High expression of Sonic hedgehog in allergic airway epithelia contributes to goblet cell metaplasia.

abstract：:Specific components of the intestinal microbiota are capable of influencing immune responses such that a mutualistic relationship is established. In mice, colonization with segmented filamentous bacteria (SFB) induces T-helper-17 (Th17) cell differentiation in the intestine, yet the effector functions of interleukin (...

journal_title：Mucosal immunology

authors： Flannigan KL,Ngo VL,Geem D,Harusato A,Hirota SA,Parkos CA,Lukacs NW,Nusrat A,Gaboriau-Routhiau V,Cerf-Bensussan N,Gewirtz AT,Denning TL

更新日期：2017-05-01 00:00:00

abstract：:Leptin is an adipocytokine that links nutrition to immunity. Previous observation that a genetic polymorphism in the leptin receptor affected susceptibility to Entamoeba histolytica infection led to the hypothesis that leptin signaling has a protective role during intestinal amebic infection. In this study we show tha...

journal_title：Mucosal immunology

authors： Guo X,Roberts MR,Becker SM,Podd B,Zhang Y,Chua SC Jr,Myers MG Jr,Duggal P,Houpt ER,Petri WA Jr

更新日期：2011-05-01 00:00:00

abstract：:De novo differentiation of CD4(+)Foxp3(+) regulatory T cells (induced (i) Tregs) occurs preferentially in the gut-associated lymphoid tissues (GALT). We addressed the contribution of background genetic factors in affecting the balance of iTreg, T helper type 1 (Th1), and Th17 cell differentiation in GALT in vivo follo...

journal_title：Mucosal immunology

authors： Valatas V,He J,Rivollier A,Kolios G,Kitamura K,Kelsall BL

更新日期：2013-05-01 00:00:00

abstract：:Most HIV transmissions among men who have sex with men (MSM), the group that accounted for 67% of new US infections in 2014, occur via exposure to the rectal mucosa. However, it is unclear how the act of condomless receptive anal intercourse (CRAI) may alter the mucosal immune environment in HIV-negative MSM. Here, we...

journal_title：Mucosal immunology

authors： Kelley CF,Kraft CS,de Man TJ,Duphare C,Lee HW,Yang J,Easley KA,Tharp GK,Mulligan MJ,Sullivan PS,Bosinger SE,Amara RR

更新日期：2017-07-01 00:00:00

abstract：:Pneumonia caused by Streptococcus pneumoniae (Sp) remains a leading cause of serious illness and death worldwide. Immunization with conjugated pneumococcal vaccine has lowered the colonization rate and consequently invasive diseases by inducing serotype-specific antibodies. However, many of the current pneumonia cases...

journal_title：Mucosal immunology

authors： Wang Y,Jiang B,Guo Y,Li W,Tian Y,Sonnenberg GF,Weiser JN,Ni X,Shen H

更新日期：2017-01-01 00:00:00

abstract：:Dectin-1 is an innate antifungal C-type lectin receptor necessary for protective antifungal immunity. We recently discovered that Dectin-1 is involved in controlling fungal infections of the gastrointestinal (GI) tract, but how this C-type lectin receptor mediates these activities is unknown. Here, we show that Dectin...

journal_title：Mucosal immunology

authors： Drummond RA,Dambuza IM,Vautier S,Taylor JA,Reid DM,Bain CC,Underhill DM,Masopust D,Kaplan DH,Brown GD

更新日期：2016-03-01 00:00:00

abstract：:Although an enrichment of orally derived bacteria is reported in the gut microbiota of patients with several diseases, it is mostly unknown whether oral bacteria can colonize and induce intestinal inflammation. In a recent paper in Science, Atarashi et al.1 from Kenya Honda's laboratory show that a subset of orally de...

journal_title：Mucosal immunology

authors： Lira-Junior R,Boström EA

更新日期：2018-03-01 00:00:00

abstract：:In a nasal vaccine against influenza, the activation of natural killer T (NKT) cells by intranasal coadministration of alpha-galactosylceramide (alpha-GalCer) can potently enhance protective immune responses. The results of this study show that the NKT cell-activated nasal vaccine can induce an effective cross-protect...

