当前位置： SCI文献检索 > Mucosal Immunology期刊下所有文献 > The emerging roles of eosinophils in mucosal homeostasis.

The emerging roles of eosinophils in mucosal homeostasis.

Abstract：

:Eosinophils are granulocytes, typically implicated as end-stage effector cells in type-II immune responses. They are capable of producing a wide array of pre-formed molecules which render them with vast potential to influence a wide variety of processes. Nonetheless, eosinophil research has traditionally focused on their role in anti-helminthic responses and pathophysiological processes in type-II immune disorders, such as allergy and asthma, where eosinophilia is a hallmark phenotype. However, a number of key studies over the past decade have placed this restricted view of eosinophil function into question, presenting additional evidence for eosinophils as critical regulators of various homeostatic processes including immune maintenance, organ development, and tissue regeneration.

journal_name

Mucosal Immunol

journal_title

Mucosal immunology

authors

Shah K,Ignacio A,McCoy KD,Harris NL

doi

10.1038/s41385-020-0281-y

subject

Has Abstract

pub_date

2020-07-01 00:00:00

pages

574-583

issue

4

eissn

1933-0219

issn

1935-3456

pii

10.1038/s41385-020-0281-y

journal_volume

13

pub_type

杂志文章,评审

相关文献

Mucosal Immunology文献大全
  • Differential effect of vitamin D on NOD2- and TLR-induced cytokines in Crohn's disease.

    abstract：:Accumulating evidence implicates defective innate immunity in the pathogenesis of Crohn's disease (CD). Ineffectual NOD2 (nucleotide-binding oligomerization domain 2) is the most common susceptibility gene contributing to CD. Vitamin D (vD), a potent modulator of innate and adaptive immunity, induces NOD2 gene express...

    journal_title：Mucosal immunology

    pub_type： 杂志文章

    doi：10.1038/mi.2014.30

    authors： Dionne S,Calderon MR,White JH,Memari B,Elimrani I,Adelson B,Piccirillo C,Seidman EG

    更新日期：2014-11-01 00:00:00

  • Correlates of protection against human rotavirus disease and the factors influencing protection in low-income settings.

    abstract：:Rotaviruses (RV) are the leading cause of gastroenteritis in infants and children worldwide and are associated with high mortality predominately in low-income settings. The virus is classified into G and P serotypes and further into P genotypes based on differences in the surface-exposed proteins VP7 and VP4, respecti...

    journal_title：Mucosal immunology

    pub_type： 杂志文章,评审

    doi：10.1038/mi.2014.114

    authors： Clarke E,Desselberger U

    更新日期：2015-01-01 00:00:00

  • Adaptation to inflammatory acidity through neutrophil-derived adenosine regulation of SLC26A3.

    abstract：:Acute intestinal inflammation includes the early accumulation of neutrophils (PMN). Based on recent evidence that PMN infiltration "imprints" changes in the local tissue environment through local oxygen depletion and the release of adenine nucleotides, we hypothesized that the interaction between transmigrating PMN an...

    journal_title：Mucosal immunology

    pub_type： 杂志文章

    doi：10.1038/s41385-019-0237-2

    authors： Cartwright IM,Curtis VF,Lanis JM,Alexeev EE,Welch N,Goldberg MS,Schaefer REM,Gao RY,Chun C,Fennimore B,Onyiah JC,Gerich ME,Dempsey PJ,Colgan SP

    更新日期：2020-03-01 00:00:00

  • Repeated vaginal administration of trimeric HIV-1 clade C gp140 induces serum and mucosal antibody responses.

    abstract：:Vaccine-mediated prevention of primary infection with human immunodeficiency virus (HIV) may require the sustained production of antibody at mucosal portals of entry. Here, we describe a novel approach of repeated mucosal immunization by delivering an HIV-1 envelope glycoprotein (gp) in a gel formulated for intravagin...

