IL-17-mediated antifungal defense in the oral mucosa is independent of neutrophils.

Abstract:

:Interleukin-17 (IL-17)-mediated immunity has emerged as a crucial host defense mechanism against Candida albicans infections in mucosal tissues and the skin. The precise mechanism by which the IL-17 pathway prevents fungal outgrowth has not been clarified. Neutrophils are critical for limiting fungal dissemination and IL-17 is generally thought to act by regulating neutrophil mobilization and trafficking to the site of infection. Using a mouse model of oropharyngeal candidiasis (OPC), we found that strikingly the IL-17 pathway is not required for the neutrophil response to C. albicans. Mice deficient for the IL-17 receptor subunits IL-17 receptor A (IL-17RA) or IL-17RC or mice depleted of IL-17A and IL-17F exhibited a normal granulocyte colony-stimulating factor (G-CSF) and CXC-chemokine response and displayed no defect in neutrophil recruitment or function. Instead, the inability of these mice to clear the fungus was associated with a selective defect in the induction of antimicrobial peptides (AMPs) in the epithelium that resulted in persistent fungal colonization. Importantly, this antifungal mechanism of IL-17A and IL-17F did not extend to the closely related family member IL-17C. Together, these data uncouple IL-17-dependent effector mechanisms from the neutrophil response and reveal a compartmentalization of the antifungal defense in the oral mucosa providing a new understanding of IL-17-mediated mucosal immunity against C. albicans.

journal_name

Mucosal Immunol

journal_title

Mucosal immunology

authors

Trautwein-Weidner K,Gladiator A,Nur S,Diethelm P,LeibundGut-Landmann S

doi

10.1038/mi.2014.57

subject

Has Abstract

pub_date

2015-03-01 00:00:00

pages

221-31

issue

2

eissn

1933-0219

issn

1935-3456

pii

mi201457

journal_volume

8

pub_type

杂志文章
  • Induction of protective immunity against Mycobacterium tuberculosis by delivery of ESX antigens into airway dendritic cells.

    abstract::As the Bacillus Calmette-Guérin (BCG) vaccine does not confer long-lasting protection against lung Mycobacterium tuberculosis infection, the development of more efficient vaccines is greatly needed. Here, we used mycobacterial low-molecular weight proteins of the 6-kDa Early Secreted Antigenic Target (ESAT-6) protein ...

    journal_title:Mucosal immunology

    pub_type: 杂志文章

    doi:10.1038/mi.2012.92

    authors: Dong H,Stanek O,Salvador FR,Länger U,Morillon E,Ung C,Sebo P,Leclerc C,Majlessi L

    更新日期:2013-05-01 00:00:00

  • Brg1 restrains the pro-inflammatory properties of ILC3s and modulates intestinal immunity.

    abstract::Group 3 innate lymphoid cells (ILC3s), a subset of the innate lymphoid cells, are abundantly present in the intestine and are crucial regulators of intestinal inflammation. Brg1 (Brahma-related gene 1), a catalytic subunit of the mammalian SWI-SNF-like chromatin-remodeling BAF complex, regulates the development and fu...

    journal_title:Mucosal immunology

    pub_type: 杂志文章

    doi:10.1038/s41385-020-0317-3

    authors: Qi X,Qiu J,Chang J,Ji Y,Yang Q,Cui G,Sun L,Chai Q,Qin J,Qiu J

    更新日期:2021-01-01 00:00:00

  • Periodontitis, Porphyromonas, and the pathogenesis of rheumatoid arthritis.

    abstract::Epidemiological data indicate a link between rheumatoid arthritis (RA) and periodontal disease (PD). In vitro and in vivo studies have sought to dissect potential mechanisms by which PD may contribute to initiation and progression of RA. However, these are both multifactorial, chronic diseases, and their complex etiol...

