mood-altering effects of opioids combined with their pharmacology, in which tolerance and physical and psychological dependence occur...
journal_title：Neurologic clinics
pub_type： 杂志文章,评审
doi：
更新日期：1993-08-01 00:00:00
abstract：:Brain metastases are a common complication of cancer and alter patient management more than metastases at any other site of distant progression. Supportive therapies include steroids and antiseizure medications. Definitive treatments include radiation therapy, surgery, and chemotherapy. The optimal choice of treatment...
journal_title：Neurologic clinics
pub_type： 杂志文章,评审
doi：10.1016/j.ncl.2007.07.011
更新日期：2007-11-01 00:00:00
abstract：:The last 2 decades represent a period of unparalleled advancement in the understanding of the pathogenesis of Parkinson disease (PD). The discovery of several forms of familial parkinsonism with mendelian inheritance has elucidated insights into the mechanisms underlying the degeneration of dopaminergic neurons of the...
journal_title：Neurologic clinics
pub_type： 杂志文章,评审
doi：10.1016/j.ncl.2014.09.010
更新日期：2015-02-01 00:00:00
abstract：:Parasomnias are classified into nonrapid eye movement and rapid eye movement sleep parasomnias. It is important for the clinician to consider other parasomnia mimics that present to the sleep disorders clinic. These conditions can be differentiated by taking a detailed sleep history and conducting nocturnal polysomnog...
journal_title：Neurologic clinics
pub_type： 杂志文章,评审
doi：10.1016/j.ncl.2012.08.016
更新日期：2012-11-01 00:00:00
abstract：:Focal, small-to-moderate and transient improvement occurred in the muscle strength and function of patients with ALS who received TRH in dose-response and screening studies. In a small pilot study of 12 patients, 3 months administration of TRH at 10 mg per kg on alternate days resulted in localized increased strength ...
journal_title：Neurologic clinics
pub_type： 临床试验,杂志文章
doi：
更新日期：1987-02-01 00:00:00
abstract：:Most patients who have endured a stroke sustain behavioral changes, although in many instances these effects can be subtle. Although behavioral changes after a stroke tend to improve, they may persist and have serious effects on daily living activities. This article reviews the more familiar behavioral changes that fo...
journal_title：Neurologic clinics
pub_type： 杂志文章,评审
doi：10.1016/j.ncl.2015.08.009
更新日期：2016-02-01 00:00:00
abstract：:The inflammatory myopathies are a heterogeneous group of disorders with recent evidence demonstrating differences in clinical features, pathologic changes, pathogenesis, and response to therapy. The inflammatory myopathies generally produce predominantly proximal, symmetric muscle weakness and wasting. Additional crit...
journal_title：Neurologic clinics
pub_type： 杂志文章,评审
doi：
更新日期：1988-08-01 00:00:00