    journal_title：Mucosal immunology

    pub_type： 杂志文章

    doi：10.1038/mi.2009.110

    authors： Cranage MP,Fraser CA,Stevens Z,Huting J,Chang M,Jeffs SA,Seaman MS,Cope A,Cole T,Shattock RJ

    更新日期：2010-01-01 00:00:00

  • Redox signaling regulates commensal-mediated mucosal homeostasis and restitution and requires formyl peptide receptor 1.

    abstract：:The mammalian gut microbiota is essential for normal intestinal development, renewal, and repair. Injury to the intestinal mucosa can occur with infection, surgical trauma, and in idiopathic inflammatory bowel disease. Repair of mucosal injury, termed restitution, as well as restoration of intestinal homeostasis invol...

    journal_title：Mucosal immunology

    pub_type： 杂志文章

    doi：10.1038/mi.2013.84

    authors： Alam A,Leoni G,Wentworth CC,Kwal JM,Wu H,Ardita CS,Swanson PA,Lambeth JD,Jones RM,Nusrat A,Neish AS

    更新日期：2014-05-01 00:00:00

  • Impaired calcineurin signaling in myeloid cells results in downregulation of pentraxin-3 and increased susceptibility to aspergillosis.

    abstract：:Treatment of post-transplant patients with immunosuppressive drugs targeting the calcineurin-nuclear factor of activated T cells (NFAT) pathway, including cyclosporine A or tacrolimus, is commonly associated with a higher incidence of opportunistic infections, such as Aspergillus fumigatus, which can lead to severe li...

    journal_title：Mucosal immunology

    pub_type： 杂志文章

    doi：10.1038/mi.2016.52

    authors： Zelante T,Wong AY,Mencarelli A,Foo S,Zolezzi F,Lee B,Poidinger M,Ricciardi-Castagnoli P,Fric J

    更新日期：2017-03-01 00:00:00

  • BLT1 mediates commensal bacteria-dependent innate immune signals to enhance antigen-specific intestinal IgA responses.

    abstract：:Leukotriene B4 receptor 1 (BLT1) triggers the migration of granulocytes and activated T cells; however, its role in B-cell function remains unclear. Here we report that BLT1 is required to induce the production of antigen-specific IgA against oral vaccine through mediating innate immune signals from commensal bacteria...

    journal_title：Mucosal immunology

    pub_type： 杂志文章

    doi：10.1038/s41385-019-0175-z

    authors： Nagatake T,Hirata SI,Koga T,Kuroda E,Kobari S,Suzuki H,Hosomi K,Matsumoto N,Yanrismet Y,Shimojou M,Morimoto S,Sasaki F,Ishii KJ,Yokomizo T,Kunisawa J

    更新日期：2019-09-01 00:00:00

  • Anti-CXCL13 antibody can inhibit the formation of gastric lymphoid follicles induced by Helicobacter infection.

    abstract：:Helicobacter suis infects the stomachs of both animals and humans, and can induce gastric mucosa-associated lymphoid tissue (MALT) lymphomas. It is known that CXC chemokine ligand 13 (CXCL13) is highly expressed in the Helicobacter-infected mice and gastric MALT lymphoma patients, but the pathway that links the activa...

    journal_title：Mucosal immunology

    pub_type： 杂志文章

    doi：10.1038/mi.2014.14

    authors： Yamamoto K,Nishiumi S,Yang L,Klimatcheva E,Pandina T,Takahashi S,Matsui H,Nakamura M,Zauderer M,Yoshida M,Azuma T

    更新日期：2014-09-01 00:00:00

  • Metal-specific CD4+ T-cell responses induced by beryllium exposure in HLA-DP2 transgenic mice.

    abstract：:Chronic beryllium disease (CBD) is a granulomatous lung disorder that is associated with the accumulation of beryllium (Be)-specific CD4(+) T cells into the lung. Genetic susceptibility is linked to HLA-DPB1 alleles that possess a glutamic acid at position 69 (βGlu69), and HLA-DPB1*02:01 is the most prevalent βGlu69-c...

