Abstract:
:Respiratory syncytial virus (RSV) is a leading cause of severe lower respiratory tract infections, especially in infants. Lung neutrophilia is a hallmark of RSV disease but the mechanism by which neutrophils are recruited and activated is unclear. Here, we investigate the innate immune signaling pathways underlying neutrophil recruitment and activation in RSV-infected mice. We show that MyD88/TRIF signaling is essential for lung neutrophil recruitment while MAVS signaling, leading to type I IFN production, is necessary for neutrophil activation. Consistent with that notion, administration of type I IFNs to the lungs of RSV-infected Mavs-/- mice partially activates lung neutrophils recruited via the MyD88/TRIF pathway. Conversely, lack of neutrophil recruitment to the lungs of RSV-infected Myd88/Trif-/- mice can be corrected by administration of chemoattractants and those neutrophils become fully activated. Interestingly, Myd88/Trif-/- mice did not have increased lung viral loads during RSV infection, suggesting that neutrophils are dispensable for viral control. Thus, two distinct pathogen sensing pathways collaborate for neutrophil recruitment and full activation during RSV infection.
journal_name
Mucosal Immunoljournal_title
Mucosal immunologyauthors
Kirsebom FCM,Kausar F,Nuriev R,Makris S,Johansson Cdoi
10.1038/s41385-019-0190-0subject
Has Abstractpub_date
2019-09-01 00:00:00pages
1244-1255issue
5eissn
1933-0219issn
1935-3456pii
10.1038/s41385-019-0190-0journal_volume
12pub_type
杂志文章abstract::Molecular mechanisms regulating transforming growth factor-beta (TGF-beta) induction of Foxp3 (forkhead box P3) expression and thus induction of induced regulatory T cells (Tregs) have been the focus of a great deal of study in recent years. It has become clear that this process is influenced by a number of factors as...
journal_title:Mucosal immunology
pub_type: 杂志文章,评审
doi:10.1038/mi.2010.7
更新日期:2010-05-01 00:00:00
abstract::Interleukin-17 (IL-17)-mediated immunity has emerged as a crucial host defense mechanism against Candida albicans infections in mucosal tissues and the skin. The precise mechanism by which the IL-17 pathway prevents fungal outgrowth has not been clarified. Neutrophils are critical for limiting fungal dissemination and...
journal_title:Mucosal immunology
pub_type: 杂志文章
doi:10.1038/mi.2014.57
更新日期:2015-03-01 00:00:00
abstract::Sphingolipids play a pivotal role in the pathogenesis of chronic obstructive pulmonary disease (COPD). However, little is known about the precise roles of sphingosine-1-phosphate (S1P), a bioactive sphingolipid metabolite, and its receptor modulation in COPD. In this study, we demonstrated that the S1P receptor modula...
journal_title:Mucosal immunology
pub_type: 杂志文章
doi:10.1038/s41385-018-0077-5
更新日期:2018-11-01 00:00:00
abstract::Cellular inhibitors of apoptosis proteins (cIAPs) are critical arbiters of cell death and key mediators of inflammation and innate immunity. cIAP2 is frequently overexpressed in colorectal cancer and in regenerating crypts of ulcerative colitis patients. However, its corresponding functions in intestinal homeostasis a...
journal_title:Mucosal immunology
pub_type: 杂志文章
doi:10.1038/mi.2015.46
更新日期:2016-01-01 00:00:00
abstract::Development of effective tuberculosis vaccines is hampered by insufficient understanding of protective immunity. Here, Woodworth et al.1 show secondary effector CD4 T cells generated after Mtb challenge of H56/CAF01 vaccinated mice display superior lung homing compared with primary effectors. Vaccination generates lar...
journal_title:Mucosal immunology
pub_type: 评论,杂志文章
doi:10.1038/mi.2016.110
更新日期:2017-03-01 00:00:00
abstract::Bacterial-induced intestinal inflammation is crucially dependent on interleukin (IL)-23 and is associated with CD4(+) T helper type 1 (Th1) and Th17 responses. However, the relative contributions of these subsets during the induction and resolution of colitis in T-cell-sufficient hosts remain unknown. We report that H...
journal_title:Mucosal immunology
pub_type: 杂志文章
doi:10.1038/mi.2013.11
更新日期:2013-11-01 00:00:00
abstract::The ultimate goal for vaccination is to stimulate protective immunological memory. Protection against infectious diseases not only relies on the magnitude of the humoral immune response, but more importantly on the quality and longevity of it. Adjuvants are critical components of most non-living vaccines. Although lit...
journal_title:Mucosal immunology
pub_type: 杂志文章,评审
doi:10.1038/mi.2010.54
更新日期:2010-11-01 00:00:00
abstract::Cholera is a severe diarrheal disease caused by the bacterium Vibrio cholerae (V. cholerae) that results in 3-4 million cases globally with 100,000-150,000 deaths reported annually. Mostly confined to developing nations, current strategies to control the spread of cholera include the provision of safe drinking water a...
