Abstract：
:The communities of bacteria that reside in the intestinal tract are in constant competition within this dynamic and densely colonized environment. At homeostasis, the equilibrium that exists between these species and strains is shaped by their metabolism and also by pathways of active antagonism, which drive competition with related and unrelated strains. Importantly, these normal activities contribute to colonization resistance by the healthy microbiota, which includes the ability to prevent the expansion of potential pathogens. Disruption of the microbiota, resulting from, for example, inflammation or antibiotic use, can reduce colonization resistance. Pathogens that engraft following disruption of the microbiota are often adapted to expand into newly created niches and compete in an altered gut environment. In this review, we examine both the interbacterial mechanisms of colonization resistance and the strategies of pathogenic strains to exploit gaps in colonization resistance.
journal_name
Mucosal Immunoljournal_title
Mucosal immunologyauthors
Sorbara MT,Pamer EGdoi
10.1038/s41385-018-0053-0subject
Has Abstractpub_date
2019-01-01 00:00:00pages
1-9issue
1eissn
1933-0219issn
1935-3456pii
10.1038/s41385-018-0053-0journal_volume
12pub_type
杂志文章,评审abstract：:Induction of mucosal immunity is critical for protection from enteric pathogens. Heat shock protein gp96 is one of the primary peptide and protein chaperones located in the endoplasmic reticulum. We reported previously that a cell-secreted gp96-Ig fusion protein (gp96-Ig) mediated strong systemic, antigen-specific CD8...
journal_title：Mucosal immunology
pub_type： 杂志文章
doi：10.1038/mi.2009.127
更新日期：2010-03-01 00:00:00
abstract：:Dectin-1 (gene symbol: Clec7a) is a receptor for β-glucans that play an important role for the host defense against fungi. Recently, we showed that Clec7a-/- mice are resistant against dextran sodium sulfate (DSS)-induced colitis because of regulatory T-cell population expansion in the colon. The regulatory T-cell exp...
journal_title：Mucosal immunology
pub_type： 杂志文章
doi：10.1038/mi.2017.86
更新日期：2018-05-01 00:00:00
abstract：:Lung resident memory CD8 T cells (TRM) are critical for protection against respiratory viruses, but the cellular interactions required for their development are poorly understood. Herein we describe the necessity of classical monocytes for the establishment of lung TRM following influenza infection. We find that, duri...
journal_title：Mucosal immunology
pub_type： 杂志文章
doi：10.1038/s41385-019-0224-7
更新日期：2020-01-01 00:00:00
abstract：:Chronic beryllium disease (CBD) is a granulomatous lung disorder that is associated with the accumulation of beryllium (Be)-specific CD4(+) T cells into the lung. Genetic susceptibility is linked to HLA-DPB1 alleles that possess a glutamic acid at position 69 (βGlu69), and HLA-DPB1*02:01 is the most prevalent βGlu69-c...
journal_title：Mucosal immunology
pub_type： 杂志文章
doi：10.1038/mi.2015.54
更新日期：2016-01-01 00:00:00
abstract：:Neutrophils are implicated in the pathogenesis of tuberculosis (TB), a disease caused by Mycobacterium tuberculosis infection, but the mechanisms by which they promote disease are not fully understood. Neutrophils can express cytokines that influence TB progression, and so we compared neutrophil and T-cell expression ...
journal_title：Mucosal immunology
pub_type： 杂志文章
doi：10.1038/s41385-019-0195-8
更新日期：2019-11-01 00:00:00
abstract：:Human papillomaviruses (HPV)-related cervical cancer is the second leading cause of cancer death in women worldwide. Despite active development, HPV E6/E7 oncogene-specific therapeutic vaccines have had limited clinical efficacy to date. Here, we report that intravaginal (IVAG) instillation of CpG-ODN (TLR9 agonist) o...
journal_title：Mucosal immunology
pub_type： 杂志文章
doi：10.1038/mi.2012.83
更新日期：2013-03-01 00:00:00
abstract：:The seasonal burden of influenza coupled with the pandemic outbreaks of more pathogenic strains underscore a critical need to understand the pathophysiology of influenza injury in the lung. Interleukin-22 (IL-22) is a promising cytokine that is critical in protecting the lung during infection. This cytokine is strongl...
journal_title：Mucosal immunology
pub_type： 杂志文章
doi：10.1038/s41385-019-0206-9
更新日期：2020-01-01 00:00:00
abstract：:T helper type (Th17) cytokines such as interleukin (IL)-17A and IL-22 are important in maintaining mucosal barrier function and may be important in the pathogenesis of inflammatory bowel diseases (IBDs). Here, we analyzed cells from the colon of IBD patients and show that Crohn's disease (CD) patients had significantl...
