Abstract:
:Human immunodeficiency virus/simian immunodeficiency virus (HIV/SIV) infections are believed to infect minimally activated CD4(+) T cells after viral entry. Not much is known about why SIV selectively targets these cells. Here we show that CD4(+) T cells that express high levels of the alpha4beta7 heterodimer are preferentially infected very early during the course of SIV infection. At days 2-4 post infection, alpha4(+)beta7(hi)CD4(+) T cells had approximately 5x more SIV-gag DNA than beta7(-)CD4(+) T cells. alpha4(+)beta7(hi)CD4(+) T cells displayed a predominantly central memory (CD45RA(-)CD28(+)CCR7(+)) and a resting (CD25(-)CD69(-)HLA-DR(-)Ki-67(-)) phenotype. Although the expression of detectable CCR5 was variable on alpha4(+)beta7(hi) and beta7(-)CD4(+) T cells, both CCR5(+) and CCR5(-) subsets of alpha4(+)beta7(hi) and beta7(-)CD4(+) T cells were found to express sufficient levels of CCR5 mRNA, suggesting that both these subsets could be efficiently infected by SIV. In line with this, we found similar levels of SIV infection in beta7(-)CD4(+)CCR5(+) and beta7(-)CD4(+)CCR5(-) T cells. alpha4beta7(hi)CD4(+) T cells were found to harbor most T helper (Th)-17 cells that were significantly depleted during acute SIV infection. Taken together, our results show that resting memory alpha4(+)beta7(hi)CD4(+) T cells in the blood are preferentially infected and depleted during acute SIV infection, and the loss of these cells alters the balance between Th-17 and Th-1 responses, thereby contributing to disease pathogenesis.
journal_name
Mucosal Immunoljournal_title
Mucosal immunologyauthors
Kader M,Wang X,Piatak M,Lifson J,Roederer M,Veazey R,Mattapallil JJdoi
10.1038/mi.2009.90subject
Has Abstractpub_date
2009-09-01 00:00:00pages
439-49issue
5eissn
1933-0219issn
1935-3456pii
mi200990journal_volume
2pub_type
杂志文章abstract::Crohn's disease (CD) is often accompanied by the complications of intestinal strictures and fistulas. These complications remain obstacles in CD treatment. In recent years, the importance of epithelial-mesenchymal transition in the pathogenesis of CD-associated fistulas and intestinal fibrosis has become apparent. Epi...
journal_title:Mucosal immunology
pub_type: 杂志文章,评审
doi:10.1038/mi.2017.107
更新日期:2018-03-01 00:00:00
abstract::The extent to which tissue-specific viral infections generate memory T cells specifically adapted to and maintained within the target infection site is unknown. Here, we show that respiratory virus-specific memory T cells in mice and humans are generated and maintained in compartmentalized niches in lungs, distinct fr...
journal_title:Mucosal immunology
pub_type: 杂志文章
doi:10.1038/mi.2013.67
更新日期:2014-05-01 00:00:00
abstract::Lung resident memory CD8 T cells (TRM) are critical for protection against respiratory viruses, but the cellular interactions required for their development are poorly understood. Herein we describe the necessity of classical monocytes for the establishment of lung TRM following influenza infection. We find that, duri...
journal_title:Mucosal immunology
pub_type: 杂志文章
doi:10.1038/s41385-019-0224-7
更新日期:2020-01-01 00:00:00
abstract::Accumulating evidence implicates defective innate immunity in the pathogenesis of Crohn's disease (CD). Ineffectual NOD2 (nucleotide-binding oligomerization domain 2) is the most common susceptibility gene contributing to CD. Vitamin D (vD), a potent modulator of innate and adaptive immunity, induces NOD2 gene express...
