abstract：:Group 3 innate lymphoid cells (ILC3s), a subset of the innate lymphoid cells, are abundantly present in the intestine and are crucial regulators of intestinal inflammation. Brg1 (Brahma-related gene 1), a catalytic subunit of the mammalian SWI-SNF-like chromatin-remodeling BAF complex, regulates the development and fu...

journal_title：Mucosal immunology

authors： Qi X,Qiu J,Chang J,Ji Y,Yang Q,Cui G,Sun L,Chai Q,Qin J,Qiu J

更新日期：2021-01-01 00:00:00

abstract：:FoxP3+ regulatory T cells (Tregs) control inflammation and maintain mucosal homeostasis, but their functions during infection are poorly understood. Th1, Th2, and Th17 cells can be identified by master transcription factors (TFs) T-bet, GATA3, and RORγT; Tregs also express these TFs. While T-bet+ Tregs can selectively...

journal_title：Mucosal immunology

authors： Clay SL,Bravo-Blas A,Wall DM,MacLeod MKL,Milling SWF

更新日期：2020-11-01 00:00:00

abstract：:Eosinophils are granulocytes, typically implicated as end-stage effector cells in type-II immune responses. They are capable of producing a wide array of pre-formed molecules which render them with vast potential to influence a wide variety of processes. Nonetheless, eosinophil research has traditionally focused on th...

journal_title：Mucosal immunology

authors： Shah K,Ignacio A,McCoy KD,Harris NL

更新日期：2020-07-01 00:00:00

abstract：:Intestinal fibrosis leading to strictures remains a significant clinical problem in inflammatory bowel diseases (IBD). The role of bacterial components in activating intestinal mesenchymal cells and driving fibrogenesis is largely unexplored. Tamoxifen-inducible α-SMA promoter Cre mice crossed with floxed MyD88 mice w...

journal_title：Mucosal immunology

authors： Zhao S,Dejanovic D,Yao P,Bhilocha S,Sadler T,Schirbel A,West G,Doyon G,Lopez R,Mao R,Kurada S,El Ouali S,Grassl G,Fox PL,Cruise M,Worthley DL,de la Motte C,Fiocchi C,Rieder F

更新日期：2020-07-01 00:00:00

abstract：:Chronic obstructive pulmonary disease (COPD) is a highly prevalent respiratory disease characterized by airflow limitation and chronic inflammation. MiR-155 is described as an ancient regulator of the immune system. Our objective was to establish a role for miR-155 in cigarette smoke (CS)-induced inflammation and COPD...

journal_title：Mucosal immunology

authors： De Smet EG,Van Eeckhoutte HP,Avila Cobos F,Blomme E,Verhamme FM,Provoost S,Verleden SE,Venken K,Maes T,Joos GF,Mestdagh P,Brusselle GG,Bracke KR

更新日期：2020-05-01 00:00:00

abstract：:Insufficient T-cell responses contribute to the increased burden of viral respiratory disease in infancy. Neonatal dendritic cells (DCs) often provide defective activation of pathogen-specific T cells through mechanisms that are incompletely understood, which hinders vaccine design for this vulnerable age group. Enhan...

journal_title：Mucosal immunology

authors： Lau-Kilby AW,Turfkruyer M,Kehl M,Yang L,Buchholz UJ,Hickey K,Malloy AMW

更新日期：2020-03-01 00:00:00

abstract：:Acute intestinal inflammation includes the early accumulation of neutrophils (PMN). Based on recent evidence that PMN infiltration "imprints" changes in the local tissue environment through local oxygen depletion and the release of adenine nucleotides, we hypothesized that the interaction between transmigrating PMN an...

journal_title：Mucosal immunology

authors： Cartwright IM,Curtis VF,Lanis JM,Alexeev EE,Welch N,Goldberg MS,Schaefer REM,Gao RY,Chun C,Fennimore B,Onyiah JC,Gerich ME,Dempsey PJ,Colgan SP

更新日期：2020-03-01 00:00:00

abstract：:Bacille Calmette-Guérin (BCG) is the only licenced tuberculosis (TB) vaccine, but has limited efficacy against pulmonary TB disease development and modest protection against extrapulmonary TB. Preventative antibiotic treatment for Mycobacterium tuberculosis (Mtb) infections in high-prevalence settings is unfeasible du...

