当前位置： SCI文献检索 > Mucosal Immunology期刊下所有文献 > The rectal mucosa and condomless receptive anal intercourse in HIV-negative MSM: implications for HIV transmission and prevention.

The rectal mucosa and condomless receptive anal intercourse in HIV-negative MSM: implications for HIV transmission and prevention.

Abstract：

:Most HIV transmissions among men who have sex with men (MSM), the group that accounted for 67% of new US infections in 2014, occur via exposure to the rectal mucosa. However, it is unclear how the act of condomless receptive anal intercourse (CRAI) may alter the mucosal immune environment in HIV-negative MSM. Here, we performed a comprehensive characterization of the rectal mucosal immune environment for the phenotype and production of pro-inflammatory cytokines by CD4 and CD8 T cells, global transcriptomic analyses, and the composition of microbiota in HIV-negative MSM. Our results show that compared with men who had never engaged in anal intercourse, the rectal mucosa of MSM engaging in CRAI has a distinct phenotype characterized by higher levels of Th17 cells, greater CD8+ T cell proliferation and production of pro-inflammatory cytokines, molecular signatures associated with mucosal injury and repair likely mediated by innate immune cells, and a microbiota enriched for the Prevotellaceae family. These data provide a high-resolution model of the immunological, molecular, and microbiological perturbations induced by CRAI, will have direct utility in understanding rectal HIV transmission among MSM, and will enhance the design of future biomedical prevention interventions, including candidate HIV vaccines.

journal_name

Mucosal Immunol

journal_title

Mucosal immunology

authors

Kelley CF,Kraft CS,de Man TJ,Duphare C,Lee HW,Yang J,Easley KA,Tharp GK,Mulligan MJ,Sullivan PS,Bosinger SE,Amara RR

doi

10.1038/mi.2016.97

subject

Has Abstract

pub_date

2017-07-01 00:00:00

pages

996-1007

issue

4

eissn

1933-0219

issn

1935-3456

pii

mi201697

journal_volume

10

pub_type

杂志文章

相关文献

Mucosal Immunology文献大全
  • The role of the gut as a primary lymphoid organ: CD8αα intraepithelial T lymphocytes in euthymic mice derive from very immature CD44+ thymocyte precursors.

    abstract：:Intestinal CD8αα intraepithelial T lymphocytes (T-IELs) have a key role in mucosal immunity and, unlike other T cells, were proposed to differentiate locally. In apparent contradiction, these cells were also shown to originate from a wave of thymus migrants colonizing the gut in the first 3 weeks after birth. We here ...

    journal_title：Mucosal immunology

    pub_type： 杂志文章

    doi：10.1038/mi.2010.47

    authors： Peaudecerf L,dos Santos PR,Boudil A,Ezine S,Pardigon N,Rocha B

    更新日期：2011-01-01 00:00:00

  • Tissue-specific differentiation of colonic macrophages requires TGFβ receptor-mediated signaling.

    abstract：:Intestinal macrophages (mφ) form one of the largest populations of mφ in the body and are vital for the maintenance of gut homeostasis. They have several unique properties and are derived from local differentiation of classical Ly6Chi monocytes, but the factors driving this tissue-specific process are not understood. ...

    journal_title：Mucosal immunology

    pub_type： 杂志文章

    doi：10.1038/mi.2016.142

    authors： Schridde A,Bain CC,Mayer JU,Montgomery J,Pollet E,Denecke B,Milling SWF,Jenkins SJ,Dalod M,Henri S,Malissen B,Pabst O,Mcl Mowat A

    更新日期：2017-11-01 00:00:00

  • Lack of IL-4 receptor expression on T helper cells reduces T helper 2 cell polyfunctionality and confers resistance in allergic bronchopulmonary mycosis.

    abstract：:T helper (Th)1 and Th2 cells play decisive roles in the regulation of resistance vs. susceptibility to pulmonary cryptococcosis. To study the function of interleukin (IL)-4 receptor (IL-4R) on Th cells in pulmonary cryptococcosis, we infected mice specifically lacking IL-4Rα on CD4(+) T cells (Lck(Cre)IL-4Rα(-/lox) mi...

