Abstract:
:The tight connection between intestinal inflammation and arthritis in spondyloarthritis (SpA) has been studied extensively. Subclinical gut inflammation, which can be considered as a model for early Crohn's disease, was shown to be strongly associated with joint inflammation. Several early mucosal abnormalities were uncovered even in the absence of histological signs of inflammation, providing clues into the pathogenesis of SpA. Nevertheless, many questions remain unanswered. In this review, we highlight recent progress on this intimate relationship between gut and joint inflammation. Emerging evidence exists favoring a role for genes beyond human leukocyte antigen B27 in the genetic predisposition of SpA and intestinal inflammation. Furthermore, the role of these predisposing genes in modulating host-pathogen interaction at mucosal surfaces and the subsequent link between gut and joint inflammation are of utmost importance in understanding the pathogenesis of SpA.
journal_name
Mucosal Immunoljournal_title
Mucosal immunologyauthors
Jacques P,Elewaut Ddoi
10.1038/mi.2008.24subject
Has Abstractpub_date
2008-09-01 00:00:00pages
364-71issue
5eissn
1933-0219issn
1935-3456pii
mi200824journal_volume
1pub_type
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journal_title:Mucosal immunology
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doi:10.1038/mi.2009.89
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doi:10.1038/mi.2008.2
更新日期:2008-05-01 00:00:00
abstract::Human immunodeficiency virus/simian immunodeficiency virus (HIV/SIV) infections are believed to infect minimally activated CD4(+) T cells after viral entry. Not much is known about why SIV selectively targets these cells. Here we show that CD4(+) T cells that express high levels of the alpha4beta7 heterodimer are pref...
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doi:10.1038/mi.2009.90
更新日期:2009-09-01 00:00:00
abstract::Vaccine-mediated prevention of primary infection with human immunodeficiency virus (HIV) may require the sustained production of antibody at mucosal portals of entry. Here, we describe a novel approach of repeated mucosal immunization by delivering an HIV-1 envelope glycoprotein (gp) in a gel formulated for intravagin...
journal_title:Mucosal immunology
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doi:10.1038/mi.2009.110
更新日期:2010-01-01 00:00:00
abstract::Neutrophils clear viruses, but excessive neutrophil responses induce tissue injury and worsen disease. Aging increases mortality to influenza infection; however, whether this is due to impaired viral clearance or a pathological host immune response is unknown. Here we show that aged mice have higher levels of lung neu...
journal_title:Mucosal immunology
pub_type: 杂志文章
doi:10.1038/s41385-018-0115-3
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abstract::Individuals with one atopic disease are far more likely to develop a second. Approximately half of all atopic dermatitis (AD) patients subsequently develop asthma, particularly those with severe AD. This association, suggesting a role for AD as an entry point for subsequent allergic disease, is a phenomenon known as t...
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