journal_title：Mucosal immunology

authors： Young C,Walzl G,Du Plessis N

更新日期：2020-03-01 00:00:00

abstract：:Natural intraepithelial lymphocytes (IELs) are thymus-derived adaptive immune cells, which are important contributors to intestinal immune homeostasis. Similar to other innate-like T cells, they are induced in the thymus through high-avidity interaction that would otherwise lead to clonal deletion in conventional CD4 ...

journal_title：Mucosal immunology

authors： Hummel JF,Zeis P,Ebert K,Fixemer J,Konrad P,Schachtrup C,Arnold SJ,Grün D,Tanriver Y

更新日期：2020-03-01 00:00:00

abstract：:Lung resident memory CD8 T cells (TRM) are critical for protection against respiratory viruses, but the cellular interactions required for their development are poorly understood. Herein we describe the necessity of classical monocytes for the establishment of lung TRM following influenza infection. We find that, duri...

journal_title：Mucosal immunology

authors： Dunbar PR,Cartwright EK,Wein AN,Tsukamoto T,Tiger Li ZR,Kumar N,Uddbäck IE,Hayward SL,Ueha S,Takamura S,Kohlmeier JE

更新日期：2020-01-01 00:00:00

abstract：:The generation of tissue-resident memory T cells (TRM) is an essential aspect of immunity at mucosal surfaces, and it has been suggested that preferential generation of TRM is one of the principal advantages of mucosally administered vaccines. We have previously shown that antigen-specific, IL-17-producing CD4+ T cell...

journal_title：Mucosal immunology

authors： O'Hara JM,Redhu NS,Cheung E,Robertson NG,Patik I,Sayed SE,Thompson CM,Herd M,Lucas KB,Conaway E,Morton CC,Farber DL,Malley R,Horwitz BH

更新日期：2020-01-01 00:00:00

abstract：:The seasonal burden of influenza coupled with the pandemic outbreaks of more pathogenic strains underscore a critical need to understand the pathophysiology of influenza injury in the lung. Interleukin-22 (IL-22) is a promising cytokine that is critical in protecting the lung during infection. This cytokine is strongl...

journal_title：Mucosal immunology

authors： Hebert KD,Mclaughlin N,Galeas-Pena M,Zhang Z,Eddens T,Govero A,Pilewski JM,Kolls JK,Pociask DA

更新日期：2020-01-01 00:00:00

abstract：:Children born by cesarean section (CS) have an increased risk of developing inflammatory bowel disease (IBD), possibly due to skewed microbial colonization during birth and consequently impaired bacterial stimulation of the developing immune system. The aim of this study was to investigate the association between CS a...

journal_title：Mucosal immunology

authors： Zachariassen LF,Hansen AK,Krych L,Nielsen DS,Holm TL,Tougaard P,Hansen CHF

更新日期：2019-11-01 00:00:00

abstract：:Alpha B-crystallin (CRYAB) is an important member of the small heat shock protein family, and plays a protective and therapeutic role in neurological inflammation. CRYAB expression was assessed in cultured HT29 and Caco-2 cells and inflamed mucosa of patients with inflammatory bowel disease (IBD) and colitis models in...

journal_title：Mucosal immunology

authors： Xu W,Guo Y,Huang Z,Zhao H,Zhou M,Huang Y,Wen D,Song J,Zhu Z,Sun M,Liu CY,Chen Y,Cui L,Wang X,Liu Z,Yang Y,Du P

更新日期：2019-11-01 00:00:00

abstract：:Neutrophils are implicated in the pathogenesis of tuberculosis (TB), a disease caused by Mycobacterium tuberculosis infection, but the mechanisms by which they promote disease are not fully understood. Neutrophils can express cytokines that influence TB progression, and so we compared neutrophil and T-cell expression ...

journal_title：Mucosal immunology

authors： Gideon HP,Phuah J,Junecko BA,Mattila JT

更新日期：2019-11-01 00:00:00

abstract：:Respiratory syncytial virus (RSV) is a leading cause of severe lower respiratory tract infections, especially in infants. Lung neutrophilia is a hallmark of RSV disease but the mechanism by which neutrophils are recruited and activated is unclear. Here, we investigate the innate immune signaling pathways underlying ne...

journal_title：Mucosal immunology

authors： Kirsebom FCM,Kausar F,Nuriev R,Makris S,Johansson C

更新日期：2019-09-01 00:00:00

abstract：:There continues to be a major need for more effective inflammatory bowel disease (IBD) therapies. IL-13Rα2 is a decoy receptor that binds the cytokine IL-13 with high affinity and diminishes its STAT6-mediated effector functions. Previously, we found that IL-13Rα2 was necessary for IBD in mice deficient in the anti-in...

