Clinical neurogenetics: autosomal dominant spinocerebellar ataxia.

abstract：:This article provides a brief overview of the psychiatric syndromes most common in the elderly patient, as well as those most frequently accompanying neurologic disease. Diagnosis, work up, and treatment of depressive, psychotic, and anxiety disorders are also reviewed. This article is directed toward the practicing n...

journal_title：Neurologic clinics

authors： Menza MA,Liberatore BL

更新日期：1998-08-01 00:00:00

abstract：:The etiology of pyogenic infections of the brain and meninges varies principally by age, predisposing causes or conditions, and anatomic site of the infection. An appreciation of these factors, plus the prudent use of noninvasive anatomic diagnostic techniques (such as CT) and examination of the CSF, will provide a ba...

journal_title：Neurologic clinics

authors： Overturf GD

更新日期：1986-02-01 00:00:00

abstract：:Psychogenic movement disorders (PMDs) can present with varied phenomenology that may resemble organic movement disorders. The diagnosis is based on clinical evaluation with a supporting history and classic features on neurologic examination. Ancillary testing, such as imaging and neurophysiologic studies, can provide ...

journal_title：Neurologic clinics

authors： Thenganatt MA,Jankovic J

更新日期：2015-02-01 00:00:00

abstract：:The criteria that characterize restless legs syndrome (RLS) and the differential diagnoses are discussed. Clinical signs include sleep disturbance, involuntary movements in sleep or wakefulness, a normal neurologic examination, a chronic clinical course, and, in some cases, a positive family history. Periodic limb mov...

journal_title：Neurologic clinics

authors： Trenkwalder C,Walters AS,Hening W

更新日期：1996-08-01 00:00:00

abstract：:Legal issues must be considered in caring for patients with epilepsy. Doctors caring for people with epilepsy may be legally involved in three primary ways: as the agent of social control, as patient advocate, and as the target of liability or malpractice suits. This article examines these factors and the implications...

journal_title：Neurologic clinics

authors： Hughes JT,Devinsky O

更新日期：1994-02-01 00:00:00

abstract：:Electronystagmography in 1990 should identify a vestibular abnormality with which to associate the clinical symptoms. The vestibular test battery method and interpretation reveals its application in neurotologic diagnosis. ...

journal_title：Neurologic clinics

authors： Brookler KH

更新日期：1990-05-01 00:00:00

abstract：:Neurologic complications are a major cause of morbidity, complicating open heart surgery, cardiac catheterization, and interventional techniques. Global or focal brain ischemia related to embolism or hypoperfusion predominates. Breakthrough cerebral hemorrhage and infection can complicate cardiac transplantation. Iden...

journal_title：Neurologic clinics

authors： Furlan AJ,Sila CA,Chimowitz MI,Jones SC

更新日期：1992-02-01 00:00:00

abstract：:This review explores the principle features of the immunopathology of multiple sclerosis (MS), particularly relapsing-remitting MS. It highlights the emerging concepts in the pathogenesis of MS in the context of known features of pathology, including the characterization of cytokine networks promoting inflammatory dam...

journal_title：Neurologic clinics

authors： Wu GF,Alvarez E

更新日期：2011-05-01 00:00:00

abstract：:Toxic myopathies may occur with a variety of prescribed medications, illicit drug abuse, or other toxins. The article discusses an overview of some of the compounds that may cause myopathy, the clinical and laboratory features, histology, mechanisms of action, and potential risk factors of myopathy. The ability to rec...

journal_title：Neurologic clinics

authors： George KK,Pourmand R

更新日期：1997-08-01 00:00:00

abstract：:Approximately 2 per cent of organ transplant recipients develop primary CNS lymphomas. There is no pathognomonic clinical or radiographic presentation of the tumor, although multicentric involvement of deep white matter is common. Evidence has linked PCNSL to immunosuppression and to infection with the EBV. The most r...

