Differentiation and heterogeneity in the mononuclear phagocyte system.

abstract：:Rotaviruses (RV) are the leading cause of gastroenteritis in infants and children worldwide and are associated with high mortality predominately in low-income settings. The virus is classified into G and P serotypes and further into P genotypes based on differences in the surface-exposed proteins VP7 and VP4, respecti...

journal_title：Mucosal immunology

authors： Clarke E,Desselberger U

更新日期：2015-01-01 00:00:00

abstract：:Alpha B-crystallin (CRYAB) is an important member of the small heat shock protein family, and plays a protective and therapeutic role in neurological inflammation. CRYAB expression was assessed in cultured HT29 and Caco-2 cells and inflamed mucosa of patients with inflammatory bowel disease (IBD) and colitis models in...

journal_title：Mucosal immunology

authors： Xu W,Guo Y,Huang Z,Zhao H,Zhou M,Huang Y,Wen D,Song J,Zhu Z,Sun M,Liu CY,Chen Y,Cui L,Wang X,Liu Z,Yang Y,Du P

更新日期：2019-11-01 00:00:00

abstract：:Allergic diseases, which have reached epidemic proportions, are caused by inappropriate immune responses to a relatively small number of environmental proteins. The molecular basis for the propensity of specific proteins to promote maladaptive, allergic responses has been difficult to define. Recent data suggest that ...

journal_title：Mucosal immunology

authors： Wills-Karp M,Nathan A,Page K,Karp CL

更新日期：2010-03-01 00:00:00

abstract：:Previously we have extensively characterized Salmonella enterica serovar Typhi (S. Typhi)-specific cell-mediated immune (CMI) responses in volunteers orally immunized with the licensed Ty21a typhoid vaccine. In this study we measured Salmonella-specific multifunctional (MF) CD8+ T-cell responses to further investigate...

journal_title：Mucosal immunology

authors： Wahid R,Fresnay S,Levine MM,Sztein MB

更新日期：2015-11-01 00:00:00

abstract：:Malaria-associated acute respiratory distress syndrome (MA-ARDS) and acute lung injury (ALI) are complications that cause lung damage and often leads to death. The MA-ARDS/ALI is associated with a Type 1 inflammatory response mediated by T lymphocytes and IFN-γ. Here, we used the Plasmodium berghei NK65 (PbN)-induced ...

journal_title：Mucosal immunology

authors： Galvão-Filho B,de Castro JT,Figueiredo MM,Rosmaninho CG,Antonelli LRDV,Gazzinelli RT

更新日期：2019-03-01 00:00:00

abstract：:Eosinophilic esophagitis (EoE) is an allergic inflammatory disease of the esophagus featuring increased esophageal interleukin-13 (IL-13) levels and impaired barrier function. Herein, we investigated leucine-rich repeat-containing protein 31 (LRRC31) in human EoE esophageal tissue and IL-13-treated esophageal epitheli...

journal_title：Mucosal immunology

authors： D'Mello RJ,Caldwell JM,Azouz NP,Wen T,Sherrill JD,Hogan SP,Rothenberg ME

更新日期：2016-05-01 00:00:00

abstract：:Cholera is a severe diarrheal disease caused by the bacterium Vibrio cholerae (V. cholerae) that results in 3-4 million cases globally with 100,000-150,000 deaths reported annually. Mostly confined to developing nations, current strategies to control the spread of cholera include the provision of safe drinking water a...

journal_title：Mucosal immunology

authors： Davitt CJH,Longet S,Albutti A,Aversa V,Nordqvist S,Hackett B,McEntee CP,Rosa M,Coulter IS,Lebens M,Tobias J,Holmgren J,Lavelle EC

更新日期：2019-07-01 00:00:00

abstract：:Intestinal epithelial Na+/H+ exchange facilitated by the apical NHE3 (Slc9a3) is a highly regulated process inhibited by intestinal pathogens and in inflammatory bowel diseases. NHE3-/- mice develop spontaneous, bacterially mediated colitis, and IBD-like dysbiosis. Disruption of epithelial Na+/H+ exchange in IBD may t...

