Abstract:
:This corrects the article DOI: 10.1038/mi.2017.46.
journal_name
Mucosal Immunoljournal_title
Mucosal immunologyauthors
Kinnear E,Lambert L,McDonald JU,Cheeseman HM,Caproni LJ,Tregoning JSdoi
10.1038/mi.2017.79subject
Has Abstractpub_date
2018-01-01 00:00:00pages
290issue
1eissn
1933-0219issn
1935-3456pii
mi201779journal_volume
11pub_type
杂志文章,已发布勘误abstract::Previously we have extensively characterized Salmonella enterica serovar Typhi (S. Typhi)-specific cell-mediated immune (CMI) responses in volunteers orally immunized with the licensed Ty21a typhoid vaccine. In this study we measured Salmonella-specific multifunctional (MF) CD8+ T-cell responses to further investigate...
journal_title:Mucosal immunology
pub_type: 杂志文章
doi:10.1038/mi.2015.24
更新日期:2015-11-01 00:00:00
abstract::Dectin-1 is an innate antifungal C-type lectin receptor necessary for protective antifungal immunity. We recently discovered that Dectin-1 is involved in controlling fungal infections of the gastrointestinal (GI) tract, but how this C-type lectin receptor mediates these activities is unknown. Here, we show that Dectin...
journal_title:Mucosal immunology
pub_type: 杂志文章
doi:10.1038/mi.2015.79
更新日期:2016-03-01 00:00:00
abstract::Alpha B-crystallin (CRYAB) is an important member of the small heat shock protein family, and plays a protective and therapeutic role in neurological inflammation. CRYAB expression was assessed in cultured HT29 and Caco-2 cells and inflamed mucosa of patients with inflammatory bowel disease (IBD) and colitis models in...
journal_title:Mucosal immunology
pub_type: 杂志文章
doi:10.1038/s41385-019-0198-5
更新日期:2019-11-01 00:00:00
abstract::Intestinal fibrosis leading to strictures remains a significant clinical problem in inflammatory bowel diseases (IBD). The role of bacterial components in activating intestinal mesenchymal cells and driving fibrogenesis is largely unexplored. Tamoxifen-inducible α-SMA promoter Cre mice crossed with floxed MyD88 mice w...
journal_title:Mucosal immunology
pub_type: 杂志文章
doi:10.1038/s41385-020-0259-9
更新日期:2020-07-01 00:00:00
abstract::T helper type (Th17) cytokines such as interleukin (IL)-17A and IL-22 are important in maintaining mucosal barrier function and may be important in the pathogenesis of inflammatory bowel diseases (IBDs). Here, we analyzed cells from the colon of IBD patients and show that Crohn's disease (CD) patients had significantl...
journal_title:Mucosal immunology
pub_type: 杂志文章
doi:10.1038/mi.2013.31
更新日期:2014-01-01 00:00:00
abstract::Insufficient T-cell responses contribute to the increased burden of viral respiratory disease in infancy. Neonatal dendritic cells (DCs) often provide defective activation of pathogen-specific T cells through mechanisms that are incompletely understood, which hinders vaccine design for this vulnerable age group. Enhan...
journal_title:Mucosal immunology
pub_type: 杂志文章
doi:10.1038/s41385-019-0234-5
更新日期:2020-03-01 00:00:00
abstract::Annual epidemics and unexpected pandemics of influenza are threats to human health. Lung immune and inflammatory responses, such as those induced by respiratory infection influenza virus, determine the outcome of pulmonary pathogenesis. Platelet-derived chemokine (C-X-C motif) ligand 4 (CXCL4) has an immunoregulatory ...
journal_title:Mucosal immunology
pub_type: 杂志文章
doi:10.1038/mi.2017.1
更新日期:2017-11-01 00:00:00
abstract::Eosinophilic esophagitis (EoE) is an allergic inflammatory disease of the esophagus featuring increased esophageal interleukin-13 (IL-13) levels and impaired barrier function. Herein, we investigated leucine-rich repeat-containing protein 31 (LRRC31) in human EoE esophageal tissue and IL-13-treated esophageal epitheli...
journal_title:Mucosal immunology
pub_type: 杂志文章
doi:10.1038/mi.2015.98
更新日期:2016-05-01 00:00:00
abstract::Mesenteric lymph nodes (MLNs), that drain the large and small intestine, are critical sites for the induction of oral tolerance. Although depletion of CD4 T cells in the intestinal lamina propria is a hallmark of HIV infection, CD4 T cell dynamics in MLNs is less known due to the lack of accessibility to these LNs. We...