    journal_title：Mucosal immunology

    pub_type： 杂志文章

    doi：10.1038/mi.2012.9

    authors： Müller U,Piehler D,Stenzel W,Köhler G,Frey O,Held J,Grahnert A,Richter T,Eschke M,Kamradt T,Brombacher F,Alber G

    更新日期：2012-05-01 00:00:00

  • Flagellin: key target of mucosal innate immunity.

    abstract：:The mucosal immune system is charged with defending the host's vast interfaces with the outside world from the enormous and diverse group of microbes that colonizes these surfaces. A key means by which the mucosal immune system protects the host from such diverse microbes is using germ-line-encoded receptors that targ...

    journal_title：Mucosal immunology

    pub_type： 杂志文章,评审

    doi：10.1038/mi.2009.9

    authors： Vijay-Kumar M,Gewirtz AT

    更新日期：2009-05-01 00:00:00

  • Neutrophil recruitment and activation are differentially dependent on MyD88/TRIF and MAVS signaling during RSV infection.

    abstract：:Respiratory syncytial virus (RSV) is a leading cause of severe lower respiratory tract infections, especially in infants. Lung neutrophilia is a hallmark of RSV disease but the mechanism by which neutrophils are recruited and activated is unclear. Here, we investigate the innate immune signaling pathways underlying ne...

    journal_title：Mucosal immunology

    pub_type： 杂志文章

    doi：10.1038/s41385-019-0190-0

    authors： Kirsebom FCM,Kausar F,Nuriev R,Makris S,Johansson C

    更新日期：2019-09-01 00:00:00

  • Anti-CXCL13 antibody can inhibit the formation of gastric lymphoid follicles induced by Helicobacter infection.

    abstract：:Helicobacter suis infects the stomachs of both animals and humans, and can induce gastric mucosa-associated lymphoid tissue (MALT) lymphomas. It is known that CXC chemokine ligand 13 (CXCL13) is highly expressed in the Helicobacter-infected mice and gastric MALT lymphoma patients, but the pathway that links the activa...

    journal_title：Mucosal immunology

    pub_type： 杂志文章

    doi：10.1038/mi.2014.14

    authors： Yamamoto K,Nishiumi S,Yang L,Klimatcheva E,Pandina T,Takahashi S,Matsui H,Nakamura M,Zauderer M,Yoshida M,Azuma T

    更新日期：2014-09-01 00:00:00

  • AIM2 contributes to the maintenance of intestinal integrity via Akt and protects against Salmonella mucosal infection.

    abstract：:The mechanism regulating the gastrointestinal epithelial barrier remains poorly understood. We herein demonstrate that Absent in melanoma-2 (AIM2) contributes to the maintenance of intestinal barrier integrity and defense against bacterial infection. AIM2-deficient mice displayed an increased susceptibility to mucosal...

    journal_title：Mucosal immunology

    pub_type： 杂志文章

    doi：10.1038/mi.2015.142

    authors： Hu GQ,Song PX,Li N,Chen W,Lei QQ,Yu SX,Zhang XJ,Du CT,Deng XM,Han WY,Yang YJ

    更新日期：2016-09-01 00:00:00

  • Retinoic acid takes effector T cells to the gallows: P2X7, the molecular hangman.

    abstract：:Effector T-cell contraction is one of the primary means by which immune homeostasis in the peripheral tissues is reestablished following an inflammatory response. In this issue of Mucosal Immunology, Hashimoto-Hill et al.1 show that retinoic acid (RA) transcriptionally upregulates P2X7 primarily in effector T cells of...

    journal_title：Mucosal immunology

    pub_type： 评论,杂志文章

    doi：10.1038/mi.2016.117

    authors： Das S,Villablanca EJ

    更新日期：2017-07-01 00:00:00

  • Adaptation to inflammatory acidity through neutrophil-derived adenosine regulation of SLC26A3.