journal_title：Mucosal immunology

authors： Harrison CA,Laubitz D,Ohland CL,Midura-Kiela MT,Patil K,Besselsen DG,Jamwal DR,Jobin C,Ghishan FK,Kiela PR

更新日期：2018-09-01 00:00:00

abstract：:Induction of mucosal immunity is critical for protection from enteric pathogens. Heat shock protein gp96 is one of the primary peptide and protein chaperones located in the endoplasmic reticulum. We reported previously that a cell-secreted gp96-Ig fusion protein (gp96-Ig) mediated strong systemic, antigen-specific CD8...

journal_title：Mucosal immunology

authors： Strbo N,Pahwa S,Kolber MA,Gonzalez L,Fisher E,Podack ER

更新日期：2010-03-01 00:00:00

abstract：:Mucus, with its burden of inspired particulates and pathogens, is cleared from mucosal surfaces of the airways by cilia beating within the periciliary layer (PCL). The PCL is held to be "watery" and free of mucus by thixotropic-like forces arising from beating cilia. With radii of gyration ~250 nm, however, polymeric ...

journal_title：Mucosal immunology

authors： Kesimer M,Ehre C,Burns KA,Davis CW,Sheehan JK,Pickles RJ

更新日期：2013-03-01 00:00:00

abstract：:Treatment of post-transplant patients with immunosuppressive drugs targeting the calcineurin-nuclear factor of activated T cells (NFAT) pathway, including cyclosporine A or tacrolimus, is commonly associated with a higher incidence of opportunistic infections, such as Aspergillus fumigatus, which can lead to severe li...

journal_title：Mucosal immunology

authors： Zelante T,Wong AY,Mencarelli A,Foo S,Zolezzi F,Lee B,Poidinger M,Ricciardi-Castagnoli P,Fric J

更新日期：2017-03-01 00:00:00

abstract：:Leptin is an adipocytokine that links nutrition to immunity. Previous observation that a genetic polymorphism in the leptin receptor affected susceptibility to Entamoeba histolytica infection led to the hypothesis that leptin signaling has a protective role during intestinal amebic infection. In this study we show tha...

journal_title：Mucosal immunology

authors： Guo X,Roberts MR,Becker SM,Podd B,Zhang Y,Chua SC Jr,Myers MG Jr,Duggal P,Houpt ER,Petri WA Jr

更新日期：2011-05-01 00:00:00

abstract：:De novo differentiation of CD4(+)Foxp3(+) regulatory T cells (induced (i) Tregs) occurs preferentially in the gut-associated lymphoid tissues (GALT). We addressed the contribution of background genetic factors in affecting the balance of iTreg, T helper type 1 (Th1), and Th17 cell differentiation in GALT in vivo follo...

journal_title：Mucosal immunology

authors： Valatas V,He J,Rivollier A,Kolios G,Kitamura K,Kelsall BL

更新日期：2013-05-01 00:00:00

abstract：:Bacterial-induced intestinal inflammation is crucially dependent on interleukin (IL)-23 and is associated with CD4(+) T helper type 1 (Th1) and Th17 responses. However, the relative contributions of these subsets during the induction and resolution of colitis in T-cell-sufficient hosts remain unknown. We report that H...

journal_title：Mucosal immunology

authors： Morrison PJ,Bending D,Fouser LA,Wright JF,Stockinger B,Cooke A,Kullberg MC

更新日期：2013-11-01 00:00:00

abstract：:Individuals with one atopic disease are far more likely to develop a second. Approximately half of all atopic dermatitis (AD) patients subsequently develop asthma, particularly those with severe AD. This association, suggesting a role for AD as an entry point for subsequent allergic disease, is a phenomenon known as t...

journal_title：Mucosal immunology

authors： Han H,Xu W,Headley MB,Jessup HK,Lee KS,Omori M,Comeau MR,Marshak-Rothstein A,Ziegler SF

