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The reproductive cycle is a pathogenic determinant during gonococcal pelvic inflammatory disease in mice.

Abstract：

:Women with asymptomatic Neisseria gonorrhoeae infection are at risk of developing pelvic inflammatory disease (PID) if the bacteria ascend from the endocervix into the uterus and oviducts. Factors that affect disease severity, ranging from mild discomfort to severe inflammation, pain, and infertility, remain elusive. Herein we perform direct transcervical inoculation of N. gonorrhoeae into the uterus of mice to establish an infection that leads to PID. Profoundly different disease outcomes were apparent at different stages of the reproductive cycle. Mice that were infected during the diestrus stage of the reproductive cycle displayed extensive gonococcal penetration into the submucosa, severe inflammation, and clinical signs reflecting discomfort. Meanwhile, infection during the intervening estrus stage showed only modest effects. Furthermore, a gonococcal-specific humoral response was only elicited following the penetrative upper genital tract (UGT) infection during diestrus but not estrus. Strikingly, the potential for antibodies to contribute to protection during re-infection also depends upon the reproductive stage, as antigonococcal antibodies within the genital tract were markedly higher when mice were in diestrus. Combined, this work establishes a robust new model reflecting gonococcal PID in humans and reveals how the reproductive cycle determines the pathogenic outcome of gonococcal infections of the UGT.

journal_name

Mucosal Immunol

journal_title

Mucosal immunology

authors

Islam EA,Shaik-Dasthagirisaheb Y,Kaushic C,Wetzler LM,Gray-Owen SD

doi

10.1038/mi.2015.122

subject

Has Abstract

pub_date

2016-07-01 00:00:00

pages

1051-64

issue

4

eissn

1933-0219

issn

1935-3456

pii

mi2015122

journal_volume

9

pub_type

杂志文章

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