Nod1, but not the ASC inflammasome, contributes to induction of IL-1β secretion in human trophoblasts after sensing of Chlamydia trachomatis.

abstract：:Periostin is an extracellular matrix protein that has been primarily studied in the context of the heart, where it has been shown to promote cardiac repair and remodeling. In this study, we focused on the role of periostin in an allergic eosinophilic inflammatory disease (eosinophilic esophagitis (EE)) known to involv...

journal_title：Mucosal immunology

authors： Blanchard C,Mingler MK,McBride M,Putnam PE,Collins MH,Chang G,Stringer K,Abonia JP,Molkentin JD,Rothenberg ME

更新日期：2008-07-01 00:00:00

abstract：:Women with asymptomatic Neisseria gonorrhoeae infection are at risk of developing pelvic inflammatory disease (PID) if the bacteria ascend from the endocervix into the uterus and oviducts. Factors that affect disease severity, ranging from mild discomfort to severe inflammation, pain, and infertility, remain elusive. ...

journal_title：Mucosal immunology

authors： Islam EA,Shaik-Dasthagirisaheb Y,Kaushic C,Wetzler LM,Gray-Owen SD

更新日期：2016-07-01 00:00:00

abstract：:Individuals with one atopic disease are far more likely to develop a second. Approximately half of all atopic dermatitis (AD) patients subsequently develop asthma, particularly those with severe AD. This association, suggesting a role for AD as an entry point for subsequent allergic disease, is a phenomenon known as t...

journal_title：Mucosal immunology

authors： Han H,Xu W,Headley MB,Jessup HK,Lee KS,Omori M,Comeau MR,Marshak-Rothstein A,Ziegler SF

更新日期：2012-05-01 00:00:00

abstract：:The mechanism regulating the gastrointestinal epithelial barrier remains poorly understood. We herein demonstrate that Absent in melanoma-2 (AIM2) contributes to the maintenance of intestinal barrier integrity and defense against bacterial infection. AIM2-deficient mice displayed an increased susceptibility to mucosal...

journal_title：Mucosal immunology

authors： Hu GQ,Song PX,Li N,Chen W,Lei QQ,Yu SX,Zhang XJ,Du CT,Deng XM,Han WY,Yang YJ

更新日期：2016-09-01 00:00:00

abstract：:In a nasal vaccine against influenza, the activation of natural killer T (NKT) cells by intranasal coadministration of alpha-galactosylceramide (alpha-GalCer) can potently enhance protective immune responses. The results of this study show that the NKT cell-activated nasal vaccine can induce an effective cross-protect...

journal_title：Mucosal immunology

authors： Kamijuku H,Nagata Y,Jiang X,Ichinohe T,Tashiro T,Mori K,Taniguchi M,Hase K,Ohno H,Shimaoka T,Yonehara S,Odagiri T,Tashiro M,Sata T,Hasegawa H,Seino KI

更新日期：2008-05-01 00:00:00

abstract：:There continues to be a major need for more effective inflammatory bowel disease (IBD) therapies. IL-13Rα2 is a decoy receptor that binds the cytokine IL-13 with high affinity and diminishes its STAT6-mediated effector functions. Previously, we found that IL-13Rα2 was necessary for IBD in mice deficient in the anti-in...

journal_title：Mucosal immunology

authors： Karmele EP,Pasricha TS,Ramalingam TR,Thompson RW,Gieseck RL 3rd,Knilans KJ,Hegen M,Farmer M,Jin F,Kleinman A,Hinds DA,23andMe Research Team.,Almeida Pereira T,de Queiroz Prado R,Bing N,Tchistiakova L,Kasaian MT,Wynn TA

更新日期：2019-09-01 00:00:00

abstract：:Induction of mucosal immunoglobulin-A (IgA) capable of providing a first line of defense against bacterial and viral pathogens remains a major goal of needle-free vaccines given via mucosal routes. Innate immune cells are known to play a central role in induction of IgA responses by mucosal vaccines, but the relative ...