    journal_title：Mucosal immunology

    pub_type： 杂志文章

    doi：10.1038/mi.2015.54

    authors： Falta MT,Tinega AN,Mack DG,Bowerman NA,Crawford F,Kappler JW,Pinilla C,Fontenot AP

    更新日期：2016-01-01 00:00:00

  • A screen of Crohn's disease-associated microbial metabolites identifies ascorbate as a novel metabolic inhibitor of activated human T cells.

    abstract：:Microbial metabolites are an emerging class of mediators influencing CD4+ T-cell function. To advance the understanding of direct causal microbial factors contributing to Crohn's disease, we screened 139 predicted Crohn's disease-associated microbial metabolites for their bioactivity on human CD4+ T-cell functions ind...

    journal_title：Mucosal immunology

    pub_type： 杂志文章

    doi：10.1038/s41385-018-0022-7

    authors： Chang YL,Rossetti M,Vlamakis H,Casero D,Sunga G,Harre N,Miller S,Humphries R,Stappenbeck T,Simpson KW,Sartor RB,Wu G,Lewis J,Bushman F,McGovern DPB,Salzman N,Borneman J,Xavier R,Huttenhower C,Braun J

    更新日期：2019-03-01 00:00:00

  • Polysaccharide-protein conjugate vaccination induces antibody production but not sustained B-cell memory in the human nasopharyngeal mucosa.

    abstract：:Colonization of the nasopharyngeal mucosa by meningococcus and other polysaccharide (PS)-encapsulated bacteria precedes invasion. PS-conjugate vaccines induce PS-specific B-cell memory (B(MEM)) and also prevent colonization, thus blocking person-to-person transmission, generating herd protection. However, in isolation...

    journal_title：Mucosal immunology

    pub_type： 杂志文章

    doi：10.1038/mi.2012.70

    authors： Clarke ET,Williams NA,Dull PM,Findlow J,Borrow R,Finn A,Heyderman RS

    更新日期：2013-03-01 00:00:00

  • Lessons from rodent models in celiac disease.

    abstract：:Over the past 25 years, studies led in humans have considerably improved our understanding of celiac disease, a complex disease that is generally defined as an autoimmune-like enteropathy induced by dietary gluten in genetically predisposed individuals. Recently, large efforts were also invested in the development of ...

    journal_title：Mucosal immunology

    pub_type： 杂志文章,评审

    doi：10.1038/mi.2014.102

    authors： Korneychuk N,Meresse B,Cerf-Bensussan N

    更新日期：2015-01-01 00:00:00

  • Epigallocatechin-3-gallate local pre-exposure application prevents SHIV rectal infection of macaques.

    abstract：:Epigallocatechin-3-gallate (EGCG), a natural and major ingredient of green tea, has been shown to have anti-inflammation and anti-HIV-1 properties. We demonstrated that the intrarectal administration of EGCG could protect rhesus macaques from repetitive, intrarectal challenges with low-dose SHIVSF162P3N. This protecti...

    journal_title：Mucosal immunology

    pub_type： 杂志文章

    doi：10.1038/s41385-018-0025-4

    authors： Liu JB,Li JL,Zhuang K,Liu H,Wang X,Xiao QH,Li XD,Zhou RH,Zhou L,Ma TC,Zhou W,Liu MQ,Ho WZ

    更新日期：2018-07-01 00:00:00

  • Flagellin: key target of mucosal innate immunity.

    abstract：:The mucosal immune system is charged with defending the host's vast interfaces with the outside world from the enormous and diverse group of microbes that colonizes these surfaces. A key means by which the mucosal immune system protects the host from such diverse microbes is using germ-line-encoded receptors that targ...

    journal_title：Mucosal immunology

    pub_type： 杂志文章,评审

    doi：10.1038/mi.2009.9

    authors： Vijay-Kumar M,Gewirtz AT

    更新日期：2009-05-01 00:00:00

  • An African perspective on mucosal immunity and HIV-1.

