Abstract：
:Mesenteric lymph nodes (MLNs), that drain the large and small intestine, are critical sites for the induction of oral tolerance. Although depletion of CD4 T cells in the intestinal lamina propria is a hallmark of HIV infection, CD4 T cell dynamics in MLNs is less known due to the lack of accessibility to these LNs. We demonstrate the early loss of memory CD4 T cells, including T follicular helper cells (Tfh) and a remodeling of MLN architecture in SIV-infected rhesus macaques (RMs). Along with the loss of Tfh cells, we observe the loss of memory B cells and of germinal center B cells. Tfh cells display a Th1 profile with increased levels of the transcription factors that negatively impact on Tfh differentiation and of Stat5 phosphorylation. MLNs of SIV-infected RMs display lower mRNA transcripts encoding for IL-12, IL-23, and IL-35, whereas those coding for IL-27 are not impaired in MLNs. In vitro, IL-27 negatively impacts on Tfh cells and recapitulates the profile observed in SIV-infected RMs. Therefore, early defects of memory CD4 T cells, as well of Tfh cells in MLNs, which play a central role in regulating the mucosal immune response, may have major implications for Aids.
journal_name
Mucosal Immunoljournal_title
Mucosal immunologyauthors
Moukambi F,Rabezanahary H,Fortier Y,Rodrigues V,Clain J,Benmadid-Laktout G,Zghidi-Abouzid O,Soundaramourty C,Laforge M,Estaquier Jdoi
10.1038/s41385-019-0174-0subject
Has Abstractpub_date
2019-07-01 00:00:00pages
1038-1054issue
4eissn
1933-0219issn
1935-3456pii
10.1038/s41385-019-0174-0journal_volume
12pub_type
杂志文章abstract：:The mucosal immune system is charged with defending the host's vast interfaces with the outside world from the enormous and diverse group of microbes that colonizes these surfaces. A key means by which the mucosal immune system protects the host from such diverse microbes is using germ-line-encoded receptors that targ...
journal_title：Mucosal immunology
pub_type： 杂志文章,评审
doi：10.1038/mi.2009.9
更新日期：2009-05-01 00:00:00
abstract：:Innate lymphoid cells (ILCs) have stormed onto the immune landscape as "newly discovered" cell types. These tissue-resident sentinels are enriched at mucosal surfaces and engage in complex cross talk with elements of the adaptive immune system and microenvironment to orchestrate immune homeostasis. Many parallels exis...
journal_title：Mucosal immunology
pub_type： 杂志文章,评审
doi：10.1038/mi.2016.64
更新日期：2016-09-01 00:00:00
abstract：:Children born by cesarean section (CS) have an increased risk of developing inflammatory bowel disease (IBD), possibly due to skewed microbial colonization during birth and consequently impaired bacterial stimulation of the developing immune system. The aim of this study was to investigate the association between CS a...
journal_title：Mucosal immunology
pub_type： 杂志文章
doi：10.1038/s41385-019-0207-8
更新日期：2019-11-01 00:00:00
abstract：:Human immunodeficiency virus-1 (HIV-1) infection disrupts the intestinal immune system, leading to microbial translocation and systemic immune activation. We investigated the impact of HIV-1 infection on the intestinal microbiome and its association with mucosal T-cell and dendritic cell (DC) frequency and activation,...
journal_title：Mucosal immunology
pub_type： 杂志文章
doi：10.1038/mi.2013.116
更新日期：2014-07-01 00:00:00
abstract：:Association mapping and candidate gene studies within inflammatory bowel diseases (IBD) linkage regions, as well as genome-wide association studies in Crohn's disease (CD) have led to the discovery of multiple risk genes, but these explain only a fraction of the genetic susceptibility observed in IBD. We have thus bee...
journal_title：Mucosal immunology
pub_type： 杂志文章,多中心研究
doi：10.1038/mi.2007.15
更新日期：2008-03-01 00:00:00
abstract：:Eosinophils are granulocytes, typically implicated as end-stage effector cells in type-II immune responses. They are capable of producing a wide array of pre-formed molecules which render them with vast potential to influence a wide variety of processes. Nonetheless, eosinophil research has traditionally focused on th...
journal_title：Mucosal immunology
pub_type： 杂志文章,评审
doi：10.1038/s41385-020-0281-y
更新日期：2020-07-01 00:00:00
abstract：:The interleukin-23 (IL-23) pathway has emerged as a promising therapeutic target for inflammatory bowel disease. Although the pathogenic role of IL-23 receptor (IL-23R) on T lymphocytes is well established, its function on innate immune cells has not been thoroughly examined. Here we investigate the consequence of IL-...
journal_title：Mucosal immunology
pub_type： 杂志文章
doi：10.1038/mi.2011.54
更新日期：2012-01-01 00:00:00
abstract：:Treatment of post-transplant patients with immunosuppressive drugs targeting the calcineurin-nuclear factor of activated T cells (NFAT) pathway, including cyclosporine A or tacrolimus, is commonly associated with a higher incidence of opportunistic infections, such as Aspergillus fumigatus, which can lead to severe li...
