当前位置： SCI文献检索 > Mucosal Immunology期刊下所有文献 > CCR2 mediates increased susceptibility to post-H1N1 bacterial pneumonia by limiting dendritic cell induction of IL-17.

CCR2 mediates increased susceptibility to post-H1N1 bacterial pneumonia by limiting dendritic cell induction of IL-17.

Abstract：

:Post influenza bacterial pneumonia is associated with significant mortality and morbidity. Dendritic cells (DCs) play a crucial role in host defense against bacterial pneumonia, but their contribution to post influenza-susceptibility to secondary bacterial pneumonia is incompletely understood. WT and CCR2-/- mice were infected with 100 plaque forming units (pfu) H1N1 intranasally alone or were challenged on day 5 with 7 × 107 colony forming units (cfu) methicillin-resistant Staphylococcus aureus intratracheally. WT mice express abundant CCL2 mRNA and protein post-H1N1 alone or dual infection. CCR2-/- mice had significantly higher survival as compared to WT mice, associated with significantly improved bacterial clearance at 24 and 48 h (10-fold and 14-fold, respectively) post bacterial challenge. There was robust upregulation of IL-23 and IL-17 as well as downregulation of IL-27 expression in CCR2-/- mice following sequential infection as compared to WT mice, which was also associated with significantly greater accumulation of CD103+ DC. Finally, WT mice treated with a CCR2 inhibitor showed improved bacterial clearance in association with similar cytokine profiles as CCR2-/- mice. Thus, CCR2 significantly contributes to increased susceptibility to bacterial infection after influenza pneumonia likely via altered dendritic cell responses and thus, CCR2 antagonism represents a potential therapeutic strategy.

journal_name

Mucosal Immunol

journal_title

Mucosal immunology

authors

Gurczynski SJ,Nathani N,Warheit-Niemi HI,Hult EM,Podsiad A,Deng J,Zemans RL,Bhan U,Moore BB

doi

10.1038/s41385-018-0106-4

subject

Has Abstract

pub_date

2019-03-01 00:00:00

pages

518-530

issue

2

eissn

1933-0219

issn

1935-3456

pii

10.1038/s41385-018-0106-4

journal_volume

12

pub_type

杂志文章

相关文献

Mucosal Immunology文献大全
  • Sphingosine-1-phosphate receptor-1 (S1P1) is expressed by lymphocytes, dendritic cells, and endothelium and modulated during inflammatory bowel disease.

    abstract：:The sphingosine-1-phosphate receptor-1 (S1P1) agonist ozanimod ameliorates ulcerative colitis, yet its mechanism of action is unknown. Here, we examine the cell subsets that express S1P1 in intestine using S1P1-eGFP mice, the regulation of S1P1 expression in lymphocytes after administration of dextran sulfate sodium (...

    journal_title：Mucosal immunology

    pub_type： 杂志文章

    doi：10.1038/mi.2016.35

    authors： Karuppuchamy T,Behrens EH,González-Cabrera P,Sarkisyan G,Gima L,Boyer JD,Bamias G,Jedlicka P,Veny M,Clark D,Peach R,Scott F,Rosen H,Rivera-Nieves J

    更新日期：2017-01-01 00:00:00

  • Immunization with Ty21a live oral typhoid vaccine elicits crossreactive multifunctional CD8+ T-cell responses against Salmonella enterica serovar Typhi, S. Paratyphi A, and S. Paratyphi B in humans.

    abstract：:Previously we have extensively characterized Salmonella enterica serovar Typhi (S. Typhi)-specific cell-mediated immune (CMI) responses in volunteers orally immunized with the licensed Ty21a typhoid vaccine. In this study we measured Salmonella-specific multifunctional (MF) CD8+ T-cell responses to further investigate...

    journal_title：Mucosal immunology

    pub_type： 杂志文章

    doi：10.1038/mi.2015.24

    authors： Wahid R,Fresnay S,Levine MM,Sztein MB

    更新日期：2015-11-01 00:00:00

  • Re-utilization of germinal centers in multiple Peyer's patches results in highly synchronized, oligoclonal, and affinity-matured gut IgA responses.