journal_title:Mucosal immunology
pub_type: 杂志文章
doi:10.1038/s41385-019-0174-0
更新日期:2019-07-01 00:00:00
abstract::Intestinal dendritic cells (DCs) continuously migrate through lymphatics to mesenteric lymph nodes where they initiate immunity or tolerance. Recent research has focused on populations of intestinal DCs expressing CD103. Here we demonstrate, for the first time, the presence of two distinct CD103(-) DC subsets in intes...
journal_title:Mucosal immunology
pub_type: 杂志文章
doi:10.1038/mi.2012.53
更新日期:2013-01-01 00:00:00
abstract::The generation of tissue-resident memory T cells (TRM) is an essential aspect of immunity at mucosal surfaces, and it has been suggested that preferential generation of TRM is one of the principal advantages of mucosally administered vaccines. We have previously shown that antigen-specific, IL-17-producing CD4+ T cell...
journal_title:Mucosal immunology
pub_type: 杂志文章
doi:10.1038/s41385-019-0218-5
更新日期:2020-01-01 00:00:00
abstract::Intranasal inoculation with influenza hemagglutinin subunit with polyinosine-polycytidylic (polyI:C), a synthetic analog for double-stranded RNA, enhances production of vaccine-specific immunoglobulin (Ig) A, which is superior to IgG in prophylactic immunity. The mechanism whereby polyI:C skews to IgA production in th...
journal_title:Mucosal immunology
pub_type: 杂志文章
doi:10.1038/mi.2017.48
更新日期:2018-01-01 00:00:00
abstract::Respiratory syncytial virus (RSV) is a leading cause of severe lower respiratory tract infections, especially in infants. Lung neutrophilia is a hallmark of RSV disease but the mechanism by which neutrophils are recruited and activated is unclear. Here, we investigate the innate immune signaling pathways underlying ne...
journal_title:Mucosal immunology
pub_type: 杂志文章
doi:10.1038/s41385-019-0190-0
更新日期:2019-09-01 00:00:00
abstract::Malaria-associated acute respiratory distress syndrome (MA-ARDS) and acute lung injury (ALI) are complications that cause lung damage and often leads to death. The MA-ARDS/ALI is associated with a Type 1 inflammatory response mediated by T lymphocytes and IFN-γ. Here, we used the Plasmodium berghei NK65 (PbN)-induced ...
journal_title:Mucosal immunology
pub_type: 杂志文章
doi:10.1038/s41385-018-0093-5
更新日期:2019-03-01 00:00:00
abstract::The mechanism regulating the gastrointestinal epithelial barrier remains poorly understood. We herein demonstrate that Absent in melanoma-2 (AIM2) contributes to the maintenance of intestinal barrier integrity and defense against bacterial infection. AIM2-deficient mice displayed an increased susceptibility to mucosal...
journal_title:Mucosal immunology
pub_type: 杂志文章
doi:10.1038/mi.2015.142
更新日期:2016-09-01 00:00:00
abstract::Epidemiological data indicate a link between rheumatoid arthritis (RA) and periodontal disease (PD). In vitro and in vivo studies have sought to dissect potential mechanisms by which PD may contribute to initiation and progression of RA. However, these are both multifactorial, chronic diseases, and their complex etiol...
journal_title:Mucosal immunology
pub_type: 杂志文章,评审
doi:10.1038/mi.2011.66
更新日期:2012-03-01 00:00:00
abstract::Vaccine-mediated prevention of primary infection with human immunodeficiency virus (HIV) may require the sustained production of antibody at mucosal portals of entry. Here, we describe a novel approach of repeated mucosal immunization by delivering an HIV-1 envelope glycoprotein (gp) in a gel formulated for intravagin...
journal_title:Mucosal immunology
pub_type: 杂志文章
doi:10.1038/mi.2009.110
更新日期:2010-01-01 00:00:00
abstract::Nucleotide oligomerization domain (NOD)2 is a member of the NOD-like receptor family of proteins that initiate inflammatory responses when exposed to ligands derived from bacterial components that gain access to the intracellular milieu. It is thus somewhat paradoxical that polymorphisms in the gene that encode NOD2 (...
journal_title:Mucosal immunology
pub_type: 杂志文章,评审
doi:10.1038/mi.2008.42
更新日期:2008-11-01 00:00:00
abstract::Celiac disease (CD) is a chronic small intestinal inflammation precipitated by gluten ingestion. According to case reports, interferon (IFN)-α administration may induce development of overt CD. Plasmacytoid dendritic cells (PDCs) were thought to be the source of IFN-α and promote a T helper type 1 response leading to ...
