Retinoic acid takes effector T cells to the gallows: P2X7, the molecular hangman.

abstract：:AIDS is mainly a sexually transmitted disease, and accordingly, mucosal tissues are the primary sites of natural human immunodeficiency virus type-1 (HIV-1) transmission. Mucosal immunoglobulin A (IgA) antibody specific for HIV-1 envelope gp41 subunit is one correlate of protection in individuals who are highly sexual...

journal_title：Mucosal immunology

authors： Tudor D,Derrien M,Diomede L,Drillet AS,Houimel M,Moog C,Reynes JM,Lopalco L,Bomsel M

更新日期：2009-09-01 00:00:00

abstract：:Molecular mechanisms regulating transforming growth factor-beta (TGF-beta) induction of Foxp3 (forkhead box P3) expression and thus induction of induced regulatory T cells (Tregs) have been the focus of a great deal of study in recent years. It has become clear that this process is influenced by a number of factors as...

journal_title：Mucosal immunology

authors： Xu L,Kitani A,Strober W

更新日期：2010-05-01 00:00:00

abstract：:Respiratory syncytial virus (RSV) is a leading cause of severe lower respiratory tract infections, especially in infants. Lung neutrophilia is a hallmark of RSV disease but the mechanism by which neutrophils are recruited and activated is unclear. Here, we investigate the innate immune signaling pathways underlying ne...

journal_title：Mucosal immunology

authors： Kirsebom FCM,Kausar F,Nuriev R,Makris S,Johansson C

更新日期：2019-09-01 00:00:00

abstract：:Microbial metabolites are an emerging class of mediators influencing CD4+ T-cell function. To advance the understanding of direct causal microbial factors contributing to Crohn's disease, we screened 139 predicted Crohn's disease-associated microbial metabolites for their bioactivity on human CD4+ T-cell functions ind...

journal_title：Mucosal immunology

authors： Chang YL,Rossetti M,Vlamakis H,Casero D,Sunga G,Harre N,Miller S,Humphries R,Stappenbeck T,Simpson KW,Sartor RB,Wu G,Lewis J,Bushman F,McGovern DPB,Salzman N,Borneman J,Xavier R,Huttenhower C,Braun J

更新日期：2019-03-01 00:00:00

abstract：:Cigarette smoke has been associated with susceptibility to different pulmonary and airway diseases. Impaired alveolar macrophages (AMs) that are major phagocytes in the lung have been associated with patients with airway diseases and active smokers. In the current report, we show that exposure to second-hand cigarette...

journal_title：Mucosal immunology

authors： Subramaniam R,Mukherjee S,Chen H,Keshava S,Neuenschwander P,Shams H

更新日期：2016-07-01 00:00:00

abstract：:Colonization of the nasopharyngeal mucosa by meningococcus and other polysaccharide (PS)-encapsulated bacteria precedes invasion. PS-conjugate vaccines induce PS-specific B-cell memory (B(MEM)) and also prevent colonization, thus blocking person-to-person transmission, generating herd protection. However, in isolation...

journal_title：Mucosal immunology

authors： Clarke ET,Williams NA,Dull PM,Findlow J,Borrow R,Finn A,Heyderman RS

更新日期：2013-03-01 00:00:00

abstract：:The mucosal immune system is charged with defending the host's vast interfaces with the outside world from the enormous and diverse group of microbes that colonizes these surfaces. A key means by which the mucosal immune system protects the host from such diverse microbes is using germ-line-encoded receptors that targ...

journal_title：Mucosal immunology

authors： Vijay-Kumar M,Gewirtz AT

更新日期：2009-05-01 00:00:00

abstract：:Leukotriene B4 receptor 1 (BLT1) triggers the migration of granulocytes and activated T cells; however, its role in B-cell function remains unclear. Here we report that BLT1 is required to induce the production of antigen-specific IgA against oral vaccine through mediating innate immune signals from commensal bacteria...

journal_title：Mucosal immunology

authors： Nagatake T,Hirata SI,Koga T,Kuroda E,Kobari S,Suzuki H,Hosomi K,Matsumoto N,Yanrismet Y,Shimojou M,Morimoto S,Sasaki F,Ishii KJ,Yokomizo T,Kunisawa J

