Abstract：
:Despite important advances in the treatment of epilepsy over the past several decades, many patients remain uncontrolled. Partial complex (psychomotor) seizures are the largest problem, with less than two thirds of patients successfully managed despite optimal medication use. In these situations, various surgical procedures may be helpful, depending on the type of epilepsy, its cerebral location of origin, and the neurologic status of the particular patient. Intensive investigation including EEG and audiovisual monitoring are utilized to evaluate the medically refractory epileptic. In some instances, specialized recordings from epidural, subdural or intracerebral locations are needed to try to pinpoint onset of focal seizure. When this is possible, and the epileptogenic area is resectable, cortical excision may provide cure or marked reduction of seizures in 60 to 90 per cent of properly selected patients with minimal morbidity. The most common operation is temporal lobectomy; this procedure itself is undergoing modifications as more is learned about the usual locations of seizure foci and the functions of this tissue. Resections in other cortical areas may be more difficult but are possible. When a single focus is not identified or is not resectable, other procedures may be used. Results in seizure control with chronic cerebellar stimulation have been variable. The results of stereotaxic lesions in various locations are difficult to evaluate with the single exception of field H of Forel, which in many reports has been effective for grand mal seizures. Generalized seizures, particularly in patients with infantile hemiplegia or frontal lobe epilepsy, are well controlled with corpus callosotomy. Surgery for epilepsy is currently practiced at several centers in this country and abroad. There is great need for more such centers and more education about this treatment as estimates indicate 100,000 patients in the United States at this time could benefit from such procedures.
journal_name
Neurol Clinjournal_title
Neurologic clinicsauthors
Spencer DD,Spencer SSsubject
Has Abstractpub_date
1985-05-01 00:00:00pages
313-30issue
2eissn
0733-8619issn
1557-9875journal_volume
3pub_type
杂志文章,评审abstract：:Nerve agents cause a rapidly fatal cholinergic crisis, but rapid, appropriate antidotal treatment saves lives. Survivors of nerve-agent poisoning generally are healthy, unlike survivors of some other chemical agent attacks. Neurologists can assist first responders and mass casualty planners materially by serving as re...
journal_title：Neurologic clinics
pub_type： 杂志文章,评审
doi：10.1016/j.ncl.2004.12.013
更新日期：2005-05-01 00:00:00
abstract：:The oldest-old represent the fastest growing segment of society, and the risk of developing dementia continues to increase with advancing age into the 9th and 10th decades of life. The most common form of dementia in the oldest-old is Alzheimer disease (AD), although there are often mixed pathologies contributing to d...
journal_title：Neurologic clinics
pub_type： 杂志文章,评审
doi：10.1016/j.ncl.2017.01.006
更新日期：2017-05-01 00:00:00
abstract：:Since its clinical introduction in the early 1980s, MRI has transformed the practice of differential diagnosis and disease monitoring for disorders affecting the central nervous system, in particular multiple sclerosis and the allied inflammatory demyelinating diseases. Widespread and dynamic inflammatory processes of...
journal_title：Neurologic clinics
pub_type： 杂志文章,评审
doi：10.1016/j.ncl.2008.09.012
更新日期：2009-02-01 00:00:00
abstract：:Neurologic emergencies are common among cancer patients and their incidence is increasing as patients live longer as a result of improved antineoplastic therapy. This article reviews acute neurologic complications in cancer patients. Among those complications reviewed are brain metastases, epidural spinal cord compres...
journal_title：Neurologic clinics
pub_type： 杂志文章,评审
doi：10.1016/s0733-8619(05)70072-4
更新日期：1998-05-01 00:00:00
abstract：:A number of changes have occurred in the management of Parkinson's disease in recent years, with the development of new therapeutic strategies based upon advances in pharmacotherapy and interventional procedures. The treatment of patients with Parkinson's disease is considered here with these advances in mind. Potenti...
journal_title：Neurologic clinics
pub_type： 杂志文章,评审
doi：10.1016/s0733-8619(05)70008-6
更新日期：2001-02-01 00:00:00
abstract：:Drug-induced seizures are a commonly encountered problem for physicians. In this article, drugs that cause seizures are discussed with regards to the incidence of seizures, associated clinical factors, risk factors, and special treatment considerations. This information should help physicians determine appropriate eva...
journal_title：Neurologic clinics
pub_type： 杂志文章,评审
doi：
更新日期：1994-02-01 00:00:00
abstract：:Animal and human research has clearly shown that anticonvulsants are teratogens and pose a risk for fetal malformations. In the case of dilantin it appears that fetal susceptibility correlates with the fetal level of the microsomal detoxifying enzyme epoxide hydrolase. The genetics of seizures in the parents does not ...