journal_title：Mucosal immunology

authors： Jee J,Bonnegarde-Bernard A,Duverger A,Iwakura Y,Cormet-Boyaka E,Martin TL,Steiner HE,Bachman RC,Boyaka PN

更新日期：2015-07-01 00:00:00

abstract：:The mucosal immune system is charged with defending the host's vast interfaces with the outside world from the enormous and diverse group of microbes that colonizes these surfaces. A key means by which the mucosal immune system protects the host from such diverse microbes is using germ-line-encoded receptors that targ...

journal_title：Mucosal immunology

authors： Vijay-Kumar M,Gewirtz AT

更新日期：2009-05-01 00:00:00

abstract：:The mechanisms underlying the massive gastrointestinal tract CD4 T-cell depletion in human immunodeficiency virus (HIV) infection are not well understood nor is it clear whether similar depletion is manifest at other mucosal surfaces. Studies of T-cell and virus dynamics in different anatomical sites have begun to ill...

journal_title：Mucosal immunology

authors： Brenchley JM,Knox KS,Asher AI,Price DA,Kohli LM,Gostick E,Hill BJ,Hage CA,Brahmi Z,Khoruts A,Twigg HL 3rd,Schacker TW,Douek DC

更新日期：2008-01-01 00:00:00

abstract：:Crohn's disease (CD) is often accompanied by the complications of intestinal strictures and fistulas. These complications remain obstacles in CD treatment. In recent years, the importance of epithelial-mesenchymal transition in the pathogenesis of CD-associated fistulas and intestinal fibrosis has become apparent. Epi...

journal_title：Mucosal immunology

authors： Jiang H,Shen J,Ran Z

更新日期：2018-03-01 00:00:00

abstract：:Nedd4 family interacting protein 1 (Ndfip1) is an adaptor protein that regulates Itch, an E3 ubiquitin ligase that ubiquitylates JunB, thereby preventing interleukin (IL)-4 and IL-5 production. Mice lacking Ndfip1 or Itch develop T helper type 2 (T(H)2)-mediated inflammation in the skin and lungs and die prematurely. ...

journal_title：Mucosal immunology

authors： Ramon HE,Riling CR,Bradfield J,Yang B,Hakonarson H,Oliver PM

更新日期：2011-05-01 00:00:00

abstract：:Previously we have extensively characterized Salmonella enterica serovar Typhi (S. Typhi)-specific cell-mediated immune (CMI) responses in volunteers orally immunized with the licensed Ty21a typhoid vaccine. In this study we measured Salmonella-specific multifunctional (MF) CD8+ T-cell responses to further investigate...

journal_title：Mucosal immunology

authors： Wahid R,Fresnay S,Levine MM,Sztein MB

更新日期：2015-11-01 00:00:00

abstract：:Pneumonia caused by Streptococcus pneumoniae (Sp) remains a leading cause of serious illness and death worldwide. Immunization with conjugated pneumococcal vaccine has lowered the colonization rate and consequently invasive diseases by inducing serotype-specific antibodies. However, many of the current pneumonia cases...

journal_title：Mucosal immunology

authors： Wang Y,Jiang B,Guo Y,Li W,Tian Y,Sonnenberg GF,Weiser JN,Ni X,Shen H

更新日期：2017-01-01 00:00:00

abstract：:Natural intraepithelial lymphocytes (IELs) are thymus-derived adaptive immune cells, which are important contributors to intestinal immune homeostasis. Similar to other innate-like T cells, they are induced in the thymus through high-avidity interaction that would otherwise lead to clonal deletion in conventional CD4 ...

journal_title：Mucosal immunology

authors： Hummel JF,Zeis P,Ebert K,Fixemer J,Konrad P,Schachtrup C,Arnold SJ,Grün D,Tanriver Y

更新日期：2020-03-01 00:00:00

abstract：:Microbial metabolites are an emerging class of mediators influencing CD4+ T-cell function. To advance the understanding of direct causal microbial factors contributing to Crohn's disease, we screened 139 predicted Crohn's disease-associated microbial metabolites for their bioactivity on human CD4+ T-cell functions ind...