journal_title：Mucosal immunology

authors： Kamijuku H,Nagata Y,Jiang X,Ichinohe T,Tashiro T,Mori K,Taniguchi M,Hase K,Ohno H,Shimaoka T,Yonehara S,Odagiri T,Tashiro M,Sata T,Hasegawa H,Seino KI

更新日期：2008-05-01 00:00:00

abstract：:This corrects the article DOI: 10.1038/mi.2017.46. ...

journal_title：Mucosal immunology

authors： Kinnear E,Lambert L,McDonald JU,Cheeseman HM,Caproni LJ,Tregoning JS

更新日期：2018-01-01 00:00:00

abstract：:Levels of reactive free radicals are elevated in the airway during asthmatic exacerbations, but their roles in the pathophysiology of asthma remain unclear. We have identified subsets of myeloid-derived suppressor-like cells as key sources of nitric oxide and superoxide in the lungs of mice with evolving experimental ...

journal_title：Mucosal immunology

authors： Deshane J,Zmijewski JW,Luther R,Gaggar A,Deshane R,Lai JF,Xu X,Spell M,Estell K,Weaver CT,Abraham E,Schwiebert LM,Chaplin DD

更新日期：2011-09-01 00:00:00

abstract：:Over the past 25 years, studies led in humans have considerably improved our understanding of celiac disease, a complex disease that is generally defined as an autoimmune-like enteropathy induced by dietary gluten in genetically predisposed individuals. Recently, large efforts were also invested in the development of ...

journal_title：Mucosal immunology

authors： Korneychuk N,Meresse B,Cerf-Bensussan N

更新日期：2015-01-01 00:00:00

abstract：:The extent to which tissue-specific viral infections generate memory T cells specifically adapted to and maintained within the target infection site is unknown. Here, we show that respiratory virus-specific memory T cells in mice and humans are generated and maintained in compartmentalized niches in lungs, distinct fr...

journal_title：Mucosal immunology

authors： Turner DL,Bickham KL,Thome JJ,Kim CY,D'Ovidio F,Wherry EJ,Farber DL

更新日期：2014-05-01 00:00:00

abstract：:The mammalian gut microbiota is essential for normal intestinal development, renewal, and repair. Injury to the intestinal mucosa can occur with infection, surgical trauma, and in idiopathic inflammatory bowel disease. Repair of mucosal injury, termed restitution, as well as restoration of intestinal homeostasis invol...

journal_title：Mucosal immunology

authors： Alam A,Leoni G,Wentworth CC,Kwal JM,Wu H,Ardita CS,Swanson PA,Lambeth JD,Jones RM,Nusrat A,Neish AS

更新日期：2014-05-01 00:00:00

abstract：:The seasonal burden of influenza coupled with the pandemic outbreaks of more pathogenic strains underscore a critical need to understand the pathophysiology of influenza injury in the lung. Interleukin-22 (IL-22) is a promising cytokine that is critical in protecting the lung during infection. This cytokine is strongl...

journal_title：Mucosal immunology

authors： Hebert KD,Mclaughlin N,Galeas-Pena M,Zhang Z,Eddens T,Govero A,Pilewski JM,Kolls JK,Pociask DA

更新日期：2020-01-01 00:00:00

abstract：:Periostin is an extracellular matrix protein that has been primarily studied in the context of the heart, where it has been shown to promote cardiac repair and remodeling. In this study, we focused on the role of periostin in an allergic eosinophilic inflammatory disease (eosinophilic esophagitis (EE)) known to involv...

journal_title：Mucosal immunology

authors： Blanchard C,Mingler MK,McBride M,Putnam PE,Collins MH,Chang G,Stringer K,Abonia JP,Molkentin JD,Rothenberg ME

更新日期：2008-07-01 00:00:00

abstract：:Allergic diseases, which have reached epidemic proportions, are caused by inappropriate immune responses to a relatively small number of environmental proteins. The molecular basis for the propensity of specific proteins to promote maladaptive, allergic responses has been difficult to define. Recent data suggest that ...

