Abstract：
:Rotaviruses (RV) are the leading cause of gastroenteritis in infants and children worldwide and are associated with high mortality predominately in low-income settings. The virus is classified into G and P serotypes and further into P genotypes based on differences in the surface-exposed proteins VP7 and VP4, respectively. Infection results in a variable level of protection from subsequent reinfection and disease. This protection is predominantly homotypic in some settings, whereas broader heterotypic protection is reported in other cohorts. Two antigenically distinct oral RV vaccines are licensed and are being rolled out widely, including in resource-poor setting, with funding provided by the GAVI alliance. First is a monovalent vaccine derived from a live-attenuated human RV strain, whereas the second is a pentavalent bovine-human reassortment vaccine. Both vaccines are highly efficacious in high-income settings, but greatly reduced levels of protection are reported in low-income countries. Here, the current challenges facing mucosal immunologists and vaccinologists aiming to define immunological correlates and to understand the variable levels of protection conferred by these vaccines in humans is considered. Such understanding is critical to maximize the public health impact of the current vaccines and also to the development of the next generation of RV vaccines, which are needed.
journal_name
Mucosal Immunoljournal_title
Mucosal immunologyauthors
Clarke E,Desselberger Udoi
10.1038/mi.2014.114subject
Has Abstractpub_date
2015-01-01 00:00:00pages
1-17issue
1eissn
1933-0219issn
1935-3456pii
mi2014114journal_volume
8pub_type
杂志文章,评审abstract：:Cholera is a severe diarrheal disease caused by the bacterium Vibrio cholerae (V. cholerae) that results in 3-4 million cases globally with 100,000-150,000 deaths reported annually. Mostly confined to developing nations, current strategies to control the spread of cholera include the provision of safe drinking water a...
journal_title：Mucosal immunology
pub_type： 杂志文章
doi：10.1038/s41385-019-0159-z
更新日期：2019-07-01 00:00:00
abstract：:Helicobacter suis infects the stomachs of both animals and humans, and can induce gastric mucosa-associated lymphoid tissue (MALT) lymphomas. It is known that CXC chemokine ligand 13 (CXCL13) is highly expressed in the Helicobacter-infected mice and gastric MALT lymphoma patients, but the pathway that links the activa...
journal_title：Mucosal immunology
pub_type： 杂志文章
doi：10.1038/mi.2014.14
更新日期：2014-09-01 00:00:00
abstract：:Natural intraepithelial lymphocytes (IELs) are thymus-derived adaptive immune cells, which are important contributors to intestinal immune homeostasis. Similar to other innate-like T cells, they are induced in the thymus through high-avidity interaction that would otherwise lead to clonal deletion in conventional CD4 ...
journal_title：Mucosal immunology
pub_type： 杂志文章
doi：10.1038/s41385-019-0220-y
更新日期：2020-03-01 00:00:00
abstract：:This corrects the article DOI: 10.1038/mi.2017.66. ...
journal_title：Mucosal immunology
pub_type： 杂志文章,已发布勘误
doi：10.1038/mi.2017.78
更新日期：2018-03-01 00:00:00
abstract：:Oral tolerance refers to the observation that prior feeding of an antigen induces local and systemic immune tolerance to that antigen. Physiologically, this process is probably of central importance for preventing inflammatory responses to the numerous dietary and microbial antigens present in the gut. Defective oral ...
journal_title：Mucosal immunology
pub_type： 杂志文章,评审
doi：10.1038/mi.2010.25
更新日期：2010-07-01 00:00:00
abstract：:Classical Whipple's disease (CWD) affects the gastrointestinal tract and rather elicits regulatory than inflammatory immune reactions. Mechanisms of malabsorption, diarrhea, and systemic immune activation are unknown. We here analyzed mucosal architecture, barrier function, and immune activation as potential diarrheal...
journal_title：Mucosal immunology
pub_type： 杂志文章
doi：10.1038/mi.2017.6
更新日期：2017-11-01 00:00:00
abstract：:Malaria-associated acute respiratory distress syndrome (MA-ARDS) and acute lung injury (ALI) are complications that cause lung damage and often leads to death. The MA-ARDS/ALI is associated with a Type 1 inflammatory response mediated by T lymphocytes and IFN-γ. Here, we used the Plasmodium berghei NK65 (PbN)-induced ...
journal_title：Mucosal immunology
pub_type： 杂志文章
doi：10.1038/s41385-018-0093-5
更新日期：2019-03-01 00:00:00
abstract：:The γ-amino butyric acid (GABA)ergic system shapes the activation and function of immune cells. The present study was conducted to explore the regulation of GABA transporter (GAT)-2 on the differentiation of Th17 cells. Here we found that Th17 cells show higher abundance of GAT-2, and have distinct cellular metabolic ...