更新日期：2019-09-01 00:00:00

abstract：:Nedd4 family interacting protein 1 (Ndfip1) is an adaptor protein that regulates Itch, an E3 ubiquitin ligase that ubiquitylates JunB, thereby preventing interleukin (IL)-4 and IL-5 production. Mice lacking Ndfip1 or Itch develop T helper type 2 (T(H)2)-mediated inflammation in the skin and lungs and die prematurely. ...

journal_title：Mucosal immunology

authors： Ramon HE,Riling CR,Bradfield J,Yang B,Hakonarson H,Oliver PM

更新日期：2011-05-01 00:00:00

abstract：:The mechanisms underlying the massive gastrointestinal tract CD4 T-cell depletion in human immunodeficiency virus (HIV) infection are not well understood nor is it clear whether similar depletion is manifest at other mucosal surfaces. Studies of T-cell and virus dynamics in different anatomical sites have begun to ill...

journal_title：Mucosal immunology

authors： Brenchley JM,Knox KS,Asher AI,Price DA,Kohli LM,Gostick E,Hill BJ,Hage CA,Brahmi Z,Khoruts A,Twigg HL 3rd,Schacker TW,Douek DC

更新日期：2008-01-01 00:00:00

abstract：:Human type-2 CD8+ T cells are a cell population with potentially important roles in allergic disease. We investigated this in the context of severe asthma with persistent airway eosinophilia-a phenotype associated with high exacerbation risk and responsiveness to type-2 cytokine-targeted therapies. In two independent ...

journal_title：Mucosal immunology

authors： Hilvering B,Hinks TSC,Stöger L,Marchi E,Salimi M,Shrimanker R,Liu W,Chen W,Luo J,Go S,Powell T,Cane J,Thulborn S,Kurioka A,Leng T,Matthews J,Connolly C,Borg C,Bafadhel M,Willberg CB,Ramasamy A,Djukanović R,Ogg

更新日期：2018-09-01 00:00:00

abstract：:Specific components of the intestinal microbiota are capable of influencing immune responses such that a mutualistic relationship is established. In mice, colonization with segmented filamentous bacteria (SFB) induces T-helper-17 (Th17) cell differentiation in the intestine, yet the effector functions of interleukin (...

journal_title：Mucosal immunology

authors： Flannigan KL,Ngo VL,Geem D,Harusato A,Hirota SA,Parkos CA,Lukacs NW,Nusrat A,Gaboriau-Routhiau V,Cerf-Bensussan N,Gewirtz AT,Denning TL

更新日期：2017-05-01 00:00:00

abstract：:Oral tolerance refers to the observation that prior feeding of an antigen induces local and systemic immune tolerance to that antigen. Physiologically, this process is probably of central importance for preventing inflammatory responses to the numerous dietary and microbial antigens present in the gut. Defective oral ...

journal_title：Mucosal immunology

authors： Verhasselt V

更新日期：2010-07-01 00:00:00

abstract：:Malaria-associated acute respiratory distress syndrome (MA-ARDS) and acute lung injury (ALI) are complications that cause lung damage and often leads to death. The MA-ARDS/ALI is associated with a Type 1 inflammatory response mediated by T lymphocytes and IFN-γ. Here, we used the Plasmodium berghei NK65 (PbN)-induced ...

journal_title：Mucosal immunology

authors： Galvão-Filho B,de Castro JT,Figueiredo MM,Rosmaninho CG,Antonelli LRDV,Gazzinelli RT

更新日期：2019-03-01 00:00:00

abstract：:Cross-presentation of cellular antigens is crucial for priming CD8(+) T cells, and generating immunity to intracellular pathogens--particularly viruses. It is unclear which intestinal phagocytes perform this function in vivo. To address this, we examined dendritic cells (DCs) from the intestinal lymph of IFABP-tOVA 23...

journal_title：Mucosal immunology

authors： Cerovic V,Houston SA,Westlund J,Utriainen L,Davison ES,Scott CL,Bain CC,Joeris T,Agace WW,Kroczek RA,Mowat AM,Yrlid U,Milling SW