    abstract：:Whereas gut IgA responses to the microbiota may be multi-centered and diverse, little is known about IgA responses to T-cell-dependent antigens following oral immunizations. Using a novel approach, gut IgA responses to oral hapten (4-hydroxy-3-nitrophenyl)acetyl-cholera toxin (NP-CT) conjugates were followed at the ce...

    journal_title：Mucosal immunology

    pub_type： 杂志文章

    doi：10.1038/mi.2012.56

    authors： Bergqvist P,Stensson A,Hazanov L,Holmberg A,Mattsson J,Mehr R,Bemark M,Lycke NY

    更新日期：2013-01-01 00:00:00

  • Generation of protective pneumococcal-specific nasal resident memory CD4+ T cells via parenteral immunization.

    abstract：:The generation of tissue-resident memory T cells (TRM) is an essential aspect of immunity at mucosal surfaces, and it has been suggested that preferential generation of TRM is one of the principal advantages of mucosally administered vaccines. We have previously shown that antigen-specific, IL-17-producing CD4+ T cell...

    journal_title：Mucosal immunology

    pub_type： 杂志文章

    doi：10.1038/s41385-019-0218-5

    authors： O'Hara JM,Redhu NS,Cheung E,Robertson NG,Patik I,Sayed SE,Thompson CM,Herd M,Lucas KB,Conaway E,Morton CC,Farber DL,Malley R,Horwitz BH

    更新日期：2020-01-01 00:00:00

  • The emergence of pathogenic TNF/iNOS producing dendritic cells (Tip-DCs) in a malaria model of acute respiratory distress syndrome (ARDS) is dependent on CCR4.

    abstract：:Malaria-associated acute respiratory distress syndrome (MA-ARDS) and acute lung injury (ALI) are complications that cause lung damage and often leads to death. The MA-ARDS/ALI is associated with a Type 1 inflammatory response mediated by T lymphocytes and IFN-γ. Here, we used the Plasmodium berghei NK65 (PbN)-induced ...

    journal_title：Mucosal immunology

    pub_type： 杂志文章

    doi：10.1038/s41385-018-0093-5

    authors： Galvão-Filho B,de Castro JT,Figueiredo MM,Rosmaninho CG,Antonelli LRDV,Gazzinelli RT

    更新日期：2019-03-01 00:00:00

  • Restoring cigarette smoke-induced impairment of efferocytosis in alveolar macrophages.

    abstract：:Cigarette smoke has been associated with susceptibility to different pulmonary and airway diseases. Impaired alveolar macrophages (AMs) that are major phagocytes in the lung have been associated with patients with airway diseases and active smokers. In the current report, we show that exposure to second-hand cigarette...

    journal_title：Mucosal immunology

    pub_type： 杂志文章

    doi：10.1038/mi.2015.120

    authors： Subramaniam R,Mukherjee S,Chen H,Keshava S,Neuenschwander P,Shams H

    更新日期：2016-07-01 00:00:00

  • Leptin signaling in intestinal epithelium mediates resistance to enteric infection by Entamoeba histolytica.

    abstract：:Leptin is an adipocytokine that links nutrition to immunity. Previous observation that a genetic polymorphism in the leptin receptor affected susceptibility to Entamoeba histolytica infection led to the hypothesis that leptin signaling has a protective role during intestinal amebic infection. In this study we show tha...

    journal_title：Mucosal immunology

    pub_type： 杂志文章

    doi：10.1038/mi.2010.76

    authors： Guo X,Roberts MR,Becker SM,Podd B,Zhang Y,Chua SC Jr,Myers MG Jr,Duggal P,Houpt ER,Petri WA Jr

    更新日期：2011-05-01 00:00:00

  • Lactobacillus johnsonii supplementation attenuates respiratory viral infection via metabolic reprogramming and immune cell modulation.

    abstract：:Regulation of respiratory mucosal immunity by microbial-derived metabolites has been a proposed mechanism that may provide airway protection. Here we examine the effect of oral Lactobacillus johnsonii supplementation on metabolic and immune response dynamics during respiratory syncytial virus (RSV) infection. L. johns...