journal_title：Mucosal immunology
pub_type： 杂志文章
doi：10.1038/s41385-018-0111-7
更新日期：2019-03-01 00:00:00
abstract：:Viral respiratory tract infections (RTI) pose a high burden on the youngest members of our society. Several risk factors are known for severe viral respiratory disease. However, a large proportion of the severe RTI cannot be explained by these risk factors. A growing body of evidence shows that the composition of the ...
journal_title：Mucosal immunology
pub_type： 杂志文章,评审
doi：10.1038/mi.2013.93
更新日期：2014-03-01 00:00:00
abstract：:The roles of macrophages in type 2-driven inflammation and fibrosis remain unclear. Here, using CD11b-diphtheria toxin receptor (DTR) transgenic mice and three models of interleukin 13 (IL-13)-dependent inflammation, fibrosis, and immunity, we show that CD11b(+) F4/80(+) Ly6C(+) macrophages are required for the mainte...
journal_title：Mucosal immunology
pub_type： 杂志文章
doi：10.1038/mi.2015.34
更新日期：2016-01-01 00:00:00
abstract：:There continues to be a major need for more effective inflammatory bowel disease (IBD) therapies. IL-13Rα2 is a decoy receptor that binds the cytokine IL-13 with high affinity and diminishes its STAT6-mediated effector functions. Previously, we found that IL-13Rα2 was necessary for IBD in mice deficient in the anti-in...
journal_title：Mucosal immunology
pub_type： 杂志文章
doi：10.1038/s41385-019-0189-6
更新日期：2019-09-01 00:00:00
abstract：:Accumulating evidence implicates defective innate immunity in the pathogenesis of Crohn's disease (CD). Ineffectual NOD2 (nucleotide-binding oligomerization domain 2) is the most common susceptibility gene contributing to CD. Vitamin D (vD), a potent modulator of innate and adaptive immunity, induces NOD2 gene express...
journal_title：Mucosal immunology
pub_type： 杂志文章
doi：10.1038/mi.2014.30
更新日期：2014-11-01 00:00:00
abstract：:Leptin is an adipocytokine that links nutrition to immunity. Previous observation that a genetic polymorphism in the leptin receptor affected susceptibility to Entamoeba histolytica infection led to the hypothesis that leptin signaling has a protective role during intestinal amebic infection. In this study we show tha...
journal_title：Mucosal immunology
pub_type： 杂志文章
doi：10.1038/mi.2010.76
更新日期：2011-05-01 00:00:00
abstract：:The study of animal immune physiology and animal models of human disease have accelerated many aspects of translational research by allowing direct, definitive investigations. In particular, the use of mice has allowed genetic manipulation, adoptive transfer, immunization, and focused cell and tissue sampling, which w...
journal_title：Mucosal immunology
pub_type： 杂志文章,评审
doi：10.1038/mi.2010.85
更新日期：2011-03-01 00:00:00
abstract：:Intestinal macrophages (mφ) form one of the largest populations of mφ in the body and are vital for the maintenance of gut homeostasis. They have several unique properties and are derived from local differentiation of classical Ly6Chi monocytes, but the factors driving this tissue-specific process are not understood. ...
journal_title：Mucosal immunology
pub_type： 杂志文章
doi：10.1038/mi.2016.142
更新日期：2017-11-01 00:00:00
abstract：:Most HIV transmissions among men who have sex with men (MSM), the group that accounted for 67% of new US infections in 2014, occur via exposure to the rectal mucosa. However, it is unclear how the act of condomless receptive anal intercourse (CRAI) may alter the mucosal immune environment in HIV-negative MSM. Here, we...
journal_title：Mucosal immunology
pub_type： 杂志文章
doi：10.1038/mi.2016.97
更新日期：2017-07-01 00:00:00
abstract：:Secondary bacterial pneumonia is a significant complication of severe influenza infection and Staphylococcus aureus and Streptococcus pneumoniae are the primary pathogens of interest. IL-22 promotes S. aureus and S. pneumoniae host defense in the lung through epithelial integrity and induction of antimicrobial peptide...
journal_title：Mucosal immunology
pub_type： 杂志文章
doi：10.1038/s41385-019-0188-7
更新日期：2019-09-01 00:00:00
abstract：:Levels of reactive free radicals are elevated in the airway during asthmatic exacerbations, but their roles in the pathophysiology of asthma remain unclear. We have identified subsets of myeloid-derived suppressor-like cells as key sources of nitric oxide and superoxide in the lungs of mice with evolving experimental ...
journal_title：Mucosal immunology
pub_type： 杂志文章
doi：10.1038/mi.2011.16
更新日期：2011-09-01 00:00:00
abstract：:The tight connection between intestinal inflammation and arthritis in spondyloarthritis (SpA) has been studied extensively. Subclinical gut inflammation, which can be considered as a model for early Crohn's disease, was shown to be strongly associated with joint inflammation. Several early mucosal abnormalities were u...