journal_title：Neurologic clinics
pub_type： 杂志文章,评审
doi：
更新日期：1994-11-01 00:00:00
abstract：:"Myasthenia gravis (MG) is the most common autoimmune neuromuscular disorder. This article highlights several cases that the practicing neurologist may encounter in the treatment of MG. Diagnostic uncertainty continues to be an issue in patients who are seronegative to the 2 most common antibodies, acetylcholine recep...
journal_title：Neurologic clinics
pub_type： 杂志文章,评审
doi：10.1016/j.ncl.2020.03.005
更新日期：2020-08-01 00:00:00
abstract：:Intensive care unit-acquired weakness (ICUAW) is a substantial contributor to long-term disability in survivors of critical illness. Critical illness polyneuropathy, critical illness myopathy, and muscle atrophy from disuse contribute in various proportions to ICUAW. ICUAW is a clinical diagnosis supported by electrop...
journal_title：Neurologic clinics
pub_type： 杂志文章,评审
doi：10.1016/j.ncl.2017.06.008
更新日期：2017-11-01 00:00:00
abstract：:Botulinum toxin therapy has emerged as a treatment modality for a variety of spastic- or contracture-related muscle diseases. Its safety has been proven for long-term use in the treatment of benign essential blepharospasm, hemifacial spasm, and certain types of strabismus. Recent approval from the Federal Drug Adminis...
journal_title：Neurologic clinics
pub_type： 杂志文章,评审
doi：
更新日期：1991-02-01 00:00:00
abstract：:Through the use of IHS criteria, large population-based epidemiologic studies in Denmark, the United States, France, Canada, and elsewhere have shed light on the descriptive epidemiology of migraine. Although migraine is a remarkably common cause of temporary disability, many migraineurs, even those with disabling hea...
journal_title：Neurologic clinics
pub_type： 杂志文章,评审
doi：10.1016/s0733-8619(05)70265-6
更新日期：1996-05-01 00:00:00
abstract：:The natural history of MS is highly variable. There is substantial heterogeneity in the clinical manifestations but, at this point, it is reasonable to consider all idiopathic inflammatory demyelinating diseases of the central nervous system as representing a spectrum of the same disease. In large populations, 20% to ...
journal_title：Neurologic clinics
pub_type： 杂志文章,评审
doi：
更新日期：1995-02-01 00:00:00
abstract：:This article defines the evolving role of the neurologist as a provider of palliative care. As neurologists care for chronically and critically ill, dying patients, and individuals whose diseases are incurable at the time of diagnosis, clinical competence requires expertise in the principles and practice of palliative...
journal_title：Neurologic clinics
pub_type： 杂志文章
doi：10.1016/s0733-8619(05)70047-5
更新日期：2001-11-01 00:00:00
abstract：:The respiratory system and the central nervous system are interconnected in a delicate balance; disorders in this equilibrium can have devastating consequences. Respiratory dysfunction, whether acute or chronic, may cause neurologic disease, including headache, encephalopathy, and in extreme cases, coma and death. Thi...
journal_title：Neurologic clinics
pub_type： 杂志文章,评审
doi：10.1016/s0733-8619(03)00062-8
更新日期：2002-02-01 00:00:00
abstract：:Personal experience indicates we sleep differently when sick. Data reviewed demonstrate the extent to which sleep is altered during the course of infection of host organisms by several classes of pathogens. One important unanswered question is whether or not the alterations in sleep during infection are of functional ...
journal_title：Neurologic clinics
pub_type： 杂志文章,评审
doi：10.1016/j.ncl.2006.03.002
更新日期：2006-08-01 00:00:00
abstract：:Ischemic stroke is a major cause of death and disability. Despite its high incidence, acute management remains controversial. Most current forms of therapy are designed to reduce complications of a recent stroke or prevent recurrences. Experimental data suggest that the optimal time for intervention is the hour immedi...
journal_title：Neurologic clinics
pub_type： 杂志文章,评审
doi：
更新日期：1992-02-01 00:00:00
abstract：:Normal cell replication is regulated by growth factors such as epidermal growth factor (EGF) and platelet-derived growth factor (PDGF) that act through binding to specific surface receptors on target cells. Oncogenes may exert their transforming activity by encoding proteins that mimic the function of the normal regul...
journal_title：Neurologic clinics
pub_type： 杂志文章,评审
doi：
更新日期：1985-11-01 00:00:00
abstract：:Meaningful symptom management can have a profound impact on quality of life. It can challenge time parameters during clinic, and therefore thought should be given to strategies that can improve efficiency and thereby make the undertaking more tenable. For any given symptom, the building blocks of care, such as vitamin...
journal_title：Neurologic clinics
pub_type： 杂志文章,评审
doi：10.1016/j.ncl.2017.08.015
更新日期：2018-02-01 00:00:00
abstract：:Overall, the majority of patients with optic pathway tumors will have stable disease regardless if they are radiated or receive chemotherapy. This is a very indolent tumor system and, for the most part, not a threat to life. Because of this, issues regarding appropriate therapeutic approaches have yet to be resolved. ...
