Abstract：
:Lung resident memory CD8 T cells (TRM) are critical for protection against respiratory viruses, but the cellular interactions required for their development are poorly understood. Herein we describe the necessity of classical monocytes for the establishment of lung TRM following influenza infection. We find that, during the initial appearance of lung TRM, monocytes and dendritic cells are the most numerous influenza antigen-bearing APCs in the lung. Surprisingly, depletion of DCs after initial T cell priming did not impact lung TRM development or maintenance. In contrast, a monocyte deficient pulmonary environment in CCR2-/- mice results in significantly less lung TRM following influenza infection, despite no defect in the antiviral effector response or in the peripheral memory pool. Imaging shows direct interaction of antigen-specific T cells with antigen-bearing monocytes in the lung, and pulmonary classical monocytes from the lungs of influenza infected mice are sufficient to drive differentiation of T cells in vitro. These data describe a novel role for pulmonary monocytes in mediating lung TRM development through direct interaction with T cells in the lung.
journal_name
Mucosal Immunoljournal_title
Mucosal immunologyauthors
Dunbar PR,Cartwright EK,Wein AN,Tsukamoto T,Tiger Li ZR,Kumar N,Uddbäck IE,Hayward SL,Ueha S,Takamura S,Kohlmeier JEdoi
10.1038/s41385-019-0224-7subject
Has Abstractpub_date
2020-01-01 00:00:00pages
161-171issue
1eissn
1933-0219issn
1935-3456pii
10.1038/s41385-019-0224-7journal_volume
13pub_type
杂志文章abstract：:Malaria-associated acute respiratory distress syndrome (MA-ARDS) and acute lung injury (ALI) are complications that cause lung damage and often leads to death. The MA-ARDS/ALI is associated with a Type 1 inflammatory response mediated by T lymphocytes and IFN-γ. Here, we used the Plasmodium berghei NK65 (PbN)-induced ...
journal_title：Mucosal immunology
pub_type： 杂志文章
doi：10.1038/s41385-018-0093-5
更新日期：2019-03-01 00:00:00
abstract：:Post influenza bacterial pneumonia is associated with significant mortality and morbidity. Dendritic cells (DCs) play a crucial role in host defense against bacterial pneumonia, but their contribution to post influenza-susceptibility to secondary bacterial pneumonia is incompletely understood. WT and CCR2-/- mice were...
journal_title：Mucosal immunology
pub_type： 杂志文章
doi：10.1038/s41385-018-0106-4
更新日期：2019-03-01 00:00:00
abstract：:Celiac disease (CD) is a chronic small intestinal inflammation precipitated by gluten ingestion. According to case reports, interferon (IFN)-α administration may induce development of overt CD. Plasmacytoid dendritic cells (PDCs) were thought to be the source of IFN-α and promote a T helper type 1 response leading to ...
journal_title：Mucosal immunology
pub_type： 杂志文章
doi：10.1038/mi.2012.136
更新日期：2013-09-01 00:00:00
abstract：:Epidemiological data indicate a link between rheumatoid arthritis (RA) and periodontal disease (PD). In vitro and in vivo studies have sought to dissect potential mechanisms by which PD may contribute to initiation and progression of RA. However, these are both multifactorial, chronic diseases, and their complex etiol...
journal_title：Mucosal immunology
pub_type： 杂志文章,评审
doi：10.1038/mi.2011.66
更新日期：2012-03-01 00:00:00
abstract：:Classical Whipple's disease (CWD) affects the gastrointestinal tract and rather elicits regulatory than inflammatory immune reactions. Mechanisms of malabsorption, diarrhea, and systemic immune activation are unknown. We here analyzed mucosal architecture, barrier function, and immune activation as potential diarrheal...
journal_title：Mucosal immunology
pub_type： 杂志文章
doi：10.1038/mi.2017.6
更新日期：2017-11-01 00:00:00
abstract：:The interleukin-23 (IL-23) pathway has emerged as a promising therapeutic target for inflammatory bowel disease. Although the pathogenic role of IL-23 receptor (IL-23R) on T lymphocytes is well established, its function on innate immune cells has not been thoroughly examined. Here we investigate the consequence of IL-...
journal_title：Mucosal immunology
pub_type： 杂志文章
doi：10.1038/mi.2011.54
更新日期：2012-01-01 00:00:00
abstract：:Chlamydia trachomatis (Ct) is an obligate intracellular bacterial pathogen. Previously, we showed that infection of human trophoblast cells by Ct triggers the secretion of the pro-inflammatory cytokine, interleukin (IL)-1β. The aim of this study was to understand the innate immune pathways involved in trophoblast prod...
journal_title：Mucosal immunology
pub_type： 杂志文章
doi：10.1038/mi.2012.63
更新日期：2013-03-01 00:00:00
abstract：:Intestinal epithelial Na+/H+ exchange facilitated by the apical NHE3 (Slc9a3) is a highly regulated process inhibited by intestinal pathogens and in inflammatory bowel diseases. NHE3-/- mice develop spontaneous, bacterially mediated colitis, and IBD-like dysbiosis. Disruption of epithelial Na+/H+ exchange in IBD may t...
