Abstract:
:The calcineurin inhibitors cyclosporine and tacrolimus are used for their immunosuppressive effects. Neurotoxic side effects include tremor, paresthesia, and headache. Rarer neurotoxicities include seizure, posterior reversible encephalopathy syndrome, and encephalopathy. Tacrolimus tends to be more neurotoxic than cyclosporine. Management of toxicities associated with calcineurin inhibitors includes dose reduction, switching between calcineurin inhibitors, or switching to a calcineurin-free regimen. Tumor necrosis factor (TNF) inhibitors are used in autoimmune diseases. Management of demyelinating conditions among patients treated with anti-TNF should follow standard of care and withdrawal of the anti-TNF. This drug class should be avoided in patients with a history of demyelinating conditions.
journal_name
Neurol Clinjournal_title
Neurologic clinicsauthors
Coe CL,Horst SN,Izzy MJdoi
10.1016/j.ncl.2020.07.009subject
Has Abstractpub_date
2020-11-01 00:00:00pages
937-951issue
4eissn
0733-8619issn
1557-9875pii
S0733-8619(20)30061-Xjournal_volume
38pub_type
杂志文章,评审abstract::Epilepsy affects over one percent of the population, including nearly one million women of childbearing potential. Women with epilepsy represent a particularly challenging group for neurologists and other health care professionals. Affected women are unaware of many of the unique issues they face, including the relati...
journal_title:Neurologic clinics
pub_type: 杂志文章,评审
doi:10.1016/s0733-8619(05)70024-4
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abstract::The needle electromyographic (EMG) examination is a challenging component of the electrophysiologic study. Knowledge of anatomy and physiology, sound EMG technique, and good patient rapport are required. Every muscle sampled by needle EMG is assessed for insertional activity, spontaneous activity, and voluntary motor-...
journal_title:Neurologic clinics
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journal_title:Neurologic clinics
pub_type: 杂志文章,评审
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更新日期:2019-08-01 00:00:00
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journal_title:Neurologic clinics
pub_type: 杂志文章,评审
doi:10.1016/s0733-8619(05)70265-6
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abstract::The major clinical uses for opioids are to control pain, suppress cough, and to treat diarrhea. These drugs, however, have the potential for abuse. It is postulated that the significant mood-altering effects of opioids combined with their pharmacology, in which tolerance and physical and psychological dependence occur...
journal_title:Neurologic clinics
pub_type: 杂志文章,评审
doi:
更新日期:1993-08-01 00:00:00
abstract::Although intravenous thrombolysis with recombinant tissue plasminogen activator is a proven effective therapy for acute ischemic stroke, it is often insufficient to achieve recanalization in patients with large intracranial artery occlusions. In these cases, intra-arterial reperfusion techniques may be useful. Intra-a...
journal_title:Neurologic clinics
pub_type: 杂志文章,评审
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journal_title:Neurologic clinics
pub_type: 杂志文章,评审
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journal_title:Neurologic clinics
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journal_title:Neurologic clinics
pub_type: 杂志文章,评审
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journal_title:Neurologic clinics
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journal_title:Neurologic clinics
pub_type: 杂志文章,评审
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更新日期:1990-11-01 00:00:00
abstract::In the current era of escalating globalization with rapid transport, changing climate, and an ever growing human population with associated changes in lifestyle, poverty, and war, the emergence of new neurologic infections is accelerated. Understanding their origins using epidemiologic and molecular tools will contrib...
journal_title:Neurologic clinics
pub_type: 杂志文章,评审
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journal_title:Neurologic clinics
pub_type: 杂志文章,评审
doi:10.1016/j.ncl.2011.12.001
更新日期:2012-05-01 00:00:00
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journal_title:Neurologic clinics
pub_type: 杂志文章,评审
doi:10.1016/s0733-8619(05)70084-0
更新日期:1998-08-01 00:00:00
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journal_title:Neurologic clinics
pub_type: 杂志文章,评审
doi:10.1016/s0733-8619(05)70244-9
更新日期:1996-02-01 00:00:00
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journal_title:Neurologic clinics
pub_type: 杂志文章,评审
doi:
更新日期:1991-02-01 00:00:00
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journal_title:Neurologic clinics
pub_type: 杂志文章,评审
doi:
更新日期:1991-11-01 00:00:00
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journal_title:Neurologic clinics
pub_type: 杂志文章,评审
doi:
更新日期:1988-11-01 00:00:00
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journal_title:Neurologic clinics
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journal_title:Neurologic clinics
pub_type: 杂志文章
doi:
更新日期:1983-02-01 00:00:00
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journal_title:Neurologic clinics
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journal_title:Neurologic clinics
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journal_title:Neurologic clinics
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journal_title:Neurologic clinics
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journal_title:Neurologic clinics
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journal_title:Neurologic clinics
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journal_title:Neurologic clinics
pub_type: 杂志文章,评审
doi:
更新日期:1985-05-01 00:00:00
abstract::The three states of mammalian being--wakefulness, REM sleep, and NREM sleep--are not mutually exclusive and may occur simultaneously, oscillate rapidly, or appear in dissociated or incomplete form to produce primary sleep parasomnias. Dysfunctions of a wide variety of organ systems may take advantage of the sleeping s...
journal_title:Neurologic clinics
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doi:10.1016/s0733-8619(05)70280-2
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journal_title:Neurologic clinics
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journal_title:Neurologic clinics
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