Abstract:
:Development of effective tuberculosis vaccines is hampered by insufficient understanding of protective immunity. Here, Woodworth et al.1 show secondary effector CD4 T cells generated after Mtb challenge of H56/CAF01 vaccinated mice display superior lung homing compared with primary effectors. Vaccination generates large populations of parenchymal lung effector cells by inducing CXCR3+KLRG1- cells that continuously migrate from lymph nodes to lung, and limiting the generation of non-protective CX3CR1+KLRG1+ intravascular effectors, providing insight vaccine-mediated protection against tuberculosis.
journal_name
Mucosal Immunoljournal_title
Mucosal immunologyauthors
Barber DLdoi
10.1038/mi.2016.110subject
Has Abstractpub_date
2017-03-01 00:00:00pages
318-321issue
2eissn
1933-0219issn
1935-3456pii
mi2016110journal_volume
10pub_type
评论,杂志文章abstract::Our studies have focused on understanding the mechanisms of interactions between the indigenous intestinal flora and the mammalian host in both physiological and nonphysiological conditions. In particular, we have focused on the function of innate microbial pattern recognition by Toll-like receptors in the context of ...
journal_title:Mucosal immunology
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abstract::Regulation of respiratory mucosal immunity by microbial-derived metabolites has been a proposed mechanism that may provide airway protection. Here we examine the effect of oral Lactobacillus johnsonii supplementation on metabolic and immune response dynamics during respiratory syncytial virus (RSV) infection. L. johns...
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abstract::Interleukin-17 (IL-17)-mediated immunity has emerged as a crucial host defense mechanism against Candida albicans infections in mucosal tissues and the skin. The precise mechanism by which the IL-17 pathway prevents fungal outgrowth has not been clarified. Neutrophils are critical for limiting fungal dissemination and...
journal_title:Mucosal immunology
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abstract::Cross-presentation of cellular antigens is crucial for priming CD8(+) T cells, and generating immunity to intracellular pathogens--particularly viruses. It is unclear which intestinal phagocytes perform this function in vivo. To address this, we examined dendritic cells (DCs) from the intestinal lymph of IFABP-tOVA 23...
journal_title:Mucosal immunology
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abstract::Leptin is an adipocytokine that links nutrition to immunity. Previous observation that a genetic polymorphism in the leptin receptor affected susceptibility to Entamoeba histolytica infection led to the hypothesis that leptin signaling has a protective role during intestinal amebic infection. In this study we show tha...
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abstract::Acute intestinal inflammation includes the early accumulation of neutrophils (PMN). Based on recent evidence that PMN infiltration "imprints" changes in the local tissue environment through local oxygen depletion and the release of adenine nucleotides, we hypothesized that the interaction between transmigrating PMN an...
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journal_title:Mucosal immunology
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journal_title:Mucosal immunology
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journal_title:Mucosal immunology
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journal_title:Mucosal immunology
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journal_title:Mucosal immunology
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journal_title:Mucosal immunology
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journal_title:Mucosal immunology
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journal_title:Mucosal immunology
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abstract::T helper (Th)1 and Th2 cells play decisive roles in the regulation of resistance vs. susceptibility to pulmonary cryptococcosis. To study the function of interleukin (IL)-4 receptor (IL-4R) on Th cells in pulmonary cryptococcosis, we infected mice specifically lacking IL-4Rα on CD4(+) T cells (Lck(Cre)IL-4Rα(-/lox) mi...
journal_title:Mucosal immunology
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journal_title:Mucosal immunology
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journal_title:Mucosal immunology
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journal_title:Mucosal immunology
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abstract::Intestinal CD8αα intraepithelial T lymphocytes (T-IELs) have a key role in mucosal immunity and, unlike other T cells, were proposed to differentiate locally. In apparent contradiction, these cells were also shown to originate from a wave of thymus migrants colonizing the gut in the first 3 weeks after birth. We here ...
journal_title:Mucosal immunology
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