journal_title：Mucosal immunology

authors： Karmele EP,Pasricha TS,Ramalingam TR,Thompson RW,Gieseck RL 3rd,Knilans KJ,Hegen M,Farmer M,Jin F,Kleinman A,Hinds DA,23andMe Research Team.,Almeida Pereira T,de Queiroz Prado R,Bing N,Tchistiakova L,Kasaian MT,Wynn TA

更新日期：2019-09-01 00:00:00

abstract：:Secondary bacterial pneumonia is a significant complication of severe influenza infection and Staphylococcus aureus and Streptococcus pneumoniae are the primary pathogens of interest. IL-22 promotes S. aureus and S. pneumoniae host defense in the lung through epithelial integrity and induction of antimicrobial peptide...

journal_title：Mucosal immunology

authors： Abood RN,McHugh KJ,Rich HE,Ortiz MA,Tobin JM,Ramanan K,Robinson KM,Bomberger JM,Kolls JK,Manni ML,Pociask DA,Alcorn JF

更新日期：2019-09-01 00:00:00

abstract：:Leukotriene B4 receptor 1 (BLT1) triggers the migration of granulocytes and activated T cells; however, its role in B-cell function remains unclear. Here we report that BLT1 is required to induce the production of antigen-specific IgA against oral vaccine through mediating innate immune signals from commensal bacteria...

journal_title：Mucosal immunology

authors： Nagatake T,Hirata SI,Koga T,Kuroda E,Kobari S,Suzuki H,Hosomi K,Matsumoto N,Yanrismet Y,Shimojou M,Morimoto S,Sasaki F,Ishii KJ,Yokomizo T,Kunisawa J

更新日期：2019-09-01 00:00:00

abstract：:Mesenteric lymph nodes (MLNs), that drain the large and small intestine, are critical sites for the induction of oral tolerance. Although depletion of CD4 T cells in the intestinal lamina propria is a hallmark of HIV infection, CD4 T cell dynamics in MLNs is less known due to the lack of accessibility to these LNs. We...

journal_title：Mucosal immunology

authors： Moukambi F,Rabezanahary H,Fortier Y,Rodrigues V,Clain J,Benmadid-Laktout G,Zghidi-Abouzid O,Soundaramourty C,Laforge M,Estaquier J

更新日期：2019-07-01 00:00:00

abstract：:Cholera is a severe diarrheal disease caused by the bacterium Vibrio cholerae (V. cholerae) that results in 3-4 million cases globally with 100,000-150,000 deaths reported annually. Mostly confined to developing nations, current strategies to control the spread of cholera include the provision of safe drinking water a...

journal_title：Mucosal immunology

authors： Davitt CJH,Longet S,Albutti A,Aversa V,Nordqvist S,Hackett B,McEntee CP,Rosa M,Coulter IS,Lebens M,Tobias J,Holmgren J,Lavelle EC

更新日期：2019-07-01 00:00:00

abstract：:Mycobacterium tuberculosis (M.tb) is deposited into the alveolus where it first encounters the alveolar lining fluid (ALF) prior contacts host cells. We demonstrated that M.tb-exposure to human ALF alters its cell surface, driving better M.tb infection control by professional phagocytes. Contrary to these findings, ou...

journal_title：Mucosal immunology

authors： Scordo JM,Olmo-Fontánez AM,Kelley HV,Sidiki S,Arcos J,Akhter A,Wewers MD,Torrelles JB

更新日期：2019-05-01 00:00:00

abstract：:Newborns are highly susceptible to pathogenic infections with significant worldwide morbidity possibly due to an immature immune system. Recently, we reported that Propionibacterium strain, P. UF1, isolated from the gut microbiota of preterm infants, induced the differentiation of bacteria-specific Th17 cells. Here, w...

journal_title：Mucosal immunology

authors： Ge Y,Gong M,Colliou N,Zadeh M,Li J,Jones DP,Li S,Mohamadzadeh M

更新日期：2019-03-01 00:00:00

abstract：:Neutrophils clear viruses, but excessive neutrophil responses induce tissue injury and worsen disease. Aging increases mortality to influenza infection; however, whether this is due to impaired viral clearance or a pathological host immune response is unknown. Here we show that aged mice have higher levels of lung neu...