journal_title:Mucosal immunology
pub_type: 杂志文章
doi:10.1038/mi.2012.136
更新日期:2013-09-01 00:00:00
abstract::Accumulating evidence implicates defective innate immunity in the pathogenesis of Crohn's disease (CD). Ineffectual NOD2 (nucleotide-binding oligomerization domain 2) is the most common susceptibility gene contributing to CD. Vitamin D (vD), a potent modulator of innate and adaptive immunity, induces NOD2 gene express...
journal_title:Mucosal immunology
pub_type: 杂志文章
doi:10.1038/mi.2014.30
更新日期:2014-11-01 00:00:00
abstract::This corrects the article DOI: 10.1038/mi.2017.66. ...
journal_title:Mucosal immunology
pub_type: 杂志文章,已发布勘误
doi:10.1038/mi.2017.78
更新日期:2018-03-01 00:00:00
abstract::The mammalian gut microbiota is essential for normal intestinal development, renewal, and repair. Injury to the intestinal mucosa can occur with infection, surgical trauma, and in idiopathic inflammatory bowel disease. Repair of mucosal injury, termed restitution, as well as restoration of intestinal homeostasis invol...
journal_title:Mucosal immunology
pub_type: 杂志文章
doi:10.1038/mi.2013.84
更新日期:2014-05-01 00:00:00
abstract::Levels of reactive free radicals are elevated in the airway during asthmatic exacerbations, but their roles in the pathophysiology of asthma remain unclear. We have identified subsets of myeloid-derived suppressor-like cells as key sources of nitric oxide and superoxide in the lungs of mice with evolving experimental ...
journal_title:Mucosal immunology
pub_type: 杂志文章
doi:10.1038/mi.2011.16
更新日期:2011-09-01 00:00:00
abstract::Intestinal CD8αα intraepithelial T lymphocytes (T-IELs) have a key role in mucosal immunity and, unlike other T cells, were proposed to differentiate locally. In apparent contradiction, these cells were also shown to originate from a wave of thymus migrants colonizing the gut in the first 3 weeks after birth. We here ...
journal_title:Mucosal immunology
pub_type: 杂志文章
doi:10.1038/mi.2010.47
更新日期:2011-01-01 00:00:00
abstract::The ultimate goal for vaccination is to stimulate protective immunological memory. Protection against infectious diseases not only relies on the magnitude of the humoral immune response, but more importantly on the quality and longevity of it. Adjuvants are critical components of most non-living vaccines. Although lit...
journal_title:Mucosal immunology
pub_type: 杂志文章,评审
doi:10.1038/mi.2010.54
更新日期:2010-11-01 00:00:00
abstract::Sonic hedgehog (SHH) is abundantly expressed and critical for morphogenesis in embryonic lungs; however, SHH expression drops to a much lower level in mice from E17.5 and in humans from the 21st gestational week. We find that SHH expression is robustly upregulated in the airway epithelia of children with asthma or mou...
journal_title:Mucosal immunology
pub_type: 杂志文章
doi:10.1038/s41385-018-0033-4
更新日期:2018-09-01 00:00:00
abstract::FoxP3+ regulatory T cells (Tregs) control inflammation and maintain mucosal homeostasis, but their functions during infection are poorly understood. Th1, Th2, and Th17 cells can be identified by master transcription factors (TFs) T-bet, GATA3, and RORγT; Tregs also express these TFs. While T-bet+ Tregs can selectively...
journal_title:Mucosal immunology
pub_type: 杂志文章
doi:10.1038/s41385-020-0299-1
更新日期:2020-11-01 00:00:00
abstract::Children born by cesarean section (CS) have an increased risk of developing inflammatory bowel disease (IBD), possibly due to skewed microbial colonization during birth and consequently impaired bacterial stimulation of the developing immune system. The aim of this study was to investigate the association between CS a...
journal_title:Mucosal immunology
pub_type: 杂志文章
doi:10.1038/s41385-019-0207-8
更新日期:2019-11-01 00:00:00
abstract::Intranasal (IN) immunization with a Plasmodium circumsporozoite (CS) protein conjugated to flagellin, a Toll-like receptor 5 agonist, was found to elicit antibody-mediated protective immunity in our previous murine studies. To better understand IN-elicited immune responses, we examined the nasopharynx-associated lymph...
journal_title:Mucosal immunology
pub_type: 杂志文章
doi:10.1038/mi.2013.48
更新日期:2014-03-01 00:00:00
abstract::Individuals with one atopic disease are far more likely to develop a second. Approximately half of all atopic dermatitis (AD) patients subsequently develop asthma, particularly those with severe AD. This association, suggesting a role for AD as an entry point for subsequent allergic disease, is a phenomenon known as t...
journal_title:Mucosal immunology
pub_type: 杂志文章
doi:10.1038/mi.2012.14
更新日期:2012-05-01 00:00:00