journal_title:Mucosal immunology
pub_type: 杂志文章
doi:10.1038/mi.2014.30
更新日期:2014-11-01 00:00:00
abstract::Chronic obstructive pulmonary disease (COPD) is a highly prevalent respiratory disease characterized by airflow limitation and chronic inflammation. MiR-155 is described as an ancient regulator of the immune system. Our objective was to establish a role for miR-155 in cigarette smoke (CS)-induced inflammation and COPD...
journal_title:Mucosal immunology
pub_type: 杂志文章
doi:10.1038/s41385-019-0241-6
更新日期:2020-05-01 00:00:00
abstract::Classical Whipple's disease (CWD) affects the gastrointestinal tract and rather elicits regulatory than inflammatory immune reactions. Mechanisms of malabsorption, diarrhea, and systemic immune activation are unknown. We here analyzed mucosal architecture, barrier function, and immune activation as potential diarrheal...
journal_title:Mucosal immunology
pub_type: 杂志文章
doi:10.1038/mi.2017.6
更新日期:2017-11-01 00:00:00
abstract::Mucus, with its burden of inspired particulates and pathogens, is cleared from mucosal surfaces of the airways by cilia beating within the periciliary layer (PCL). The PCL is held to be "watery" and free of mucus by thixotropic-like forces arising from beating cilia. With radii of gyration ~250 nm, however, polymeric ...
journal_title:Mucosal immunology
pub_type: 杂志文章
doi:10.1038/mi.2012.81
更新日期:2013-03-01 00:00:00
abstract::Group 3 innate lymphoid cells (ILC3s), a subset of the innate lymphoid cells, are abundantly present in the intestine and are crucial regulators of intestinal inflammation. Brg1 (Brahma-related gene 1), a catalytic subunit of the mammalian SWI-SNF-like chromatin-remodeling BAF complex, regulates the development and fu...
journal_title:Mucosal immunology
pub_type: 杂志文章
doi:10.1038/s41385-020-0317-3
更新日期:2021-01-01 00:00:00
abstract::Bacterial-induced intestinal inflammation is crucially dependent on interleukin (IL)-23 and is associated with CD4(+) T helper type 1 (Th1) and Th17 responses. However, the relative contributions of these subsets during the induction and resolution of colitis in T-cell-sufficient hosts remain unknown. We report that H...
journal_title:Mucosal immunology
pub_type: 杂志文章
doi:10.1038/mi.2013.11
更新日期:2013-11-01 00:00:00
abstract::Over the past 25 years, studies led in humans have considerably improved our understanding of celiac disease, a complex disease that is generally defined as an autoimmune-like enteropathy induced by dietary gluten in genetically predisposed individuals. Recently, large efforts were also invested in the development of ...
journal_title:Mucosal immunology
pub_type: 杂志文章,评审
doi:10.1038/mi.2014.102
更新日期:2015-01-01 00:00:00
abstract::Celiac disease is caused by inflammatory T-cell responses against the insoluble dietary protein gliadin. We have shown that, in humanized mice, oral tolerance to deamidated chymotrypsin-digested gliadin (CT-TG2-gliadin) is driven by tolerogenic interferon (IFN)-γ- and interleukin (IL)-10-secreting type 1 regulatory T-...
journal_title:Mucosal immunology
pub_type: 杂志文章
doi:10.1038/mi.2016.76
更新日期:2017-05-01 00:00:00
abstract::Newborns are highly susceptible to pathogenic infections with significant worldwide morbidity possibly due to an immature immune system. Recently, we reported that Propionibacterium strain, P. UF1, isolated from the gut microbiota of preterm infants, induced the differentiation of bacteria-specific Th17 cells. Here, w...
journal_title:Mucosal immunology
pub_type: 杂志文章
doi:10.1038/s41385-018-0125-1
更新日期:2019-03-01 00:00:00
abstract::Pneumonia caused by Streptococcus pneumoniae (Sp) remains a leading cause of serious illness and death worldwide. Immunization with conjugated pneumococcal vaccine has lowered the colonization rate and consequently invasive diseases by inducing serotype-specific antibodies. However, many of the current pneumonia cases...