journal_title：Mucosal immunology
pub_type： 杂志文章,评审
doi：10.1038/mi.2008.24
更新日期：2008-09-01 00:00:00
abstract：:Human papillomaviruses (HPV)-related cervical cancer is the second leading cause of cancer death in women worldwide. Despite active development, HPV E6/E7 oncogene-specific therapeutic vaccines have had limited clinical efficacy to date. Here, we report that intravaginal (IVAG) instillation of CpG-ODN (TLR9 agonist) o...
journal_title：Mucosal immunology
pub_type： 杂志文章
doi：10.1038/mi.2012.83
更新日期：2013-03-01 00:00:00
abstract：:T helper (Th)1 and Th2 cells play decisive roles in the regulation of resistance vs. susceptibility to pulmonary cryptococcosis. To study the function of interleukin (IL)-4 receptor (IL-4R) on Th cells in pulmonary cryptococcosis, we infected mice specifically lacking IL-4Rα on CD4(+) T cells (Lck(Cre)IL-4Rα(-/lox) mi...
journal_title：Mucosal immunology
pub_type： 杂志文章
doi：10.1038/mi.2012.9
更新日期：2012-05-01 00:00:00
abstract：:Peroxisome proliferator-activated receptor-γ (PPAR-γ) is widely expressed in macrophages and has been identified as a putative target for the development of novel therapies against inflammatory bowel disease (IBD). Computational simulations identified macrophages as key targets for therapeutic interventions against IB...
journal_title：Mucosal immunology
pub_type： 杂志文章
doi：10.1038/mi.2010.75
更新日期：2011-05-01 00:00:00
abstract：:Epidemiological data indicate a link between rheumatoid arthritis (RA) and periodontal disease (PD). In vitro and in vivo studies have sought to dissect potential mechanisms by which PD may contribute to initiation and progression of RA. However, these are both multifactorial, chronic diseases, and their complex etiol...
journal_title：Mucosal immunology
pub_type： 杂志文章,评审
doi：10.1038/mi.2011.66
更新日期：2012-03-01 00:00:00
abstract：:The ultimate goal for vaccination is to stimulate protective immunological memory. Protection against infectious diseases not only relies on the magnitude of the humoral immune response, but more importantly on the quality and longevity of it. Adjuvants are critical components of most non-living vaccines. Although lit...
journal_title：Mucosal immunology
pub_type： 杂志文章,评审
doi：10.1038/mi.2010.54
更新日期：2010-11-01 00:00:00
abstract：:The gut mucosa is an important site of HIV immunopathogenesis with severe depletion of CD4+ T cells occurring during acute infection. The effect of prolonged anti-retroviral therapy (ART) on cycling and restoration of T lymphocytes in the gut remains unclear. Colon and terminal ileal biopsies and peripheral blood samp...
journal_title：Mucosal immunology
pub_type： 杂志文章
doi：10.1038/mi.2009.129
更新日期：2010-03-01 00:00:00
abstract：:Vaccine-mediated prevention of primary infection with human immunodeficiency virus (HIV) may require the sustained production of antibody at mucosal portals of entry. Here, we describe a novel approach of repeated mucosal immunization by delivering an HIV-1 envelope glycoprotein (gp) in a gel formulated for intravagin...
journal_title：Mucosal immunology
pub_type： 杂志文章
doi：10.1038/mi.2009.110
更新日期：2010-01-01 00:00:00
abstract：:Individuals with one atopic disease are far more likely to develop a second. Approximately half of all atopic dermatitis (AD) patients subsequently develop asthma, particularly those with severe AD. This association, suggesting a role for AD as an entry point for subsequent allergic disease, is a phenomenon known as t...
journal_title：Mucosal immunology
pub_type： 杂志文章
doi：10.1038/mi.2012.14
更新日期：2012-05-01 00:00:00
abstract：:Eosinophils are granulocytes, typically implicated as end-stage effector cells in type-II immune responses. They are capable of producing a wide array of pre-formed molecules which render them with vast potential to influence a wide variety of processes. Nonetheless, eosinophil research has traditionally focused on th...
journal_title：Mucosal immunology
pub_type： 杂志文章,评审
doi：10.1038/s41385-020-0281-y
更新日期：2020-07-01 00:00:00
abstract：:Treatment of post-transplant patients with immunosuppressive drugs targeting the calcineurin-nuclear factor of activated T cells (NFAT) pathway, including cyclosporine A or tacrolimus, is commonly associated with a higher incidence of opportunistic infections, such as Aspergillus fumigatus, which can lead to severe li...
journal_title：Mucosal immunology
pub_type： 杂志文章
doi：10.1038/mi.2016.52
更新日期：2017-03-01 00:00:00
abstract：:This corrects the article DOI: 10.1038/mi.2017.46. ...
journal_title：Mucosal immunology
pub_type： 杂志文章,已发布勘误
doi：10.1038/mi.2017.79
更新日期：2018-01-01 00:00:00