    abstract：:HIV prevention mandates an understanding of the mechanisms of mucosal immunity with attention to some unique features of the epidemic and mucosal environment in the developing world. An effective vaccine will have to induce mucosal protection against a highly diverse virus, which is equipped with a number of immune ev...

    journal_title：Mucosal immunology

    pub_type： 杂志文章,评审

    doi：10.1038/mi.2009.23

    authors： Pala P,Gomez-Roman VR,Gilmour J,Kaleebu P

    更新日期：2009-07-01 00:00:00

  • Re-utilization of germinal centers in multiple Peyer's patches results in highly synchronized, oligoclonal, and affinity-matured gut IgA responses.

    abstract：:Whereas gut IgA responses to the microbiota may be multi-centered and diverse, little is known about IgA responses to T-cell-dependent antigens following oral immunizations. Using a novel approach, gut IgA responses to oral hapten (4-hydroxy-3-nitrophenyl)acetyl-cholera toxin (NP-CT) conjugates were followed at the ce...

    journal_title：Mucosal immunology

    pub_type： 杂志文章

    doi：10.1038/mi.2012.56

    authors： Bergqvist P,Stensson A,Hazanov L,Holmberg A,Mattsson J,Mehr R,Bemark M,Lycke NY

    更新日期：2013-01-01 00:00:00

  • Noxa/HSP27 complex delays degradation of ubiquitylated IkBα in airway epithelial cells to reduce pulmonary inflammation.

    abstract：:IFN-γ is known as a pro-inflammatory cytokine, but can also block inflammation in certain chronic diseases although the underlying mechanisms are poorly understood. We found that IFN-γ rapidly induced Noxa expression and that extent of inflammation by repeated house dust mite exposure was enhanced in noxa-/- compared ...

    journal_title：Mucosal immunology

    pub_type： 杂志文章

    doi：10.1038/mi.2017.117

    authors： Zhang C,Jones JT,Chand HS,Wathelet MG,Evans CM,Dickey B,Xiang J,Mebratu YA,Tesfaigzi Y

    更新日期：2018-05-01 00:00:00

  • Leptin signaling in intestinal epithelium mediates resistance to enteric infection by Entamoeba histolytica.

    abstract：:Leptin is an adipocytokine that links nutrition to immunity. Previous observation that a genetic polymorphism in the leptin receptor affected susceptibility to Entamoeba histolytica infection led to the hypothesis that leptin signaling has a protective role during intestinal amebic infection. In this study we show tha...

    journal_title：Mucosal immunology

    pub_type： 杂志文章

    doi：10.1038/mi.2010.76

    authors： Guo X,Roberts MR,Becker SM,Podd B,Zhang Y,Chua SC Jr,Myers MG Jr,Duggal P,Houpt ER,Petri WA Jr

    更新日期：2011-05-01 00:00:00

  • MyD88 dependence of beryllium-induced dendritic cell trafficking and CD4⁺ T-cell priming.

    abstract：:Beryllium exposure results in beryllium hypersensitivity in a subset of exposed individuals, leading to granulomatous inflammation and fibrosis in the lung. In addition to its antigenic properties, beryllium has potent adjuvant activity that contributes to sensitization via unknown pathways. Here we show that berylliu...

    journal_title：Mucosal immunology

    pub_type： 杂志文章

    doi：10.1038/mi.2015.14

    authors： McKee AS,Mack DG,Crawford F,Fontenot AP

    更新日期：2015-11-01 00:00:00

  • Retinoic acid takes effector T cells to the gallows: P2X7, the molecular hangman.

    abstract：:Effector T-cell contraction is one of the primary means by which immune homeostasis in the peripheral tissues is reestablished following an inflammatory response. In this issue of Mucosal Immunology, Hashimoto-Hill et al.1 show that retinoic acid (RA) transcriptionally upregulates P2X7 primarily in effector T cells of...