更新日期：2012-05-01 00:00:00

abstract：:Innate lymphoid cells (ILCs) have stormed onto the immune landscape as "newly discovered" cell types. These tissue-resident sentinels are enriched at mucosal surfaces and engage in complex cross talk with elements of the adaptive immune system and microenvironment to orchestrate immune homeostasis. Many parallels exis...

journal_title：Mucosal immunology

authors： Almeida FF,Belz GT

更新日期：2016-09-01 00:00:00

abstract：:Celiac disease is a multifactorial disorder and provides a privileged model to decipher how the interplay between environmental and genetic factors can alter mucosal tolerance to a food antigen, lead to chronic intestinal inflammation, and ultimately promote T-cell lymphomagenesis. Here we summarize how HLA-DQ2/8 mole...

journal_title：Mucosal immunology

authors： Meresse B,Ripoche J,Heyman M,Cerf-Bensussan N

更新日期：2009-01-01 00:00:00

abstract：:FoxP3+ regulatory T cells (Tregs) control inflammation and maintain mucosal homeostasis, but their functions during infection are poorly understood. Th1, Th2, and Th17 cells can be identified by master transcription factors (TFs) T-bet, GATA3, and RORγT; Tregs also express these TFs. While T-bet+ Tregs can selectively...

journal_title：Mucosal immunology

authors： Clay SL,Bravo-Blas A,Wall DM,MacLeod MKL,Milling SWF

更新日期：2020-11-01 00:00:00

abstract：:Post influenza bacterial pneumonia is associated with significant mortality and morbidity. Dendritic cells (DCs) play a crucial role in host defense against bacterial pneumonia, but their contribution to post influenza-susceptibility to secondary bacterial pneumonia is incompletely understood. WT and CCR2-/- mice were...

journal_title：Mucosal immunology

authors： Gurczynski SJ,Nathani N,Warheit-Niemi HI,Hult EM,Podsiad A,Deng J,Zemans RL,Bhan U,Moore BB

更新日期：2019-03-01 00:00:00

abstract：:Celiac disease is caused by inflammatory T-cell responses against the insoluble dietary protein gliadin. We have shown that, in humanized mice, oral tolerance to deamidated chymotrypsin-digested gliadin (CT-TG2-gliadin) is driven by tolerogenic interferon (IFN)-γ- and interleukin (IL)-10-secreting type 1 regulatory T-...

journal_title：Mucosal immunology

authors： van Leeuwen MA,Costes LMM,van Berkel LA,Simons-Oosterhuis Y,du Pré MF,Kozijn AE,Raatgeep HC,Lindenbergh-Kortleve DJ,van Rooijen N,Koning F,Samsom JN

更新日期：2017-05-01 00:00:00

abstract：:The gut mucosa is an important site of HIV immunopathogenesis with severe depletion of CD4+ T cells occurring during acute infection. The effect of prolonged anti-retroviral therapy (ART) on cycling and restoration of T lymphocytes in the gut remains unclear. Colon and terminal ileal biopsies and peripheral blood samp...

journal_title：Mucosal immunology

authors： Ciccone EJ,Read SW,Mannon PJ,Yao MD,Hodge JN,Dewar R,Chairez CL,Proschan MA,Kovacs JA,Sereti I

更新日期：2010-03-01 00:00:00

abstract：:Leukotriene B4 receptor 1 (BLT1) triggers the migration of granulocytes and activated T cells; however, its role in B-cell function remains unclear. Here we report that BLT1 is required to induce the production of antigen-specific IgA against oral vaccine through mediating innate immune signals from commensal bacteria...

journal_title：Mucosal immunology

authors： Nagatake T,Hirata SI,Koga T,Kuroda E,Kobari S,Suzuki H,Hosomi K,Matsumoto N,Yanrismet Y,Shimojou M,Morimoto S,Sasaki F,Ishii KJ,Yokomizo T,Kunisawa J