journal_title：Mucosal immunology

authors： Kulkarni U,Zemans RL,Smith CA,Wood SC,Deng JC,Goldstein DR

更新日期：2019-03-01 00:00:00

abstract：:The γ-amino butyric acid (GABA)ergic system shapes the activation and function of immune cells. The present study was conducted to explore the regulation of GABA transporter (GAT)-2 on the differentiation of Th17 cells. Here we found that Th17 cells show higher abundance of GAT-2, and have distinct cellular metabolic ...

journal_title：Mucosal immunology

authors： Ren W,Liao Y,Ding X,Jiang Y,Yan J,Xia Y,Tan B,Lin Z,Duan J,Jia X,Yang G,Deng J,Zhu C,Hardwidge PR,Li J,Zhu G,Yin Y

更新日期：2019-03-01 00:00:00

abstract：:Post influenza bacterial pneumonia is associated with significant mortality and morbidity. Dendritic cells (DCs) play a crucial role in host defense against bacterial pneumonia, but their contribution to post influenza-susceptibility to secondary bacterial pneumonia is incompletely understood. WT and CCR2-/- mice were...

journal_title：Mucosal immunology

authors： Gurczynski SJ,Nathani N,Warheit-Niemi HI,Hult EM,Podsiad A,Deng J,Zemans RL,Bhan U,Moore BB

更新日期：2019-03-01 00:00:00

abstract：:Malaria-associated acute respiratory distress syndrome (MA-ARDS) and acute lung injury (ALI) are complications that cause lung damage and often leads to death. The MA-ARDS/ALI is associated with a Type 1 inflammatory response mediated by T lymphocytes and IFN-γ. Here, we used the Plasmodium berghei NK65 (PbN)-induced ...

journal_title：Mucosal immunology

authors： Galvão-Filho B,de Castro JT,Figueiredo MM,Rosmaninho CG,Antonelli LRDV,Gazzinelli RT

更新日期：2019-03-01 00:00:00

abstract：:Microbial metabolites are an emerging class of mediators influencing CD4+ T-cell function. To advance the understanding of direct causal microbial factors contributing to Crohn's disease, we screened 139 predicted Crohn's disease-associated microbial metabolites for their bioactivity on human CD4+ T-cell functions ind...

journal_title：Mucosal immunology

authors： Chang YL,Rossetti M,Vlamakis H,Casero D,Sunga G,Harre N,Miller S,Humphries R,Stappenbeck T,Simpson KW,Sartor RB,Wu G,Lewis J,Bushman F,McGovern DPB,Salzman N,Borneman J,Xavier R,Huttenhower C,Braun J

更新日期：2019-03-01 00:00:00

abstract：:The communities of bacteria that reside in the intestinal tract are in constant competition within this dynamic and densely colonized environment. At homeostasis, the equilibrium that exists between these species and strains is shaped by their metabolism and also by pathways of active antagonism, which drive competiti...

journal_title：Mucosal immunology

authors： Sorbara MT,Pamer EG

更新日期：2019-01-01 00:00:00

abstract：:Sphingolipids play a pivotal role in the pathogenesis of chronic obstructive pulmonary disease (COPD). However, little is known about the precise roles of sphingosine-1-phosphate (S1P), a bioactive sphingolipid metabolite, and its receptor modulation in COPD. In this study, we demonstrated that the S1P receptor modula...

journal_title：Mucosal immunology

authors： Asakura T,Ishii M,Namkoong H,Suzuki S,Kagawa S,Yagi K,Komiya T,Hashimoto T,Okamori S,Kamata H,Tasaka S,Kihara A,Hegab AE,Hasegawa N,Betsuyaku T

更新日期：2018-11-01 00:00:00

abstract：:Human type-2 CD8+ T cells are a cell population with potentially important roles in allergic disease. We investigated this in the context of severe asthma with persistent airway eosinophilia-a phenotype associated with high exacerbation risk and responsiveness to type-2 cytokine-targeted therapies. In two independent ...

journal_title：Mucosal immunology

authors： Hilvering B,Hinks TSC,Stöger L,Marchi E,Salimi M,Shrimanker R,Liu W,Chen W,Luo J,Go S,Powell T,Cane J,Thulborn S,Kurioka A,Leng T,Matthews J,Connolly C,Borg C,Bafadhel M,Willberg CB,Ramasamy A,Djukanović R,Ogg