    abstract：:Acute intestinal inflammation includes the early accumulation of neutrophils (PMN). Based on recent evidence that PMN infiltration "imprints" changes in the local tissue environment through local oxygen depletion and the release of adenine nucleotides, we hypothesized that the interaction between transmigrating PMN an...

    journal_title：Mucosal immunology

    pub_type： 杂志文章

    doi：10.1038/s41385-019-0237-2

    authors： Cartwright IM,Curtis VF,Lanis JM,Alexeev EE,Welch N,Goldberg MS,Schaefer REM,Gao RY,Chun C,Fennimore B,Onyiah JC,Gerich ME,Dempsey PJ,Colgan SP

    更新日期：2020-03-01 00:00:00

  • Severe viral respiratory infections: are bugs bugging?

    abstract：:Viral respiratory tract infections (RTI) pose a high burden on the youngest members of our society. Several risk factors are known for severe viral respiratory disease. However, a large proportion of the severe RTI cannot be explained by these risk factors. A growing body of evidence shows that the composition of the ...

    journal_title：Mucosal immunology

    pub_type： 杂志文章,评审

    doi：10.1038/mi.2013.93

    authors： Vissers M,de Groot R,Ferwerda G

    更新日期：2014-03-01 00:00:00

  • Excessive neutrophil levels in the lung underlie the age-associated increase in influenza mortality.

    abstract：:Neutrophils clear viruses, but excessive neutrophil responses induce tissue injury and worsen disease. Aging increases mortality to influenza infection; however, whether this is due to impaired viral clearance or a pathological host immune response is unknown. Here we show that aged mice have higher levels of lung neu...

    journal_title：Mucosal immunology

    pub_type： 杂志文章

    doi：10.1038/s41385-018-0115-3

    authors： Kulkarni U,Zemans RL,Smith CA,Wood SC,Deng JC,Goldstein DR

    更新日期：2019-03-01 00:00:00

  • IL-17A-mediated neutrophil recruitment limits expansion of segmented filamentous bacteria.

    abstract：:Specific components of the intestinal microbiota are capable of influencing immune responses such that a mutualistic relationship is established. In mice, colonization with segmented filamentous bacteria (SFB) induces T-helper-17 (Th17) cell differentiation in the intestine, yet the effector functions of interleukin (...

    journal_title：Mucosal immunology

    pub_type： 杂志文章

    doi：10.1038/mi.2016.80

    authors： Flannigan KL,Ngo VL,Geem D,Harusato A,Hirota SA,Parkos CA,Lukacs NW,Nusrat A,Gaboriau-Routhiau V,Cerf-Bensussan N,Gewirtz AT,Denning TL

    更新日期：2017-05-01 00:00:00

  • Architectural and functional alterations of the small intestinal mucosa in classical Whipple's disease.

    abstract：:Classical Whipple's disease (CWD) affects the gastrointestinal tract and rather elicits regulatory than inflammatory immune reactions. Mechanisms of malabsorption, diarrhea, and systemic immune activation are unknown. We here analyzed mucosal architecture, barrier function, and immune activation as potential diarrheal...

    journal_title：Mucosal immunology

    pub_type： 杂志文章

    doi：10.1038/mi.2017.6

    authors： Epple HJ,Friebel J,Moos V,Troeger H,Krug SM,Allers K,Schinnerling K,Fromm A,Siegmund B,Fromm M,Schulzke JD,Schneider T

    更新日期：2017-11-01 00:00:00

  • Alpha4(+)beta7(hi)CD4(+) memory T cells harbor most Th-17 cells and are preferentially infected during acute SIV infection.

    abstract：:Human immunodeficiency virus/simian immunodeficiency virus (HIV/SIV) infections are believed to infect minimally activated CD4(+) T cells after viral entry. Not much is known about why SIV selectively targets these cells. Here we show that CD4(+) T cells that express high levels of the alpha4beta7 heterodimer are pref...

