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Lessons from rodent models in celiac disease.

Abstract：

:Over the past 25 years, studies led in humans have considerably improved our understanding of celiac disease, a complex disease that is generally defined as an autoimmune-like enteropathy induced by dietary gluten in genetically predisposed individuals. Recently, large efforts were also invested in the development of mouse models in order to explore pathogenic hypotheses, and also with the goal to design pretherapeutic models that could be used to test innovative therapies. Yet, modeling this complex multifactorial disease has been a very challenging task. Herein, we review how approaches in rodents have provided insight into celiac disease pathophysiology and also highlight the difficulties met to fully recapitulate the human disease.

journal_name

Mucosal Immunol

journal_title

Mucosal immunology

authors

Korneychuk N,Meresse B,Cerf-Bensussan N

doi

10.1038/mi.2014.102

subject

Has Abstract

pub_date

2015-01-01 00:00:00

pages

18-28

issue

1

eissn

1933-0219

issn

1935-3456

pii

mi2014102

journal_volume

8

pub_type

杂志文章,评审

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