journal_title:Mucosal immunology
pub_type: 杂志文章
doi:10.1038/s41385-019-0159-z
更新日期:2019-07-01 00:00:00
abstract::Neutrophils are implicated in the pathogenesis of tuberculosis (TB), a disease caused by Mycobacterium tuberculosis infection, but the mechanisms by which they promote disease are not fully understood. Neutrophils can express cytokines that influence TB progression, and so we compared neutrophil and T-cell expression ...
journal_title:Mucosal immunology
pub_type: 杂志文章
doi:10.1038/s41385-019-0195-8
更新日期:2019-11-01 00:00:00
abstract::Alpha B-crystallin (CRYAB) is an important member of the small heat shock protein family, and plays a protective and therapeutic role in neurological inflammation. CRYAB expression was assessed in cultured HT29 and Caco-2 cells and inflamed mucosa of patients with inflammatory bowel disease (IBD) and colitis models in...
journal_title:Mucosal immunology
pub_type: 杂志文章
doi:10.1038/s41385-019-0198-5
更新日期:2019-11-01 00:00:00
abstract::Microbial metabolites are an emerging class of mediators influencing CD4+ T-cell function. To advance the understanding of direct causal microbial factors contributing to Crohn's disease, we screened 139 predicted Crohn's disease-associated microbial metabolites for their bioactivity on human CD4+ T-cell functions ind...
journal_title:Mucosal immunology
pub_type: 杂志文章
doi:10.1038/s41385-018-0022-7
更新日期:2019-03-01 00:00:00
abstract::Dectin-1 (gene symbol: Clec7a) is a receptor for β-glucans that play an important role for the host defense against fungi. Recently, we showed that Clec7a-/- mice are resistant against dextran sodium sulfate (DSS)-induced colitis because of regulatory T-cell population expansion in the colon. The regulatory T-cell exp...
journal_title:Mucosal immunology
pub_type: 杂志文章
doi:10.1038/mi.2017.86
更新日期:2018-05-01 00:00:00
abstract::Natural intraepithelial lymphocytes (IELs) are thymus-derived adaptive immune cells, which are important contributors to intestinal immune homeostasis. Similar to other innate-like T cells, they are induced in the thymus through high-avidity interaction that would otherwise lead to clonal deletion in conventional CD4 ...
journal_title:Mucosal immunology
pub_type: 杂志文章
doi:10.1038/s41385-019-0220-y
更新日期:2020-03-01 00:00:00
abstract::Intestinal epithelial Na+/H+ exchange facilitated by the apical NHE3 (Slc9a3) is a highly regulated process inhibited by intestinal pathogens and in inflammatory bowel diseases. NHE3-/- mice develop spontaneous, bacterially mediated colitis, and IBD-like dysbiosis. Disruption of epithelial Na+/H+ exchange in IBD may t...
journal_title:Mucosal immunology
pub_type: 杂志文章
doi:10.1038/s41385-018-0035-2
更新日期:2018-09-01 00:00:00
abstract::Over the past 25 years, studies led in humans have considerably improved our understanding of celiac disease, a complex disease that is generally defined as an autoimmune-like enteropathy induced by dietary gluten in genetically predisposed individuals. Recently, large efforts were also invested in the development of ...
journal_title:Mucosal immunology
pub_type: 杂志文章,评审
doi:10.1038/mi.2014.102
更新日期:2015-01-01 00:00:00
abstract::The generation of tissue-resident memory T cells (TRM) is an essential aspect of immunity at mucosal surfaces, and it has been suggested that preferential generation of TRM is one of the principal advantages of mucosally administered vaccines. We have previously shown that antigen-specific, IL-17-producing CD4+ T cell...
journal_title:Mucosal immunology
pub_type: 杂志文章
doi:10.1038/s41385-019-0218-5
更新日期:2020-01-01 00:00:00
abstract::There continues to be a major need for more effective inflammatory bowel disease (IBD) therapies. IL-13Rα2 is a decoy receptor that binds the cytokine IL-13 with high affinity and diminishes its STAT6-mediated effector functions. Previously, we found that IL-13Rα2 was necessary for IBD in mice deficient in the anti-in...
journal_title:Mucosal immunology
pub_type: 杂志文章
doi:10.1038/s41385-019-0189-6
更新日期:2019-09-01 00:00:00
abstract::HIV prevention mandates an understanding of the mechanisms of mucosal immunity with attention to some unique features of the epidemic and mucosal environment in the developing world. An effective vaccine will have to induce mucosal protection against a highly diverse virus, which is equipped with a number of immune ev...
journal_title:Mucosal immunology
pub_type: 杂志文章,评审
doi:10.1038/mi.2009.23
更新日期:2009-07-01 00:00:00
abstract::The Gram-positive bacterium Streptococcus pneumoniae causes life-threatening infections, especially among immunocompromised patients. The host's immune system senses S. pneumoniae via different families of pattern recognition receptors, in particular the Toll-like receptor (TLR) family that promotes immune cell activa...