    journal_title:Mucosal immunology

    pub_type: 杂志文章,评审

    doi:10.1038/mi.2011.66

    authors: Farquharson D,Butcher JP,Culshaw S

    更新日期:2012-03-01 00:00:00

  • Metal-specific CD4+ T-cell responses induced by beryllium exposure in HLA-DP2 transgenic mice.

    abstract::Chronic beryllium disease (CBD) is a granulomatous lung disorder that is associated with the accumulation of beryllium (Be)-specific CD4(+) T cells into the lung. Genetic susceptibility is linked to HLA-DPB1 alleles that possess a glutamic acid at position 69 (βGlu69), and HLA-DPB1*02:01 is the most prevalent βGlu69-c...

    journal_title:Mucosal immunology

    pub_type: 杂志文章

    doi:10.1038/mi.2015.54

    authors: Falta MT,Tinega AN,Mack DG,Bowerman NA,Crawford F,Kappler JW,Pinilla C,Fontenot AP

    更新日期:2016-01-01 00:00:00

  • Slc6a13 deficiency promotes Th17 responses during intestinal bacterial infection.

    abstract::The γ-amino butyric acid (GABA)ergic system shapes the activation and function of immune cells. The present study was conducted to explore the regulation of GABA transporter (GAT)-2 on the differentiation of Th17 cells. Here we found that Th17 cells show higher abundance of GAT-2, and have distinct cellular metabolic ...

    journal_title:Mucosal immunology

    pub_type: 杂志文章

    doi:10.1038/s41385-018-0111-7

    authors: Ren W,Liao Y,Ding X,Jiang Y,Yan J,Xia Y,Tan B,Lin Z,Duan J,Jia X,Yang G,Deng J,Zhu C,Hardwidge PR,Li J,Zhu G,Yin Y

    更新日期:2019-03-01 00:00:00

  • Macrophage-mediated gliadin degradation and concomitant IL-27 production drive IL-10- and IFN-γ-secreting Tr1-like-cell differentiation in a murine model for gluten tolerance.

    abstract::Celiac disease is caused by inflammatory T-cell responses against the insoluble dietary protein gliadin. We have shown that, in humanized mice, oral tolerance to deamidated chymotrypsin-digested gliadin (CT-TG2-gliadin) is driven by tolerogenic interferon (IFN)-γ- and interleukin (IL)-10-secreting type 1 regulatory T-...

    journal_title:Mucosal immunology

    pub_type: 杂志文章

    doi:10.1038/mi.2016.76

    authors: van Leeuwen MA,Costes LMM,van Berkel LA,Simons-Oosterhuis Y,du Pré MF,Kozijn AE,Raatgeep HC,Lindenbergh-Kortleve DJ,van Rooijen N,Koning F,Samsom JN

    更新日期:2017-05-01 00:00:00

  • Targeting the IL-22/IL-22BP axis enhances tight junctions and reduces inflammation during influenza infection.

    abstract::The seasonal burden of influenza coupled with the pandemic outbreaks of more pathogenic strains underscore a critical need to understand the pathophysiology of influenza injury in the lung. Interleukin-22 (IL-22) is a promising cytokine that is critical in protecting the lung during infection. This cytokine is strongl...

    journal_title:Mucosal immunology

    pub_type: 杂志文章

    doi:10.1038/s41385-019-0206-9

    authors: Hebert KD,Mclaughlin N,Galeas-Pena M,Zhang Z,Eddens T,Govero A,Pilewski JM,Kolls JK,Pociask DA

    更新日期:2020-01-01 00:00:00

  • Interbacterial mechanisms of colonization resistance and the strategies pathogens use to overcome them.

    abstract::The communities of bacteria that reside in the intestinal tract are in constant competition within this dynamic and densely colonized environment. At homeostasis, the equilibrium that exists between these species and strains is shaped by their metabolism and also by pathways of active antagonism, which drive competiti...