journal_title：Mucosal immunology
pub_type： 杂志文章
doi：10.1038/mi.2016.52
更新日期：2017-03-01 00:00:00
abstract：:Intestinal dendritic cells (DCs) continuously migrate through lymphatics to mesenteric lymph nodes where they initiate immunity or tolerance. Recent research has focused on populations of intestinal DCs expressing CD103. Here we demonstrate, for the first time, the presence of two distinct CD103(-) DC subsets in intes...
journal_title：Mucosal immunology
pub_type： 杂志文章
doi：10.1038/mi.2012.53
更新日期：2013-01-01 00:00:00
abstract：:Vaccine-mediated prevention of primary infection with human immunodeficiency virus (HIV) may require the sustained production of antibody at mucosal portals of entry. Here, we describe a novel approach of repeated mucosal immunization by delivering an HIV-1 envelope glycoprotein (gp) in a gel formulated for intravagin...
journal_title：Mucosal immunology
pub_type： 杂志文章
doi：10.1038/mi.2009.110
更新日期：2010-01-01 00:00:00
abstract：:Helminth infection leads to the local proliferation and accumulation of macrophages in tissues. However, the function of macrophages during helminth infection remains unclear. SH2-containing inositol 5'-phosphatase 1 (Ship1, Inpp5d) is a lipid phosphatase that has been shown to play a critical role in macrophage funct...
journal_title：Mucosal immunology
pub_type： 杂志文章
doi：10.1038/mi.2012.29
更新日期：2012-09-01 00:00:00
abstract：:Natural intraepithelial lymphocytes (IELs) are thymus-derived adaptive immune cells, which are important contributors to intestinal immune homeostasis. Similar to other innate-like T cells, they are induced in the thymus through high-avidity interaction that would otherwise lead to clonal deletion in conventional CD4 ...
journal_title：Mucosal immunology
pub_type： 杂志文章
doi：10.1038/s41385-019-0220-y
更新日期：2020-03-01 00:00:00
abstract：:Bacterial-induced intestinal inflammation is crucially dependent on interleukin (IL)-23 and is associated with CD4(+) T helper type 1 (Th1) and Th17 responses. However, the relative contributions of these subsets during the induction and resolution of colitis in T-cell-sufficient hosts remain unknown. We report that H...
journal_title：Mucosal immunology
pub_type： 杂志文章
doi：10.1038/mi.2013.11
更新日期：2013-11-01 00:00:00
abstract：:Women with asymptomatic Neisseria gonorrhoeae infection are at risk of developing pelvic inflammatory disease (PID) if the bacteria ascend from the endocervix into the uterus and oviducts. Factors that affect disease severity, ranging from mild discomfort to severe inflammation, pain, and infertility, remain elusive. ...
journal_title：Mucosal immunology
pub_type： 杂志文章
doi：10.1038/mi.2015.122
更新日期：2016-07-01 00:00:00
abstract：:Intestinal epithelial Na+/H+ exchange facilitated by the apical NHE3 (Slc9a3) is a highly regulated process inhibited by intestinal pathogens and in inflammatory bowel diseases. NHE3-/- mice develop spontaneous, bacterially mediated colitis, and IBD-like dysbiosis. Disruption of epithelial Na+/H+ exchange in IBD may t...
journal_title：Mucosal immunology
pub_type： 杂志文章
doi：10.1038/s41385-018-0035-2
更新日期：2018-09-01 00:00:00
abstract：:The study of animal immune physiology and animal models of human disease have accelerated many aspects of translational research by allowing direct, definitive investigations. In particular, the use of mice has allowed genetic manipulation, adoptive transfer, immunization, and focused cell and tissue sampling, which w...
journal_title：Mucosal immunology
pub_type： 杂志文章,评审
doi：10.1038/mi.2010.85
更新日期：2011-03-01 00:00:00
abstract：:The roles of macrophages in type 2-driven inflammation and fibrosis remain unclear. Here, using CD11b-diphtheria toxin receptor (DTR) transgenic mice and three models of interleukin 13 (IL-13)-dependent inflammation, fibrosis, and immunity, we show that CD11b(+) F4/80(+) Ly6C(+) macrophages are required for the mainte...
journal_title：Mucosal immunology
pub_type： 杂志文章
doi：10.1038/mi.2015.34
更新日期：2016-01-01 00:00:00
abstract：:Leukotriene B4 receptor 1 (BLT1) triggers the migration of granulocytes and activated T cells; however, its role in B-cell function remains unclear. Here we report that BLT1 is required to induce the production of antigen-specific IgA against oral vaccine through mediating innate immune signals from commensal bacteria...
journal_title：Mucosal immunology
pub_type： 杂志文章
doi：10.1038/s41385-019-0175-z
更新日期：2019-09-01 00:00:00
abstract：:Rotaviruses (RV) are the leading cause of gastroenteritis in infants and children worldwide and are associated with high mortality predominately in low-income settings. The virus is classified into G and P serotypes and further into P genotypes based on differences in the surface-exposed proteins VP7 and VP4, respecti...