    journal_title：Mucosal immunology

    pub_type： 杂志文章

    doi：10.1038/mi.2009.90

    authors： Kader M,Wang X,Piatak M,Lifson J,Roederer M,Veazey R,Mattapallil JJ

    更新日期：2009-09-01 00:00:00

  • Redox signaling regulates commensal-mediated mucosal homeostasis and restitution and requires formyl peptide receptor 1.

    abstract：:The mammalian gut microbiota is essential for normal intestinal development, renewal, and repair. Injury to the intestinal mucosa can occur with infection, surgical trauma, and in idiopathic inflammatory bowel disease. Repair of mucosal injury, termed restitution, as well as restoration of intestinal homeostasis invol...

    journal_title：Mucosal immunology

    pub_type： 杂志文章

    doi：10.1038/mi.2013.84

    authors： Alam A,Leoni G,Wentworth CC,Kwal JM,Wu H,Ardita CS,Swanson PA,Lambeth JD,Jones RM,Nusrat A,Neish AS

    更新日期：2014-05-01 00:00:00

  • Neutrophils express pro- and anti-inflammatory cytokines in granulomas from Mycobacterium tuberculosis-infected cynomolgus macaques.

    abstract：:Neutrophils are implicated in the pathogenesis of tuberculosis (TB), a disease caused by Mycobacterium tuberculosis infection, but the mechanisms by which they promote disease are not fully understood. Neutrophils can express cytokines that influence TB progression, and so we compared neutrophil and T-cell expression ...

    journal_title：Mucosal immunology

    pub_type： 杂志文章

    doi：10.1038/s41385-019-0195-8

    authors： Gideon HP,Phuah J,Junecko BA,Mattila JT

    更新日期：2019-11-01 00:00:00

  • Generation of protective pneumococcal-specific nasal resident memory CD4+ T cells via parenteral immunization.

    abstract：:The generation of tissue-resident memory T cells (TRM) is an essential aspect of immunity at mucosal surfaces, and it has been suggested that preferential generation of TRM is one of the principal advantages of mucosally administered vaccines. We have previously shown that antigen-specific, IL-17-producing CD4+ T cell...

    journal_title：Mucosal immunology

    pub_type： 杂志文章

    doi：10.1038/s41385-019-0218-5

    authors： O'Hara JM,Redhu NS,Cheung E,Robertson NG,Patik I,Sayed SE,Thompson CM,Herd M,Lucas KB,Conaway E,Morton CC,Farber DL,Malley R,Horwitz BH

    更新日期：2020-01-01 00:00:00

  • The molecular basis of NOD2 susceptibility mutations in Crohn's disease.

    abstract：:Nucleotide oligomerization domain (NOD)2 is a member of the NOD-like receptor family of proteins that initiate inflammatory responses when exposed to ligands derived from bacterial components that gain access to the intracellular milieu. It is thus somewhat paradoxical that polymorphisms in the gene that encode NOD2 (...

    journal_title：Mucosal immunology

    pub_type： 杂志文章,评审

    doi：10.1038/mi.2008.42

    authors： Strober W,Kitani A,Fuss I,Asano N,Watanabe T

    更新日期：2008-11-01 00:00:00

  • The emergence of pathogenic TNF/iNOS producing dendritic cells (Tip-DCs) in a malaria model of acute respiratory distress syndrome (ARDS) is dependent on CCR4.

    abstract：:Malaria-associated acute respiratory distress syndrome (MA-ARDS) and acute lung injury (ALI) are complications that cause lung damage and often leads to death. The MA-ARDS/ALI is associated with a Type 1 inflammatory response mediated by T lymphocytes and IFN-γ. Here, we used the Plasmodium berghei NK65 (PbN)-induced ...

    journal_title：Mucosal immunology

    pub_type： 杂志文章

    doi：10.1038/s41385-018-0093-5

    authors： Galvão-Filho B,de Castro JT,Figueiredo MM,Rosmaninho CG,Antonelli LRDV,Gazzinelli RT