journal_title：Mucosal immunology

authors： Chang YL,Rossetti M,Vlamakis H,Casero D,Sunga G,Harre N,Miller S,Humphries R,Stappenbeck T,Simpson KW,Sartor RB,Wu G,Lewis J,Bushman F,McGovern DPB,Salzman N,Borneman J,Xavier R,Huttenhower C,Braun J

更新日期：2019-03-01 00:00:00

abstract：:Intestinal CD8αα intraepithelial T lymphocytes (T-IELs) have a key role in mucosal immunity and, unlike other T cells, were proposed to differentiate locally. In apparent contradiction, these cells were also shown to originate from a wave of thymus migrants colonizing the gut in the first 3 weeks after birth. We here ...

journal_title：Mucosal immunology

authors： Peaudecerf L,dos Santos PR,Boudil A,Ezine S,Pardigon N,Rocha B

更新日期：2011-01-01 00:00:00

abstract：:While recent studies suggest that interleukin (IL)-1β production is modulated by macroautophagy or sensors of endoplasmic reticulum (ER) stress upon pro-inflammatory insult, autophagy and IL-1β production during viral infection has not been fully investigated. This was addressed using respiratory syncytial virus (RSV)...

journal_title：Mucosal immunology

authors： Reed M,Morris SH,Owczarczyk AB,Lukacs NW

更新日期：2015-09-01 00:00:00

abstract：:The study of animal immune physiology and animal models of human disease have accelerated many aspects of translational research by allowing direct, definitive investigations. In particular, the use of mice has allowed genetic manipulation, adoptive transfer, immunization, and focused cell and tissue sampling, which w...

journal_title：Mucosal immunology

authors： Gibbons DL,Spencer J

更新日期：2011-03-01 00:00:00

abstract：:Children born by cesarean section (CS) have an increased risk of developing inflammatory bowel disease (IBD), possibly due to skewed microbial colonization during birth and consequently impaired bacterial stimulation of the developing immune system. The aim of this study was to investigate the association between CS a...

journal_title：Mucosal immunology

authors： Zachariassen LF,Hansen AK,Krych L,Nielsen DS,Holm TL,Tougaard P,Hansen CHF

更新日期：2019-11-01 00:00:00

abstract：:Cigarette smoke has been associated with susceptibility to different pulmonary and airway diseases. Impaired alveolar macrophages (AMs) that are major phagocytes in the lung have been associated with patients with airway diseases and active smokers. In the current report, we show that exposure to second-hand cigarette...

journal_title：Mucosal immunology

authors： Subramaniam R,Mukherjee S,Chen H,Keshava S,Neuenschwander P,Shams H

更新日期：2016-07-01 00:00:00

abstract：:Colonization of the nasopharyngeal mucosa by meningococcus and other polysaccharide (PS)-encapsulated bacteria precedes invasion. PS-conjugate vaccines induce PS-specific B-cell memory (B(MEM)) and also prevent colonization, thus blocking person-to-person transmission, generating herd protection. However, in isolation...

journal_title：Mucosal immunology

authors： Clarke ET,Williams NA,Dull PM,Findlow J,Borrow R,Finn A,Heyderman RS

更新日期：2013-03-01 00:00:00

abstract：:Interleukin-17 (IL-17)-mediated immunity has emerged as a crucial host defense mechanism against Candida albicans infections in mucosal tissues and the skin. The precise mechanism by which the IL-17 pathway prevents fungal outgrowth has not been clarified. Neutrophils are critical for limiting fungal dissemination and...

journal_title：Mucosal immunology

authors： Trautwein-Weidner K,Gladiator A,Nur S,Diethelm P,LeibundGut-Landmann S

更新日期：2015-03-01 00:00:00

abstract：:Our studies have focused on understanding the mechanisms of interactions between the indigenous intestinal flora and the mammalian host in both physiological and nonphysiological conditions. In particular, we have focused on the function of innate microbial pattern recognition by Toll-like receptors in the context of ...