    journal_title：Mucosal immunology

    pub_type： 杂志文章

    doi：10.1038/mi.2017.13

    authors： Fonseca W,Lucey K,Jang S,Fujimura KE,Rasky A,Ting HA,Petersen J,Johnson CC,Boushey HA,Zoratti E,Ownby DR,Levine AM,Bobbit KR,Lynch SV,Lukacs NW

    更新日期：2017-11-01 00:00:00

  • Plasmacytoid dendritic cells are scarcely represented in the human gut mucosa and are not recruited to the celiac lesion.

    abstract：:Celiac disease (CD) is a chronic small intestinal inflammation precipitated by gluten ingestion. According to case reports, interferon (IFN)-α administration may induce development of overt CD. Plasmacytoid dendritic cells (PDCs) were thought to be the source of IFN-α and promote a T helper type 1 response leading to ...

    journal_title：Mucosal immunology

    pub_type： 杂志文章

    doi：10.1038/mi.2012.136

    authors： Ráki M,Beitnes AC,Lundin KE,Jahnsen J,Jahnsen FL,Sollid LM

    更新日期：2013-09-01 00:00:00

  • Airway T cells protect against RSV infection in the absence of antibody.

    abstract：:This corrects the article DOI: 10.1038/mi.2017.46. ...

    journal_title：Mucosal immunology

    pub_type： 杂志文章,已发布勘误

    doi：10.1038/mi.2017.79

    authors： Kinnear E,Lambert L,McDonald JU,Cheeseman HM,Caproni LJ,Tregoning JS

    更新日期：2018-01-01 00:00:00

  • Periodontitis, Porphyromonas, and the pathogenesis of rheumatoid arthritis.

    abstract：:Epidemiological data indicate a link between rheumatoid arthritis (RA) and periodontal disease (PD). In vitro and in vivo studies have sought to dissect potential mechanisms by which PD may contribute to initiation and progression of RA. However, these are both multifactorial, chronic diseases, and their complex etiol...

    journal_title：Mucosal immunology

    pub_type： 杂志文章,评审

    doi：10.1038/mi.2011.66

    authors： Farquharson D,Butcher JP,Culshaw S

    更新日期：2012-03-01 00:00:00

  • Macrophages are critical to the maintenance of IL-13-dependent lung inflammation and fibrosis.

    abstract：:The roles of macrophages in type 2-driven inflammation and fibrosis remain unclear. Here, using CD11b-diphtheria toxin receptor (DTR) transgenic mice and three models of interleukin 13 (IL-13)-dependent inflammation, fibrosis, and immunity, we show that CD11b(+) F4/80(+) Ly6C(+) macrophages are required for the mainte...

    journal_title：Mucosal immunology

    pub_type： 杂志文章

    doi：10.1038/mi.2015.34

    authors： Borthwick LA,Barron L,Hart KM,Vannella KM,Thompson RW,Oland S,Cheever A,Sciurba J,Ramalingam TR,Fisher AJ,Wynn TA

    更新日期：2016-01-01 00:00:00

  • Mechanism of NKT cell activation by intranasal coadministration of alpha-galactosylceramide, which can induce cross-protection against influenza viruses.

    abstract：:In a nasal vaccine against influenza, the activation of natural killer T (NKT) cells by intranasal coadministration of alpha-galactosylceramide (alpha-GalCer) can potently enhance protective immune responses. The results of this study show that the NKT cell-activated nasal vaccine can induce an effective cross-protect...

    journal_title：Mucosal immunology

    pub_type： 杂志文章

    doi：10.1038/mi.2008.2

    authors： Kamijuku H,Nagata Y,Jiang X,Ichinohe T,Tashiro T,Mori K,Taniguchi M,Hase K,Ohno H,Shimaoka T,Yonehara S,Odagiri T,Tashiro M,Sata T,Hasegawa H,Seino KI