更新日期：2018-09-01 00:00:00

abstract：:Intestinal epithelial Na+/H+ exchange facilitated by the apical NHE3 (Slc9a3) is a highly regulated process inhibited by intestinal pathogens and in inflammatory bowel diseases. NHE3-/- mice develop spontaneous, bacterially mediated colitis, and IBD-like dysbiosis. Disruption of epithelial Na+/H+ exchange in IBD may t...

journal_title：Mucosal immunology

authors： Harrison CA,Laubitz D,Ohland CL,Midura-Kiela MT,Patil K,Besselsen DG,Jamwal DR,Jobin C,Ghishan FK,Kiela PR

更新日期：2018-09-01 00:00:00

abstract：:Sonic hedgehog (SHH) is abundantly expressed and critical for morphogenesis in embryonic lungs; however, SHH expression drops to a much lower level in mice from E17.5 and in humans from the 21st gestational week. We find that SHH expression is robustly upregulated in the airway epithelia of children with asthma or mou...

journal_title：Mucosal immunology

authors： Xu C,Zou C,Hussain M,Shi W,Shao Y,Jiang Z,Wu X,Lu M,Wu J,Xie Q,Ke Y,Long F,Tang L,Wu X

更新日期：2018-09-01 00:00:00

abstract：:Epigallocatechin-3-gallate (EGCG), a natural and major ingredient of green tea, has been shown to have anti-inflammation and anti-HIV-1 properties. We demonstrated that the intrarectal administration of EGCG could protect rhesus macaques from repetitive, intrarectal challenges with low-dose SHIVSF162P3N. This protecti...

journal_title：Mucosal immunology

authors： Liu JB,Li JL,Zhuang K,Liu H,Wang X,Xiao QH,Li XD,Zhou RH,Zhou L,Ma TC,Zhou W,Liu MQ,Ho WZ

更新日期：2018-07-01 00:00:00

abstract：:IFN-γ is known as a pro-inflammatory cytokine, but can also block inflammation in certain chronic diseases although the underlying mechanisms are poorly understood. We found that IFN-γ rapidly induced Noxa expression and that extent of inflammation by repeated house dust mite exposure was enhanced in noxa-/- compared ...

journal_title：Mucosal immunology

authors： Zhang C,Jones JT,Chand HS,Wathelet MG,Evans CM,Dickey B,Xiang J,Mebratu YA,Tesfaigzi Y

更新日期：2018-05-01 00:00:00

abstract：:Dectin-1 (gene symbol: Clec7a) is a receptor for β-glucans that play an important role for the host defense against fungi. Recently, we showed that Clec7a-/- mice are resistant against dextran sodium sulfate (DSS)-induced colitis because of regulatory T-cell population expansion in the colon. The regulatory T-cell exp...

journal_title：Mucosal immunology

authors： Kamiya T,Tang C,Kadoki M,Oshima K,Hattori M,Saijo S,Adachi Y,Ohno N,Iwakura Y

更新日期：2018-05-01 00:00:00

abstract：:Crohn's disease (CD) is often accompanied by the complications of intestinal strictures and fistulas. These complications remain obstacles in CD treatment. In recent years, the importance of epithelial-mesenchymal transition in the pathogenesis of CD-associated fistulas and intestinal fibrosis has become apparent. Epi...

journal_title：Mucosal immunology

authors： Jiang H,Shen J,Ran Z

更新日期：2018-03-01 00:00:00

abstract：:Although an enrichment of orally derived bacteria is reported in the gut microbiota of patients with several diseases, it is mostly unknown whether oral bacteria can colonize and induce intestinal inflammation. In a recent paper in Science, Atarashi et al.1 from Kenya Honda's laboratory show that a subset of orally de...

journal_title：Mucosal immunology

authors： Lira-Junior R,Boström EA

更新日期：2018-03-01 00:00:00

abstract：:This corrects the article DOI: 10.1038/mi.2017.66. ...

journal_title：Mucosal immunology

authors： Bücker R,Krug SM,Moos V,Bojarski C,Schweiger MR,Kerick M,Fromm A,Janßen S,Fromm M,Hering NA,Siegmund B,Schneider T,Barmeyer C,Schulzke JD

更新日期：2018-03-01 00:00:00

abstract：:This corrects the article DOI: 10.1038/mi.2017.46. ...

journal_title：Mucosal immunology

authors： Kinnear E,Lambert L,McDonald JU,Cheeseman HM,Caproni LJ,Tregoning JS

更新日期：2018-01-01 00:00:00