    更新日期：2019-03-01 00:00:00

  • Therapeutic host-directed strategies to improve outcome in tuberculosis.

    abstract：:Bacille Calmette-Guérin (BCG) is the only licenced tuberculosis (TB) vaccine, but has limited efficacy against pulmonary TB disease development and modest protection against extrapulmonary TB. Preventative antibiotic treatment for Mycobacterium tuberculosis (Mtb) infections in high-prevalence settings is unfeasible du...

    journal_title：Mucosal immunology

    pub_type： 杂志文章,评审

    doi：10.1038/s41385-019-0226-5

    authors： Young C,Walzl G,Du Plessis N

    更新日期：2020-03-01 00:00:00

  • Deficiency of autophagy protein Map1-LC3b mediates IL-17-dependent lung pathology during respiratory viral infection via ER stress-associated IL-1.

    abstract：:While recent studies suggest that interleukin (IL)-1β production is modulated by macroautophagy or sensors of endoplasmic reticulum (ER) stress upon pro-inflammatory insult, autophagy and IL-1β production during viral infection has not been fully investigated. This was addressed using respiratory syncytial virus (RSV)...

    journal_title：Mucosal immunology

    pub_type： 杂志文章

    doi：10.1038/mi.2015.3

    authors： Reed M,Morris SH,Owczarczyk AB,Lukacs NW

    更新日期：2015-09-01 00:00:00

  • Mouse and human intestinal immunity: same ballpark, different players; different rules, same score.

    abstract：:The study of animal immune physiology and animal models of human disease have accelerated many aspects of translational research by allowing direct, definitive investigations. In particular, the use of mice has allowed genetic manipulation, adoptive transfer, immunization, and focused cell and tissue sampling, which w...

    journal_title：Mucosal immunology

    pub_type： 杂志文章,评审

    doi：10.1038/mi.2010.85

    authors： Gibbons DL,Spencer J

    更新日期：2011-03-01 00:00:00

  • Toll-like receptor 3 in nasal CD103+ dendritic cells is involved in immunoglobulin A production.

    abstract：:Intranasal inoculation with influenza hemagglutinin subunit with polyinosine-polycytidylic (polyI:C), a synthetic analog for double-stranded RNA, enhances production of vaccine-specific immunoglobulin (Ig) A, which is superior to IgG in prophylactic immunity. The mechanism whereby polyI:C skews to IgA production in th...

    journal_title：Mucosal immunology

    pub_type： 杂志文章

    doi：10.1038/mi.2017.48

    authors： Takaki H,Kure S,Oshiumi H,Sakoda Y,Suzuki T,Ainai A,Hasegawa H,Matsumoto M,Seya T

    更新日期：2018-01-01 00:00:00

  • Host-dependent control of early regulatory and effector T-cell differentiation underlies the genetic susceptibility of RAG2-deficient mouse strains to transfer colitis.

    abstract：:De novo differentiation of CD4(+)Foxp3(+) regulatory T cells (induced (i) Tregs) occurs preferentially in the gut-associated lymphoid tissues (GALT). We addressed the contribution of background genetic factors in affecting the balance of iTreg, T helper type 1 (Th1), and Th17 cell differentiation in GALT in vivo follo...

    journal_title：Mucosal immunology

    pub_type： 杂志文章

    doi：10.1038/mi.2012.102

    authors： Valatas V,He J,Rivollier A,Kolios G,Kitamura K,Kelsall BL

    更新日期：2013-05-01 00:00:00

  • Macrophage-mediated gliadin degradation and concomitant IL-27 production drive IL-10- and IFN-γ-secreting Tr1-like-cell differentiation in a murine model for gluten tolerance.

    abstract：:Celiac disease is caused by inflammatory T-cell responses against the insoluble dietary protein gliadin. We have shown that, in humanized mice, oral tolerance to deamidated chymotrypsin-digested gliadin (CT-TG2-gliadin) is driven by tolerogenic interferon (IFN)-γ- and interleukin (IL)-10-secreting type 1 regulatory T-...

