Abstract:
:Oral tolerance refers to the observation that prior feeding of an antigen induces local and systemic immune tolerance to that antigen. Physiologically, this process is probably of central importance for preventing inflammatory responses to the numerous dietary and microbial antigens present in the gut. Defective oral tolerance can lead to gut inflammatory disease, food allergies, and celiac disease. In the last two cases, the diseases develop early in life, stressing the necessity of understanding how oral tolerance is set up in neonates. This article reviews the parameters that have been outlined in adult animal models as necessary for tolerance induction and assesses whether these factors operate in neonates. In addition, we highlight the factors that are specific for this period of life and discuss how they could have an impact on oral tolerance. We pay particular attention to maternal influence on early oral tolerance induction through breast-feeding and outline the major parameters that could be modified to optimize tolerance induction in early life and possibly prevent allergic diseases.
journal_name
Mucosal Immunoljournal_title
Mucosal immunologyauthors
Verhasselt Vdoi
10.1038/mi.2010.25subject
Has Abstractpub_date
2010-07-01 00:00:00pages
326-33issue
4eissn
1933-0219issn
1935-3456pii
mi201025journal_volume
3pub_type
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journal_title:Mucosal immunology
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journal_title:Mucosal immunology
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pub_type: 杂志文章,评审
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更新日期:2008-11-01 00:00:00
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pub_type: 评论,杂志文章
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pub_type: 临床试验,杂志文章,多中心研究
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