更新日期：2019-09-01 00:00:00

abstract：:The extent to which tissue-specific viral infections generate memory T cells specifically adapted to and maintained within the target infection site is unknown. Here, we show that respiratory virus-specific memory T cells in mice and humans are generated and maintained in compartmentalized niches in lungs, distinct fr...

journal_title：Mucosal immunology

authors： Turner DL,Bickham KL,Thome JJ,Kim CY,D'Ovidio F,Wherry EJ,Farber DL

更新日期：2014-05-01 00:00:00

abstract：:Women with asymptomatic Neisseria gonorrhoeae infection are at risk of developing pelvic inflammatory disease (PID) if the bacteria ascend from the endocervix into the uterus and oviducts. Factors that affect disease severity, ranging from mild discomfort to severe inflammation, pain, and infertility, remain elusive. ...

journal_title：Mucosal immunology

authors： Islam EA,Shaik-Dasthagirisaheb Y,Kaushic C,Wetzler LM,Gray-Owen SD

更新日期：2016-07-01 00:00:00

abstract：:Cigarette smoke has been associated with susceptibility to different pulmonary and airway diseases. Impaired alveolar macrophages (AMs) that are major phagocytes in the lung have been associated with patients with airway diseases and active smokers. In the current report, we show that exposure to second-hand cigarette...

journal_title：Mucosal immunology

authors： Subramaniam R,Mukherjee S,Chen H,Keshava S,Neuenschwander P,Shams H

更新日期：2016-07-01 00:00:00

abstract：:T helper type (Th17) cytokines such as interleukin (IL)-17A and IL-22 are important in maintaining mucosal barrier function and may be important in the pathogenesis of inflammatory bowel diseases (IBDs). Here, we analyzed cells from the colon of IBD patients and show that Crohn's disease (CD) patients had significantl...

journal_title：Mucosal immunology

authors： Leung JM,Davenport M,Wolff MJ,Wiens KE,Abidi WM,Poles MA,Cho I,Ullman T,Mayer L,Loke P

更新日期：2014-01-01 00:00:00

abstract：:The mucosal immune system is charged with defending the host's vast interfaces with the outside world from the enormous and diverse group of microbes that colonizes these surfaces. A key means by which the mucosal immune system protects the host from such diverse microbes is using germ-line-encoded receptors that targ...

journal_title：Mucosal immunology

authors： Vijay-Kumar M,Gewirtz AT

更新日期：2009-05-01 00:00:00

abstract：:Accumulating evidence implicates defective innate immunity in the pathogenesis of Crohn's disease (CD). Ineffectual NOD2 (nucleotide-binding oligomerization domain 2) is the most common susceptibility gene contributing to CD. Vitamin D (vD), a potent modulator of innate and adaptive immunity, induces NOD2 gene express...

journal_title：Mucosal immunology

authors： Dionne S,Calderon MR,White JH,Memari B,Elimrani I,Adelson B,Piccirillo C,Seidman EG

更新日期：2014-11-01 00:00:00

abstract：:Nedd4 family interacting protein 1 (Ndfip1) is an adaptor protein that regulates Itch, an E3 ubiquitin ligase that ubiquitylates JunB, thereby preventing interleukin (IL)-4 and IL-5 production. Mice lacking Ndfip1 or Itch develop T helper type 2 (T(H)2)-mediated inflammation in the skin and lungs and die prematurely. ...

journal_title：Mucosal immunology

authors： Ramon HE,Riling CR,Bradfield J,Yang B,Hakonarson H,Oliver PM

更新日期：2011-05-01 00:00:00

abstract：:Beryllium exposure results in beryllium hypersensitivity in a subset of exposed individuals, leading to granulomatous inflammation and fibrosis in the lung. In addition to its antigenic properties, beryllium has potent adjuvant activity that contributes to sensitization via unknown pathways. Here we show that berylliu...

journal_title：Mucosal immunology

authors： McKee AS,Mack DG,Crawford F,Fontenot AP

更新日期：2015-11-01 00:00:00