更新日期：2015-01-01 00:00:00

abstract：:How the immune system senses aeroallergens and triggers an aberrant inflammation is poorly understood. Dectin-2 is a house dust mite (HDM)-sensing pattern recognition receptor. In a 3-week mouse model of repeated intranasal HDM challenge, anti-Dectin-2 potently attenuated the characteristic allergic inflammation and a...

journal_title：Mucosal immunology

authors： Clarke DL,Davis NH,Campion CL,Foster ML,Heasman SC,Lewis AR,Anderson IK,Corkill DJ,Sleeman MA,May RD,Robinson MJ

更新日期：2014-05-01 00:00:00

abstract：:Group 3 innate lymphoid cells (ILC3s), a subset of the innate lymphoid cells, are abundantly present in the intestine and are crucial regulators of intestinal inflammation. Brg1 (Brahma-related gene 1), a catalytic subunit of the mammalian SWI-SNF-like chromatin-remodeling BAF complex, regulates the development and fu...

journal_title：Mucosal immunology

authors： Qi X,Qiu J,Chang J,Ji Y,Yang Q,Cui G,Sun L,Chai Q,Qin J,Qiu J

更新日期：2021-01-01 00:00:00

abstract：:Eosinophils are granulocytes, typically implicated as end-stage effector cells in type-II immune responses. They are capable of producing a wide array of pre-formed molecules which render them with vast potential to influence a wide variety of processes. Nonetheless, eosinophil research has traditionally focused on th...

journal_title：Mucosal immunology

authors： Shah K,Ignacio A,McCoy KD,Harris NL

更新日期：2020-07-01 00:00:00

abstract：:The impact of topical antiretrovirals for pre-exposure prophylaxis on humoral responses following HIV infection is unknown. Using a binding antibody multiplex assay, we investigated HIV-specific IgG and IgA responses to envelope glycoproteins, p24 Gag and p66, in the genital tract (GT) and plasma following HIV acquisi...

journal_title：Mucosal immunology

authors： Archary D,Seaton KE,Passmore JS,Werner L,Deal A,Dunphy LJ,Arnold KB,Yates NL,Lauffenburger DA,Bergin P,Liebenberg LJ,Samsunder N,Mureithi MW,Altfeld M,Garrett N,Karim QA,Karim SA,Morris L,Tomaras GD

更新日期：2016-05-01 00:00:00

abstract：:The extent to which tissue-specific viral infections generate memory T cells specifically adapted to and maintained within the target infection site is unknown. Here, we show that respiratory virus-specific memory T cells in mice and humans are generated and maintained in compartmentalized niches in lungs, distinct fr...

journal_title：Mucosal immunology

authors： Turner DL,Bickham KL,Thome JJ,Kim CY,D'Ovidio F,Wherry EJ,Farber DL

更新日期：2014-05-01 00:00:00

abstract：:Celiac disease is caused by inflammatory T-cell responses against the insoluble dietary protein gliadin. We have shown that, in humanized mice, oral tolerance to deamidated chymotrypsin-digested gliadin (CT-TG2-gliadin) is driven by tolerogenic interferon (IFN)-γ- and interleukin (IL)-10-secreting type 1 regulatory T-...

journal_title：Mucosal immunology

authors： van Leeuwen MA,Costes LMM,van Berkel LA,Simons-Oosterhuis Y,du Pré MF,Kozijn AE,Raatgeep HC,Lindenbergh-Kortleve DJ,van Rooijen N,Koning F,Samsom JN

更新日期：2017-05-01 00:00:00

abstract：:Eosinophilic esophagitis (EoE) is an allergic inflammatory disease of the esophagus featuring increased esophageal interleukin-13 (IL-13) levels and impaired barrier function. Herein, we investigated leucine-rich repeat-containing protein 31 (LRRC31) in human EoE esophageal tissue and IL-13-treated esophageal epitheli...

journal_title：Mucosal immunology

authors： D'Mello RJ,Caldwell JM,Azouz NP,Wen T,Sherrill JD,Hogan SP,Rothenberg ME

更新日期：2016-05-01 00:00:00

abstract：:The mammalian gut microbiota is essential for normal intestinal development, renewal, and repair. Injury to the intestinal mucosa can occur with infection, surgical trauma, and in idiopathic inflammatory bowel disease. Repair of mucosal injury, termed restitution, as well as restoration of intestinal homeostasis invol...