    journal_title:Mucosal immunology

    pub_type: 杂志文章,评审

    doi:10.1038/s41385-018-0053-0

    authors: Sorbara MT,Pamer EG

    更新日期:2019-01-01 00:00:00

  • Alpha-galactosylceramide enhances mucosal immunity to oral whole-cell cholera vaccines.

    abstract::Cholera is a severe diarrheal disease caused by the bacterium Vibrio cholerae (V. cholerae) that results in 3-4 million cases globally with 100,000-150,000 deaths reported annually. Mostly confined to developing nations, current strategies to control the spread of cholera include the provision of safe drinking water a...

    journal_title:Mucosal immunology

    pub_type: 杂志文章

    doi:10.1038/s41385-019-0159-z

    authors: Davitt CJH,Longet S,Albutti A,Aversa V,Nordqvist S,Hackett B,McEntee CP,Rosa M,Coulter IS,Lebens M,Tobias J,Holmgren J,Lavelle EC

    更新日期:2019-07-01 00:00:00

  • A screen of Crohn's disease-associated microbial metabolites identifies ascorbate as a novel metabolic inhibitor of activated human T cells.

    abstract::Microbial metabolites are an emerging class of mediators influencing CD4+ T-cell function. To advance the understanding of direct causal microbial factors contributing to Crohn's disease, we screened 139 predicted Crohn's disease-associated microbial metabolites for their bioactivity on human CD4+ T-cell functions ind...

    journal_title:Mucosal immunology

    pub_type: 杂志文章

    doi:10.1038/s41385-018-0022-7

    authors: Chang YL,Rossetti M,Vlamakis H,Casero D,Sunga G,Harre N,Miller S,Humphries R,Stappenbeck T,Simpson KW,Sartor RB,Wu G,Lewis J,Bushman F,McGovern DPB,Salzman N,Borneman J,Xavier R,Huttenhower C,Braun J

    更新日期:2019-03-01 00:00:00

  • Vaccination for Mycobacterium tuberculosis infection: reprogramming CD4 T-cell homing into the lung.

    abstract::Development of effective tuberculosis vaccines is hampered by insufficient understanding of protective immunity. Here, Woodworth et al.1 show secondary effector CD4 T cells generated after Mtb challenge of H56/CAF01 vaccinated mice display superior lung homing compared with primary effectors. Vaccination generates lar...

    journal_title:Mucosal immunology

    pub_type: 评论,杂志文章

    doi:10.1038/mi.2016.110

    authors: Barber DL

    更新日期:2017-03-01 00:00:00

  • MyD88 dependence of beryllium-induced dendritic cell trafficking and CD4⁺ T-cell priming.

    abstract::Beryllium exposure results in beryllium hypersensitivity in a subset of exposed individuals, leading to granulomatous inflammation and fibrosis in the lung. In addition to its antigenic properties, beryllium has potent adjuvant activity that contributes to sensitization via unknown pathways. Here we show that berylliu...

    journal_title:Mucosal immunology

    pub_type: 杂志文章

    doi:10.1038/mi.2015.14

    authors: McKee AS,Mack DG,Crawford F,Fontenot AP

    更新日期:2015-11-01 00:00:00

  • Joint expedition: linking gut inflammation to arthritis.

    abstract::The tight connection between intestinal inflammation and arthritis in spondyloarthritis (SpA) has been studied extensively. Subclinical gut inflammation, which can be considered as a model for early Crohn's disease, was shown to be strongly associated with joint inflammation. Several early mucosal abnormalities were u...

    journal_title:Mucosal immunology

    pub_type: 杂志文章,评审

    doi:10.1038/mi.2008.24

    authors: Jacques P,Elewaut D

    更新日期:2008-09-01 00:00:00

  • Celiac disease: from oral tolerance to intestinal inflammation, autoimmunity and lymphomagenesis.