    更新日期：2008-05-01 00:00:00

  • The role of the gut as a primary lymphoid organ: CD8αα intraepithelial T lymphocytes in euthymic mice derive from very immature CD44+ thymocyte precursors.

    abstract：:Intestinal CD8αα intraepithelial T lymphocytes (T-IELs) have a key role in mucosal immunity and, unlike other T cells, were proposed to differentiate locally. In apparent contradiction, these cells were also shown to originate from a wave of thymus migrants colonizing the gut in the first 3 weeks after birth. We here ...

    journal_title：Mucosal immunology

    pub_type： 杂志文章

    doi：10.1038/mi.2010.47

    authors： Peaudecerf L,dos Santos PR,Boudil A,Ezine S,Pardigon N,Rocha B

    更新日期：2011-01-01 00:00:00

  • Tissue-specific differentiation of colonic macrophages requires TGFβ receptor-mediated signaling.

    abstract：:Intestinal macrophages (mφ) form one of the largest populations of mφ in the body and are vital for the maintenance of gut homeostasis. They have several unique properties and are derived from local differentiation of classical Ly6Chi monocytes, but the factors driving this tissue-specific process are not understood. ...

    journal_title：Mucosal immunology

    pub_type： 杂志文章

    doi：10.1038/mi.2016.142

    authors： Schridde A,Bain CC,Mayer JU,Montgomery J,Pollet E,Denecke B,Milling SWF,Jenkins SJ,Dalod M,Henri S,Malissen B,Pabst O,Mcl Mowat A

    更新日期：2017-11-01 00:00:00

  • IL-22-producing CD4+ cells are depleted in actively inflamed colitis tissue.

    abstract：:T helper type (Th17) cytokines such as interleukin (IL)-17A and IL-22 are important in maintaining mucosal barrier function and may be important in the pathogenesis of inflammatory bowel diseases (IBDs). Here, we analyzed cells from the colon of IBD patients and show that Crohn's disease (CD) patients had significantl...

    journal_title：Mucosal immunology

    pub_type： 杂志文章

    doi：10.1038/mi.2013.31

    authors： Leung JM,Davenport M,Wolff MJ,Wiens KE,Abidi WM,Poles MA,Cho I,Ullman T,Mayer L,Loke P

    更新日期：2014-01-01 00:00:00

  • BLT1 mediates commensal bacteria-dependent innate immune signals to enhance antigen-specific intestinal IgA responses.

    abstract：:Leukotriene B4 receptor 1 (BLT1) triggers the migration of granulocytes and activated T cells; however, its role in B-cell function remains unclear. Here we report that BLT1 is required to induce the production of antigen-specific IgA against oral vaccine through mediating innate immune signals from commensal bacteria...

    journal_title：Mucosal immunology

    pub_type： 杂志文章

    doi：10.1038/s41385-019-0175-z

    authors： Nagatake T,Hirata SI,Koga T,Kuroda E,Kobari S,Suzuki H,Hosomi K,Matsumoto N,Yanrismet Y,Shimojou M,Morimoto S,Sasaki F,Ishii KJ,Yokomizo T,Kunisawa J

    更新日期：2019-09-01 00:00:00

  • Innate lymphoid cells: models of plasticity for immune homeostasis and rapid responsiveness in protection.

    abstract：:Innate lymphoid cells (ILCs) have stormed onto the immune landscape as "newly discovered" cell types. These tissue-resident sentinels are enriched at mucosal surfaces and engage in complex cross talk with elements of the adaptive immune system and microenvironment to orchestrate immune homeostasis. Many parallels exis...

    journal_title：Mucosal immunology

    pub_type： 杂志文章,评审

    doi：10.1038/mi.2016.64

    authors： Almeida FF,Belz GT

    更新日期：2016-09-01 00:00:00

  • Joint expedition: linking gut inflammation to arthritis.

    abstract：:The tight connection between intestinal inflammation and arthritis in spondyloarthritis (SpA) has been studied extensively. Subclinical gut inflammation, which can be considered as a model for early Crohn's disease, was shown to be strongly associated with joint inflammation. Several early mucosal abnormalities were u...