journal_title：Mucosal immunology
pub_type： 杂志文章,评审
doi：10.1038/mi.2014.114
更新日期：2015-01-01 00:00:00
abstract：:Induction of mucosal immunity is critical for protection from enteric pathogens. Heat shock protein gp96 is one of the primary peptide and protein chaperones located in the endoplasmic reticulum. We reported previously that a cell-secreted gp96-Ig fusion protein (gp96-Ig) mediated strong systemic, antigen-specific CD8...
journal_title：Mucosal immunology
pub_type： 杂志文章
doi：10.1038/mi.2009.127
更新日期：2010-03-01 00:00:00
abstract：:The communities of bacteria that reside in the intestinal tract are in constant competition within this dynamic and densely colonized environment. At homeostasis, the equilibrium that exists between these species and strains is shaped by their metabolism and also by pathways of active antagonism, which drive competiti...
journal_title：Mucosal immunology
pub_type： 杂志文章,评审
doi：10.1038/s41385-018-0053-0
更新日期：2019-01-01 00:00:00
abstract：:Nedd4 family interacting protein 1 (Ndfip1) is an adaptor protein that regulates Itch, an E3 ubiquitin ligase that ubiquitylates JunB, thereby preventing interleukin (IL)-4 and IL-5 production. Mice lacking Ndfip1 or Itch develop T helper type 2 (T(H)2)-mediated inflammation in the skin and lungs and die prematurely. ...
journal_title：Mucosal immunology
pub_type： 杂志文章
doi：10.1038/mi.2010.69
更新日期：2011-05-01 00:00:00
abstract：:Oral tolerance refers to the observation that prior feeding of an antigen induces local and systemic immune tolerance to that antigen. Physiologically, this process is probably of central importance for preventing inflammatory responses to the numerous dietary and microbial antigens present in the gut. Defective oral ...
journal_title：Mucosal immunology
pub_type： 杂志文章,评审
doi：10.1038/mi.2010.25
更新日期：2010-07-01 00:00:00
abstract：:Individuals with one atopic disease are far more likely to develop a second. Approximately half of all atopic dermatitis (AD) patients subsequently develop asthma, particularly those with severe AD. This association, suggesting a role for AD as an entry point for subsequent allergic disease, is a phenomenon known as t...
journal_title：Mucosal immunology
pub_type： 杂志文章
doi：10.1038/mi.2012.14
更新日期：2012-05-01 00:00:00
abstract：:Intestinal CD8αα intraepithelial T lymphocytes (T-IELs) have a key role in mucosal immunity and, unlike other T cells, were proposed to differentiate locally. In apparent contradiction, these cells were also shown to originate from a wave of thymus migrants colonizing the gut in the first 3 weeks after birth. We here ...
journal_title：Mucosal immunology
pub_type： 杂志文章
doi：10.1038/mi.2010.47
更新日期：2011-01-01 00:00:00
abstract：:Acute intestinal inflammation includes the early accumulation of neutrophils (PMN). Based on recent evidence that PMN infiltration "imprints" changes in the local tissue environment through local oxygen depletion and the release of adenine nucleotides, we hypothesized that the interaction between transmigrating PMN an...
journal_title：Mucosal immunology
pub_type： 杂志文章
doi：10.1038/s41385-019-0237-2
更新日期：2020-03-01 00:00:00
abstract：:Newborns are highly susceptible to pathogenic infections with significant worldwide morbidity possibly due to an immature immune system. Recently, we reported that Propionibacterium strain, P. UF1, isolated from the gut microbiota of preterm infants, induced the differentiation of bacteria-specific Th17 cells. Here, w...
journal_title：Mucosal immunology
pub_type： 杂志文章
doi：10.1038/s41385-018-0125-1
更新日期：2019-03-01 00:00:00
abstract：:How the immune system senses aeroallergens and triggers an aberrant inflammation is poorly understood. Dectin-2 is a house dust mite (HDM)-sensing pattern recognition receptor. In a 3-week mouse model of repeated intranasal HDM challenge, anti-Dectin-2 potently attenuated the characteristic allergic inflammation and a...
journal_title：Mucosal immunology
pub_type： 杂志文章
doi：10.1038/mi.2013.74
更新日期：2014-05-01 00:00:00
abstract：:Cigarette smoke has been associated with susceptibility to different pulmonary and airway diseases. Impaired alveolar macrophages (AMs) that are major phagocytes in the lung have been associated with patients with airway diseases and active smokers. In the current report, we show that exposure to second-hand cigarette...
journal_title：Mucosal immunology
pub_type： 杂志文章
doi：10.1038/mi.2015.120
更新日期：2016-07-01 00:00:00
abstract：:Eosinophilic esophagitis (EoE) is an allergic inflammatory disease of the esophagus featuring increased esophageal interleukin-13 (IL-13) levels and impaired barrier function. Herein, we investigated leucine-rich repeat-containing protein 31 (LRRC31) in human EoE esophageal tissue and IL-13-treated esophageal epitheli...
journal_title：Mucosal immunology
pub_type： 杂志文章
doi：10.1038/mi.2015.98
更新日期：2016-05-01 00:00:00