    abstract::Celiac disease is a multifactorial disorder and provides a privileged model to decipher how the interplay between environmental and genetic factors can alter mucosal tolerance to a food antigen, lead to chronic intestinal inflammation, and ultimately promote T-cell lymphomagenesis. Here we summarize how HLA-DQ2/8 mole...

    journal_title:Mucosal immunology

    pub_type: 评论,杂志文章,评审

    doi:10.1038/mi.2008.75

    authors: Meresse B,Ripoche J,Heyman M,Cerf-Bensussan N

    更新日期:2009-01-01 00:00:00

  • Molecular mechanisms regulating TGF-beta-induced Foxp3 expression.

    abstract::Molecular mechanisms regulating transforming growth factor-beta (TGF-beta) induction of Foxp3 (forkhead box P3) expression and thus induction of induced regulatory T cells (Tregs) have been the focus of a great deal of study in recent years. It has become clear that this process is influenced by a number of factors as...

    journal_title:Mucosal immunology

    pub_type: 杂志文章,评审

    doi:10.1038/mi.2010.7

    authors: Xu L,Kitani A,Strober W

    更新日期:2010-05-01 00:00:00

  • Oral tolerance in neonates: from basics to potential prevention of allergic disease.

    abstract::Oral tolerance refers to the observation that prior feeding of an antigen induces local and systemic immune tolerance to that antigen. Physiologically, this process is probably of central importance for preventing inflammatory responses to the numerous dietary and microbial antigens present in the gut. Defective oral ...

    journal_title:Mucosal immunology

    pub_type: 杂志文章,评审

    doi:10.1038/mi.2010.25

    authors: Verhasselt V

    更新日期:2010-07-01 00:00:00

  • Severe viral respiratory infections: are bugs bugging?

    abstract::Viral respiratory tract infections (RTI) pose a high burden on the youngest members of our society. Several risk factors are known for severe viral respiratory disease. However, a large proportion of the severe RTI cannot be explained by these risk factors. A growing body of evidence shows that the composition of the ...

    journal_title:Mucosal immunology

    pub_type: 杂志文章,评审

    doi:10.1038/mi.2013.93

    authors: Vissers M,de Groot R,Ferwerda G

    更新日期:2014-03-01 00:00:00

  • Airway T cells protect against RSV infection in the absence of antibody.

    abstract::This corrects the article DOI: 10.1038/mi.2017.46. ...

    journal_title:Mucosal immunology

    pub_type: 杂志文章,已发布勘误

    doi:10.1038/mi.2017.79

    authors: Kinnear E,Lambert L,McDonald JU,Cheeseman HM,Caproni LJ,Tregoning JS

    更新日期:2018-01-01 00:00:00

  • Sphingosine 1-phosphate receptor modulator ONO-4641 stimulates CD11b+Gr-1+ cell expansion and inhibits lymphocyte infiltration in the lungs to ameliorate murine pulmonary emphysema.

    abstract::Sphingolipids play a pivotal role in the pathogenesis of chronic obstructive pulmonary disease (COPD). However, little is known about the precise roles of sphingosine-1-phosphate (S1P), a bioactive sphingolipid metabolite, and its receptor modulation in COPD. In this study, we demonstrated that the S1P receptor modula...

    journal_title:Mucosal immunology

    pub_type: 杂志文章

    doi:10.1038/s41385-018-0077-5

    authors: Asakura T,Ishii M,Namkoong H,Suzuki S,Kagawa S,Yagi K,Komiya T,Hashimoto T,Okamori S,Kamata H,Tasaka S,Kihara A,Hegab AE,Hasegawa N,Betsuyaku T

    更新日期:2018-11-01 00:00:00

  • Type I IFN ineffectively activates neonatal dendritic cells limiting respiratory antiviral T-cell responses.

    abstract::Insufficient T-cell responses contribute to the increased burden of viral respiratory disease in infancy. Neonatal dendritic cells (DCs) often provide defective activation of pathogen-specific T cells through mechanisms that are incompletely understood, which hinders vaccine design for this vulnerable age group. Enhan...