journal_title：Mucosal immunology

authors： Alam A,Leoni G,Wentworth CC,Kwal JM,Wu H,Ardita CS,Swanson PA,Lambeth JD,Jones RM,Nusrat A,Neish AS

更新日期：2014-05-01 00:00:00

abstract：:Sonic hedgehog (SHH) is abundantly expressed and critical for morphogenesis in embryonic lungs; however, SHH expression drops to a much lower level in mice from E17.5 and in humans from the 21st gestational week. We find that SHH expression is robustly upregulated in the airway epithelia of children with asthma or mou...

journal_title：Mucosal immunology

authors： Xu C,Zou C,Hussain M,Shi W,Shao Y,Jiang Z,Wu X,Lu M,Wu J,Xie Q,Ke Y,Long F,Tang L,Wu X

更新日期：2018-09-01 00:00:00

abstract：:Whereas gut IgA responses to the microbiota may be multi-centered and diverse, little is known about IgA responses to T-cell-dependent antigens following oral immunizations. Using a novel approach, gut IgA responses to oral hapten (4-hydroxy-3-nitrophenyl)acetyl-cholera toxin (NP-CT) conjugates were followed at the ce...

journal_title：Mucosal immunology

authors： Bergqvist P,Stensson A,Hazanov L,Holmberg A,Mattsson J,Mehr R,Bemark M,Lycke NY

更新日期：2013-01-01 00:00:00

abstract：:This corrects the article DOI: 10.1038/mi.2017.66. ...

journal_title：Mucosal immunology

authors： Bücker R,Krug SM,Moos V,Bojarski C,Schweiger MR,Kerick M,Fromm A,Janßen S,Fromm M,Hering NA,Siegmund B,Schneider T,Barmeyer C,Schulzke JD

更新日期：2018-03-01 00:00:00

abstract：:In a nasal vaccine against influenza, the activation of natural killer T (NKT) cells by intranasal coadministration of alpha-galactosylceramide (alpha-GalCer) can potently enhance protective immune responses. The results of this study show that the NKT cell-activated nasal vaccine can induce an effective cross-protect...

journal_title：Mucosal immunology

authors： Kamijuku H,Nagata Y,Jiang X,Ichinohe T,Tashiro T,Mori K,Taniguchi M,Hase K,Ohno H,Shimaoka T,Yonehara S,Odagiri T,Tashiro M,Sata T,Hasegawa H,Seino KI

更新日期：2008-05-01 00:00:00

abstract：:De novo differentiation of CD4(+)Foxp3(+) regulatory T cells (induced (i) Tregs) occurs preferentially in the gut-associated lymphoid tissues (GALT). We addressed the contribution of background genetic factors in affecting the balance of iTreg, T helper type 1 (Th1), and Th17 cell differentiation in GALT in vivo follo...

journal_title：Mucosal immunology

authors： Valatas V,He J,Rivollier A,Kolios G,Kitamura K,Kelsall BL

更新日期：2013-05-01 00:00:00

abstract：:Accumulating evidence implicates defective innate immunity in the pathogenesis of Crohn's disease (CD). Ineffectual NOD2 (nucleotide-binding oligomerization domain 2) is the most common susceptibility gene contributing to CD. Vitamin D (vD), a potent modulator of innate and adaptive immunity, induces NOD2 gene express...

journal_title：Mucosal immunology

authors： Dionne S,Calderon MR,White JH,Memari B,Elimrani I,Adelson B,Piccirillo C,Seidman EG

更新日期：2014-11-01 00:00:00

abstract：:The roles of macrophages in type 2-driven inflammation and fibrosis remain unclear. Here, using CD11b-diphtheria toxin receptor (DTR) transgenic mice and three models of interleukin 13 (IL-13)-dependent inflammation, fibrosis, and immunity, we show that CD11b(+) F4/80(+) Ly6C(+) macrophages are required for the mainte...

journal_title：Mucosal immunology

authors： Borthwick LA,Barron L,Hart KM,Vannella KM,Thompson RW,Oland S,Cheever A,Sciurba J,Ramalingam TR,Fisher AJ,Wynn TA

更新日期：2016-01-01 00:00:00