    journal_title：Mucosal immunology

    pub_type： 杂志文章,评审

    doi：10.1038/mi.2008.24

    authors： Jacques P,Elewaut D

    更新日期：2008-09-01 00:00:00

  • Neonatal intestinal immune regulation by the commensal bacterium, P. UF1.

    abstract：:Newborns are highly susceptible to pathogenic infections with significant worldwide morbidity possibly due to an immature immune system. Recently, we reported that Propionibacterium strain, P. UF1, isolated from the gut microbiota of preterm infants, induced the differentiation of bacteria-specific Th17 cells. Here, w...

    journal_title：Mucosal immunology

    pub_type： 杂志文章

    doi：10.1038/s41385-018-0125-1

    authors： Ge Y,Gong M,Colliou N,Zadeh M,Li J,Jones DP,Li S,Mohamadzadeh M

    更新日期：2019-03-01 00:00:00

  • Innate immune recognition of the indigenous microbial flora.

    abstract：:Our studies have focused on understanding the mechanisms of interactions between the indigenous intestinal flora and the mammalian host in both physiological and nonphysiological conditions. In particular, we have focused on the function of innate microbial pattern recognition by Toll-like receptors in the context of ...

    journal_title：Mucosal immunology

    pub_type： 杂志文章,评审

    doi：10.1038/mi.2008.49

    authors： Rakoff-Nahoum S,Medzhitov R

    更新日期：2008-11-01 00:00:00

  • A critical role for cellular inhibitor of protein 2 (cIAP2) in colitis-associated colorectal cancer and intestinal homeostasis mediated by the inflammasome and survival pathways.

    abstract：:Cellular inhibitors of apoptosis proteins (cIAPs) are critical arbiters of cell death and key mediators of inflammation and innate immunity. cIAP2 is frequently overexpressed in colorectal cancer and in regenerating crypts of ulcerative colitis patients. However, its corresponding functions in intestinal homeostasis a...

    journal_title：Mucosal immunology

    pub_type： 杂志文章

    doi：10.1038/mi.2015.46

    authors： Dagenais M,Dupaul-Chicoine J,Champagne C,Skeldon A,Morizot A,Saleh M

    更新日期：2016-01-01 00:00:00

  • Anti-CXCL13 antibody can inhibit the formation of gastric lymphoid follicles induced by Helicobacter infection.

    abstract：:Helicobacter suis infects the stomachs of both animals and humans, and can induce gastric mucosa-associated lymphoid tissue (MALT) lymphomas. It is known that CXC chemokine ligand 13 (CXCL13) is highly expressed in the Helicobacter-infected mice and gastric MALT lymphoma patients, but the pathway that links the activa...

    journal_title：Mucosal immunology

    pub_type： 杂志文章

    doi：10.1038/mi.2014.14

    authors： Yamamoto K,Nishiumi S,Yang L,Klimatcheva E,Pandina T,Takahashi S,Matsui H,Nakamura M,Zauderer M,Yoshida M,Azuma T

    更新日期：2014-09-01 00:00:00

  • Lung epithelium and myeloid cells cooperate to clear acute pneumococcal infection.

    abstract：:The Gram-positive bacterium Streptococcus pneumoniae causes life-threatening infections, especially among immunocompromised patients. The host's immune system senses S. pneumoniae via different families of pattern recognition receptors, in particular the Toll-like receptor (TLR) family that promotes immune cell activa...

    journal_title：Mucosal immunology

    pub_type： 杂志文章

    doi：10.1038/mi.2015.128

    authors： Dudek M,Puttur F,Arnold-Schrauf C,Kühl AA,Holzmann B,Henriques-Normark B,Berod L,Sparwasser T

    更新日期：2016-09-01 00:00:00

  • Type I IFN ineffectively activates neonatal dendritic cells limiting respiratory antiviral T-cell responses.

    abstract：:Insufficient T-cell responses contribute to the increased burden of viral respiratory disease in infancy. Neonatal dendritic cells (DCs) often provide defective activation of pathogen-specific T cells through mechanisms that are incompletely understood, which hinders vaccine design for this vulnerable age group. Enhan...

