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Repeated vaginal administration of trimeric HIV-1 clade C gp140 induces serum and mucosal antibody responses.

Abstract：

:Vaccine-mediated prevention of primary infection with human immunodeficiency virus (HIV) may require the sustained production of antibody at mucosal portals of entry. Here, we describe a novel approach of repeated mucosal immunization by delivering an HIV-1 envelope glycoprotein (gp) in a gel formulated for intravaginal delivery. Rabbits were immunized over one to three 19-day cycles of intravaginal dosing with soluble recombinant trimeric HIV-1 clade C gp140 administered in Carbopol gel. The formulation was well tolerated. A single immunization cycle induced immunoglobulin G (IgG) antibody detected in the serum and female genital tract, and titers were boosted on further immunization. Vaccine-induced serum antibodies neutralized the infectivity of a pseudovirus carrying a heterologous clade C envelope. Our data prove the concept that repeated exposure of the female genital tract to HIV envelope can induce mucosally detectable antibody.

journal_name

Mucosal Immunol

journal_title

Mucosal immunology

authors

Cranage MP,Fraser CA,Stevens Z,Huting J,Chang M,Jeffs SA,Seaman MS,Cope A,Cole T,Shattock RJ

doi

10.1038/mi.2009.110

subject

Has Abstract

pub_date

2010-01-01 00:00:00

pages

57-68

issue

1

eissn

1933-0219

issn

1935-3456

pii

mi2009110

journal_volume

3

pub_type

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