journal_title:Mucosal immunology
pub_type: 杂志文章
doi:10.1038/mi.2016.41
更新日期:2017-01-01 00:00:00
abstract::The Gram-positive bacterium Streptococcus pneumoniae causes life-threatening infections, especially among immunocompromised patients. The host's immune system senses S. pneumoniae via different families of pattern recognition receptors, in particular the Toll-like receptor (TLR) family that promotes immune cell activa...
journal_title:Mucosal immunology
pub_type: 杂志文章
doi:10.1038/mi.2015.128
更新日期:2016-09-01 00:00:00
abstract::Previously we have extensively characterized Salmonella enterica serovar Typhi (S. Typhi)-specific cell-mediated immune (CMI) responses in volunteers orally immunized with the licensed Ty21a typhoid vaccine. In this study we measured Salmonella-specific multifunctional (MF) CD8+ T-cell responses to further investigate...
journal_title:Mucosal immunology
pub_type: 杂志文章
doi:10.1038/mi.2015.24
更新日期:2015-11-01 00:00:00
abstract::T helper (Th)1 and Th2 cells play decisive roles in the regulation of resistance vs. susceptibility to pulmonary cryptococcosis. To study the function of interleukin (IL)-4 receptor (IL-4R) on Th cells in pulmonary cryptococcosis, we infected mice specifically lacking IL-4Rα on CD4(+) T cells (Lck(Cre)IL-4Rα(-/lox) mi...
journal_title:Mucosal immunology
pub_type: 杂志文章
doi:10.1038/mi.2012.9
更新日期:2012-05-01 00:00:00
abstract::Regulation of respiratory mucosal immunity by microbial-derived metabolites has been a proposed mechanism that may provide airway protection. Here we examine the effect of oral Lactobacillus johnsonii supplementation on metabolic and immune response dynamics during respiratory syncytial virus (RSV) infection. L. johns...
journal_title:Mucosal immunology
pub_type: 杂志文章
doi:10.1038/mi.2017.13
更新日期:2017-11-01 00:00:00
abstract::Our studies have focused on understanding the mechanisms of interactions between the indigenous intestinal flora and the mammalian host in both physiological and nonphysiological conditions. In particular, we have focused on the function of innate microbial pattern recognition by Toll-like receptors in the context of ...
journal_title:Mucosal immunology
pub_type: 杂志文章,评审
doi:10.1038/mi.2008.49
更新日期:2008-11-01 00:00:00
abstract::Mycobacterium tuberculosis (M.tb) is deposited into the alveolus where it first encounters the alveolar lining fluid (ALF) prior contacts host cells. We demonstrated that M.tb-exposure to human ALF alters its cell surface, driving better M.tb infection control by professional phagocytes. Contrary to these findings, ou...
journal_title:Mucosal immunology
pub_type: 杂志文章
doi:10.1038/s41385-019-0156-2
更新日期:2019-05-01 00:00:00
abstract::Beryllium exposure results in beryllium hypersensitivity in a subset of exposed individuals, leading to granulomatous inflammation and fibrosis in the lung. In addition to its antigenic properties, beryllium has potent adjuvant activity that contributes to sensitization via unknown pathways. Here we show that berylliu...
journal_title:Mucosal immunology
pub_type: 杂志文章
doi:10.1038/mi.2015.14
更新日期:2015-11-01 00:00:00
abstract::Colonization of the nasopharyngeal mucosa by meningococcus and other polysaccharide (PS)-encapsulated bacteria precedes invasion. PS-conjugate vaccines induce PS-specific B-cell memory (B(MEM)) and also prevent colonization, thus blocking person-to-person transmission, generating herd protection. However, in isolation...
journal_title:Mucosal immunology
pub_type: 杂志文章
doi:10.1038/mi.2012.70
更新日期:2013-03-01 00:00:00
abstract::The communities of bacteria that reside in the intestinal tract are in constant competition within this dynamic and densely colonized environment. At homeostasis, the equilibrium that exists between these species and strains is shaped by their metabolism and also by pathways of active antagonism, which drive competiti...