    journal_title：Mucosal immunology

    pub_type： 评论,杂志文章

    doi：10.1038/mi.2016.117

    authors： Das S,Villablanca EJ

    更新日期：2017-07-01 00:00:00

  • Immunization with Ty21a live oral typhoid vaccine elicits crossreactive multifunctional CD8+ T-cell responses against Salmonella enterica serovar Typhi, S. Paratyphi A, and S. Paratyphi B in humans.

    abstract：:Previously we have extensively characterized Salmonella enterica serovar Typhi (S. Typhi)-specific cell-mediated immune (CMI) responses in volunteers orally immunized with the licensed Ty21a typhoid vaccine. In this study we measured Salmonella-specific multifunctional (MF) CD8+ T-cell responses to further investigate...

    journal_title：Mucosal immunology

    pub_type： 杂志文章

    doi：10.1038/mi.2015.24

    authors： Wahid R,Fresnay S,Levine MM,Sztein MB

    更新日期：2015-11-01 00:00:00

  • Alpha4(+)beta7(hi)CD4(+) memory T cells harbor most Th-17 cells and are preferentially infected during acute SIV infection.

    abstract：:Human immunodeficiency virus/simian immunodeficiency virus (HIV/SIV) infections are believed to infect minimally activated CD4(+) T cells after viral entry. Not much is known about why SIV selectively targets these cells. Here we show that CD4(+) T cells that express high levels of the alpha4beta7 heterodimer are pref...

    journal_title：Mucosal immunology

    pub_type： 杂志文章

    doi：10.1038/mi.2009.90

    authors： Kader M,Wang X,Piatak M,Lifson J,Roederer M,Veazey R,Mattapallil JJ

    更新日期：2009-09-01 00:00:00

  • New insights into innate immune mechanisms underlying allergenicity.

    abstract：:Allergic diseases, which have reached epidemic proportions, are caused by inappropriate immune responses to a relatively small number of environmental proteins. The molecular basis for the propensity of specific proteins to promote maladaptive, allergic responses has been difficult to define. Recent data suggest that ...

    journal_title：Mucosal immunology

    pub_type： 杂志文章,评审

    doi：10.1038/mi.2009.138

    authors： Wills-Karp M,Nathan A,Page K,Karp CL

    更新日期：2010-03-01 00:00:00

  • The human lung mucosa drives differential Mycobacterium tuberculosis infection outcome in the alveolar epithelium.

    abstract：:Mycobacterium tuberculosis (M.tb) is deposited into the alveolus where it first encounters the alveolar lining fluid (ALF) prior contacts host cells. We demonstrated that M.tb-exposure to human ALF alters its cell surface, driving better M.tb infection control by professional phagocytes. Contrary to these findings, ou...

    journal_title：Mucosal immunology

    pub_type： 杂志文章

    doi：10.1038/s41385-019-0156-2

    authors： Scordo JM,Olmo-Fontánez AM,Kelley HV,Sidiki S,Arcos J,Akhter A,Wewers MD,Torrelles JB

    更新日期：2019-05-01 00:00:00

  • Selective deletion of MyD88 signaling in α-SMA positive cells ameliorates experimental intestinal fibrosis via post-transcriptional regulation.

    abstract：:Intestinal fibrosis leading to strictures remains a significant clinical problem in inflammatory bowel diseases (IBD). The role of bacterial components in activating intestinal mesenchymal cells and driving fibrogenesis is largely unexplored. Tamoxifen-inducible α-SMA promoter Cre mice crossed with floxed MyD88 mice w...

    journal_title：Mucosal immunology

    pub_type： 杂志文章

    doi：10.1038/s41385-020-0259-9

    authors： Zhao S,Dejanovic D,Yao P,Bhilocha S,Sadler T,Schirbel A,West G,Doyon G,Lopez R,Mao R,Kurada S,El Ouali S,Grassl G,Fox PL,Cruise M,Worthley DL,de la Motte C,Fiocchi C,Rieder F