journal_title：Neurologic clinics

authors： Patchell RA

更新日期：1988-05-01 00:00:00

abstract：:The term thoracic outlet syndromes, is a group designation for several distinct disorders (one of questionable validity) involving various components of the brachial plexus, the blood vessels, or both, at various points between the base of the neck and the axilla. Four of the five subgroups (true neurologic TOS, arter...

journal_title：Neurologic clinics

authors： Wilbourn AJ

更新日期：1999-08-01 00:00:00

abstract：:There are a number of medications that effectively relieve symptoms in patients with functionally disabling tics. Neuroleptic drugs remain the most predictably effective tic-suppressing agents, but other approaches may be beneficial. This article reviews the spectrum of available therapies to suppress tics and provide...

journal_title：Neurologic clinics

authors： Kurlan R

更新日期：1997-05-01 00:00:00

abstract：:Primary angiitis of the central nervous system (PACNS) is a vasculitis of small arteries and veins of unknown cause restricted to the central nervous system (CNS), and controversy and disagreement exist over the means to establish the diagnosis. Cerebral arteriography, cerebrospinal fluid examination, and MRI singly o...

journal_title：Neurologic clinics

authors： Powers WJ

更新日期：2015-05-01 00:00:00

abstract：:The evaluation, diagnosis, and treatment of childhood epilepsy or isolated seizures deserve special consideration. Whenever possible, a working diagnosis of an epilepsy syndrome should be implemented early in the course of evaluation to help plan the necessary investigations and acute and chronic treatment. The plan w...

journal_title：Neurologic clinics

authors： Pellock JM

更新日期：1993-11-01 00:00:00

abstract：:Primary brain tumors consist of neoplasms with varied molecular defects, morphologic phenotypes, and clinical outcomes. The genetic and signaling abnormalities involved in tumor initiation and progression of the most prevalent adult primary brain tumors, including gliomas, meningiomas, and medulloblastomas, are descri...

journal_title：Neurologic clinics

authors： Sauvageot CM,Kesari S,Stiles CD

更新日期：2007-11-01 00:00:00

abstract：:The major clinical uses for opioids are to control pain, suppress cough, and to treat diarrhea. These drugs, however, have the potential for abuse. It is postulated that the significant mood-altering effects of opioids combined with their pharmacology, in which tolerance and physical and psychological dependence occur...

journal_title：Neurologic clinics

authors： Foley KM

更新日期：1993-08-01 00:00:00

abstract：:Progressive muscular atrophy (PMA) is a rare, sporadic, adult-onset motor neuron disease, clinically characterized by isolated lower motor neuron features; however, clinically evident upper motor neuron signs may emerge in some patients. Subclinical upper motor neuron involvement is identified pathologically, radiolog...

journal_title：Neurologic clinics

authors： Liewluck T,Saperstein DS

更新日期：2015-11-01 00:00:00

abstract：:Reye syndrome has emerged as the quintessential example of an acute metabolic encephalopathy. The clinical presentation is quite stereotyped in most instances permitting rapid, accurate diagnosis and early therapeutic intervention. Intoxications and certain inborn metabolic errors may mimic Reye syndrome. All patients...

journal_title：Neurologic clinics

authors： De Vivo DC

更新日期：1985-02-01 00:00:00

abstract：:Intensive care unit-acquired weakness (ICUAW) is a substantial contributor to long-term disability in survivors of critical illness. Critical illness polyneuropathy, critical illness myopathy, and muscle atrophy from disuse contribute in various proportions to ICUAW. ICUAW is a clinical diagnosis supported by electrop...

journal_title：Neurologic clinics

authors： Kramer CL

更新日期：2017-11-01 00:00:00

abstract：:Although intravenous thrombolysis with recombinant tissue plasminogen activator is a proven effective therapy for acute ischemic stroke, it is often insufficient to achieve recanalization in patients with large intracranial artery occlusions. In these cases, intra-arterial reperfusion techniques may be useful. Intra-a...