    journal_title：Mucosal immunology

    pub_type： 杂志文章

    doi：10.1038/mi.2016.76

    authors： van Leeuwen MA,Costes LMM,van Berkel LA,Simons-Oosterhuis Y,du Pré MF,Kozijn AE,Raatgeep HC,Lindenbergh-Kortleve DJ,van Rooijen N,Koning F,Samsom JN

    更新日期：2017-05-01 00:00:00

  • Celiac disease: from oral tolerance to intestinal inflammation, autoimmunity and lymphomagenesis.

    abstract：:Celiac disease is a multifactorial disorder and provides a privileged model to decipher how the interplay between environmental and genetic factors can alter mucosal tolerance to a food antigen, lead to chronic intestinal inflammation, and ultimately promote T-cell lymphomagenesis. Here we summarize how HLA-DQ2/8 mole...

    journal_title：Mucosal immunology

    pub_type： 评论,杂志文章,评审

    doi：10.1038/mi.2008.75

    authors： Meresse B,Ripoche J,Heyman M,Cerf-Bensussan N

    更新日期：2009-01-01 00:00:00

  • Differential effect of vitamin D on NOD2- and TLR-induced cytokines in Crohn's disease.

    abstract：:Accumulating evidence implicates defective innate immunity in the pathogenesis of Crohn's disease (CD). Ineffectual NOD2 (nucleotide-binding oligomerization domain 2) is the most common susceptibility gene contributing to CD. Vitamin D (vD), a potent modulator of innate and adaptive immunity, induces NOD2 gene express...

    journal_title：Mucosal immunology

    pub_type： 杂志文章

    doi：10.1038/mi.2014.30

    authors： Dionne S,Calderon MR,White JH,Memari B,Elimrani I,Adelson B,Piccirillo C,Seidman EG

    更新日期：2014-11-01 00:00:00

  • Innate immune recognition of the indigenous microbial flora.

    abstract：:Our studies have focused on understanding the mechanisms of interactions between the indigenous intestinal flora and the mammalian host in both physiological and nonphysiological conditions. In particular, we have focused on the function of innate microbial pattern recognition by Toll-like receptors in the context of ...

    journal_title：Mucosal immunology

    pub_type： 杂志文章,评审

    doi：10.1038/mi.2008.49

    authors： Rakoff-Nahoum S,Medzhitov R

    更新日期：2008-11-01 00:00:00

  • Cross-protective mucosal immunity mediated by memory Th17 cells against Streptococcus pneumoniae lung infection.

    abstract：:Pneumonia caused by Streptococcus pneumoniae (Sp) remains a leading cause of serious illness and death worldwide. Immunization with conjugated pneumococcal vaccine has lowered the colonization rate and consequently invasive diseases by inducing serotype-specific antibodies. However, many of the current pneumonia cases...

    journal_title：Mucosal immunology

    pub_type： 杂志文章

    doi：10.1038/mi.2016.41

    authors： Wang Y,Jiang B,Guo Y,Li W,Tian Y,Sonnenberg GF,Weiser JN,Ni X,Shen H

    更新日期：2017-01-01 00:00:00

  • Neutrophils negatively regulate induction of mucosal IgA responses after sublingual immunization.

    abstract：:Induction of mucosal immunoglobulin-A (IgA) capable of providing a first line of defense against bacterial and viral pathogens remains a major goal of needle-free vaccines given via mucosal routes. Innate immune cells are known to play a central role in induction of IgA responses by mucosal vaccines, but the relative ...

    journal_title：Mucosal immunology

    pub_type： 杂志文章

    doi：10.1038/mi.2014.105

    authors： Jee J,Bonnegarde-Bernard A,Duverger A,Iwakura Y,Cormet-Boyaka E,Martin TL,Steiner HE,Bachman RC,Boyaka PN

    更新日期：2015-07-01 00:00:00