journal_title：Neurologic clinics
pub_type： 杂志文章,评审
doi：
更新日期：1991-05-01 00:00:00
abstract：:The inflammatory myopathies are a heterogeneous group of disorders with recent evidence demonstrating differences in clinical features, pathologic changes, pathogenesis, and response to therapy. The inflammatory myopathies generally produce predominantly proximal, symmetric muscle weakness and wasting. Additional crit...
journal_title：Neurologic clinics
pub_type： 杂志文章,评审
doi：
更新日期：1988-08-01 00:00:00
abstract：:Smartphones make mobile computing at point of care practical. Smartphones can think, sync, and link. Built-in and user-installed applications facilitate communications between neurologists and their medical colleagues and patients and augment data acquisition and processing in the core medical information domains of p...
journal_title：Neurologic clinics
pub_type： 杂志文章
doi：10.1016/j.ncl.2009.11.001
更新日期：2010-05-01 00:00:00
abstract：:Antidepressants are the most commonly prescribed class of medications in the United States. The clinician should be mindful of the many antidepressants that can produce seizures following an accidental exposure or an overdose. A broader understanding of the seizure potential of antidepressants, combined with the abili...
journal_title：Neurologic clinics
pub_type： 杂志文章,评审
doi：10.1016/j.ncl.2011.05.003
更新日期：2011-08-01 00:00:00
abstract：:Rapidly progressive dementias (RPDs) are neurologic conditions that develop subacutely over weeks to months or, rarely, acutely over days. In contrast to most dementing conditions that take years to progress to death, RPD quickly can be fatal. It is critical to evaluate patients who have RPD without delay, usually in ...
journal_title：Neurologic clinics
pub_type： 杂志文章,评审
doi：10.1016/j.ncl.2007.04.001
更新日期：2007-08-01 00:00:00
abstract：:Encephalitis is an acute infection of brain parenchyma characterized clinically by fever, headache, and an altered level of consciousness. There may also be focal or multifocal neurologic deficits, and focal or generalized seizure activity. This article discusses the clinical presentation, diagnosis, and treatment of ...
journal_title：Neurologic clinics
pub_type： 杂志文章,评审
doi：10.1016/s0733-8619(05)70168-7
更新日期：1999-11-01 00:00:00
abstract：:Although intravenous thrombolysis with recombinant tissue plasminogen activator is a proven effective therapy for acute ischemic stroke, it is often insufficient to achieve recanalization in patients with large intracranial artery occlusions. In these cases, intra-arterial reperfusion techniques may be useful. Intra-a...
journal_title：Neurologic clinics
pub_type： 杂志文章,评审
doi：10.1016/j.ncl.2013.03.009
更新日期：2013-08-01 00:00:00
abstract：:In this article, the authors provide a conceptual framework in which to consider alternative approaches to identify the developmental consequences of exposing the developing brain to neurotoxic substances. Concepts underlying brain development and issues regarding neurobehavioral testing in children are reviewed. In a...
journal_title：Neurologic clinics
pub_type： 杂志文章,评审
doi：10.1016/s0733-8619(05)70210-3
更新日期：2000-08-01 00:00:00
abstract：:Injury to cranial nerves is a common sequela of blunt head trauma. The olfactory, facial, and audiovestibular nerves are damaged most often, followed by the optic and ocular motor nerves. The trigeminal and lower cranial nerves are rarely involved. Chances of recovery are greatest for the facial nerve, intermediate fo...
journal_title：Neurologic clinics
pub_type： 杂志文章,评审
doi：
更新日期：1992-11-01 00:00:00
abstract：:The nervous system is involved in approximately 25% of patients with classical Wegener's granulomatosis. The spectrum of this disease has been broadened with the discovery of the anti-neutrophil cytoplasmic antibodies, which are found in diseases sharing many clinical features. The ANCA testing may indicate a common m...
journal_title：Neurologic clinics
pub_type： 杂志文章,评审
doi：10.1016/s0733-8619(05)70353-4
更新日期：1997-11-01 00:00:00
abstract：:There are a number of medications that effectively relieve symptoms in patients with functionally disabling tics. Neuroleptic drugs remain the most predictably effective tic-suppressing agents, but other approaches may be beneficial. This article reviews the spectrum of available therapies to suppress tics and provide...
journal_title：Neurologic clinics
pub_type： 杂志文章,评审
doi：10.1016/s0733-8619(05)70321-2
更新日期：1997-05-01 00:00:00
abstract：:The appropriate diagnosis of the patient with epilepsy is first dependent on a determination of the type of seizure. When the type of seizure has been determined, consideration must be given to the nature of the epileptic syndrome, including concerns regarding the etiology of the attacks. The gradual evolution of the ...
journal_title：Neurologic clinics
pub_type： 杂志文章
doi：
更新日期：1986-08-01 00:00:00