journal_title：Neurologic clinics

authors： Cohen JE,Leker RR,Rabinstein A

更新日期：2013-08-01 00:00:00

abstract：:Channelopathies, neuromuscular junction disorders, and myopathies represent multiple mechanisms by which toxins can affect the peripheral nervous system. These toxins include ciguatoxin, tetrodotoxin, botulinum toxin, metabolic poisons, venomous snake bites, and several medications. These toxins are important to be aw...

journal_title：Neurologic clinics

authors： Janecek J,Kushlaf H

更新日期：2020-11-01 00:00:00

abstract：:Dementia, defined as progressive cognitive decline, is a feature of a wide variety of genetic disorders. For example, a search of "dementia" in the Online Mendelian Inheritance in Man (www.ncbi.nlm.nih.gov/Omim) reveals 162 entries. Therefore this article cannot be encyclopedic and will be necessarily restricted to mo...

journal_title：Neurologic clinics

authors： Hedera P,Turner RS

更新日期：2002-08-01 00:00:00

abstract：:The vasculitides are a heterogeneous group of disorders that cause blood vessel inflammation and necrosis. Vasculitis may represent a primary disease process or a secondary manifestation of an underlying systemic condition. Neurologic symptoms and signs are common in most of the vasculitic syndromes and may be the pre...

journal_title：Neurologic clinics

authors： Kissel JT

更新日期：1989-08-01 00:00:00

abstract：:A large body of medical and ethical opinion holds that it is justifiable to terminate medical treatment for permanently unconscious persons. But opponents of particular decisions to withhold or withdraw treatment may argue that the decisions violate laws against homicide, pose a threat to the lives of other less sever...

journal_title：Neurologic clinics

authors： Beresford HR

更新日期：1989-11-01 00:00:00

abstract：:Selecting appropriate laboratory tests in diagnosing peripheral neuropathies is important because it increases the yield of correct diagnoses and is cost effective. A large number of tests are available. This article provides a guide to selecting appropriate tests and reviews the clinical situations that suggest speci...

journal_title：Neurologic clinics

authors： Griffin JW,Hsieh ST,McArthur JC,Cornblath DR

更新日期：1996-02-01 00:00:00

abstract：:The fourth edition of The Diagnostic and Statistical Manual of Mental Disorders defines delirium as "a reversible state of confusion with a reduced level of consciousness manifest as an inability to focus, sustain or shift attention." Pharmacologic agents are important contributors to delirium in hospitalized elderly ...

journal_title：Neurologic clinics

authors： Hanson MR,Gálvez-Jiménez N

更新日期：2004-05-01 00:00:00

abstract：:Neoplastic meningitis appears to be increasing in frequency with improvements in the treatment of many cancers. It is most often recognized in patients with leukemia, breast cancer, lymphomas, and small-cell cancer of the lung, although it may be seen with virtually any malignancy. Treatment should include intrathecal...

journal_title：Neurologic clinics

authors： Grossman SA,Moynihan TJ

更新日期：1991-11-01 00:00:00

abstract：:The respiratory system and the central nervous system are interconnected in a delicate balance; disorders in this equilibrium can have devastating consequences. Respiratory dysfunction, whether acute or chronic, may cause neurologic disease, including headache, encephalopathy, and in extreme cases, coma and death. Thi...

journal_title：Neurologic clinics

authors： Kirsch DB,Józefowicz RF

更新日期：2002-02-01 00:00:00

abstract：:There is no single definition of pharmacoresistant (intractable, refractory) epilepsy. Prospective identification of pharmacoresistance is complicated by the variability of its appearance across different types of epilepsy and the variability of seizure control within a given patient over time. Failure of informative ...

journal_title：Neurologic clinics

authors： Berg AT

更新日期：2009-11-01 00:00:00

abstract：:The diagnostic approach to the patient with cancer with suspected CNS infection depends on an analysis of the patient's immune defect, the time course of development of manifestations of infection, and the type of clinical syndrome with supportive evidence for a specific diagnosis coming from laboratory and neuroradio...

journal_title：Neurologic clinics

authors： Pruitt AA

更新日期：2003-02-01 00:00:00