journal_title：Mucosal immunology

authors： Wills-Karp M,Nathan A,Page K,Karp CL

更新日期：2010-03-01 00:00:00

abstract：:Cholera is a severe diarrheal disease caused by the bacterium Vibrio cholerae (V. cholerae) that results in 3-4 million cases globally with 100,000-150,000 deaths reported annually. Mostly confined to developing nations, current strategies to control the spread of cholera include the provision of safe drinking water a...

journal_title：Mucosal immunology

authors： Davitt CJH,Longet S,Albutti A,Aversa V,Nordqvist S,Hackett B,McEntee CP,Rosa M,Coulter IS,Lebens M,Tobias J,Holmgren J,Lavelle EC

更新日期：2019-07-01 00:00:00

abstract：:Chronic beryllium disease (CBD) is a granulomatous lung disorder that is associated with the accumulation of beryllium (Be)-specific CD4(+) T cells into the lung. Genetic susceptibility is linked to HLA-DPB1 alleles that possess a glutamic acid at position 69 (βGlu69), and HLA-DPB1*02:01 is the most prevalent βGlu69-c...

journal_title：Mucosal immunology

authors： Falta MT,Tinega AN,Mack DG,Bowerman NA,Crawford F,Kappler JW,Pinilla C,Fontenot AP

更新日期：2016-01-01 00:00:00

abstract：:Induction of mucosal immunoglobulin-A (IgA) capable of providing a first line of defense against bacterial and viral pathogens remains a major goal of needle-free vaccines given via mucosal routes. Innate immune cells are known to play a central role in induction of IgA responses by mucosal vaccines, but the relative ...

journal_title：Mucosal immunology

authors： Jee J,Bonnegarde-Bernard A,Duverger A,Iwakura Y,Cormet-Boyaka E,Martin TL,Steiner HE,Bachman RC,Boyaka PN

更新日期：2015-07-01 00:00:00

abstract：:Intestinal epithelial Na+/H+ exchange facilitated by the apical NHE3 (Slc9a3) is a highly regulated process inhibited by intestinal pathogens and in inflammatory bowel diseases. NHE3-/- mice develop spontaneous, bacterially mediated colitis, and IBD-like dysbiosis. Disruption of epithelial Na+/H+ exchange in IBD may t...

journal_title：Mucosal immunology

authors： Harrison CA,Laubitz D,Ohland CL,Midura-Kiela MT,Patil K,Besselsen DG,Jamwal DR,Jobin C,Ghishan FK,Kiela PR

更新日期：2018-09-01 00:00:00

abstract：:T helper (Th)1 and Th2 cells play decisive roles in the regulation of resistance vs. susceptibility to pulmonary cryptococcosis. To study the function of interleukin (IL)-4 receptor (IL-4R) on Th cells in pulmonary cryptococcosis, we infected mice specifically lacking IL-4Rα on CD4(+) T cells (Lck(Cre)IL-4Rα(-/lox) mi...

journal_title：Mucosal immunology

authors： Müller U,Piehler D,Stenzel W,Köhler G,Frey O,Held J,Grahnert A,Richter T,Eschke M,Kamradt T,Brombacher F,Alber G

更新日期：2012-05-01 00:00:00

abstract：:Classical Whipple's disease (CWD) affects the gastrointestinal tract and rather elicits regulatory than inflammatory immune reactions. Mechanisms of malabsorption, diarrhea, and systemic immune activation are unknown. We here analyzed mucosal architecture, barrier function, and immune activation as potential diarrheal...

journal_title：Mucosal immunology

authors： Epple HJ,Friebel J,Moos V,Troeger H,Krug SM,Allers K,Schinnerling K,Fromm A,Siegmund B,Fromm M,Schulzke JD,Schneider T

更新日期：2017-11-01 00:00:00

abstract：:Individuals with one atopic disease are far more likely to develop a second. Approximately half of all atopic dermatitis (AD) patients subsequently develop asthma, particularly those with severe AD. This association, suggesting a role for AD as an entry point for subsequent allergic disease, is a phenomenon known as t...