    更新日期：2020-07-01 00:00:00

  • Restoring cigarette smoke-induced impairment of efferocytosis in alveolar macrophages.

    abstract：:Cigarette smoke has been associated with susceptibility to different pulmonary and airway diseases. Impaired alveolar macrophages (AMs) that are major phagocytes in the lung have been associated with patients with airway diseases and active smokers. In the current report, we show that exposure to second-hand cigarette...

    journal_title：Mucosal immunology

    pub_type： 杂志文章

    doi：10.1038/mi.2015.120

    authors： Subramaniam R,Mukherjee S,Chen H,Keshava S,Neuenschwander P,Shams H

    更新日期：2016-07-01 00:00:00

  • Mucosal adjuvants and long-term memory development with special focus on CTA1-DD and other ADP-ribosylating toxins.

    abstract：:The ultimate goal for vaccination is to stimulate protective immunological memory. Protection against infectious diseases not only relies on the magnitude of the humoral immune response, but more importantly on the quality and longevity of it. Adjuvants are critical components of most non-living vaccines. Although lit...

    journal_title：Mucosal immunology

    pub_type： 杂志文章,评审

    doi：10.1038/mi.2010.54

    authors： Lycke N,Bemark M

    更新日期：2010-11-01 00:00:00

  • Synergistic activation of pro-inflammatory type-2 CD8+ T lymphocytes by lipid mediators in severe eosinophilic asthma.

    abstract：:Human type-2 CD8+ T cells are a cell population with potentially important roles in allergic disease. We investigated this in the context of severe asthma with persistent airway eosinophilia-a phenotype associated with high exacerbation risk and responsiveness to type-2 cytokine-targeted therapies. In two independent ...

    journal_title：Mucosal immunology

    pub_type： 杂志文章

    doi：10.1038/s41385-018-0049-9

    authors： Hilvering B,Hinks TSC,Stöger L,Marchi E,Salimi M,Shrimanker R,Liu W,Chen W,Luo J,Go S,Powell T,Cane J,Thulborn S,Kurioka A,Leng T,Matthews J,Connolly C,Borg C,Bafadhel M,Willberg CB,Ramasamy A,Djukanović R,Ogg

    更新日期：2018-09-01 00:00:00

  • Celiac disease: from oral tolerance to intestinal inflammation, autoimmunity and lymphomagenesis.

    abstract：:Celiac disease is a multifactorial disorder and provides a privileged model to decipher how the interplay between environmental and genetic factors can alter mucosal tolerance to a food antigen, lead to chronic intestinal inflammation, and ultimately promote T-cell lymphomagenesis. Here we summarize how HLA-DQ2/8 mole...

    journal_title：Mucosal immunology

    pub_type： 评论,杂志文章,评审

    doi：10.1038/mi.2008.75

    authors： Meresse B,Ripoche J,Heyman M,Cerf-Bensussan N

    更新日期：2009-01-01 00:00:00

  • HIV-1 gp41-specific monoclonal mucosal IgAs derived from highly exposed but IgG-seronegative individuals block HIV-1 epithelial transcytosis and neutralize CD4(+) cell infection: an IgA gene and functional analysis.

    abstract：:AIDS is mainly a sexually transmitted disease, and accordingly, mucosal tissues are the primary sites of natural human immunodeficiency virus type-1 (HIV-1) transmission. Mucosal immunoglobulin A (IgA) antibody specific for HIV-1 envelope gp41 subunit is one correlate of protection in individuals who are highly sexual...

    journal_title：Mucosal immunology

    pub_type： 杂志文章

    doi：10.1038/mi.2009.89

    authors： Tudor D,Derrien M,Diomede L,Drillet AS,Houimel M,Moog C,Reynes JM,Lopalco L,Bomsel M

    更新日期：2009-09-01 00:00:00