journal_title:Mucosal immunology
pub_type: 杂志文章,评审
doi:10.1038/s41385-018-0053-0
更新日期:2019-01-01 00:00:00
abstract::In a nasal vaccine against influenza, the activation of natural killer T (NKT) cells by intranasal coadministration of alpha-galactosylceramide (alpha-GalCer) can potently enhance protective immune responses. The results of this study show that the NKT cell-activated nasal vaccine can induce an effective cross-protect...
journal_title:Mucosal immunology
pub_type: 杂志文章
doi:10.1038/mi.2008.2
更新日期:2008-05-01 00:00:00
abstract::Vaccine-mediated prevention of primary infection with human immunodeficiency virus (HIV) may require the sustained production of antibody at mucosal portals of entry. Here, we describe a novel approach of repeated mucosal immunization by delivering an HIV-1 envelope glycoprotein (gp) in a gel formulated for intravagin...
journal_title:Mucosal immunology
pub_type: 杂志文章
doi:10.1038/mi.2009.110
更新日期:2010-01-01 00:00:00
abstract::Dectin-1 is an innate antifungal C-type lectin receptor necessary for protective antifungal immunity. We recently discovered that Dectin-1 is involved in controlling fungal infections of the gastrointestinal (GI) tract, but how this C-type lectin receptor mediates these activities is unknown. Here, we show that Dectin...
journal_title:Mucosal immunology
pub_type: 杂志文章
doi:10.1038/mi.2015.79
更新日期:2016-03-01 00:00:00
abstract::Human type-2 CD8+ T cells are a cell population with potentially important roles in allergic disease. We investigated this in the context of severe asthma with persistent airway eosinophilia-a phenotype associated with high exacerbation risk and responsiveness to type-2 cytokine-targeted therapies. In two independent ...
journal_title:Mucosal immunology
pub_type: 杂志文章
doi:10.1038/s41385-018-0049-9
更新日期:2018-09-01 00:00:00
abstract::Cells of the mononuclear phagocyte system (MPS) are found in large numbers in every organ of the body, where they contribute to innate and acquired immunity and homeostasis. This review considers the locations of MPS cells, surface markers that distinguish subsets of monocytes and macrophages, the pathways of MPS diff...
journal_title:Mucosal immunology
pub_type: 杂志文章,评审
doi:10.1038/mi.2008.36
更新日期:2008-11-01 00:00:00
abstract::Effector T-cell contraction is one of the primary means by which immune homeostasis in the peripheral tissues is reestablished following an inflammatory response. In this issue of Mucosal Immunology, Hashimoto-Hill et al.1 show that retinoic acid (RA) transcriptionally upregulates P2X7 primarily in effector T cells of...
journal_title:Mucosal immunology
pub_type: 评论,杂志文章
doi:10.1038/mi.2016.117
更新日期:2017-07-01 00:00:00
abstract::Individuals with one atopic disease are far more likely to develop a second. Approximately half of all atopic dermatitis (AD) patients subsequently develop asthma, particularly those with severe AD. This association, suggesting a role for AD as an entry point for subsequent allergic disease, is a phenomenon known as t...
journal_title:Mucosal immunology
pub_type: 杂志文章
doi:10.1038/mi.2012.14
更新日期:2012-05-01 00:00:00
abstract::Intestinal CD8αα intraepithelial T lymphocytes (T-IELs) have a key role in mucosal immunity and, unlike other T cells, were proposed to differentiate locally. In apparent contradiction, these cells were also shown to originate from a wave of thymus migrants colonizing the gut in the first 3 weeks after birth. We here ...
journal_title:Mucosal immunology
pub_type: 杂志文章
doi:10.1038/mi.2010.47
更新日期:2011-01-01 00:00:00