journal_title：Mucosal immunology

authors： Han H,Xu W,Headley MB,Jessup HK,Lee KS,Omori M,Comeau MR,Marshak-Rothstein A,Ziegler SF

更新日期：2012-05-01 00:00:00

abstract：:The roles of macrophages in type 2-driven inflammation and fibrosis remain unclear. Here, using CD11b-diphtheria toxin receptor (DTR) transgenic mice and three models of interleukin 13 (IL-13)-dependent inflammation, fibrosis, and immunity, we show that CD11b(+) F4/80(+) Ly6C(+) macrophages are required for the mainte...

journal_title：Mucosal immunology

authors： Borthwick LA,Barron L,Hart KM,Vannella KM,Thompson RW,Oland S,Cheever A,Sciurba J,Ramalingam TR,Fisher AJ,Wynn TA

更新日期：2016-01-01 00:00:00

abstract：:Malaria-associated acute respiratory distress syndrome (MA-ARDS) and acute lung injury (ALI) are complications that cause lung damage and often leads to death. The MA-ARDS/ALI is associated with a Type 1 inflammatory response mediated by T lymphocytes and IFN-γ. Here, we used the Plasmodium berghei NK65 (PbN)-induced ...

journal_title：Mucosal immunology

authors： Galvão-Filho B,de Castro JT,Figueiredo MM,Rosmaninho CG,Antonelli LRDV,Gazzinelli RT

更新日期：2019-03-01 00:00:00

abstract：:Bacille Calmette-Guérin (BCG) is the only licenced tuberculosis (TB) vaccine, but has limited efficacy against pulmonary TB disease development and modest protection against extrapulmonary TB. Preventative antibiotic treatment for Mycobacterium tuberculosis (Mtb) infections in high-prevalence settings is unfeasible du...

journal_title：Mucosal immunology

authors： Young C,Walzl G,Du Plessis N

更新日期：2020-03-01 00:00:00

abstract：:Crohn's disease (CD) is often accompanied by the complications of intestinal strictures and fistulas. These complications remain obstacles in CD treatment. In recent years, the importance of epithelial-mesenchymal transition in the pathogenesis of CD-associated fistulas and intestinal fibrosis has become apparent. Epi...

journal_title：Mucosal immunology

authors： Jiang H,Shen J,Ran Z

更新日期：2018-03-01 00:00:00

abstract：:Our studies have focused on understanding the mechanisms of interactions between the indigenous intestinal flora and the mammalian host in both physiological and nonphysiological conditions. In particular, we have focused on the function of innate microbial pattern recognition by Toll-like receptors in the context of ...

journal_title：Mucosal immunology

authors： Rakoff-Nahoum S,Medzhitov R

更新日期：2008-11-01 00:00:00

abstract：:Microbial metabolites are an emerging class of mediators influencing CD4+ T-cell function. To advance the understanding of direct causal microbial factors contributing to Crohn's disease, we screened 139 predicted Crohn's disease-associated microbial metabolites for their bioactivity on human CD4+ T-cell functions ind...

journal_title：Mucosal immunology

authors： Chang YL,Rossetti M,Vlamakis H,Casero D,Sunga G,Harre N,Miller S,Humphries R,Stappenbeck T,Simpson KW,Sartor RB,Wu G,Lewis J,Bushman F,McGovern DPB,Salzman N,Borneman J,Xavier R,Huttenhower C,Braun J

更新日期：2019-03-01 00:00:00

abstract：:The mechanisms underlying the massive gastrointestinal tract CD4 T-cell depletion in human immunodeficiency virus (HIV) infection are not well understood nor is it clear whether similar depletion is manifest at other mucosal surfaces. Studies of T-cell and virus dynamics in different anatomical sites have begun to ill...

journal_title：Mucosal immunology

authors： Brenchley JM,Knox KS,Asher AI,Price DA,Kohli LM,Gostick E,Hill BJ,Hage CA,Brahmi Z,Khoruts A,Twigg HL 3rd,Schacker TW,Douek DC

更新日期：2008-01-01 00:00:00