journal_title：Mucosal immunology
pub_type： 杂志文章
doi：10.1038/s41385-018-0035-2
更新日期：2018-09-01 00:00:00
abstract：:Over the past 25 years, studies led in humans have considerably improved our understanding of celiac disease, a complex disease that is generally defined as an autoimmune-like enteropathy induced by dietary gluten in genetically predisposed individuals. Recently, large efforts were also invested in the development of ...
journal_title：Mucosal immunology
pub_type： 杂志文章,评审
doi：10.1038/mi.2014.102
更新日期：2015-01-01 00:00:00
abstract：:Mycobacterium tuberculosis (M.tb) is deposited into the alveolus where it first encounters the alveolar lining fluid (ALF) prior contacts host cells. We demonstrated that M.tb-exposure to human ALF alters its cell surface, driving better M.tb infection control by professional phagocytes. Contrary to these findings, ou...
journal_title：Mucosal immunology
pub_type： 杂志文章
doi：10.1038/s41385-019-0156-2
更新日期：2019-05-01 00:00:00
abstract：:The Gram-positive bacterium Streptococcus pneumoniae causes life-threatening infections, especially among immunocompromised patients. The host's immune system senses S. pneumoniae via different families of pattern recognition receptors, in particular the Toll-like receptor (TLR) family that promotes immune cell activa...
journal_title：Mucosal immunology
pub_type： 杂志文章
doi：10.1038/mi.2015.128
更新日期：2016-09-01 00:00:00
abstract：:While recent studies suggest that interleukin (IL)-1β production is modulated by macroautophagy or sensors of endoplasmic reticulum (ER) stress upon pro-inflammatory insult, autophagy and IL-1β production during viral infection has not been fully investigated. This was addressed using respiratory syncytial virus (RSV)...
journal_title：Mucosal immunology
pub_type： 杂志文章
doi：10.1038/mi.2015.3
更新日期：2015-09-01 00:00:00
abstract：:The roles of macrophages in type 2-driven inflammation and fibrosis remain unclear. Here, using CD11b-diphtheria toxin receptor (DTR) transgenic mice and three models of interleukin 13 (IL-13)-dependent inflammation, fibrosis, and immunity, we show that CD11b(+) F4/80(+) Ly6C(+) macrophages are required for the mainte...
journal_title：Mucosal immunology
pub_type： 杂志文章
doi：10.1038/mi.2015.34
更新日期：2016-01-01 00:00:00
abstract：:Pneumonia caused by Streptococcus pneumoniae (Sp) remains a leading cause of serious illness and death worldwide. Immunization with conjugated pneumococcal vaccine has lowered the colonization rate and consequently invasive diseases by inducing serotype-specific antibodies. However, many of the current pneumonia cases...
journal_title：Mucosal immunology
pub_type： 杂志文章
doi：10.1038/mi.2016.41
更新日期：2017-01-01 00:00:00
abstract：:Intestinal macrophages (mφ) form one of the largest populations of mφ in the body and are vital for the maintenance of gut homeostasis. They have several unique properties and are derived from local differentiation of classical Ly6Chi monocytes, but the factors driving this tissue-specific process are not understood. ...
journal_title：Mucosal immunology
pub_type： 杂志文章
doi：10.1038/mi.2016.142
更新日期：2017-11-01 00:00:00
abstract：:Neutrophils clear viruses, but excessive neutrophil responses induce tissue injury and worsen disease. Aging increases mortality to influenza infection; however, whether this is due to impaired viral clearance or a pathological host immune response is unknown. Here we show that aged mice have higher levels of lung neu...
journal_title：Mucosal immunology
pub_type： 杂志文章
doi：10.1038/s41385-018-0115-3
更新日期：2019-03-01 00:00:00
abstract：:Leptin is an adipocytokine that links nutrition to immunity. Previous observation that a genetic polymorphism in the leptin receptor affected susceptibility to Entamoeba histolytica infection led to the hypothesis that leptin signaling has a protective role during intestinal amebic infection. In this study we show tha...
journal_title：Mucosal immunology
pub_type： 杂志文章
doi：10.1038/mi.2010.76
更新日期：2011-05-01 00:00:00
abstract：:Allergic diseases, which have reached epidemic proportions, are caused by inappropriate immune responses to a relatively small number of environmental proteins. The molecular basis for the propensity of specific proteins to promote maladaptive, allergic responses has been difficult to define. Recent data suggest that ...
journal_title：Mucosal immunology
pub_type： 杂志文章,评审
doi：10.1038/mi.2009.138
更新日期：2010-03-01 00:00:00
abstract：:Whereas gut IgA responses to the microbiota may be multi-centered and diverse, little is known about IgA responses to T-cell-dependent antigens following oral immunizations. Using a novel approach, gut IgA responses to oral hapten (4-hydroxy-3-nitrophenyl)acetyl-cholera toxin (NP-CT) conjugates were followed at the ce...
