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Lactobacillus johnsonii supplementation attenuates respiratory viral infection via metabolic reprogramming and immune cell modulation.

Abstract：

:Regulation of respiratory mucosal immunity by microbial-derived metabolites has been a proposed mechanism that may provide airway protection. Here we examine the effect of oral Lactobacillus johnsonii supplementation on metabolic and immune response dynamics during respiratory syncytial virus (RSV) infection. L. johnsonii supplementation reduced airway T helper type 2 cytokines and dendritic cell (DC) function, increased regulatory T cells, and was associated with a reprogrammed circulating metabolic environment, including docosahexanoic acid (DHA) enrichment. RSV-infected bone marrow-derived DCs (BMDCs) from L. johnsonii-supplemented mice had altered cytokine secretion, reduced expression of co-stimulatory molecules, and modified CD4+ T-cell cytokines. This was replicated upon co-incubation of wild-type BMDCs with either plasma from L. johnsonii-supplemented mice or DHA. Finally, airway transfer of BMDCs from L. johnsonii-supplemented mice or with wild-type derived BMDCs pretreated with plasma from L. johnsonii-supplemented mice reduced airway pathological responses to infection in recipient animals. Thus L. johnsonii supplementation mediates airway mucosal protection via immunomodulatory metabolites and altered immune function.

journal_name

Mucosal Immunol

journal_title

Mucosal immunology

authors

Fonseca W,Lucey K,Jang S,Fujimura KE,Rasky A,Ting HA,Petersen J,Johnson CC,Boushey HA,Zoratti E,Ownby DR,Levine AM,Bobbit KR,Lynch SV,Lukacs NW

doi

10.1038/mi.2017.13

subject

Has Abstract

pub_date

2017-11-01 00:00:00

pages

1569-1580

issue

6

eissn

1933-0219

issn

1935-3456

pii

mi201713

journal_volume

10

pub_type

杂志文章

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