journal_title：Mucosal immunology

authors： Rakoff-Nahoum S,Medzhitov R

更新日期：2008-11-01 00:00:00

abstract：:Respiratory syncytial virus (RSV) is a leading cause of severe lower respiratory tract infections, especially in infants. Lung neutrophilia is a hallmark of RSV disease but the mechanism by which neutrophils are recruited and activated is unclear. Here, we investigate the innate immune signaling pathways underlying ne...

journal_title：Mucosal immunology

authors： Kirsebom FCM,Kausar F,Nuriev R,Makris S,Johansson C

更新日期：2019-09-01 00:00:00

abstract：:As the Bacillus Calmette-Guérin (BCG) vaccine does not confer long-lasting protection against lung Mycobacterium tuberculosis infection, the development of more efficient vaccines is greatly needed. Here, we used mycobacterial low-molecular weight proteins of the 6-kDa Early Secreted Antigenic Target (ESAT-6) protein ...

journal_title：Mucosal immunology

authors： Dong H,Stanek O,Salvador FR,Länger U,Morillon E,Ung C,Sebo P,Leclerc C,Majlessi L

更新日期：2013-05-01 00:00:00

abstract：:Celiac disease is a multifactorial disorder and provides a privileged model to decipher how the interplay between environmental and genetic factors can alter mucosal tolerance to a food antigen, lead to chronic intestinal inflammation, and ultimately promote T-cell lymphomagenesis. Here we summarize how HLA-DQ2/8 mole...

journal_title：Mucosal immunology

authors： Meresse B,Ripoche J,Heyman M,Cerf-Bensussan N

更新日期：2009-01-01 00:00:00

abstract：:Acute intestinal inflammation includes the early accumulation of neutrophils (PMN). Based on recent evidence that PMN infiltration "imprints" changes in the local tissue environment through local oxygen depletion and the release of adenine nucleotides, we hypothesized that the interaction between transmigrating PMN an...

journal_title：Mucosal immunology

authors： Cartwright IM,Curtis VF,Lanis JM,Alexeev EE,Welch N,Goldberg MS,Schaefer REM,Gao RY,Chun C,Fennimore B,Onyiah JC,Gerich ME,Dempsey PJ,Colgan SP

更新日期：2020-03-01 00:00:00

abstract：:Eosinophilic esophagitis (EoE) is an allergic inflammatory disease of the esophagus featuring increased esophageal interleukin-13 (IL-13) levels and impaired barrier function. Herein, we investigated leucine-rich repeat-containing protein 31 (LRRC31) in human EoE esophageal tissue and IL-13-treated esophageal epitheli...

journal_title：Mucosal immunology

authors： D'Mello RJ,Caldwell JM,Azouz NP,Wen T,Sherrill JD,Hogan SP,Rothenberg ME

更新日期：2016-05-01 00:00:00

abstract：:Epigallocatechin-3-gallate (EGCG), a natural and major ingredient of green tea, has been shown to have anti-inflammation and anti-HIV-1 properties. We demonstrated that the intrarectal administration of EGCG could protect rhesus macaques from repetitive, intrarectal challenges with low-dose SHIVSF162P3N. This protecti...

journal_title：Mucosal immunology

authors： Liu JB,Li JL,Zhuang K,Liu H,Wang X,Xiao QH,Li XD,Zhou RH,Zhou L,Ma TC,Zhou W,Liu MQ,Ho WZ

更新日期：2018-07-01 00:00:00

abstract：:Lung resident memory CD8 T cells (TRM) are critical for protection against respiratory viruses, but the cellular interactions required for their development are poorly understood. Herein we describe the necessity of classical monocytes for the establishment of lung TRM following influenza infection. We find that, duri...

journal_title：Mucosal immunology

authors： Dunbar PR,Cartwright EK,Wein AN,Tsukamoto T,Tiger Li ZR,Kumar N,Uddbäck IE,Hayward SL,Ueha S,Takamura S,Kohlmeier JE

更新日期：2020-01-01 00:00:00