    journal_title：Mucosal immunology

    pub_type： 杂志文章

    doi：10.1038/s41385-019-0234-5

    authors： Lau-Kilby AW,Turfkruyer M,Kehl M,Yang L,Buchholz UJ,Hickey K,Malloy AMW

    更新日期：2020-03-01 00:00:00

  • Critical role of CXCL4 in the lung pathogenesis of influenza (H1N1) respiratory infection.

    abstract：:Annual epidemics and unexpected pandemics of influenza are threats to human health. Lung immune and inflammatory responses, such as those induced by respiratory infection influenza virus, determine the outcome of pulmonary pathogenesis. Platelet-derived chemokine (C-X-C motif) ligand 4 (CXCL4) has an immunoregulatory ...

    journal_title：Mucosal immunology

    pub_type： 杂志文章

    doi：10.1038/mi.2017.1

    authors： Guo L,Feng K,Wang YC,Mei JJ,Ning RT,Zheng HW,Wang JJ,Worthen GS,Wang X,Song J,Li QH,Liu LD

    更新日期：2017-11-01 00:00:00

  • Redox signaling regulates commensal-mediated mucosal homeostasis and restitution and requires formyl peptide receptor 1.

    abstract：:The mammalian gut microbiota is essential for normal intestinal development, renewal, and repair. Injury to the intestinal mucosa can occur with infection, surgical trauma, and in idiopathic inflammatory bowel disease. Repair of mucosal injury, termed restitution, as well as restoration of intestinal homeostasis invol...

    journal_title：Mucosal immunology

    pub_type： 杂志文章

    doi：10.1038/mi.2013.84

    authors： Alam A,Leoni G,Wentworth CC,Kwal JM,Wu H,Ardita CS,Swanson PA,Lambeth JD,Jones RM,Nusrat A,Neish AS

    更新日期：2014-05-01 00:00:00

  • Epithelial-mesenchymal transition in Crohn's disease.

    abstract：:Crohn's disease (CD) is often accompanied by the complications of intestinal strictures and fistulas. These complications remain obstacles in CD treatment. In recent years, the importance of epithelial-mesenchymal transition in the pathogenesis of CD-associated fistulas and intestinal fibrosis has become apparent. Epi...

    journal_title：Mucosal immunology

    pub_type： 杂志文章,评审

    doi：10.1038/mi.2017.107

    authors： Jiang H,Shen J,Ran Z

    更新日期：2018-03-01 00:00:00

  • Regulatory T cells control the dynamic and site-specific polarization of total CD4 T cells following Salmonella infection.

    abstract：:FoxP3+ regulatory T cells (Tregs) control inflammation and maintain mucosal homeostasis, but their functions during infection are poorly understood. Th1, Th2, and Th17 cells can be identified by master transcription factors (TFs) T-bet, GATA3, and RORγT; Tregs also express these TFs. While T-bet+ Tregs can selectively...

    journal_title：Mucosal immunology

    pub_type： 杂志文章

    doi：10.1038/s41385-020-0299-1

    authors： Clay SL,Bravo-Blas A,Wall DM,MacLeod MKL,Milling SWF

    更新日期：2020-11-01 00:00:00

  • An altered intestinal mucosal microbiome in HIV-1 infection is associated with mucosal and systemic immune activation and endotoxemia.

    abstract：:Human immunodeficiency virus-1 (HIV-1) infection disrupts the intestinal immune system, leading to microbial translocation and systemic immune activation. We investigated the impact of HIV-1 infection on the intestinal microbiome and its association with mucosal T-cell and dendritic cell (DC) frequency and activation,...

    journal_title：Mucosal immunology

    pub_type： 杂志文章

    doi：10.1038/mi.2013.116

    authors： Dillon SM,Lee EJ,Kotter CV,Austin GL,Dong Z,Hecht DK,Gianella S,Siewe B,Smith DM,Landay AL,Robertson CE,Frank DN,Wilson CC

    更新日期：2014-07-01 00:00:00