journal_title:Mucosal immunology
pub_type: 杂志文章
doi:10.1038/mi.2015.128
更新日期:2016-09-01 00:00:00
abstract::Human immunodeficiency virus/simian immunodeficiency virus (HIV/SIV) infections are believed to infect minimally activated CD4(+) T cells after viral entry. Not much is known about why SIV selectively targets these cells. Here we show that CD4(+) T cells that express high levels of the alpha4beta7 heterodimer are pref...
journal_title:Mucosal immunology
pub_type: 杂志文章
doi:10.1038/mi.2009.90
更新日期:2009-09-01 00:00:00
abstract::Leukotriene B4 receptor 1 (BLT1) triggers the migration of granulocytes and activated T cells; however, its role in B-cell function remains unclear. Here we report that BLT1 is required to induce the production of antigen-specific IgA against oral vaccine through mediating innate immune signals from commensal bacteria...
journal_title:Mucosal immunology
pub_type: 杂志文章
doi:10.1038/s41385-019-0175-z
更新日期:2019-09-01 00:00:00
abstract::Treatment of post-transplant patients with immunosuppressive drugs targeting the calcineurin-nuclear factor of activated T cells (NFAT) pathway, including cyclosporine A or tacrolimus, is commonly associated with a higher incidence of opportunistic infections, such as Aspergillus fumigatus, which can lead to severe li...
journal_title:Mucosal immunology
pub_type: 杂志文章
doi:10.1038/mi.2016.52
更新日期:2017-03-01 00:00:00
abstract::Group 3 innate lymphoid cells (ILC3s), a subset of the innate lymphoid cells, are abundantly present in the intestine and are crucial regulators of intestinal inflammation. Brg1 (Brahma-related gene 1), a catalytic subunit of the mammalian SWI-SNF-like chromatin-remodeling BAF complex, regulates the development and fu...
journal_title:Mucosal immunology
pub_type: 杂志文章
doi:10.1038/s41385-020-0317-3
更新日期:2021-01-01 00:00:00
abstract::Rotaviruses (RV) are the leading cause of gastroenteritis in infants and children worldwide and are associated with high mortality predominately in low-income settings. The virus is classified into G and P serotypes and further into P genotypes based on differences in the surface-exposed proteins VP7 and VP4, respecti...
journal_title:Mucosal immunology
pub_type: 杂志文章,评审
doi:10.1038/mi.2014.114
更新日期:2015-01-01 00:00:00
abstract::Insufficient T-cell responses contribute to the increased burden of viral respiratory disease in infancy. Neonatal dendritic cells (DCs) often provide defective activation of pathogen-specific T cells through mechanisms that are incompletely understood, which hinders vaccine design for this vulnerable age group. Enhan...
journal_title:Mucosal immunology
pub_type: 杂志文章
doi:10.1038/s41385-019-0234-5
更新日期:2020-03-01 00:00:00
abstract::Helicobacter suis infects the stomachs of both animals and humans, and can induce gastric mucosa-associated lymphoid tissue (MALT) lymphomas. It is known that CXC chemokine ligand 13 (CXCL13) is highly expressed in the Helicobacter-infected mice and gastric MALT lymphoma patients, but the pathway that links the activa...
journal_title:Mucosal immunology
pub_type: 杂志文章
doi:10.1038/mi.2014.14
更新日期:2014-09-01 00:00:00
abstract::Whereas gut IgA responses to the microbiota may be multi-centered and diverse, little is known about IgA responses to T-cell-dependent antigens following oral immunizations. Using a novel approach, gut IgA responses to oral hapten (4-hydroxy-3-nitrophenyl)acetyl-cholera toxin (NP-CT) conjugates were followed at the ce...
journal_title:Mucosal immunology
pub_type: 杂志文章
doi:10.1038/mi.2012.56
更新日期:2013-01-01 00:00:00
abstract::The mucosal immune system is charged with defending the host's vast interfaces with the outside world from the enormous and diverse group of microbes that colonizes these surfaces. A key means by which the mucosal immune system protects the host from such diverse microbes is using germ-line-encoded receptors that targ...
journal_title:Mucosal immunology
pub_type: 杂志文章,评审
doi:10.1038/mi.2009.9
更新日期:2009-05-01 00:00:00
abstract::Allergic diseases, which have reached epidemic proportions, are caused by inappropriate immune responses to a relatively small number of environmental proteins. The molecular basis for the propensity of specific proteins to promote maladaptive, allergic responses has been difficult to define. Recent data suggest that ...
journal_title:Mucosal immunology
pub_type: 杂志文章,评审
doi:10.1038/mi.2009.138
更新日期:2010-03-01 00:00:00
abstract::Induction of mucosal immunoglobulin-A (IgA) capable of providing a first line of defense against bacterial and viral pathogens remains a major goal of needle-free vaccines given via mucosal routes. Innate immune cells are known to play a central role in induction of IgA responses by mucosal vaccines, but the relative ...
journal_title:Mucosal immunology
pub_type: 杂志文章
doi:10.1038/mi.2014.105
更新日期:2015-07-01 00:00:00