journal_title：Mucosal immunology
pub_type： 杂志文章
doi：10.1038/mi.2013.31
更新日期：2014-01-01 00:00:00
abstract：:Celiac disease is a multifactorial disorder and provides a privileged model to decipher how the interplay between environmental and genetic factors can alter mucosal tolerance to a food antigen, lead to chronic intestinal inflammation, and ultimately promote T-cell lymphomagenesis. Here we summarize how HLA-DQ2/8 mole...
journal_title：Mucosal immunology
pub_type： 评论,杂志文章,评审
doi：10.1038/mi.2008.75
更新日期：2009-01-01 00:00:00
abstract：:Chlamydia trachomatis (Ct) is an obligate intracellular bacterial pathogen. Previously, we showed that infection of human trophoblast cells by Ct triggers the secretion of the pro-inflammatory cytokine, interleukin (IL)-1β. The aim of this study was to understand the innate immune pathways involved in trophoblast prod...
journal_title：Mucosal immunology
pub_type： 杂志文章
doi：10.1038/mi.2012.63
更新日期：2013-03-01 00:00:00
abstract：:Cholera is a severe diarrheal disease caused by the bacterium Vibrio cholerae (V. cholerae) that results in 3-4 million cases globally with 100,000-150,000 deaths reported annually. Mostly confined to developing nations, current strategies to control the spread of cholera include the provision of safe drinking water a...
journal_title：Mucosal immunology
pub_type： 杂志文章
doi：10.1038/s41385-019-0159-z
更新日期：2019-07-01 00:00:00
abstract：:The study of animal immune physiology and animal models of human disease have accelerated many aspects of translational research by allowing direct, definitive investigations. In particular, the use of mice has allowed genetic manipulation, adoptive transfer, immunization, and focused cell and tissue sampling, which w...
journal_title：Mucosal immunology
pub_type： 杂志文章,评审
doi：10.1038/mi.2010.85
更新日期：2011-03-01 00:00:00
abstract：:Individuals with one atopic disease are far more likely to develop a second. Approximately half of all atopic dermatitis (AD) patients subsequently develop asthma, particularly those with severe AD. This association, suggesting a role for AD as an entry point for subsequent allergic disease, is a phenomenon known as t...
journal_title：Mucosal immunology
pub_type： 杂志文章
doi：10.1038/mi.2012.14
更新日期：2012-05-01 00:00:00
abstract：:Cells of the mononuclear phagocyte system (MPS) are found in large numbers in every organ of the body, where they contribute to innate and acquired immunity and homeostasis. This review considers the locations of MPS cells, surface markers that distinguish subsets of monocytes and macrophages, the pathways of MPS diff...
journal_title：Mucosal immunology
pub_type： 杂志文章,评审
doi：10.1038/mi.2008.36
更新日期：2008-11-01 00:00:00
abstract：:Women with asymptomatic Neisseria gonorrhoeae infection are at risk of developing pelvic inflammatory disease (PID) if the bacteria ascend from the endocervix into the uterus and oviducts. Factors that affect disease severity, ranging from mild discomfort to severe inflammation, pain, and infertility, remain elusive. ...
journal_title：Mucosal immunology
pub_type： 杂志文章
doi：10.1038/mi.2015.122
更新日期：2016-07-01 00:00:00
abstract：:Neutrophils clear viruses, but excessive neutrophil responses induce tissue injury and worsen disease. Aging increases mortality to influenza infection; however, whether this is due to impaired viral clearance or a pathological host immune response is unknown. Here we show that aged mice have higher levels of lung neu...
journal_title：Mucosal immunology
pub_type： 杂志文章
doi：10.1038/s41385-018-0115-3
更新日期：2019-03-01 00:00:00
abstract：:In a nasal vaccine against influenza, the activation of natural killer T (NKT) cells by intranasal coadministration of alpha-galactosylceramide (alpha-GalCer) can potently enhance protective immune responses. The results of this study show that the NKT cell-activated nasal vaccine can induce an effective cross-protect...
journal_title：Mucosal immunology
pub_type： 杂志文章
doi：10.1038/mi.2008.2
更新日期：2008-05-01 00:00:00
abstract：:Mucus, with its burden of inspired particulates and pathogens, is cleared from mucosal surfaces of the airways by cilia beating within the periciliary layer (PCL). The PCL is held to be "watery" and free of mucus by thixotropic-like forces arising from beating cilia. With radii of gyration ~250 nm, however, polymeric ...
journal_title：Mucosal immunology
pub_type： 杂志文章
doi：10.1038/mi.2012.81
更新日期：2013-03-01 00:00:00
abstract：:Secondary bacterial pneumonia is a significant complication of severe influenza infection and Staphylococcus aureus and Streptococcus pneumoniae are the primary pathogens of interest. IL-22 promotes S. aureus and S. pneumoniae host defense in the lung through epithelial integrity and induction of antimicrobial peptide...
