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Mechanism of NKT cell activation by intranasal coadministration of alpha-galactosylceramide, which can induce cross-protection against influenza viruses.

Abstract：

:In a nasal vaccine against influenza, the activation of natural killer T (NKT) cells by intranasal coadministration of alpha-galactosylceramide (alpha-GalCer) can potently enhance protective immune responses. The results of this study show that the NKT cell-activated nasal vaccine can induce an effective cross-protection against different strains of influenza virus, including H5 type. To analyze the mechanism of NKT cell activation by this nasal vaccine, we prepared fluorescence-labeled alpha-GalCer by which we detect a direct interaction between NKT cells and alpha-GalCer-stored dendritic cells in nasal mucosa-associated tissues. Accordingly, although very few NKT cells exist at mucosa, the nasal vaccination induced a localized increase in NKT cell population, which is partly dependent on CXCL16/CXCR6. Furthermore, we found that NKT cell activation stimulates mucosal IgA production by a mechanism that is dependent on interleukin (IL)-4 production. These results strengthen the basis of nasal vaccination via NKT cell activation, which can induce immune cross-protection.

journal_name

Mucosal Immunol

journal_title

Mucosal immunology

authors

Kamijuku H,Nagata Y,Jiang X,Ichinohe T,Tashiro T,Mori K,Taniguchi M,Hase K,Ohno H,Shimaoka T,Yonehara S,Odagiri T,Tashiro M,Sata T,Hasegawa H,Seino KI

doi

10.1038/mi.2008.2

subject

Has Abstract

pub_date

2008-05-01 00:00:00

pages

208-18

issue

3

eissn

1933-0219

issn

1935-3456

pii

mi20082

journal_volume

1

pub_type

杂志文章

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