    journal_title:Mucosal immunology

    pub_type: 杂志文章

    doi:10.1038/s41385-019-0234-5

    authors: Lau-Kilby AW,Turfkruyer M,Kehl M,Yang L,Buchholz UJ,Hickey K,Malloy AMW

    更新日期:2020-03-01 00:00:00

  • IL-17A-mediated neutrophil recruitment limits expansion of segmented filamentous bacteria.

    abstract::Specific components of the intestinal microbiota are capable of influencing immune responses such that a mutualistic relationship is established. In mice, colonization with segmented filamentous bacteria (SFB) induces T-helper-17 (Th17) cell differentiation in the intestine, yet the effector functions of interleukin (...

    journal_title:Mucosal immunology

    pub_type: 杂志文章

    doi:10.1038/mi.2016.80

    authors: Flannigan KL,Ngo VL,Geem D,Harusato A,Hirota SA,Parkos CA,Lukacs NW,Nusrat A,Gaboriau-Routhiau V,Cerf-Bensussan N,Gewirtz AT,Denning TL

    更新日期:2017-05-01 00:00:00

  • Epigallocatechin-3-gallate local pre-exposure application prevents SHIV rectal infection of macaques.

    abstract::Epigallocatechin-3-gallate (EGCG), a natural and major ingredient of green tea, has been shown to have anti-inflammation and anti-HIV-1 properties. We demonstrated that the intrarectal administration of EGCG could protect rhesus macaques from repetitive, intrarectal challenges with low-dose SHIVSF162P3N. This protecti...

    journal_title:Mucosal immunology

    pub_type: 杂志文章

    doi:10.1038/s41385-018-0025-4

    authors: Liu JB,Li JL,Zhuang K,Liu H,Wang X,Xiao QH,Li XD,Zhou RH,Zhou L,Ma TC,Zhou W,Liu MQ,Ho WZ

    更新日期:2018-07-01 00:00:00

  • An African perspective on mucosal immunity and HIV-1.

    abstract::HIV prevention mandates an understanding of the mechanisms of mucosal immunity with attention to some unique features of the epidemic and mucosal environment in the developing world. An effective vaccine will have to induce mucosal protection against a highly diverse virus, which is equipped with a number of immune ev...

    journal_title:Mucosal immunology

    pub_type: 杂志文章,评审

    doi:10.1038/mi.2009.23

    authors: Pala P,Gomez-Roman VR,Gilmour J,Kaleebu P

    更新日期:2009-07-01 00:00:00

  • Lactobacillus johnsonii supplementation attenuates respiratory viral infection via metabolic reprogramming and immune cell modulation.

    abstract::Regulation of respiratory mucosal immunity by microbial-derived metabolites has been a proposed mechanism that may provide airway protection. Here we examine the effect of oral Lactobacillus johnsonii supplementation on metabolic and immune response dynamics during respiratory syncytial virus (RSV) infection. L. johns...

    journal_title:Mucosal immunology

    pub_type: 杂志文章

    doi:10.1038/mi.2017.13

    authors: Fonseca W,Lucey K,Jang S,Fujimura KE,Rasky A,Ting HA,Petersen J,Johnson CC,Boushey HA,Zoratti E,Ownby DR,Levine AM,Bobbit KR,Lynch SV,Lukacs NW

    更新日期:2017-11-01 00:00:00

  • Anti-IL-13Rα2 therapy promotes recovery in a murine model of inflammatory bowel disease.

    abstract::There continues to be a major need for more effective inflammatory bowel disease (IBD) therapies. IL-13Rα2 is a decoy receptor that binds the cytokine IL-13 with high affinity and diminishes its STAT6-mediated effector functions. Previously, we found that IL-13Rα2 was necessary for IBD in mice deficient in the anti-in...