journal_title：Mucosal immunology
pub_type： 杂志文章
doi：10.1038/s41385-019-0188-7
更新日期：2019-09-01 00:00:00
abstract：:How the immune system senses aeroallergens and triggers an aberrant inflammation is poorly understood. Dectin-2 is a house dust mite (HDM)-sensing pattern recognition receptor. In a 3-week mouse model of repeated intranasal HDM challenge, anti-Dectin-2 potently attenuated the characteristic allergic inflammation and a...
journal_title：Mucosal immunology
pub_type： 杂志文章
doi：10.1038/mi.2013.74
更新日期：2014-05-01 00:00:00
abstract：:The mechanisms underlying the massive gastrointestinal tract CD4 T-cell depletion in human immunodeficiency virus (HIV) infection are not well understood nor is it clear whether similar depletion is manifest at other mucosal surfaces. Studies of T-cell and virus dynamics in different anatomical sites have begun to ill...
journal_title：Mucosal immunology
pub_type： 杂志文章
doi：10.1038/mi.2007.5
更新日期：2008-01-01 00:00:00
abstract：:Sonic hedgehog (SHH) is abundantly expressed and critical for morphogenesis in embryonic lungs; however, SHH expression drops to a much lower level in mice from E17.5 and in humans from the 21st gestational week. We find that SHH expression is robustly upregulated in the airway epithelia of children with asthma or mou...
journal_title：Mucosal immunology
pub_type： 杂志文章
doi：10.1038/s41385-018-0033-4
更新日期：2018-09-01 00:00:00
abstract：:Insufficient T-cell responses contribute to the increased burden of viral respiratory disease in infancy. Neonatal dendritic cells (DCs) often provide defective activation of pathogen-specific T cells through mechanisms that are incompletely understood, which hinders vaccine design for this vulnerable age group. Enhan...
journal_title：Mucosal immunology
pub_type： 杂志文章
doi：10.1038/s41385-019-0234-5
更新日期：2020-03-01 00:00:00
abstract：:The mammalian gut microbiota is essential for normal intestinal development, renewal, and repair. Injury to the intestinal mucosa can occur with infection, surgical trauma, and in idiopathic inflammatory bowel disease. Repair of mucosal injury, termed restitution, as well as restoration of intestinal homeostasis invol...
journal_title：Mucosal immunology
pub_type： 杂志文章
doi：10.1038/mi.2013.84
更新日期：2014-05-01 00:00:00
abstract：:Most HIV transmissions among men who have sex with men (MSM), the group that accounted for 67% of new US infections in 2014, occur via exposure to the rectal mucosa. However, it is unclear how the act of condomless receptive anal intercourse (CRAI) may alter the mucosal immune environment in HIV-negative MSM. Here, we...
journal_title：Mucosal immunology
pub_type： 杂志文章
doi：10.1038/mi.2016.97
更新日期：2017-07-01 00:00:00
abstract：:The extent to which tissue-specific viral infections generate memory T cells specifically adapted to and maintained within the target infection site is unknown. Here, we show that respiratory virus-specific memory T cells in mice and humans are generated and maintained in compartmentalized niches in lungs, distinct fr...
journal_title：Mucosal immunology
pub_type： 杂志文章
doi：10.1038/mi.2013.67
更新日期：2014-05-01 00:00:00
abstract：:This corrects the article DOI: 10.1038/mi.2017.66. ...
journal_title：Mucosal immunology
pub_type： 杂志文章,已发布勘误
doi：10.1038/mi.2017.78
更新日期：2018-03-01 00:00:00
abstract：:The generation of tissue-resident memory T cells (TRM) is an essential aspect of immunity at mucosal surfaces, and it has been suggested that preferential generation of TRM is one of the principal advantages of mucosally administered vaccines. We have previously shown that antigen-specific, IL-17-producing CD4+ T cell...
journal_title：Mucosal immunology
pub_type： 杂志文章
doi：10.1038/s41385-019-0218-5
更新日期：2020-01-01 00:00:00
abstract：:Respiratory syncytial virus (RSV) is a leading cause of severe lower respiratory tract infections, especially in infants. Lung neutrophilia is a hallmark of RSV disease but the mechanism by which neutrophils are recruited and activated is unclear. Here, we investigate the innate immune signaling pathways underlying ne...
journal_title：Mucosal immunology
pub_type： 杂志文章
doi：10.1038/s41385-019-0190-0
更新日期：2019-09-01 00:00:00
abstract：:Over the past 25 years, studies led in humans have considerably improved our understanding of celiac disease, a complex disease that is generally defined as an autoimmune-like enteropathy induced by dietary gluten in genetically predisposed individuals. Recently, large efforts were also invested in the development of ...
journal_title：Mucosal immunology
pub_type： 杂志文章,评审
doi：10.1038/mi.2014.102
更新日期：2015-01-01 00:00:00