journal_title：Mucosal immunology
pub_type： 杂志文章
doi：10.1038/mi.2012.56
更新日期：2013-01-01 00:00:00
abstract：:The generation of tissue-resident memory T cells (TRM) is an essential aspect of immunity at mucosal surfaces, and it has been suggested that preferential generation of TRM is one of the principal advantages of mucosally administered vaccines. We have previously shown that antigen-specific, IL-17-producing CD4+ T cell...
journal_title：Mucosal immunology
pub_type： 杂志文章
doi：10.1038/s41385-019-0218-5
更新日期：2020-01-01 00:00:00
abstract：:Oral tolerance refers to the observation that prior feeding of an antigen induces local and systemic immune tolerance to that antigen. Physiologically, this process is probably of central importance for preventing inflammatory responses to the numerous dietary and microbial antigens present in the gut. Defective oral ...
journal_title：Mucosal immunology
pub_type： 杂志文章,评审
doi：10.1038/mi.2010.25
更新日期：2010-07-01 00:00:00
abstract：:Bacterial-induced intestinal inflammation is crucially dependent on interleukin (IL)-23 and is associated with CD4(+) T helper type 1 (Th1) and Th17 responses. However, the relative contributions of these subsets during the induction and resolution of colitis in T-cell-sufficient hosts remain unknown. We report that H...
journal_title：Mucosal immunology
pub_type： 杂志文章
doi：10.1038/mi.2013.11
更新日期：2013-11-01 00:00:00
abstract：:Proper colonic injury response requires myeloid-derived cells and Toll-like receptor/Myd88 signaling. However, the precise role of Myd88 signaling specifically in myeloid-derived cells that occurs during tissue damage is unclear. Therefore, we created a mouse line with Myd88 expression restricted to myeloid lineages (...
journal_title：Mucosal immunology
pub_type： 杂志文章
doi：10.1038/mi.2011.65
更新日期：2012-03-01 00:00:00
abstract：:AIDS is mainly a sexually transmitted disease, and accordingly, mucosal tissues are the primary sites of natural human immunodeficiency virus type-1 (HIV-1) transmission. Mucosal immunoglobulin A (IgA) antibody specific for HIV-1 envelope gp41 subunit is one correlate of protection in individuals who are highly sexual...
journal_title：Mucosal immunology
pub_type： 杂志文章
doi：10.1038/mi.2009.89
更新日期：2009-09-01 00:00:00
abstract：:Periostin is an extracellular matrix protein that has been primarily studied in the context of the heart, where it has been shown to promote cardiac repair and remodeling. In this study, we focused on the role of periostin in an allergic eosinophilic inflammatory disease (eosinophilic esophagitis (EE)) known to involv...
journal_title：Mucosal immunology
pub_type： 杂志文章
doi：10.1038/mi.2008.15
更新日期：2008-07-01 00:00:00
abstract：:Cholera is a severe diarrheal disease caused by the bacterium Vibrio cholerae (V. cholerae) that results in 3-4 million cases globally with 100,000-150,000 deaths reported annually. Mostly confined to developing nations, current strategies to control the spread of cholera include the provision of safe drinking water a...
journal_title：Mucosal immunology
pub_type： 杂志文章
doi：10.1038/s41385-019-0159-z
更新日期：2019-07-01 00:00:00
abstract：:IFN-γ is known as a pro-inflammatory cytokine, but can also block inflammation in certain chronic diseases although the underlying mechanisms are poorly understood. We found that IFN-γ rapidly induced Noxa expression and that extent of inflammation by repeated house dust mite exposure was enhanced in noxa-/- compared ...
journal_title：Mucosal immunology
pub_type： 杂志文章
doi：10.1038/mi.2017.117
更新日期：2018-05-01 00:00:00
abstract：:Chronic beryllium disease (CBD) is a granulomatous lung disorder that is associated with the accumulation of beryllium (Be)-specific CD4(+) T cells into the lung. Genetic susceptibility is linked to HLA-DPB1 alleles that possess a glutamic acid at position 69 (βGlu69), and HLA-DPB1*02:01 is the most prevalent βGlu69-c...
journal_title：Mucosal immunology
pub_type： 杂志文章
doi：10.1038/mi.2015.54
更新日期：2016-01-01 00:00:00
abstract：:Colonization of the nasopharyngeal mucosa by meningococcus and other polysaccharide (PS)-encapsulated bacteria precedes invasion. PS-conjugate vaccines induce PS-specific B-cell memory (B(MEM)) and also prevent colonization, thus blocking person-to-person transmission, generating herd protection. However, in isolation...
journal_title：Mucosal immunology
pub_type： 杂志文章
doi：10.1038/mi.2012.70
更新日期：2013-03-01 00:00:00
abstract：:Individuals with one atopic disease are far more likely to develop a second. Approximately half of all atopic dermatitis (AD) patients subsequently develop asthma, particularly those with severe AD. This association, suggesting a role for AD as an entry point for subsequent allergic disease, is a phenomenon known as t...
journal_title：Mucosal immunology
pub_type： 杂志文章
doi：10.1038/mi.2012.14
更新日期：2012-05-01 00:00:00