    journal_title:Mucosal immunology

    pub_type: 杂志文章

    doi:10.1038/s41385-019-0189-6

    authors: Karmele EP,Pasricha TS,Ramalingam TR,Thompson RW,Gieseck RL 3rd,Knilans KJ,Hegen M,Farmer M,Jin F,Kleinman A,Hinds DA,23andMe Research Team.,Almeida Pereira T,de Queiroz Prado R,Bing N,Tchistiakova L,Kasaian MT,Wynn TA

    更新日期:2019-09-01 00:00:00

  • Correlates of protection against human rotavirus disease and the factors influencing protection in low-income settings.

    abstract::Rotaviruses (RV) are the leading cause of gastroenteritis in infants and children worldwide and are associated with high mortality predominately in low-income settings. The virus is classified into G and P serotypes and further into P genotypes based on differences in the surface-exposed proteins VP7 and VP4, respecti...

    journal_title:Mucosal immunology

    pub_type: 杂志文章,评审

    doi:10.1038/mi.2014.114

    authors: Clarke E,Desselberger U

    更新日期:2015-01-01 00:00:00

  • Polysaccharide-protein conjugate vaccination induces antibody production but not sustained B-cell memory in the human nasopharyngeal mucosa.

    abstract::Colonization of the nasopharyngeal mucosa by meningococcus and other polysaccharide (PS)-encapsulated bacteria precedes invasion. PS-conjugate vaccines induce PS-specific B-cell memory (B(MEM)) and also prevent colonization, thus blocking person-to-person transmission, generating herd protection. However, in isolation...

    journal_title:Mucosal immunology

    pub_type: 杂志文章

    doi:10.1038/mi.2012.70

    authors: Clarke ET,Williams NA,Dull PM,Findlow J,Borrow R,Finn A,Heyderman RS

    更新日期:2013-03-01 00:00:00

  • Neonatal intestinal immune regulation by the commensal bacterium, P. UF1.

    abstract::Newborns are highly susceptible to pathogenic infections with significant worldwide morbidity possibly due to an immature immune system. Recently, we reported that Propionibacterium strain, P. UF1, isolated from the gut microbiota of preterm infants, induced the differentiation of bacteria-specific Th17 cells. Here, w...

    journal_title:Mucosal immunology

    pub_type: 杂志文章

    doi:10.1038/s41385-018-0125-1

    authors: Ge Y,Gong M,Colliou N,Zadeh M,Li J,Jones DP,Li S,Mohamadzadeh M

    更新日期:2019-03-01 00:00:00

  • New insights into innate immune mechanisms underlying allergenicity.

    abstract::Allergic diseases, which have reached epidemic proportions, are caused by inappropriate immune responses to a relatively small number of environmental proteins. The molecular basis for the propensity of specific proteins to promote maladaptive, allergic responses has been difficult to define. Recent data suggest that ...

    journal_title:Mucosal immunology

    pub_type: 杂志文章,评审

    doi:10.1038/mi.2009.138

    authors: Wills-Karp M,Nathan A,Page K,Karp CL

    更新日期:2010-03-01 00:00:00

  • Generation of protective pneumococcal-specific nasal resident memory CD4+ T cells via parenteral immunization.

    abstract::The generation of tissue-resident memory T cells (TRM) is an essential aspect of immunity at mucosal surfaces, and it has been suggested that preferential generation of TRM is one of the principal advantages of mucosally administered vaccines. We have previously shown that antigen-specific, IL-17-producing CD4+ T cell...

    journal_title:Mucosal immunology

    pub_type: 杂志文章

    doi:10.1038/s41385-019-0218-5

    authors: O'Hara JM,Redhu NS,Cheung E,Robertson NG,Patik I,Sayed SE,Thompson CM,Herd M,Lucas KB,Conaway E,Morton CC,Farber DL,Malley R,Horwitz BH

    更新日期:2020-01-01 00:00:00